KEGG ORTHOLOGY: K05429

ORTHOLOGY: K05429

Entry

K05429                      KO

Symbol

IL2

Name

interleukin 2

Pathway

map04060

Cytokine-cytokine receptor interaction

map04061

Viral protein interaction with cytokine and cytokine receptor

map04151

PI3K-Akt signaling pathway

map04625

C-type lectin receptor signaling pathway

map04630

JAK-STAT signaling pathway

map04658

Th1 and Th2 cell differentiation

map04659

Th17 cell differentiation

map04660

T cell receptor signaling pathway

map04672

Intestinal immune network for IgA production

map04940

Type I diabetes mellitus

map05135

Yersinia infection

map05142

Chagas disease

map05162

Measles

map05166

Human T-cell leukemia virus 1 infection

map05171

Coronavirus disease - COVID-19

map05200

Pathways in cancer

map05320

Autoimmune thyroid disease

map05321

Inflammatory bowel disease

map05330

Allograft rejection

map05332

Graft-versus-host disease

Disease

H00084

Graft-versus-host disease

H00408

Type 1 diabetes mellitus

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    K05429  IL2; interleukin 2
   04151 PI3K-Akt signaling pathway
    K05429  IL2; interleukin 2
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K05429  IL2; interleukin 2
   04061 Viral protein interaction with cytokine and cytokine receptor
    K05429  IL2; interleukin 2
09150 Organismal Systems
  09151 Immune system
   04625 C-type lectin receptor signaling pathway
    K05429  IL2; interleukin 2
   04660 T cell receptor signaling pathway
    K05429  IL2; interleukin 2
   04658 Th1 and Th2 cell differentiation
    K05429  IL2; interleukin 2
   04659 Th17 cell differentiation
    K05429  IL2; interleukin 2
   04672 Intestinal immune network for IgA production
    K05429  IL2; interleukin 2
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K05429  IL2; interleukin 2
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K05429  IL2; interleukin 2
   05171 Coronavirus disease - COVID-19
    K05429  IL2; interleukin 2
   05162 Measles
    K05429  IL2; interleukin 2
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    K05429  IL2; interleukin 2
  09174 Infectious disease: parasitic
   05142 Chagas disease
    K05429  IL2; interleukin 2
  09163 Immune disease
   05320 Autoimmune thyroid disease
    K05429  IL2; interleukin 2
   05321 Inflammatory bowel disease
    K05429  IL2; interleukin 2
   05330 Allograft rejection
    K05429  IL2; interleukin 2
   05332 Graft-versus-host disease
    K05429  IL2; interleukin 2
  09167 Endocrine and metabolic disease
   04940 Type I diabetes mellitus
    K05429  IL2; interleukin 2
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides
    K05429  IL2; interleukin 2
   00536 Glycosaminoglycan binding proteins
    K05429  IL2; interleukin 2
Cytokines and neuropeptides [BR:ko04052]
Cytokines
  Interleukins
   K05429  IL2; interleukin 2
Glycosaminoglycan binding proteins [BR:ko00536]
Heparan sulfate / Heparin
  Cytokines
   K05429  IL2; interleukin 2

Other DBs

GO:

0005134

Genes

HSA:

3558(IL2)

PTR:	461472(IL2)

PPS:	100984780(IL2)

GGO:	101132394(IL2)

PON:	100455248(IL2)

PPYG:

129034997(IL2)

NLE:	100591126(IL2)

HMH:	116479944(IL2)

SSYN:

129480656(IL2)

MCC:	708017(IL2)

MCF:	102129830(IL2)

MTHB:

126955754

MNI:	105486135(IL2)

CSAB:

103236209(IL2)

CATY:

105595801(IL2)

PANU:

100126754(IL2)

TGE:	112624904(IL2)

MLEU:

105538406(IL2)

RRO:	104661748(IL2)

RBB:	108515581(IL2)

TFN:	117084792(IL2)

PTEH:

111546287(IL2)

CANG:

105516414(IL2)

CJC:	100386848(IL2)

SBQ:	101028427(IL2)

CIMI:

108297648(IL2)

ANAN:

105731298(IL2)

CSYR:

103270878(IL2)

MMUR:

105882081(IL2)

LCAT:

123637712(IL2)

PCOQ:

105815260(IL2)

OGA:	100942002(IL2)

MMU:	16183(Il2)

MCAL:

110291180(Il2)

MPAH:

110320556(Il2)

RNO:	116562(Il2)

MCOC:

116094798(Il2)

ANU:	117707066(Il2)

ASYL:

127682390(Il2)

MUN:	110545874(Il2) 110560079

CGE:	100755773(Il2)

MAUA:

101835410(Il2)

PROB:

127223186(Il2)

PLEU:

114707177(Il2)

MORG:

121452714(Il2)

MFOT:

126499332

AAMP:

119825919(Il2)

NGI:	103746951(Il2)

HGL:	101720581(Il2)

CPOC:

100379540(Il2)

CCAN:

109691916(Il2)

DORD:

105989886(Il2)

DSP:	122119081(Il2)

DMER:

138826807(Il2)

PLOP:

125341318(Il2)

NCAR:

124994815

MMMA:

107136571(Il2)

ITI:	101967608(Il2)

OCU:	100302458(IL2)

OPI:	101519556(IL2)

TUP:	102478615(IL2)

GVR:	103593609(IL2)

CFA:	403989(IL2)

CLUD:

112642744(IL2)

VVP:	112933619(IL2)

VLG:	121492803(IL2)

NPO:	129504325(IL2)

AML:	100480862(IL2)

UMR:	103661804(IL2)

UAH:	113255635(IL2)

UAR:	123793114(IL2)

ELK:

111154869

LLV:

125093350

MPUF:

101674110(IL2)

MNP:	132014406(IL2)

MLK:	131828386(IL2)

NVS:	122890130(IL2)

ORO:	101386196(IL2)

EJU:	114208234(IL2)

ZCA:	113925933(IL2)

MLX:	118022354(IL2)

NSU:	110573034(IL2)

LWW:	102742200(IL2)

FCA:	751114(IL2)

PYU:	121030128(IL2)

PCOO:

112858002(IL2)

PBG:	122476434(IL2)

PVIV:

125164688(IL2)

LRUF:

124520662

LGF:	123592954(IL2)

AJU:

106977102

PTG:	102957506(IL2)

PPAD:

109248906(IL2)

PUC:

125923086

PLEZ:

122217892(IL2)

HHV:	120238026(IL2)

BTA:	280822(IL2)

BOM:	102272426(IL2)

BIU:	109571028(IL2)

BBUB:

102395421(IL2)

BBIS:

105003236(IL2)

CHX:	102183089(IL2)

OAS:	443401(IL2)

BTAX:

128062529(IL2)

CSUM:

138093855(IL2)

ODA:	120870984(IL2)

CCAD:

122453281(IL2)

MREE:

136145870(IL2)

OVR:	110130303(IL2)

MBEZ:

129542297(IL2)

SSC:	396868(IL2)

CFR:	102514894(IL2)

CBAI:

105067115(IL2)

CDK:	105093664(IL2)

VPC:	102532988(IL2)

BACU:

103017896(IL2)

BMUS:

118895628(IL2)

LVE:	103071508(IL2)

OOR:	101274648(IL2)

LALB:

132519498(IL2)

GMF:	115857330(IL2)

DDP:	132425596(IL2)

DLE:	111186150(IL2)

PCAD:

102990654(IL2)

PSIU:

116754231(IL2)

PPHC:

136123467(IL2)

NASI:

112399755(IL2)

ECB:	100034204(IL2)

EPZ:	103557874(IL2)

EAI:	106834088(IL2)

MYB:	102246940(IL2)

MYD:	102773629(IL2)

MMYO:

118658725(IL2)

MLF:	102433200(IL2)

MDT:	132234311(IL2)

MYUM:

139011700(IL2)

PKL:	118711847(IL2)

EFUS:

103287584(IL2)

MNA:	107529760(IL2)

DRO:	112312503(IL2)

SHON:

118995277(IL2)

AJM:	119037638(IL2)

PDIC:

114502552(IL2)

PHAS:

123814106(IL2)

MMF:	118643998(IL2)

PPAM:

129061444(IL2)

HAI:	109395924(IL2)

RFQ:	117038186(IL2)

PALE:

102895516(IL2)

PGIG:

120616276(IL2)

PVP:	105302208(IL2)

RAY:	107505383(IL2)

MJV:	108383567(IL2)

TOD:	119233628(IL2)

SARA:

101556429(IL2)

SFUM:

130042363(IL2)

SETR:

126004457(IL2)

LAV:	100656398(IL2)

TMU:

101360180

ETF:	101658181(IL2)

DNM:	101413757(IL2)

MDO:	100619184(IL2)

GAS:	123251137(IL2)

SHR:

100935068

AFZ:

127541142

PCW:

110223001

TVP:	118852823(IL2)

PBRV:

138174507(IL2)

TACU:

119947609

GGA:	373958(IL2)

PCOC:

116231224

MGP:

100303688

LMUT:

125692515

APLA:

101794925(IL-2)

ACYG:

125184558

ATRC:

139602464

FAB:	101807567(IL2)

CBRC:

CCRI:

TALA:

HALD:

HLE:

AGEN:

AFOR:

GSTE:

CLV:

PGUU:

TEO:

ASAO:

Reference

PMID:6312994

Authors

Maeda S, Nishino N, Obaru K, Mita S, Nomiyama H, Shimada K, Fujimoto K, Teranishi T, Hirano T, Onoue K

Title

Cloning of interleukin 2 mRNAs from human tonsils.

Journal

Biochem Biophys Res Commun 115:1040-7 (1983)
DOI:10.1016/S0006-291X(83)80040-0

Sequence

[hsa:3558]

LinkDB

ORTHOLOGY: K05434

Entry

K05434                      KO

Symbol

IL21

Name

interleukin 21

Pathway

map04060

Cytokine-cytokine receptor interaction

map04630

JAK-STAT signaling pathway

map04659

Th17 cell differentiation

map05321

Inflammatory bowel disease

Disease

H00088

Common variable immunodeficiency

H00408

Type 1 diabetes mellitus

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    K05434  IL21; interleukin 21
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K05434  IL21; interleukin 21
09150 Organismal Systems
  09151 Immune system
   04659 Th17 cell differentiation
    K05434  IL21; interleukin 21
09160 Human Diseases
  09163 Immune disease
   05321 Inflammatory bowel disease
    K05434  IL21; interleukin 21
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides
    K05434  IL21; interleukin 21
Cytokines and neuropeptides [BR:ko04052]
Cytokines
  Interleukins
   K05434  IL21; interleukin 21

Other DBs

GO:

0001531

Genes

HSA:	59067(IL21)

PTR:	471295(IL21)

PPS:	100984436(IL21)

GGO:	101133146(IL21)

PON:	100455621(IL21)

PPYG:

129035001(IL21)

NLE:	100591664(IL21)

HMH:	116479950(IL21)

SSYN:

129480655(IL21)

MCC:	708125(IL21)

MCF:	102130762(IL21)

MTHB:

126955752

MNI:	105486137(IL21)

CSAB:

103236210(IL21)

CATY:

105595800(IL21)

PANU:

101001633(IL21)

TGE:	112625044(IL21)

MLEU:

105538405(IL21)

RRO:	104661749(IL21)

RBB:	108515583(IL21)

TFN:	117085868(IL21) 117089946

PTEH:

111546235(IL21)

CANG:

105516416(IL21)

CJC:	100386141(IL21)

SBQ:	101029390(IL21)

CIMI:

108304183(IL21)

ANAN:

105731299(IL21)

CSYR:

103270877(IL21)

MMUR:

105882101(IL21)

LCAT:

123637711(IL21)

PCOQ:

105815254(IL21)

OGA:	100953479(IL21)

MMU:	60505(Il21)

MCAL:

110291773(Il21)

MPAH:

110320935(Il21)

RNO:	365769(Il21)

MCOC:

116094799(Il21)

ANU:	117707876(Il21)

ASYL:

127683402(Il21)

MUN:	110545880(Il21)

CGE:	100755479(Il21)

MAUA:

101835151(Il21)

PROB:

127223185(Il21)

PLEU:

114707173(Il21)

MFOT:

126499171

AAMP:

119826008(Il21)

NGI:	103746950(Il21)

HGL:	101720915(Il21)

CPOC:

100726049(Il21)

CCAN:

109692012(Il21)

DORD:

105989887(Il21)

DSP:	122119074(Il21)

DMER:

138826808(Il21)

PLOP:

125341319(Il21)

NCAR:

124995016

MMMA:

107136742(Il21)

ITI:	101967894(Il21)

OCU:

100344172

OPI:	101519804(IL21)

TUP:	102478178(IL21)

GVR:	103605901(IL21)

CFA:	442935(IL21)

CLUD:

112642745(IL21)

VVP:	112933640(IL21)

VLG:	121492720(IL21)

NPO:	129504327(IL21)

AML:	100480614(IL21)

UMR:	103661805(IL21)

UAH:	113255465(IL21)

UAR:	123793113(IL21)

ELK:

111157589

LLV:

125094288

MPUF:

101672961(IL21)

MNP:	132014411(IL21)

MLK:	131828323(IL21)

NVS:	122890127(IL21)

ORO:	101385902(IL21)

EJU:	114208150(IL21)

ZCA:	113925935(IL21)

MLX:	118022355(IL21)

NSU:	110573033(IL21)

LWW:	102741895(IL21)

FCA:	101087399(IL21)

PYU:	121030102(IL21)

PCOO:

112858959(IL21)

PBG:	122476407(IL21)

PVIV:

125163952(IL21)

LRUF:

124520056

LGF:	123592904(IL21)

AJU:

106977093

PTG:	102956388(IL21)

PPAD:

109248912(IL21)

PUC:

125923088

PLEZ:

122217889(IL21)

HHV:	120238023(IL21)

BTA:	378475(IL21)

BOM:	102285740(IL21)

BIU:	109571034(IL21)

BBUB:

102395107(IL21)

BBIS:

105003235(IL21)

CHX:	100861248(IL21)

OAS:	100862657(IL21)

BTAX:

128062628(IL21)

CSUM:

138094144(IL21)

ODA:	120870983(IL21)

CCAD:

122453225(IL21)

MREE:

136146113(IL21)

OVR:	110130304(IL21)

SSC:	403123(IL21)

CFR:	102515160(IL21)

CBAI:

105067114(IL21)

CDK:	105093665(IL21)

VPC:	102532752(IL21)

BACU:

103017608(IL21)

BMUS:

118895936(IL21)

LVE:

103084127

OOR:	101274894(IL21)

LALB:

132519139(IL21)

DDP:	132426332(IL21)

DLE:	111186103(IL21)

PCAD:

102990393(IL21)

PSIU:

116754430(IL21)

PPHC:

136123550(IL21)

NASI:

112399791(IL21)

ECB:	100063803(IL21)

EPZ:	103557875(IL21)

EAI:	106834089(IL21)

MYB:	102261365(IL21)

MYD:	102763101(IL21)

MMYO:

118657777(IL21)

MLF:	102424235(IL21)

MDT:	132234310(IL21)

MYUM:

139011701(IL21)

PKL:	118711371(IL21)

EFUS:

103287593(IL21)

MNA:	107529740(IL21)

DRO:	112312207(IL21)

SHON:

118995486(IL21)

AJM:	119037587(IL21)

PDIC:

114502310(IL21)

PHAS:

123813968(IL21)

MMF:	118616396(IL21)

PPAM:

129061440(IL21)

HAI:	109374209(IL21)

RFQ:	117038214(IL21)

PALE:

102895772(IL21)

PGIG:

120616223(IL21)

PVP:	105302207(IL21)

RAY:	107505384(IL21)

MJV:	108383569(IL21)

SARA:

101556153(IL21)

SFUM:

130042380(IL21)

SETR:

126004456(IL21)

LAV:	100656684(IL21)

TMU:

101360445

ETF:	101658502(IL21)

DNM:	101412897(IL21)

GAS:	123251789(IL21)

SHR:	105751011(IL21)

PCW:	110222957(IL21)

TVP:	118854401(IL21)

PBRV:

138174506(IL21)

GGA:	554218(IL21)

PCOC:

116231223(IL21)

MGP:	100550694(IL21)

CJO:	107313576(IL21)

TPAI:

128080442(IL21)

LMUT:

125692517(IL21)

APLA:

101794729(IL21)

ACYG:

106042431(IL21)

CATA:

118251285(IL21)

AFUL:

116488605(IL21)

TGU:	100223945(IL21)

OTC:	121339806(IL21)

PRUF:

121361518(IL21)

ATRC:

139602456(IL21)

GFR:	102035531(IL21)

FAB:	101807374(IL21)

OMA:	130252451(IL21)

CCW:	104693711(IL21)

ACOE:

138109359(IL21)

ETL:	114061103(IL21)

ZAB:	102068084(IL21)

ZLE:	135447376(IL21)

ACHL:

103811311(IL21)

MMEA:

130579952(IL21)

HRT:	120753326(IL21)

SATI:

136360847(IL21)

CCIC:

134044450(IL21)

NNT:	104403184(IL21)

SHAB:

115605331(IL21)

ACUN:

113479458(IL21)

TALA:

104359389(IL21)

ACHC:

121233533

HLE:	104836858(IL21)

HHAR:

128152357(IL21)

CSTI:

104563560(IL21)

LDI:	104346777(IL21)

MNB:	103769140(IL21)

PPUS:

135178990(IL21)

AVIT:

104272489(IL21)

BRHI:

104495931(IL21)

NNI:	104019142(IL21)

PCAO:

104053719(IL21)

CBOY:

140652529(IL21)

CLV:	102091768(IL21)

CNIC:

135988768(IL21)

MUI:	104544006(IL21)

PGUU:

104461077(IL21)

EHS:	104505967(IL21)

CMAC:

104479983(IL21)

TEO:	104375917(IL21)

ACAR:

104531726(IL21)

RTD:	128910476(IL21)

CRID:

134516519(IL21)

LMIC:

141743340(IL21)

AAM:	106491934(IL21)

AROW:

112973516(IL21)

DNE:	112996766(IL21)

AMJ:	109284804(IL21)

CMY:	122465509(IL21)

CCAY:

125635467(IL21)

DCC:	122459805(IL21)

MRV:	120406761(IL21)

PVT:	110072830(IL21)

XTR:	100145684(il21)

DTC:	141086196(IL21)

DRE:	100150203(il21)

SRX:	107729329 107731359

SANH:

107662181 107704638

SGH:

107552337

CCAR:

109093595

CAUA:

113091917(il21)

CGIB:

127971546 128027725

PTET:

122357358(il21)

LROH:

127175890(il21)

GRF:	141287900(il21)

OMC:	131553538(il21)

PPRM:

120465341(il21)

RKG:	130072089(il21)

MAMB:

125266853(il21)

CIDE:

127494858

CERY:

137018681(il21)

MASI:

127413408

TROS:

130563731(il21) 130563732

TDW:	130438465(il21)

MANU:

129422295(il21)

PDAB:

135752362(il21)

IFU:	128618206(il21)

PHYP:

113530157

SMEO:

124392734(il21)

TFD:	125145654(il21)

TVC:	132856991(il21)

CGAR:

128509032(il21)

NGRA:

132874225(il21)

CMAO:

118811283(il21)

CHAR:

116225273(il21)

SPIL:

134068887(il21)

TRU:	654314(il-21)

CGOB:

115008663

EMAC:

134859937

SLUC:

118495661(il21)

CLUM:

117737872(il21)

CANA:

137794848(il21)

CVE:	137868486(il21) 137885121(il15)

MSAM:

119888863(il21)

SCHU:

122880635(il21)

CUD:	121507833 121516219(il21)

SPUL:

138598720(il21)

LMIX:

132981686(il21)

ALAT:

119007777(il21)

ASTR:

137603114(il21)

MZE:

105940966

ONL:

106098085

OAU:	116322840(il21)

OML:

112151674

EJA:	138210368(il21)

BFRE:

138631524(il21)

SSEN:

122778972(il21)

SSOE:

131472153(il21)

HHIP:

117769011(il21)

HSP:	118111901(il21)

PPLT:

128446488(il21)

SMAU:

118319854(il21)

LCF:	108901512(il21)

SDU:	111232744(il21)

SLAL:

111644669

XGL:	120785577(il21)

HCQ:

109529047

SBIA:

133508704(il21)

PEE:	133407677(il21)

PTAO:

133484895(il21)

BSPL:

114864906

SSCO:

133986300(il21)

SASA:

106604597(IL21A) 106611666(il21)

STRU:

115205151(il21)

OMY:	100653437(il21) 110505089

OGO:	123992418(il21) 124010443

OKI:	109864758 109905248(il21)

OKE:	118383964(il21)

OCLA:

139365994 139391206

SALP:

111968187(il21)

SNH:	120062111(il21)

SFON:

129827260

PKI:	111832813(il15)

AANG:

118232308(il21)

AROT:

135258600(il21)

CCOG:

133131728(il21)

LCM:	102365373(IL21)

SCLV:

120328511

VRI:

117927774

» show all

Reference

PMID:11081504

Authors

Parrish-Novak J, Dillon SR, Nelson A, Hammond A, Sprecher C, Gross JA, Johnston J, Madden K, Xu W, West J, Schrader S, Burkhead S, Heipel M, Brandt C, Kuijper JL, Kramer J, Conklin D, Presnell SR, Berry J, Shiota F, Bort S, Hambly K, Mudri S, Clegg C, Moore M, Grant FJ, Lofton-Day C, Gilbert T, Rayond F, Ching A, Yao L, Smith D, Webster P, Whitmore T, Maurer M, Kaushansky K, Holly RD, Foster D

Title

Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function.

Journal

Nature 408:57-63 (2000)
DOI:10.1038/35040504

Sequence

[hsa:59067]

LinkDB

DBGET integrated database retrieval system