KEGG   PATHWAY: bta00230
Entry
bta00230                    Pathway                                
Name
Purine metabolism - Bos taurus (cow)
Class
Metabolism; Nucleotide metabolism
Pathway map
bta00230  Purine metabolism
bta00230

Module
bta_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:bta00230]
bta_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:bta00230]
bta_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:bta00230]
bta_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:bta00230]
bta_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:bta00230]
bta_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:bta00230]
bta_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:bta00230]
Other DBs
GO: 0006163 0042278
Organism
Bos taurus (cow) [GN:bta]
Gene
100124505  PDE4B; cAMP-specific 3',5'-cyclic phosphodiesterase 4B [KO:K13293] [EC:3.1.4.53]
100126045  ENTPD2; ectonucleoside triphosphate diphosphohydrolase 2 [KO:K01509] [EC:3.6.1.-]
100296324  URAH; 5-hydroxyisourate hydrolase isoform X1 [KO:K07127] [EC:3.5.2.17]
100849042  PDE7A; high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform X1 [KO:K18436] [EC:3.1.4.53]
102216273  AK6; adenylate kinase isoenzyme 6 [KO:K18532] [EC:2.7.4.3]
104968435  [KO:K00940] [EC:2.7.4.6]
107131388  PDE8B; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X1 [KO:K18437] [EC:3.1.4.53]
112449027  [KO:K12319] [EC:4.6.1.2]
280712  ADA; adenosine deaminase [KO:K01488] [EC:3.5.4.4]
280715  AK1; adenylate kinase isoenzyme 1 [KO:K00939] [EC:2.7.4.3]
280716  AK2; adenylate kinase 2, mitochondrial [KO:K00939] [EC:2.7.4.3]
280960  XDH; xanthine dehydrogenase/oxidase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
281183  GART; trifunctional purine biosynthetic protein adenosine-3 [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
281216  GUCY1A1; guanylate cyclase soluble subunit alpha-1 [KO:K12318] [EC:4.6.1.2]
281217  GUK1; guanylate kinase isoform b [KO:K00942] [EC:2.7.4.8]
281229  HPRT1; hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
281357  NPR2; atrial natriuretic peptide receptor 2 precursor [KO:K12324] [EC:4.6.1.2]
281363  NT5E; 5'-nucleotidase precursor [KO:K19970] [EC:3.1.3.5]
281601  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
281603  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
281613  AK3; GTP:AMP phosphotransferase AK3, mitochondrial [KO:K00944] [EC:2.7.4.10]
281951  NT5C2; cytosolic purine 5'-nucleotidase [KO:K01081] [EC:3.1.3.5]
281969  PDE1A; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A [KO:K13755] [EC:3.1.4.17]
281970  PDE1B; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B [KO:K13755] [EC:3.1.4.17]
281971  PDE2A; cGMP-dependent 3',5'-cyclic phosphodiesterase isoform PDE2A1 [KO:K18283] [EC:3.1.4.17]
281972  PDE5A; cGMP-specific 3',5'-cyclic phosphodiesterase [KO:K13762] [EC:3.1.4.35]
281973  PDE6A; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha [KO:K08718] [EC:3.1.4.35]
281974  PDE6B; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta [KO:K13756] [EC:3.1.4.35]
281975  PDE6C; cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' [KO:K13757] [EC:3.1.4.35]
281976  PDE6D; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta [KO:K13758]
281977  PDE6G; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13759]
281978  PDE6H; retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13760]
282223  ENTPD1; ectonucleoside triphosphate diphosphohydrolase 1 [KO:K01510] [EC:3.6.1.5]
282244  GUCY2C; guanylyl cyclase C precursor [KO:K12320] [EC:4.6.1.2]
282245  GUCY2D; retinal guanylyl cyclase 1 precursor [KO:K12321] [EC:4.6.1.2]
282246  GUCY2F; retinal guanylyl cyclase 2 precursor [KO:K12322] [EC:4.6.1.2]
282433  GUCY1B1; guanylate cyclase soluble subunit beta-1 [KO:K12319] [EC:4.6.1.2]
404170  PAICS; multifunctional protein ADE2 [KO:K01587] [EC:4.1.1.21 6.3.2.6]
404189  NME1; nucleoside diphosphate kinase A 2 [KO:K00940] [EC:2.7.4.6]
493724  PNP; purine nucleoside phosphorylase [KO:K03783] [EC:2.4.2.1]
504248  PRPS1L1; ribose-phosphate pyrophosphokinase 3 [KO:K00948] [EC:2.7.6.1]
504305  IMPDH1; inosine-5'-monophosphate dehydrogenase 1 [KO:K00088] [EC:1.1.1.205]
504439  PAPSS1; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
504454  NT5C1A; cytosolic 5'-nucleotidase 1A [KO:K01081] [EC:3.1.3.5]
504511  AK9; adenylate kinase 9 isoform X2 [KO:K18533] [EC:2.7.4.3 2.7.4.6]
505537  RRM1; ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
505740  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
506061  PDE10A; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X1 [KO:K18438] [EC:3.1.4.17 3.1.4.35]
506087  ENTPD3; ectonucleoside triphosphate diphosphohydrolase 3 [KO:K01510] [EC:3.6.1.5]
506343  ATIC; bifunctional purine biosynthesis protein ATIC [KO:K00602] [EC:2.1.2.3 3.5.4.10]
506787  PDE8A; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A [KO:K18437] [EC:3.1.4.53]
506980  PGM2; phosphopentomutase [KO:K15779] [EC:5.4.2.2 5.4.2.7]
508097  ENTPD6; ectonucleoside triphosphate diphosphohydrolase 6 [KO:K01511] [EC:3.6.1.6]
508167  RRM2; ribonucleoside-diphosphate reductase subunit M2 isoform 1 [KO:K10808] [EC:1.17.4.1]
509282  HDDC2; 5'-deoxynucleotidase HDDC2 [KO:K07023] [EC:3.1.3.89]
509354  NME6; nucleoside diphosphate kinase 6 [KO:K00940] [EC:2.7.4.6]
509652  PPAT; amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
509834  DGUOK; deoxyguanosine kinase, mitochondrial [KO:K00904] [EC:2.7.1.113]
509936  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
510369  [KO:K00760] [EC:2.4.2.8]
510708  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
510949  ADSL; adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
511200  GMPS; GMP synthase [glutamine-hydrolyzing] [KO:K01951] [EC:6.3.5.2]
511269  AK7; adenylate kinase 7 [KO:K00939] [EC:2.7.4.3]
511665  PDE9A; high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X2 [KO:K13761] [EC:3.1.4.35]
511969  IMPDH2; inosine-5'-monophosphate dehydrogenase 2 [KO:K00088] [EC:1.1.1.205]
512222  PDE4A; cAMP-specific 3',5'-cyclic phosphodiesterase 4A [KO:K13293] [EC:3.1.4.53]
512320  NUDT16; U8 snoRNA-decapping enzyme [KO:K16855] [EC:3.6.1.62 3.6.1.64]
512748  AMPD1; AMP deaminase 1 [KO:K01490] [EC:3.5.4.6]
514113  UOX; uricase [KO:K00365] [EC:1.7.3.3]
514185  AMPD2; AMP deaminase 2 [KO:K01490] [EC:3.5.4.6]
515532  ENTPD8; ectonucleoside triphosphate diphosphohydrolase 8 [KO:K01510] [EC:3.6.1.5]
515663  NME3; nucleoside diphosphate kinase 3 precursor [KO:K00940] [EC:2.7.4.6]
515837  GMPR2; GMP reductase 2 [KO:K00364] [EC:1.7.1.7]
517063  AK4; adenylate kinase 4, mitochondrial [KO:K00939] [EC:2.7.4.3]
517589  NUDT9; ADP-ribose pyrophosphatase, mitochondrial precursor [KO:K13988] [EC:3.6.1.13]
518086  CANT1; soluble calcium-activated nucleotidase 1 [KO:K12304] [EC:3.6.1.6]
518364  URAD; 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase [KO:K13485] [EC:4.1.1.97]
519017  APRT; adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
519803  AMPD3; LOW QUALITY PROTEIN: AMP deaminase 3 [KO:K01490] [EC:3.5.4.6]
520318  PFAS; phosphoribosylformylglycinamidine synthase [KO:K01952] [EC:6.3.5.3]
521103  NTPCR; cancer-related nucleoside-triphosphatase homolog [KO:K06928] [EC:3.6.1.15]
521844  ADCY10; adenylate cyclase type 10 isoform X1 [KO:K11265] [EC:4.6.1.1]
522509  PDE7B; cAMP-specific 3',5'-cyclic phosphodiesterase 7B [KO:K18436] [EC:3.1.4.53]
522529  ADSS; adenylosuccinate synthetase isozyme 2 [KO:K01939] [EC:6.3.4.4]
522726  NT5DC4; LOW QUALITY PROTEIN: 5'-nucleotidase domain-containing protein 4 [KO:K01081] [EC:3.1.3.5]
524446  PDE11A; dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A [KO:K13298] [EC:3.1.4.17 3.1.4.35]
524624  PDE4C; cAMP-specific 3',5'-cyclic phosphodiesterase 4C [KO:K13293] [EC:3.1.4.53]
524973  PRUNE1; exopolyphosphatase PRUNE1 [KO:K01514] [EC:3.6.1.11]
525482  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
525937  GDA; guanine deaminase [KO:K01487] [EC:3.5.4.3]
526211  PDE1C; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X6 [KO:K13755] [EC:3.1.4.17]
527380  NT5C1B; cytosolic 5'-nucleotidase 1B [KO:K01081] [EC:3.1.3.5]
528311  ALLC; probable inactive allantoicase [KO:K01477] [EC:3.5.3.4]
528960  RRM2B; ribonucleoside-diphosphate reductase subunit M2 B isoform X2 [KO:K10808] [EC:1.17.4.1]
529405  ENPP3; ectonucleotide pyrophosphatase/phosphodiesterase family member 3 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
530642  DCK; deoxycytidine kinase [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
531411  ENTPD4; ectonucleoside triphosphate diphosphohydrolase 4 [KO:K12305] [EC:3.6.1.6]
531747  [KO:K11265] [EC:4.6.1.1]
532399  NT5C; 5'(3')-deoxyribonucleotidase, cytosolic type [KO:K01081] [EC:3.1.3.5]
533000  GMPR; GMP reductase 1 [KO:K00364] [EC:1.7.1.7]
533048  NPR1; atrial natriuretic peptide receptor 1 precursor [KO:K12323] [EC:4.6.1.2]
533096  ENTPD5; ectonucleoside triphosphate diphosphohydrolase 5 precursor [KO:K01511] [EC:3.6.1.6]
533323  PDE3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B [KO:K13296] [EC:3.1.4.17]
534038  ADPRM; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
534402  PGM1; phosphoglucomutase-1 [KO:K01835] [EC:5.4.2.2]
534611  NME7; nucleoside diphosphate kinase 7 [KO:K00940] [EC:2.7.4.6]
535017  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
535603  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
536409  PAPSS2; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
536636  PDE3A; LOW QUALITY PROTEIN: cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A [KO:K19021] [EC:3.1.4.17]
537649  LACC1; purine nucleoside phosphorylase LACC1 [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
537688  PRPS2; ribose-phosphate pyrophosphokinase 2 [KO:K00948] [EC:2.7.6.1]
538583  ENPP4; bis(5'-adenosyl)-triphosphatase ENPP4 precursor [KO:K18424] [EC:3.6.1.29]
539556  PDE4D; cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X4 [KO:K13293] [EC:3.1.4.53]
613382  HDDC3; guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 [KO:K21138] [EC:3.1.7.2]
613448  AK5; adenylate kinase isoenzyme 5 [KO:K00939] [EC:2.7.4.3]
613600  GUCY1A2; guanylate cyclase soluble subunit alpha-2 [KO:K12318] [EC:4.6.1.2]
613653  ITPA; inosine triphosphate pyrophosphatase [KO:K01519] [EC:3.6.1.66]
614149  NUDT5; ADP-sugar pyrophosphatase [KO:K13987] [EC:3.6.1.13 3.6.1.58 2.7.7.96]
615447  NME2; nucleoside diphosphate kinase B [KO:K00940] [EC:2.7.4.6]
615535  ENPP1; ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
615606  AK8; adenylate kinase 8 [KO:K00939] [EC:2.7.4.3]
616992  NT5M; 5'(3')-deoxyribonucleotidase, mitochondrial [KO:K01081] [EC:3.1.3.5]
617805  ADA2; adenosine deaminase 2 isoform X3 [KO:K19572] [EC:3.5.4.4]
692183  FHIT; bis(5'-adenosyl)-triphosphatase [KO:K01522] [EC:3.6.1.29]
768044  NUDT2; bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] [KO:K01518] [EC:3.6.1.17]
781227  PRPS1; ribose-phosphate pyrophosphokinase 1 [KO:K00948] [EC:2.7.6.1]
783572  ADK; adenosine kinase [KO:K00856] [EC:2.7.1.20]
784089  ADSS1; adenylosuccinate synthetase isozyme 1 [KO:K01939] [EC:6.3.4.4]
788151  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
789324  NME4; nucleoside diphosphate kinase, mitochondrial precursor [KO:K00940] [EC:2.7.4.6]
790312  [KO:K03783] [EC:2.4.2.1]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
bta00030  Pentose phosphate pathway
bta00220  Arginine biosynthesis
bta00250  Alanine, aspartate and glutamate metabolism
bta00260  Glycine, serine and threonine metabolism
bta00340  Histidine metabolism
bta00630  Glyoxylate and dicarboxylate metabolism
bta00730  Thiamine metabolism
bta00740  Riboflavin metabolism
bta00790  Folate biosynthesis
KO pathway
ko00230   

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