Entry Name mTOR signaling pathway - Castor canadensis (American beaver)
Description The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class Environmental Information Processing; Signal transductionBRITE hierarchy
Pathway map Organism Castor canadensis (American beaver) [GN:
ccan ]
Gene 109674455 Dvl2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353 ]
109681149 Dvl1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353 ]
109681589 Grb2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364 ]
109681900 Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
109682432 Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649 ]
109682791 Tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158 ]
109683436 Mapkap1; target of rapamycin complex 2 subunit MAPKAP1 [KO:K20410 ]
109684064 Eif4b; eukaryotic translation initiation factor 4B isoform X1 [KO:K03258 ]
109684698 Lrp6; LOW QUALITY PROTEIN: low-density lipoprotein receptor-related protein 6 [KO:K03068 ]
109685780 Eif4e1b; eukaryotic translation initiation factor 4E type 1B [KO:K03259 ]
109688332 Rictor; rapamycin-insensitive companion of mTOR isoform X1 [KO:K08267 ]
109688934 Eif4ebp1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205 ]
109689664 Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
109689889 Rptor; regulatory-associated protein of mTOR isoform X1 [KO:K07204 ]
109690139 Telo2; telomere length regulation protein TEL2 homolog isoform X1 [KO:K11137 ]
109690158 Mlst8; target of rapamycin complex subunit LST8 isoform X1 [KO:K08266 ]
109690390 Atp6v1g2; V-type proton ATPase subunit G 2 isoform X1 [KO:K02152 ]
109690419 Deptor; DEP domain-containing mTOR-interacting protein [KO:K20402 ]
109691734 Slc38a9; sodium-coupled neutral amino acid transporter 9 [KO:K14995 ]
109692285 Eif4e2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259 ]
109692804 Fnip2; LOW QUALITY PROTEIN: folliculin-interacting protein 2 [KO:K20401 ]
109693842 Slc3a2; 4F2 cell-surface antigen heavy chain isoform X1 [KO:K06519 ]
109694105 Dvl3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353 ]
109694489 Lamtor4; ragulator complex protein LAMTOR4 isoform X1 [KO:K20399 ]
109694666 Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
109694816 Nprl3; nitrogen permease regulator 3-like protein isoform X1 [KO:K20406 ]
109696641 Atp6v1b2; V-type proton ATPase subunit B, brain isoform [KO:K02147 ]
109696750 Irs1; LOW QUALITY PROTEIN: insulin receptor substrate 1 [KO:K16172 ]
109697377 Atp6v1b1; LOW QUALITY PROTEIN: V-type proton ATPase subunit B, kidney isoform [KO:K02147 ]
109697415 Lamtor3; ragulator complex protein LAMTOR3 isoform X1 [KO:K04370 ]
109700148 Atp6v1e2; LOW QUALITY PROTEIN: V-type proton ATPase subunit E 2 [KO:K02150 ]
109700613 Grb10; growth factor receptor-bound protein 10 isoform X1 [KO:K20064 ]
Compound C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference Authors Kennedy BK, Lamming DW
Title The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
Journal Reference Authors Shimobayashi M, Hall MN
Title Making new contacts: the mTOR network in metabolism and signalling crosstalk.
Journal Reference Authors Huang K, Fingar DC
Title Growing knowledge of the mTOR signaling network.
Journal Reference Authors Bockaert J, Marin P
Title mTOR in Brain Physiology and Pathologies.
Journal Reference Authors Caron A, Richard D, Laplante M
Title The Roles of mTOR Complexes in Lipid Metabolism.
Journal Reference Authors Shimobayashi M, Hall MN
Title Multiple amino acid sensing inputs to mTORC1.
Journal Reference Authors Bar-Peled L, Sabatini DM
Title Regulation of mTORC1 by amino acids.
Journal Reference Authors Fingar DC
Title Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
Journal Reference Authors Cai H, Dong LQ, Liu F
Title Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
Journal Reference Authors Eyre TA, Collins GP, Goldstone AH, Cwynarski K
Title Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
Journal Reference Authors Jewell JL, Guan KL
Title Nutrient signaling to mTOR and cell growth.
Journal Reference Authors Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
Title mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
Journal Reference Authors Kim SG, Buel GR, Blenis J
Title Nutrient regulation of the mTOR complex 1 signaling pathway.
Journal Reference Authors Laplante M, Sabatini DM
Title mTOR signaling at a glance.
Journal Reference Authors Alessi DR, Sakamoto K, Bayascas JR
Title LKB1-dependent signaling pathways.
Journal Reference Authors Dan HC, Antonia RJ, Baldwin AS
Title PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
Journal Reference Authors Saxton RA, Sabatini DM
Title mTOR Signaling in Growth, Metabolism, and Disease.
Journal Related KO pathway
