KEGG   PATHWAY: caty04151
Entry
caty04151                   Pathway                                
Name
PI3K-Akt signaling pathway - Cercocebus atys (sooty mangabey)
Description
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
Class
Environmental Information Processing; Signal transduction
Pathway map
caty04151  PI3K-Akt signaling pathway
caty04151

Other DBs
GO: 0043491
Organism
Cercocebus atys (sooty mangabey) [GN:caty]
Gene
105571321  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
105571343  EIF4E; eukaryotic translation initiation factor 4E isoform X1 [KO:K03259]
105571369  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
105571434  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
105571572  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
105571784  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
105572413  COL4A6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
105572608  PRL; prolactin isoform X1 [KO:K05439]
105572781  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
105572871  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
105572942  IL7; interleukin-7 isoform X1 [KO:K05431]
105572960  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
105573059  CDK6; cyclin-dependent kinase 6 isoform X1 [KO:K02091] [EC:2.7.11.22]
105573290  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
105573294  HSP90B1; endoplasmin [KO:K09487]
105573305  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
105573457  MLST8; target of rapamycin complex subunit LST8 [KO:K08266]
105573530  TSC2; tuberin isoform X1 [KO:K07207]
105573682  LAMB2; laminin subunit beta-2 [KO:K06243]
105573759  MTCP1; protein p13 MTCP-1 [KO:K16837]
105573773  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
105573915  ITGA9; integrin alpha-9 [KO:K06585]
105574042  [KO:K06856]
105574050  [KO:K06856]
105574052  [KO:K06856]
105574060  [KO:K06856]
105574071  [KO:K06856]
105574077  [KO:K06856]
105574081  [KO:K06856]
105574082  [KO:K06856]
105574084  [KO:K06856]
105574099  TNXB; tenascin-X isoform X1 [KO:K06252]
105574100  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
105574105  [KO:K06252]
105574152  THBS1; thrombospondin-1 [KO:K16857]
105574688  FIGF; vascular endothelial growth factor D [KO:K05449]
105574782  IL3RA; LOW QUALITY PROTEIN: interleukin-3 receptor subunit alpha [KO:K04737]
105574942  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105575378  IFNAR1; interferon alpha/beta receptor 1 isoform X1 [KO:K05130]
105575556  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
105575559  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
105575579  IFNAR2; interferon alpha/beta receptor 2 [KO:K05131]
105575714  OSM; oncostatin-M isoform X1 [KO:K05418]
105575761  YWHAH; 14-3-3 protein eta [KO:K16198]
105575817  IL2RB; interleukin-2 receptor subunit beta isoform X1 [KO:K05069]
105575920  [KO:K06856]
105575923  [KO:K06856]
105575925  [KO:K06856]
105576036  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
105576169  LAMC3; laminin subunit gamma-3 [KO:K06247]
105576216  PKN3; serine/threonine-protein kinase N3 isoform X1 [KO:K23692]
105576539  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
105576625  [KO:K06856]
105576626  [KO:K06856]
105576658  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
105576753  SPP1; osteopontin isoform X1 [KO:K06250]
105576757  IBSP; bone sialoprotein 2 [KO:K06253]
105576825  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
105576872  AREG; amphiregulin [KO:K09782]
105576873  EREG; proepiregulin [KO:K09784]
105577041  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform isoform X1 [KO:K11584]
105577076  LAMB3; laminin subunit beta-3 isoform X1 [KO:K06244]
105577130  [KO:K06856]
105577139  [KO:K06856]
105577141  [KO:K06856]
105577142  [KO:K06856]
105577143  [KO:K06856]
105577144  [KO:K06856]
105577151  [KO:K06856]
105577198  HRAS; GTPase HRas isoform X1 [KO:K02833]
105577261  INS; insulin [KO:K04526]
105577264  IGF2; insulin-like growth factor II isoform X1 [KO:K13769]
105577303  FGF3; fibroblast growth factor 3 [KO:K04358]
105577304  FGF4; fibroblast growth factor 4 [KO:K04358]
105577305  FGF19; fibroblast growth factor 19 [KO:K22603]
105577306  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
105577354  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
105577432  RELA; transcription factor p65 isoform X1 [KO:K04735]
105577467  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
105577493  BAD; bcl2-associated agonist of cell death [KO:K02158]
105577498  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
105577528  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
105577543  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
105577720  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
105577731  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
105577985  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
105578100  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
105578227  COL6A3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
105578270  PHLPP2; PH domain leucine-rich repeat-containing protein phosphatase 2 isoform X1 [KO:K16340] [EC:3.1.3.16]
105578338  [KO:K06238]
105578364  COL6A5; collagen alpha-5(VI) chain [KO:K06238]
105578365  COL6A6; LOW QUALITY PROTEIN: collagen alpha-6(VI) chain [KO:K06238]
105579128  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
105579187  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
105579245  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
105579298  LAMA1; laminin subunit alpha-1 isoform X1 [KO:K05637]
105579435  CHAD; chondroadherin [KO:K06248]
105579443  COL1A1; collagen alpha-1(I) chain isoform X1 [KO:K06236]
105579450  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
105579459  NGFR; tumor necrosis factor receptor superfamily member 16 isoform X1 [KO:K02583]
105579462  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
105579553  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
105579566  CSF3; granulocyte colony-stimulating factor isoform X1 [KO:K05423]
105579695  G6PC; glucose-6-phosphatase [KO:K01084] [EC:3.1.3.9]
105579705  BRCA1; breast cancer type 1 susceptibility protein isoform X1 [KO:K10605] [EC:2.3.2.27]
105579756  SYK; tyrosine-protein kinase SYK [KO:K05855] [EC:2.7.10.2]
105579809  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
105579833  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
105579895  ITGA4; integrin alpha-4 isoform X1 [KO:K06483]
105579920  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
105580103  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
105580144  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
105580156  FN1; fibronectin isoform X1 [KO:K05717]
105580164  G6PC2; LOW QUALITY PROTEIN: glucose-6-phosphatase 2 [KO:K01084] [EC:3.1.3.9]
105580236  ITGA5; integrin alpha-5 [KO:K06484]
105580281  LAMC1; LOW QUALITY PROTEIN: laminin subunit gamma-1 [KO:K05635]
105580282  ITGB7; integrin beta-7 isoform X1 [KO:K06590]
105580283  LAMC2; laminin subunit gamma-2 [KO:K06246]
105580323  NR4A1; nuclear receptor subfamily 4 group A member 1 isoform X1 [KO:K04465]
105580434  COL2A1; collagen alpha-1(II) chain isoform X1 [KO:K19719]
105580475  EIF4B; eukaryotic translation initiation factor 4B [KO:K03258]
105580532  RXRA; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
105580685  TLR2; toll-like receptor 2 [KO:K10159]
105580742  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
105580870  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
105580892  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
105581292  PTK2; focal adhesion kinase 1 [KO:K05725] [EC:2.7.10.2]
105581343  FOXO3; forkhead box protein O3 isoform X1 [KO:K09408]
105581392  LAMA4; laminin subunit alpha-4 [KO:K06241]
105581531  [KO:K04546]
105581649  FGF18; fibroblast growth factor 18 isoform X1 [KO:K04358]
105581686  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290]
105581693  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 isoform X1 [KO:K21290]
105581706  EIF4E1B; eukaryotic translation initiation factor 4E type 1B isoform X1 [KO:K03259]
105581716  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
105581776  PIK3AP1; phosphoinositide 3-kinase adapter protein 1 isoform X1 [KO:K12230]
105581830  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
105581863  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
105581939  FGF16; fibroblast growth factor 16 [KO:K04358]
105582199  ANGPT4; angiopoietin-4 isoform X1 [KO:K05467]
105582225  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
105582236  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
105582812  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform [KO:K11584]
105582988  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
105582993  FGF23; fibroblast growth factor 23 [KO:K22428]
105583006  NTF3; neurotrophin-3 isoform X1 [KO:K04356]
105583007  VWF; von Willebrand factor [KO:K03900]
105583023  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
105583036  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
105583130  LAMB4; laminin subunit beta-4 isoform X1 [KO:K06245]
105583134  LAMB1; laminin subunit beta-1 isoform X1 [KO:K05636]
105583147  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1 [KO:K21289] [EC:2.7.1.153]
105583175  RELN; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
105583213  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
105583231  MAGI2; LOW QUALITY PROTEIN: membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 [KO:K05629]
105583339  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
105583415  PRLR; prolactin receptor [KO:K05081]
105583419  IL7R; interleukin-7 receptor subunit alpha [KO:K05072]
105583443  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
105583450  OSMR; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057]
105583464  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
105583480  GHR; growth hormone receptor isoform X1 [KO:K05080]
105583515  FGF10; fibroblast growth factor 10 [KO:K04358]
105583846  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
105583909  LAMA3; laminin subunit alpha-3 isoform X1 [KO:K06240]
105584002  IFNB1; interferon beta [KO:K05415]
105584014  [KO:K02991]
105584100  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
105584243  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
105584325  YWHAE; 14-3-3 protein epsilon isoform X1 [KO:K06630]
105584356  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
105584442  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
105584446  EPO; erythropoietin isoform X1 [KO:K05437]
105584496  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
105584734  NOS3; nitric oxide synthase, endothelial isoform X1 [KO:K13242] [EC:1.14.13.39]
105584756  RHEB; GTP-binding protein Rheb isoform X1 [KO:K07208]
105584909  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
105584910  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
105584999  G6PC3; glucose-6-phosphatase 3 isoform X1 [KO:K01084] [EC:3.1.3.9]
105585038  KRAS; GTPase KRas isoform X1 [KO:K07827]
105585062  GYS2; glycogen [starch] synthase, liver [KO:K00693] [EC:2.4.1.11]
105585139  CDKN1B; cyclin-dependent kinase inhibitor 1B isoform X1 [KO:K06624]
105585282  ITGA2B; integrin alpha-IIb isoform X1 [KO:K06476]
105585286  SGK3; LOW QUALITY PROTEIN: serine/threonine-protein kinase Sgk3 [KO:K13304] [EC:2.7.11.1]
105585335  PCK1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] isoform X1 [KO:K01596] [EC:4.1.1.32]
105585423  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
105585485  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
105585661  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
105585803  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
105586122  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
105586383  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
105586412  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
105586495  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
105586543  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
105586615  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
105586728  SOS2; son of sevenless homolog 2 [KO:K03099]
105586970  COL4A4; collagen alpha-4(IV) chain isoform X1 [KO:K06237]
105586971  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
105586974  IRS1; insulin receptor substrate 1 [KO:K16172]
105587171  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
105587240  CDK4; cyclin-dependent kinase 4 isoform X1 [KO:K02089] [EC:2.7.11.22]
105587314  ERBB3; receptor tyrosine-protein kinase erbB-3 isoform X1 [KO:K05084] [EC:2.7.10.1]
105587320  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
105587332  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
105587538  YWHAQ; 14-3-3 protein theta isoform X1 [KO:K16197]
105587763  LPAR6; lysophosphatidic acid receptor 6 [KO:K04273]
105588213  FGF7; fibroblast growth factor 7 [KO:K04358]
105588269  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
105588384  MYC; myc proto-oncogene protein [KO:K04377]
105588449  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
105588530  SGK2; serine/threonine-protein kinase Sgk2 [KO:K13303] [EC:2.7.11.1]
105588623  RPTOR; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
105588637  RBL2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
105588701  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
105588762  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
105589065  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
105589163  INSR; LOW QUALITY PROTEIN: insulin receptor [KO:K04527] [EC:2.7.10.1]
105589176  COL9A1; collagen alpha-1(IX) chain isoform X1 [KO:K08131]
105589534  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
105589633  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
105589639  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
105589738  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
105589795  ITGB5; integrin beta-5 [KO:K06588]
105589873  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
105589876  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
105590005  PHLPP1; PH domain leucine-rich repeat-containing protein phosphatase 1 [KO:K16340] [EC:3.1.3.16]
105590006  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
105590194  MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 isoform X1 [KO:K02539]
105590243  THEM4; acyl-coenzyme A thioesterase THEM4 isoform X1 [KO:K16339] [EC:3.1.2.2]
105590313  PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [KO:K11583]
105590424  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
105590709  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
105590745  [KO:K05438]
105590746  [KO:K05438]
105590765  [KO:K05438]
105590788  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
105590801  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
105590861  PGF; placenta growth factor isoform X1 [KO:K16859]
105591024  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
105591145  BCL2L11; bcl-2-like protein 11 isoform X1 [KO:K16341]
105591224  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
105591300  TEK; angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
105591326  [KO:K05414]
105591327  IFNA8; interferon alpha-8 [KO:K05414]
105591328  IFNA2; interferon alpha-2 [KO:K05414]
105591330  [KO:K05414]
105591332  [KO:K05414]
105591336  [KO:K05414]
105591337  [KO:K05414]
105591338  [KO:K05414]
105591516  VTN; vitronectin [KO:K06251]
105591568  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform X1 [KO:K11584]
105591628  EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
105591678  FGF22; fibroblast growth factor 22 isoform X1 [KO:K04358]
105591707  STK11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
105591709  EFNA2; ephrin-A2 [KO:K05462]
105591800  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
105591802  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
105591815  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
105591840  NRTN; neurturin [KO:K25414]
105591856  PSPN; persephin [KO:K25416]
105591918  FGF9; fibroblast growth factor 9 [KO:K04358]
105591984  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
105591986  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
105592013  PDGFRA; LOW QUALITY PROTEIN: platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
105592179  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
105592180  GNG11; LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
105592183  COL1A2; collagen alpha-2(I) chain [KO:K06236]
105592375  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
105592376  LAMA5; laminin subunit alpha-5 [KO:K06240]
105592567  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
105592792  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X1 [KO:K09048]
105592859  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
105593380  YWHAG; 14-3-3 protein gamma [KO:K16198]
105593476  CRTC2; CREB-regulated transcription coactivator 2 isoform X1 [KO:K16333]
105593478  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
105593509  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
105593511  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
105593518  EFNA1; ephrin-A1 [KO:K05462]
105593526  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
105593544  IL6R; interleukin-6 receptor subunit alpha [KO:K05055]
105593574  LPAR3; lysophosphatidic acid receptor 3 [KO:K04294]
105593612  PKN2; serine/threonine-protein kinase N2 isoform X1 [KO:K23691]
105594004  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
105594171  TSC1; hamartin isoform X1 [KO:K07206]
105594196  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
105594283  [KO:K06856]
105594352  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
105594434  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
105594539  NTRK1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
105594576  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
105594633  ARTN; artemin [KO:K25415]
105594700  COL9A2; collagen alpha-2(IX) chain isoform X1 [KO:K08131]
105594754  CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
105595256  FGF21; fibroblast growth factor 21 [KO:K22429]
105595268  GYS1; glycogen [starch] synthase, muscle isoform X1 [KO:K00693] [EC:2.4.1.11]
105595271  NTF4; neurotrophin-4 [KO:K12457]
105595290  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
105595383  IL6; interleukin-6 isoform X1 [KO:K05405]
105595396  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
105595544  LPAR1; lysophosphatidic acid receptor 1 isoform X1 [KO:K04289]
105595759  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
105595795  FGF2; fibroblast growth factor 2 [KO:K18497]
105595801  IL2; interleukin-2 [KO:K05429]
105595886  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
105595926  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
105595971  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
105595984  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
105596153  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
105596338  NGF; beta-nerve growth factor isoform X1 [KO:K02582]
105596344  NRAS; GTPase NRas isoform X1 [KO:K07828]
105596650  TCL1B; T-cell leukemia/lymphoma protein 1B [KO:K16836]
105596715  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
105596717  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
105596769  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105596830  KITLG; kit ligand [KO:K05461]
105597013  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
105597061  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
105597064  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
105597205  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
105597303  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
105597428  IL2RA; interleukin-2 receptor subunit alpha isoform X1 [KO:K05068]
105597502  THBS2; thrombospondin-2 isoform X1 [KO:K04659]
105597557  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
105597588  TNR; tenascin-R isoform X1 [KO:K06252]
105597592  TNN; tenascin-N [KO:K06252]
105597716  PIK3CA; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
105597720  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
105597772  VEGFC; vascular endothelial growth factor C [KO:K05449]
105597890  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
105597977  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105598094  ITGA2; integrin alpha-2 isoform X1 [KO:K06481]
105598098  ITGA1; LOW QUALITY PROTEIN: integrin alpha-1 [KO:K06480]
105598130  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
105598233  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
105598447  IL4R; interleukin-4 receptor subunit alpha [KO:K05071]
105598464  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
105598476  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
105598562  CD19; LOW QUALITY PROTEIN: B-lymphocyte antigen CD19 [KO:K06465]
105598850  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
105599017  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
105599189  F2R; proteinase-activated receptor 1 [KO:K03914]
105599262  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
105599275  THBS4; thrombospondin-4 [KO:K04659]
105599331  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
105599419  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
105599438  EPHA2; ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
105599729  IL3; interleukin-3 [KO:K04736]
105599747  IL4; interleukin-4 [KO:K05430]
105599769  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform isoform X1 [KO:K04382] [EC:3.1.3.16]
105599949  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
105599971  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
105600256  PCK2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial isoform X1 [KO:K01596] [EC:4.1.1.32]
105600415  TLR4; toll-like receptor 4 isoform X1 [KO:K10160]
105600417  MYB; transcriptional activator Myb isoform X1 [KO:K09420]
105600428  [KO:K13302] [EC:2.7.11.1]
105600471  LAMA2; LOW QUALITY PROTEIN: laminin subunit alpha-2 [KO:K05637]
105600499  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
105600508  TNC; tenascin isoform X1 [KO:K06252]
105600967  ITGA11; integrin alpha-11 isoform X1 [KO:K06587]
105601141  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
105601165  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
105601381  FGF20; fibroblast growth factor 20 [KO:K04358]
105601446  CDC37; hsp90 co-chaperone Cdc37 [KO:K09554]
105601484  EPOR; erythropoietin receptor [KO:K05079]
105601524  [KO:K04347]
105601587  PKN1; serine/threonine-protein kinase N1 isoform X1 [KO:K06071] [EC:2.7.11.13]
105601679  JAK3; tyrosine-protein kinase JAK3 isoform X1 [KO:K11218] [EC:2.7.10.2]
105601714  COMP; cartilage oligomeric matrix protein [KO:K04659]
105601742  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
Compound
C00020  AMP
C00533  Nitric oxide
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:16847462
  Authors
Engelman JA, Luo J, Cantley LC
  Title
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
  Journal
Nat Rev Genet 7:606-19 (2006)
DOI:10.1038/nrg1879
Reference
PMID:15784165
  Authors
Song G, Ouyang G, Bao S
  Title
The activation of Akt/PKB signaling pathway and cell survival.
  Journal
J Cell Mol Med 9:59-71 (2005)
DOI:10.1111/j.1582-4934.2005.tb00337.x
Reference
PMID:21620960
  Authors
Hers I, Vincent EE, Tavare JM
  Title
Akt signalling in health and disease.
  Journal
Cell Signal 23:1515-27 (2011)
DOI:10.1016/j.cellsig.2011.05.004
Reference
PMID:18842113
  Authors
Duronio V
  Title
The life of a cell: apoptosis regulation by the PI3K/PKB pathway.
  Journal
Biochem J 415:333-44 (2008)
DOI:10.1042/BJ20081056
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
PMID:12660731
  Authors
Koyasu S
  Title
The role of PI3K in immune cells.
  Journal
Nat Immunol 4:313-9 (2003)
DOI:10.1038/ni0403-313
Reference
PMID:12669022
  Authors
Okkenhaug K, Vanhaesebroeck B.
  Title
PI3K in lymphocyte development, differentiation and activation.
  Journal
Nat Rev Immunol 3:317-30 (2003)
DOI:10.1038/nri1056
Reference
PMID:15209374
  Authors
Richardson CJ, Schalm SS, Blenis J
  Title
PI3-kinase and TOR: PIKTORing cell growth.
  Journal
Semin Cell Dev Biol 15:147-59 (2004)
DOI:10.1016/j.semcdb.2003.12.023
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:21779440
  Authors
Georgescu MM
  Title
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
  Journal
Genes Cancer 1:1170-7 (2010)
DOI:10.1177/1947601911407325
Reference
PMID:12531180
  Authors
West KA, Castillo SS, Dennis PA
  Title
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
  Journal
Drug Resist Updat 5:234-48 (2002)
DOI:10.1016/S1368-7646(02)00120-6
Reference
PMID:9838078
  Authors
Wymann MP, Pirola L
  Title
Structure and function of phosphoinositide 3-kinases.
  Journal
Biochim Biophys Acta 1436:127-50 (1998)
DOI:10.1016/S0005-2760(98)00139-8
Reference
PMID:12048182
  Authors
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M
  Title
Regulation of Raf-Akt Cross-talk.
  Journal
J Biol Chem 277:31099-106 (2002)
DOI:10.1074/jbc.M111974200
Reference
PMID:16187290
  Authors
Kikani CK, Dong LQ, Liu F
  Title
"New"-clear functions of PDK1: beyond a master kinase in the cytosol?
  Journal
J Cell Biochem 96:1157-62 (2005)
DOI:10.1002/jcb.20651
Reference
PMID:11357143
  Authors
Blume-Jensen P, Hunter T
  Title
Oncogenic kinase signalling.
  Journal
Nature 411:355-65 (2001)
DOI:10.1038/35077225
Reference
PMID:15505410
  Authors
Osaki M, Oshimura M, Ito H
  Title
PI3K-Akt pathway: its functions and alterations in human cancer.
  Journal
Apoptosis 9:667-76 (2004)
DOI:10.1023/B:APPT.0000045801.15585.dd
Reference
PMID:17360849
  Authors
Noguchi M, Ropars V, Roumestand C, Suizu F
  Title
Proto-oncogene TCL1: more than just a coactivator for Akt.
  Journal
FASEB J 21:2273-84 (2007)
DOI:10.1096/fj.06-7684com
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Related
pathway
caty00010  Glycolysis / Gluconeogenesis
caty04010  MAPK signaling pathway
caty04012  ErbB signaling pathway
caty04062  Chemokine signaling pathway
caty04064  NF-kappa B signaling pathway
caty04068  FoxO signaling pathway
caty04110  Cell cycle
caty04115  p53 signaling pathway
caty04150  mTOR signaling pathway
caty04210  Apoptosis
caty04370  VEGF signaling pathway
caty04510  Focal adhesion
caty04620  Toll-like receptor signaling pathway
caty04630  JAK-STAT signaling pathway
caty04662  B cell receptor signaling pathway
caty04910  Insulin signaling pathway
KO pathway
ko04151   

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