KEGG   PATHWAY: asao04060
Entry
asao04060                   Pathway                                
Name
Cytokine-cytokine receptor interaction - Anolis sagrei ordinatus (Brown anole)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
asao04060  Cytokine-cytokine receptor interaction
asao04060

Organism
Anolis sagrei ordinatus (Brown anole) [GN:asao]
Gene
132760954  BMP4; bone morphogenetic protein 4 [KO:K04662]
132760997  IFNGR1; interferon gamma receptor 1 [KO:K05132]
132761412  TGFB2; transforming growth factor beta-2 proprotein [KO:K13376]
132761916  INHA; inhibin alpha chain [KO:K05500]
132761924  [KO:K05050]
132761925  [KO:K05050]
132762329  IL16; pro-interleukin-16 isoform X1 [KO:K22628]
132762871  IL13RA1; interleukin-13 receptor subunit alpha-1 [KO:K05076]
132762891  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
132763070  CD40LG; CD40 ligand [KO:K03161]
132763140  BMP15; bone morphogenetic protein 15 [KO:K05498]
132763179  EDA; ectodysplasin-A [KO:K05480]
132763195  EDA2R; tumor necrosis factor receptor superfamily member 27 [KO:K05163]
132763652  TNFSF8; tumor necrosis factor ligand superfamily member 8 [KO:K05471]
132763653  TNFSF15; tumor necrosis factor ligand superfamily member 15 isoform X1 [KO:K05478]
132763895  [KO:K12499]
132763896  [KO:K12964]
132764094  IL6R; interleukin-6 receptor subunit alpha [KO:K05055]
132764247  TGFB3; LOW QUALITY PROTEIN: transforming growth factor beta-3 proprotein [KO:K13377]
132764403  [KO:K13376]
132764880  TNFRSF14; tumor necrosis factor receptor superfamily member 14 [KO:K05152]
132764975  TNFRSF9; tumor necrosis factor receptor superfamily member 9 [KO:K05146]
132765010  [KO:K05154]
132765406  [KO:K05414]
132765408  [KO:K05414]
132765409  [KO:K05414]
132765410  [KO:K05414]
132765411  [KO:K05414]
132765412  [KO:K05414]
132765413  [KO:K05414]
132765564  IL12B; interleukin-12 subunit beta [KO:K05425]
132766394  [KO:K16062]
132766408  IL7R; interleukin-7 receptor subunit alpha [KO:K05072]
132766469  [KO:K05414]
132766565  TNFSF14; tumor necrosis factor ligand superfamily member 14 [KO:K05477]
132766598  IL23A; interleukin-23 subunit alpha [KO:K05426]
132766766  [KO:K03156]
132766767  [KO:K03156]
132766768  [KO:K03156]
132766799  IL11RA; interleukin-11 receptor subunit alpha isoform X1 [KO:K05056]
132766802  [KO:K05512]
132766815  CNTFR; ciliary neurotrophic factor receptor subunit alpha isoform X1 [KO:K05059]
132766922  PRLR; prolactin receptor [KO:K05081]
132766937  [KO:K05058]
132766939  [KO:K05057]
132766957  GHR; growth hormone receptor [KO:K05080]
132766967  CCL28; C-C motif chemokine 28 [KO:K05513]
132766996  IL31RA; interleukin-31 receptor subunit alpha [KO:K22630]
132766997  IL6ST; interleukin-6 receptor subunit beta [KO:K05060]
132767057  [KO:K05414]
132767536  [KO:K06454]
132767661  AMHR2; anti-Muellerian hormone type-2 receptor [KO:K04672] [EC:2.7.11.30]
132767728  [KO:K22689]
132767942  [KO:K03158]
132768014  EPOR; erythropoietin receptor [KO:K05079]
132768062  IL27RA; interleukin-27 receptor subunit alpha [KO:K19598]
132768216  GDF11; growth/differentiation factor 11 [KO:K22679]
132768301  ACVRL1; serine/threonine-protein kinase receptor R3 [KO:K13594] [EC:2.7.11.30]
132768303  ACVR1B; activin receptor type-1B [KO:K13567] [EC:2.7.11.30]
132768802  IL17B; interleukin-17B [KO:K05490]
132768866  GDF9; growth/differentiation factor 9 [KO:K22673]
132768900  CXCL14; C-X-C motif chemokine 14 [KO:K10033]
132768947  CSF1R; macrophage colony-stimulating factor 1 receptor isoform X1 [KO:K05090] [EC:2.7.10.1]
132769272  IL17RB; interleukin-17 receptor B [KO:K05165]
132769469  IL17RE; interleukin-17 receptor E [KO:K05168]
132769475  IL17RC; interleukin-17 receptor C [KO:K05166]
132769753  [KO:K05507]
132769854  CCL20; C-C motif chemokine 20 [KO:K14625]
132769950  GDF2; growth/differentiation factor 2 [KO:K05503]
132769979  IL18RAP; interleukin-18 receptor accessory protein [KO:K05174]
132770044  [KO:K05507]
132770061  IL17D; interleukin-17D [KO:K05492]
132770175  NODAL; LOW QUALITY PROTEIN: nodal homolog [KO:K04666]
132770226  CRLF2; cytokine receptor-like factor 2 [KO:K05078]
132770367  IL1RAP; interleukin-1 receptor accessory protein [KO:K04723]
132770457  THPO; thrombopoietin [KO:K06854]
132770503  TNFSF10; tumor necrosis factor ligand superfamily member 10 [KO:K04721]
132771115  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
132771234  BMPR1A; bone morphogenetic protein receptor type-1A [KO:K04673] [EC:2.7.11.30]
132771343  TNFSF11; tumor necrosis factor ligand superfamily member 11 [KO:K05473]
132771391  CXCL12; stromal cell-derived factor 1 [KO:K10031]
132771542  EDAR; tumor necrosis factor receptor superfamily member EDAR [KO:K05162]
132771566  IL18R1; interleukin-18 receptor 1 [KO:K05173]
132771567  IL1RL1; interleukin-1 receptor-like 1 isoform X1 [KO:K05171]
132771568  IL1R1; interleukin-1 receptor type 1 isoform X1 [KO:K04386]
132771569  [KO:K04386]
132771570  IL1R2; interleukin-1 receptor type 2 isoform X1 [KO:K04387]
132771633  [KO:K05066]
132771879  [KO:K05133]
132771883  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
132771884  [KO:K05135]
132771885  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
132772139  TNFRSF19; tumor necrosis factor receptor superfamily member 19 [KO:K05155]
132772296  GDF7; growth/differentiation factor 7 [KO:K20013]
132772303  RELT; tumor necrosis factor receptor superfamily member 19L isoform X1 [KO:K05156]
132772565  TNFRSF6B; tumor necrosis factor receptor superfamily member 6B [KO:K05143]
132772636  [KO:K22667]
132772637  IL10; interleukin-10 [KO:K05443]
132772687  CNTF; ciliary neurotrophic factor [KO:K05420]
132772713  CD40; tumor necrosis factor receptor superfamily member 5 [KO:K03160]
132772749  FASLG; LOW QUALITY PROTEIN: tumor necrosis factor ligand superfamily member 6 [KO:K04389]
132773106  BMP7; bone morphogenetic protein 7 isoform X1 [KO:K16621]
132773230  CLCF1; cardiotrophin-like cytokine factor 1 isoform X1 [KO:K05421]
132773277  GDF5; growth/differentiation factor 5 [KO:K04664]
132773331  NGF; beta-nerve growth factor [KO:K02582]
132773403  IL12RB2; interleukin-12 receptor subunit beta-2 [KO:K05064]
132773471  TNFRSF11A; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 11A [KO:K05147]
132773787  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
132774020  LEPR; leptin receptor [KO:K05062]
132774278  RELL2; RELT-like protein 2 isoform X1 [KO:K26541]
132774305  INHBB; inhibin beta B chain [KO:K22687]
132774576  BMP6; bone morphogenetic protein 6 [KO:K16620]
132774634  PRL; prolactin [KO:K05439]
132774781  [KO:K04388] [EC:2.7.11.30]
132775000  GDF6; growth/differentiation factor 6 [KO:K20012]
132775073  TNFRSF11B; tumor necrosis factor receptor superfamily member 11B [KO:K05148]
132775215  CXCR4; C-X-C chemokine receptor type 4 isoform X1 [KO:K04189]
132775382  IL22; interleukin-22 isoform X1 [KO:K05445]
132775383  [KO:K04687]
132775507  [KO:K10032]
132775509  CXCL9; C-X-C motif chemokine 9 [KO:K12672]
132775576  CCR6; C-C chemokine receptor type 6 [KO:K04181]
132775577  ACVR2A; activin receptor type-2A isoform X1 [KO:K04670] [EC:2.7.11.30]
132775631  IL2RA; interleukin-2 receptor subunit alpha [KO:K05068]
132775770  IL17RA; interleukin-17 receptor A [KO:K05164]
132775906  CSF2RB; cytokine receptor common subunit beta [KO:K04738]
132776061  ACVR1C; activin receptor type-1C [KO:K13568] [EC:2.7.11.30]
132776067  ACVR1; activin receptor type-1 [KO:K04675] [EC:2.7.11.30]
132776327  RELL1; RELT-like protein 1 [KO:K26541]
132776833  IL15; interleukin-15 [KO:K05433]
132776874  [KO:K05429]
132776996  BMPR1B; bone morphogenetic protein receptor type-1B [KO:K13578] [EC:2.7.11.30]
132777050  BMP3; bone morphogenetic protein 3 [KO:K05496]
132777274  [KO:K10032]
132777275  [KO:K10032]
132777309  LEP; leptin [KO:K05424]
132777364  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
132777370  [KO:K05151]
132777451  CXCL16; C-X-C motif chemokine 16 isoform X1 [KO:K10035]
132777497  EPO; erythropoietin [KO:K05437]
132777732  CTF1; cardiotrophin-1 isoform X1 [KO:K24382]
132777787  TNFRSF12A; tumor necrosis factor receptor superfamily member 12A [KO:K05149]
132777951  MSTN; growth/differentiation factor 8 [KO:K05497]
132778158  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
132778418  [KO:K10030]
132778483  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
132778540  INHBA; inhibin beta A chain [KO:K04667]
132778618  [KO:K04180]
132778619  [KO:K04180]
132778628  ACKR4; atypical chemokine receptor 4 [KO:K04186]
132778673  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
132778995  ACVR2B; activin receptor type-2B [KO:K13596] [EC:2.7.11.30]
132779046  [KO:K02583]
132779140  CXCR6; C-X-C chemokine receptor type 6 [KO:K04191]
132779144  IL6; interleukin-6 [KO:K05405]
132779173  TNFSF12; tumor necrosis factor ligand superfamily member 12 [KO:K05474]
132779195  IL25; interleukin-25 [KO:K05493]
132779349  [KO:K24382]
132779395  [KO:K22629]
132779420  BMPR2; bone morphogenetic protein receptor type-2 [KO:K04671] [EC:2.7.11.30]
132779450  CCR7; C-C chemokine receptor type 7 [KO:K04182]
132779454  [KO:K05423]
132779466  [KO:K05438]
132779472  CCR10; C-C chemokine receptor type 10 [KO:K04185]
132779476  [KO:K10030]
132779491  IL11; interleukin-11 [KO:K05417]
132779665  CCR9; C-C chemokine receptor type 9 [KO:K04184]
132779751  [KO:K04179]
132779752  [KO:K04192]
132779754  XCR1; chemokine XC receptor 1 [KO:K04193]
132779755  [KO:K04180]
132780051  TGFB1; transforming growth factor beta-1 proprotein [KO:K13375]
132780062  [KO:K04662]
132780153  [KO:K04188]
132780268  [KO:K21283]
132780284  GDF15; growth/differentiation factor 15 [KO:K05504]
132780302  EBI3; interleukin-27 subunit beta [KO:K24476]
132780304  IL20RB; interleukin-20 receptor subunit beta [KO:K05137]
132780329  ACKR3; atypical chemokine receptor 3 [KO:K04304]
132780375  CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
132780394  [KO:K16622]
132780508  IFNLR1; interferon lambda receptor 1 [KO:K05140]
132780526  [KO:K04188]
132780532  [KO:K22669]
132780542  IL22RA1; interleukin-22 receptor subunit alpha-1 [KO:K05138]
132780778  TNFRSF13B; tumor necrosis factor receptor superfamily member 13B [KO:K05150]
132781027  TNFSF13B; tumor necrosis factor ligand superfamily member 13B [KO:K05476]
132781121  GDF1; embryonic growth/differentiation factor 1 [KO:K05495]
132781138  AMH; muellerian-inhibiting factor [KO:K04665]
132781206  TNFRSF21; tumor necrosis factor receptor superfamily member 21 [KO:K05157]
132781428  BMP2; bone morphogenetic protein 2 [KO:K21283]
132781464  [KO:K21283]
132781481  [KO:K05060]
132781894  IL21R; interleukin-21 receptor [KO:K05075]
132782277  [KO:K05481]
132782337  [KO:K05482]
132782492  [KO:K04722]
132782525  [KO:K05488]
132782531  IL1B; interleukin-1 beta [KO:K04519]
132782644  CXCR5; C-X-C chemokine receptor type 5 [KO:K04190]
132782647  BMP10; bone morphogenetic protein 10 [KO:K22670]
132782665  [KO:K05481]
132782711  [KO:K05483]
132782716  [KO:K05488]
132782758  [KO:K05481]
132782790  [KO:K04666]
132782792  [KO:K05484]
132782804  IL10RA; interleukin-10 receptor subunit alpha isoform X1 [KO:K05134]
132783046  BMP5; bone morphogenetic protein 5 [KO:K04663]
132783071  IL17C; interleukin-17C [KO:K05491]
132783344  [KO:K21083]
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Reference
PMID:21106488
  Authors
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V
  Title
Evolutionary divergence and functions of the human interleukin (IL) gene family.
  Journal
Hum Genomics 5:30-55 (2010)
DOI:10.1186/1479-7364-5-1-30
Reference
PMID:27577879
  Authors
Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA
  Title
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases.
  Journal
J Allergy Clin Immunol 138:984-1010 (2016)
DOI:10.1016/j.jaci.2016.06.033
Reference
PMID:15500860
  Authors
Boulanger MJ, Garcia KC
  Title
Shared cytokine signaling receptors: structural insights from the gp130 system.
  Journal
Adv Protein Chem 68:107-46 (2004)
DOI:10.1016/S0065-3233(04)68004-1
Reference
PMID:16034365
  Authors
Allan SM, Tyrrell PJ, Rothwell NJ
  Title
Interleukin-1 and neuronal injury.
  Journal
Nat Rev Immunol 5:629-40 (2005)
DOI:10.1038/nri1664
Reference
PMID:23847622
  Authors
Lopetuso LR, Chowdhry S, Pizarro TT
  Title
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
  Journal
Front Immunol 4:181 (2013)
DOI:10.3389/fimmu.2013.00181
Reference
PMID:21349428
  Authors
Iwakura Y, Ishigame H, Saijo S, Nakae S
  Title
Functional specialization of interleukin-17 family members.
  Journal
Immunity 34:149-62 (2011)
DOI:10.1016/j.immuni.2011.02.012
Reference
PMID:17530315
  Authors
Fischer P, Hilfiker-Kleiner D
  Title
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
  Journal
Basic Res Cardiol 102:279-97 (2007)
DOI:10.1007/s00395-007-0658-z
Reference
PMID:24381786
  Authors
Richards CD
  Title
The enigmatic cytokine oncostatin m and roles in disease.
  Journal
ISRN Inflamm 2013:512103 (2013)
DOI:10.1155/2013/512103
Reference
PMID:18926762
  Authors
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W
  Title
Structures and biological functions of IL-31 and IL-31 receptors.
  Journal
Cytokine Growth Factor Rev 19:347-56 (2008)
DOI:10.1016/j.cytogfr.2008.08.003
Reference
PMID:21155715
  Authors
Meenhuis A, Verwijmeren C, Roovers O, Touw IP
  Title
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.
  Journal
Biochem J 434:343-51 (2011)
DOI:10.1042/BJ20101628
Reference
PMID:22410872
  Authors
de Weerd NA, Nguyen T
  Title
The interferons and their receptors--distribution and regulation.
  Journal
Immunol Cell Biol 90:483-91 (2012)
DOI:10.1038/icb.2012.9
Reference
PMID:12949498
  Authors
Aggarwal BB
  Title
Signalling pathways of the TNF superfamily: a double-edged sword.
  Journal
Nat Rev Immunol 3:745-56 (2003)
DOI:10.1038/nri1184
Reference
PMID:12189384
  Authors
Ashkenazi A
  Title
Targeting death and decoy receptors of the tumour-necrosis factor superfamily.
  Journal
Nat Rev Cancer 2:420-30 (2002)
DOI:10.1038/nrc821
Reference
PMID:26115564
  Authors
Seeger P, Musso T, Sozzani S
  Title
The TGF-beta superfamily in dendritic cell biology.
  Journal
Cytokine Growth Factor Rev 26:647-57 (2015)
DOI:10.1016/j.cytogfr.2015.06.002
Reference
PMID:23612460
  Authors
Wakefield LM, Hill CS
  Title
Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer.
  Journal
Nat Rev Cancer 13:328-41 (2013)
DOI:10.1038/nrc3500
Reference
PMID:22710174
  Authors
Mueller TD, Nickel J
  Title
Promiscuity and specificity in BMP receptor activation.
  Journal
FEBS Lett 586:1846-59 (2012)
DOI:10.1016/j.febslet.2012.02.043
KO pathway
ko04060   

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