KEGG   PATHWAY: ccan04010
Entry
ccan04010                   Pathway                                
Name
MAPK signaling pathway - Castor canadensis (American beaver)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
ccan04010  MAPK signaling pathway
ccan04010

Other DBs
GO: 0000165
Organism
Castor canadensis (American beaver) [GN:ccan]
Gene
109681262  Cacna1a; LOW QUALITY PROTEIN: voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
109693749  voltage-dependent N-type calcium channel subunit alpha-1B-like isoform X1 [KO:K04849]
109674812  Cacna1d; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
109680409  Cacna1e; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
109697195  Cacna1f; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
109681484  Cacna1g; LOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1G [KO:K04854]
109690189  voltage-dependent T-type calcium channel subunit alpha-1H-like [KO:K04855]
109692658  Cacna1i; LOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
109696593  voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
109681780  Cacna2d1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
109693218  Cacna2d2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X1 [KO:K04859]
109678616  voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1 [KO:K04860]
109702845  LOW QUALITY PROTEIN: voltage-dependent calcium channel subunit alpha-2/delta-4-like [KO:K04861]
109691957  Cacnb1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
109700367  Cacnb2; voltage-dependent L-type calcium channel subunit beta-2 [KO:K04863]
109695485  Cacnb3; voltage-dependent L-type calcium channel subunit beta-3 [KO:K04864]
109695158  Cacnb4; voltage-dependent L-type calcium channel subunit beta-4 [KO:K04865]
109695684  Cacng1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
109685199  Cacng2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
109683730  Cacng3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
109702646  Cacng4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
109687321  Cacng5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
109693152  Cacng6; voltage-dependent calcium channel gamma-6 subunit isoform X1 [KO:K04871]
109693147  Cacng7; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
109693145  Cacng8; voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
109688706  cAMP-dependent protein kinase catalytic subunit beta-like [KO:K04345] [EC:2.7.11.11]
109681298  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
109688701  cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
109687351  Prkca; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
109683738  Prkcb; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
109693140  Prkcg; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
109683409  Gna12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
109681247  uncharacterized LOC105372280 homolog [KO:K04347]
109698314  Gng12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
109688186  LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like [KO:K04348] [EC:3.1.3.16]
109681777  Ppp3cc; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348] [EC:3.1.3.16]
109682626  Ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
109696247  Ppp3r2; calcineurin subunit B type 2 [KO:K06268]
109693705  Ppp3r1; calcineurin subunit B type 1 [KO:K06268]
109697208  Rasgrf1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
109682292  Rasgrf2; LOW QUALITY PROTEIN: ras-specific guanine nucleotide-releasing factor 2 [KO:K12326]
109699067  Rasgrp1; RAS guanyl-releasing protein 1 [KO:K04350]
109687177  Rasgrp2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
109694257  Rasgrp3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
109695823  Rasgrp4; RAS guanyl-releasing protein 4 isoform X1 [KO:K12363]
109689106  LOW QUALITY PROTEIN: rap guanine nucleotide exchange factor 2-like [KO:K08018]
109685215  Nf1; neurofibromin [KO:K08052]
109694624  Rasa1; ras GTPase-activating protein 1 [KO:K04352]
109690889  Rasa2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
109695156  Rap1a; ras-related protein Rap-1A [KO:K04353]
109699305  ras-related protein Rap-1b [KO:K07836]
109700925  Egf; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
109701504  Tgfa; protransforming growth factor alpha [KO:K08774]
109681117  Ereg; proepiregulin [KO:K09784]
109681114  Areg; amphiregulin [KO:K09782]
109684968  Fgf1; fibroblast growth factor 1 [KO:K18496]
109684969  fibroblast growth factor 1-like [KO:K18496]
109702471  Fgf5; fibroblast growth factor 5 [KO:K04358]
109675851  Fgf9; fibroblast growth factor 9 [KO:K04358]
109695172  Fgf17; fibroblast growth factor 17 isoform X1 [KO:K04358]
109680643  Fgf10; fibroblast growth factor 10 [KO:K04358]
109696354  Fgf4; fibroblast growth factor 4 [KO:K04358]
109696355  Fgf3; fibroblast growth factor 3 [KO:K04358]
109693681  Fgf22; fibroblast growth factor 22 [KO:K04358]
109696982  Fgf18; fibroblast growth factor 18 [KO:K04358]
109702196  Fgf6; fibroblast growth factor 6 [KO:K04358]
109676636  Fgf7; fibroblast growth factor 7 [KO:K04358]
109698751  Fgf20; fibroblast growth factor 20 [KO:K04358]
109691333  Fgf8; fibroblast growth factor 8 isoform X1 [KO:K04358]
109675784  Fgf16; fibroblast growth factor 16 [KO:K04358]
109682677  Fgf21; fibroblast growth factor 21 [KO:K22429]
109702197  Fgf23; fibroblast growth factor 23 [KO:K22428]
109676961  Ngf; LOW QUALITY PROTEIN: beta-nerve growth factor [KO:K02582]
109695020  Bdnf; LOW QUALITY PROTEIN: brain-derived neurotrophic factor [KO:K04355]
109682761  Ntf3; neurotrophin-3 isoform X1 [KO:K04356]
109682692  Ntf4; neurotrophin-4 [KO:K12457]
109689794  insulin [KO:K04526]
109677734  insulin-like growth factor I [KO:K05459]
109697466  Igf1; insulin-like growth factor I [KO:K05459]
109689792  Igf2; insulin-like growth factor II isoform X1 [KO:K13769]
109684500  Pdgfa; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
109692977  Pdgfb; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
109702404  Pdgfd; platelet-derived growth factor D [KO:K05450]
109701575  Pdgfc; platelet-derived growth factor C [KO:K05450]
109694805  Csf1; macrophage colony-stimulating factor 1 [KO:K05453]
109685488  Kitlg; kit ligand isoform X1 [KO:K05461]
109683848  Flt3lg; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
109682127  Vegfa; vascular endothelial growth factor A isoform X1 [KO:K05448]
109683276  Vegfb; vascular endothelial growth factor B isoform X1 [KO:K16858]
109694002  Pgf; placenta growth factor [KO:K16859]
109676954  Vegfc; vascular endothelial growth factor C [KO:K05449]
109702790  LOW QUALITY PROTEIN: angiopoietin-1-like [KO:K05465]
109697772  Angpt2; angiopoietin-2 isoform X1 [KO:K05466]
109698999  Angpt4; angiopoietin-4 [KO:K05467]
109691023  Efna2; ephrin-A2 [KO:K05462]
109693629  Efna5; ephrin-A5 isoform X1 [KO:K05462]
109687979  Efna1; ephrin-A1 [KO:K05462]
109687980  Efna3; ephrin-A3 [KO:K05462]
109687982  Efna4; ephrin-A4 isoform X1 [KO:K05462]
109685455  Gdnf; glial cell line-derived neurotrophic factor [KO:K05452]
109688204  Nrtn; neurturin [KO:K25414]
109681559  Artn; artemin [KO:K25415]
109696795  Pspn; persephin [KO:K25416]
109693753  Egfr; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
109693877  Erbb2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
109686062  Erbb3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
109688936  Fgfr1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
109691649  Fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
109695016  Fgfr3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
109685768  Fgfr4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
109691411  Ngfr; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
109686202  Ntrk1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
109677416  Ntrk2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
109694006  Insr; LOW QUALITY PROTEIN: insulin receptor [KO:K04527] [EC:2.7.10.1]
109687530  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
109702274  LOW QUALITY PROTEIN: platelet-derived growth factor receptor alpha-like [KO:K04363] [EC:2.7.10.1]
109685094  Pdgfra; LOW QUALITY PROTEIN: platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
109685664  Pdgfrb; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
109683164  Csf1r; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
109698965  Kit; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
109694695  Flt3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
109694691  Flt1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
109700252  Flt4; LOW QUALITY PROTEIN: vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
109698964  Kdr; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
109689877  Met; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
109686627  Tek; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
109698845  Epha2; LOW QUALITY PROTEIN: ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
109676742  Ret; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
109681589  Grb2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
109685242  Sos1; son of sevenless homolog 1 [KO:K03099]
109686538  son of sevenless homolog 2 [KO:K03099]
109698042  Hras; GTPase HRas isoform X1 [KO:K02833]
109687060  Kras; GTPase KRas [KO:K07827]
109696062  Nras; GTPase NRas [KO:K07828]
109683851  Rras; ras-related protein R-Ras isoform X1 [KO:K07829]
109695442  Rras2; ras-related protein R-Ras2 [KO:K07830]
109693559  Mras; ras-related protein M-Ras [KO:K07831]
109696670  Araf; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
109682021  serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
109698982  LOW QUALITY PROTEIN: serine/threonine-protein kinase B-raf-like [KO:K04365] [EC:2.7.11.1]
109694940  Raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
109687824  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
109687808  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
109697415  Lamtor3; ragulator complex protein LAMTOR3 isoform X1 [KO:K04370]
109683259  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
109684381  Mapk1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
109695463  Mknk1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
109698290  MAP kinase-interacting serine/threonine-protein kinase 2-like isoform X1 [KO:K04372] [EC:2.7.11.1]
109698867  Mknk2; MAP kinase-interacting serine/threonine-protein kinase 2 [KO:K04372] [EC:2.7.11.1]
109683070  Rps6ka2; ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
109683087  Rps6ka1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
109689144  Rps6ka3; ribosomal protein S6 kinase alpha-3 [KO:K04373] [EC:2.7.11.1]
109693025  Atf4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
109696675  Elk1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
109695078  Elk4; ETS domain-containing protein Elk-4 [KO:K04376]
109699943  Myc; myc proto-oncogene protein [KO:K04377]
109682143  Srf; serum response factor isoform X1 [KO:K04378]
109694000  Fos; proto-oncogene c-Fos [KO:K04379]
109684813  Mapt; LOW QUALITY PROTEIN: microtubule-associated protein tau [KO:K04380]
109683054  Stmn1; stathmin [KO:K04381]
109678488  Pla2g4d; LOW QUALITY PROTEIN: cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
109693126  Pla2g4e; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
109697572  cytosolic phospholipase A2 gamma-like isoform X1 [KO:K16342] [EC:3.1.1.4]
109697577  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
109697580  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
109697581  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
109682660  Pla2g4f; LOW QUALITY PROTEIN: cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
109685136  Pla2g4a; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
109690391  Tnf; tumor necrosis factor isoform X1 [KO:K03156]
109702296  Il1a; interleukin-1 alpha [KO:K04383]
109701168  Il1b; interleukin-1 beta isoform X1 [KO:K04519]
109685632  Tgfb1; transforming growth factor beta-1 [KO:K13375]
109698650  Tgfb2; transforming growth factor beta-2 isoform X1 [KO:K13376]
109686152  Tgfb3; transforming growth factor beta-3 [KO:K13377]
109682791  Tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
109682273  Il1r1; interleukin-1 receptor type 1 isoform X1 [KO:K04386]
109683830  interleukin-1 receptor accessory protein [KO:K04723]
109683835  interleukin-1 receptor accessory protein-like [KO:K04723]
109691424  Tgfbr1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
109681522  Tgfbr2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
109689125  Faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
109691142  Fas; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
109682106  Cd14; monocyte differentiation antigen CD14 [KO:K04391]
109692922  Rac1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
109698248  Rac2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
109702872  Rac3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
109694921  Cdc42; cell division control protein 42 homolog [KO:K04393]
109694060  Tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
109678444  caspase-3 [KO:K02187] [EC:3.4.22.56]
109678454  caspase-3-like [KO:K02187] [EC:3.4.22.56]
109699331  Traf2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
109686666  Daxx; death domain-associated protein 6 isoform X1 [KO:K02308]
109684529  Myd88; LOW QUALITY PROTEIN: myeloid differentiation primary response protein MyD88 [KO:K04729]
109690874  Irak1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
109684435  interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
109693564  Traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
109691045  Gadd45b; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
109696612  Gadd45g; growth arrest and DNA damage-inducible protein GADD45 gamma isoform X1 [KO:K04402]
109698312  Gadd45a; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
109692995  Tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
109692528  Tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
109692584  Ecsit; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial isoform X1 [KO:K04405]
109685240  Map4k3; mitogen-activated protein kinase kinase kinase kinase 3 [KO:K04406] [EC:2.7.11.1]
109682277  Map4k4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
109695822  Map4k1; mitogen-activated protein kinase kinase kinase kinase 1 isoform X1 [KO:K04408] [EC:2.7.11.1]
109690046  Pak2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
109681302  Stk4; serine/threonine-protein kinase 4 isoform X1 [KO:K04411]
109688653  Stk3; LOW QUALITY PROTEIN: serine/threonine-protein kinase 3 [KO:K04412]
109687172  Map4k2; mitogen-activated protein kinase kinase kinase kinase 2 isoform X1 [KO:K04414] [EC:2.7.11.1]
109695913  Map3k8; mitogen-activated protein kinase kinase kinase 8 isoform X1 [KO:K04415] [EC:2.7.11.25]
109695531  Map3k1; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
109687144  Map3k11; mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
109699113  Map3k2; mitogen-activated protein kinase kinase kinase 2 isoform X1 [KO:K04420] [EC:2.7.11.25]
109703189  Map3k3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
109700426  Map3k9; mitogen-activated protein kinase kinase kinase 9 isoform X1 [KO:K04417] [EC:2.7.11.25]
109688533  Map3k10; mitogen-activated protein kinase kinase kinase 10 isoform X1 [KO:K04418] [EC:2.7.11.25]
109684077  Map3k12; mitogen-activated protein kinase kinase kinase 12 [KO:K04423] [EC:2.7.11.25]
109699287  Map3k13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
109687931  mitogen-activated protein kinase kinase kinase MLT-like [KO:K04424] [EC:2.7.11.25]
109702680  mitogen-activated protein kinase kinase kinase MLT-like [KO:K04424] [EC:2.7.11.25]
109696078  Map3k6; mitogen-activated protein kinase kinase kinase 6 isoform X1 [KO:K04425] [EC:2.7.11.25]
109697041  Map3k5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
109698497  Map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
109700149  Map3k4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
109683154  Taok2; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
109683764  Taok1; serine/threonine-protein kinase TAO1 isoform X1 [KO:K04429] [EC:2.7.11.1]
109700140  serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
109693003  Map2k4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
109698434  Map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
109692052  Map2k3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
109698990  Map2k6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
109692011  Mapk8ip1; C-Jun-amino-terminal kinase-interacting protein 1 [KO:K04434]
109697312  Mapk8ip2; LOW QUALITY PROTEIN: C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
109690191  Mapk8ip3; C-Jun-amino-terminal kinase-interacting protein 3 [KO:K04436]
109696859  Flna; filamin-A isoform X1 [KO:K04437]
109682600  Crk; adapter molecule crk isoform X1 [KO:K04438]
109684371  Crkl; crk-like protein isoform X1 [KO:K04438]
109697447  Arrb2; beta-arrestin-2 isoform X1 [KO:K04439]
109680800  Arrb1; beta-arrestin-1 isoform X1 [KO:K04439]
109686728  Mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
109686738  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
109703004  mitogen-activated protein kinase 10-like [KO:K04440] [EC:2.7.11.24]
109697389  Mapk11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
109689865  Mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
109689849  Mapk14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
109697648  Mapk12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
109695391  Mapkapk5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
109688375  Mapkapk2; MAP kinase-activated protein kinase 2 isoform X1 [KO:K04443] [EC:2.7.11.1]
109693236  Mapkapk3; MAP kinase-activated protein kinase 3 isoform X1 [KO:K04444] [EC:2.7.11.1]
109699395  ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
109685550  ribosomal protein S6 kinase alpha-4-like [KO:K16510] [EC:2.7.11.1]
109685553  ribosomal protein S6 kinase alpha-4 isoform X1 [KO:K16510] [EC:2.7.11.1]
109691288  Cdc25b; M-phase inducer phosphatase 2 isoform X1 [KO:K05866] [EC:3.1.3.48]
109686431  Nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
109691260  Nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
109700777  Jun; transcription factor AP-1 [KO:K04448]
109683690  Jund; LOW QUALITY PROTEIN: transcription factor jun-D [KO:K04449]
109689841  Atf2; LOW QUALITY PROTEIN: cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
109674834  Tp53; cellular tumor antigen p53 isoform X1 [KO:K04451]
109686362  Ddit3; DNA damage-inducible transcript 3 protein [KO:K04452]
109675714  LOW QUALITY PROTEIN: DNA damage-inducible transcript 3 protein-like [KO:K04452]
109691135  Max; protein max isoform X1 [KO:K04453]
109695254  Mef2c; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
109681577  Hspb1; heat shock protein beta-1 [KO:K04455]
109688536  Akt2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
109691810  Akt1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
109686235  Akt3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
109691691  protein phosphatase 1A-like [KO:K04457] [EC:3.1.3.16]
109701512  Ppm1a; protein phosphatase 1A [KO:K04457] [EC:3.1.3.16]
109691422  LOW QUALITY PROTEIN: receptor-type tyrosine-protein phosphatase R-like [KO:K04458] [EC:3.1.3.48]
109696898  Ptpn5; tyrosine-protein phosphatase non-receptor type 5 isoform X1 [KO:K18018] [EC:3.1.3.48]
109682253  Ptpn7; tyrosine-protein phosphatase non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
109694781  Dusp1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
109677688  Dusp5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
109695218  Dusp2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
109689766  Dusp8; dual specificity protein phosphatase 8 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
109676463  Dusp4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
109685355  Dusp7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
109684643  Dusp16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
109696668  Dusp6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
109688198  dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
109697054  Dusp3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
109691236  Ppp5c; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
109700490  Ppm1b; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
109689570  LOW QUALITY PROTEIN: heat shock 70 kDa protein 1-like [KO:K03283]
109689571  heat shock 70 kDa protein 1 [KO:K03283]
109689572  LOW QUALITY PROTEIN: heat shock 70 kDa protein 1-like [KO:K03283]
109697755  Hspa8; heat shock cognate 71 kDa protein [KO:K03283]
109693503  LOW QUALITY PROTEIN: heat shock 70 kDa protein 6-like [KO:K03283]
109700158  Mecom; MDS1 and EVI1 complex locus protein EVI1 isoform X1 [KO:K04462] [EC:2.1.1.367]
109685304  Map2k5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
109699716  Mapk7; mitogen-activated protein kinase 7 isoform X1 [KO:K04464] [EC:2.7.11.24]
109685524  nuclear receptor subfamily 4 group A member 1-like [KO:K04465]
109685527  Nr4a1; nuclear receptor subfamily 4 group A member 1 isoform X1 [KO:K04465]
109691665  Map3k14; mitogen-activated protein kinase kinase kinase 14 isoform X1 [KO:K04466] [EC:2.7.11.25]
109681514  Chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
109696400  Ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
109691919  Ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
109698362  Nlk; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
109682963  Nfkb1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
109691303  Nfkb2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
109687142  Rela; transcription factor p65 isoform X1 [KO:K04735]
109692401  Relb; transcription factor RelB isoform X1 [KO:K09253]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
  Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
ccan04070  Phosphatidylinositol signaling system
ccan04110  Cell cycle
ccan04115  p53 signaling pathway
ccan04210  Apoptosis
ccan04310  Wnt signaling pathway
ccan04668  TNF signaling pathway
KO pathway
ko04010   
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