Entry Name Osteoclast differentiation - Cercocebus atys (sooty mangabey)
Description The osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways activated by RANK and immune receptors, whose ligands are expressed on the surface of osteoblasts. Signaling from RANK changes gene expression patterns through transcription factors like NFATc1 and characterizes the active osteoclast.
Class Organismal Systems; Development and regenerationBRITE hierarchy
Pathway map Other DBs Organism Cercocebus atys (sooty mangabey) [GN:
caty ]
Gene 105571321 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
105571365 PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
105571369 NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580 ]
105572923 TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403 ]
105578201 TYROBP; TYRO protein tyrosine kinase-binding protein isoform X1 [KO:K07992 ]
105579229 PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
105579958 STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220 ]
105580103 CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870 ]
105580892 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
105581879 NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469 ]
105582175 SIRPA; tyrosine-protein phosphatase non-receptor type substrate 1 isoform X1 [KO:K06551 ]
105583011 TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158 ]
105583616 FHL2; four and a half LIM domains protein 2 isoform X1 [KO:K14380 ]
105584356 RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392 ]
105584542 TNFRSF11B; tumor necrosis factor receptor superfamily member 11B [KO:K05148 ]
105585377 NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332 ]
105585681 MITF; microphthalmia-associated transcription factor isoform X1 [KO:K09455 ]
105585726 ITPR1; LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958 ]
105585799 PPARG; peroxisome proliferator-activated receptor gamma isoform X1 [KO:K08530 ]
105586383 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
105587295 STAT2; signal transducer and activator of transcription 2 [KO:K11221 ]
105587810 TNFSF11; tumor necrosis factor ligand superfamily member 11 isoform X1 [KO:K05473 ]
105588814 TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404 ]
105589236 FCGR2B; low affinity immunoglobulin gamma Fc region receptor II-b isoform X1 [KO:K12560 ]
105589239 FCGR2A; low affinity immunoglobulin gamma Fc region receptor II-a isoform X1 [KO:K06472 ]
105589398 PLCG2; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859 ] [EC:3.1.4.11 ]
105589999 TNFRSF11A; tumor necrosis factor receptor superfamily member 11A isoform X1 [KO:K05147 ]
105592093 TREM2; triggering receptor expressed on myeloid cells 2 [KO:K14378 ]
105593244 ITPR3; LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960 ]
105594352 CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453 ]
105594576 PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649 ]
105595680 OSCAR; LOW QUALITY PROTEIN: osteoclast-associated immunoglobulin-like receptor [KO:K14377 ]
105595688 LILRA5; leukocyte immunoglobulin-like receptor subfamily A member 5 [KO:K06512 ]
105596502 NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446 ]
105597329 PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
105597716 PIK3CA; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
105599262 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
105601409 ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959 ]
105601697 JUND; LOW QUALITY PROTEIN: transcription factor jun-D [KO:K04449 ]
Compound C01245 D-myo-Inositol 1,4,5-trisphosphate
Reference Authors Takayanagi H, Sato K, Takaoka A, Taniguchi T
Title Interplay between interferon and other cytokine systems in bone metabolism.
Journal Reference Authors Takayanagi H
Title New immune connections in osteoclast formation.
Journal Reference Authors Nakashima T, Takayanagi H
Title Osteoimmunology: crosstalk between the immune and bone systems.
Journal Reference Authors Caetano-Lopes J, Canhao H, Fonseca JE
Title Osteoimmunology--the hidden immune regulation of bone.
Journal Reference Authors Lorenzo J, Horowitz M, Choi Y
Title Osteoimmunology: interactions of the bone and immune system.
Journal Reference Authors David JP
Title Osteoimmunology: a view from the bone.
Journal Reference Authors Jimi E, Ghosh S
Title Role of nuclear factor-kappaB in the immune system and bone.
Journal Reference Authors Boyle WJ, Simonet WS, Lacey DL
Title Osteoclast differentiation and activation.
Journal Reference Authors Darnay BG, Besse A, Poblenz AT, Lamothe B, Jacoby JJ
Title TRAFs in RANK signaling.
Journal Reference Authors Baron R
Title Arming the osteoclast.
Journal Reference Authors Takayanagi H
Title Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems.
Journal Reference Authors Krum SA, Chang J, Miranda-Carboni G, Wang CY
Title Novel functions for NFkappaB: inhibition of bone formation.
Journal Reference Authors Lee NK, Choi YG, Baik JY, Han SY, Jeong DW, Bae YS, Kim N, Lee SY
Title A crucial role for reactive oxygen species in RANKL-induced osteoclast differentiation.
Journal Reference Authors Shinohara M, Koga T, Okamoto K, Sakaguchi S, Arai K, Yasuda H, Takai T, Kodama T, Morio T, Geha RS, Kitamura D, Kurosaki T, Ellmeier W, Takayanagi H
Title Tyrosine kinases Btk and Tec regulate osteoclast differentiation by linking RANK and ITAM signals.
Journal Reference Authors Takayanagi H, Kim S, Koga T, Taniguchi T
Title Stat1-mediated cytoplasmic attenuation in osteoimmunology.
Journal Reference Authors Jin W, Chang M, Paul EM, Babu G, Lee AJ, Reiley W, Wright A, Zhang M, You J, Sun SC
Title Deubiquitinating enzyme CYLD negatively regulates RANK signaling and osteoclastogenesis in mice.
Journal Reference Authors Bai S, Kitaura H, Zhao H, Chen J, Muller JM, Schule R, Darnay B, Novack DV, Ross FP, Teitelbaum SL
Title FHL2 inhibits the activated osteoclast in a TRAF6-dependent manner.
Journal Reference Authors Takayanagi H, Kim S, Taniguchi T
Title Signaling crosstalk between RANKL and interferons in osteoclast differentiation.
Journal Related KO pathway
