KEGG   PATHWAY: dle04148
Entry
dle04148                    Pathway                                
Name
Efferocytosis - Delphinapterus leucas (beluga whale)
Class
Cellular Processes; Transport and catabolism
Pathway map
dle04148  Efferocytosis
dle04148

Organism
Delphinapterus leucas (beluga whale) [GN:dle]
Gene
111162913  CRKL; crk-like protein [KO:K04438]
111163022  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
111163327  C1QB; complement C1q subcomponent subunit B [KO:K03987]
111163328  C1QA; complement C1q subcomponent subunit A [KO:K03986]
111163329  C1QC; complement C1q subcomponent subunit C [KO:K03988]
111163363  SLC66A1; lysosomal amino acid transporter 1 homolog isoform X1 [KO:K23678]
111163372  XKR8; XK-related protein 8 [KO:K26813]
111164202  NFATC4; LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
111164464  ODC1; ornithine decarboxylase [KO:K01581] [EC:4.1.1.17]
111164496  ADAM17; disintegrin and metalloproteinase domain-containing protein 17 isoform X1 [KO:K06059] [EC:3.4.24.86]
111164586  ATP11C; phospholipid-transporting ATPase IG isoform X1 [KO:K26934]
111164620  [KO:K06259]
111164621  [KO:K06259]
111164713  [KO:K01581] [EC:4.1.1.17]
111164777  RAB5A; ras-related protein Rab-5A isoform X1 [KO:K07887]
111165046  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
111165354  CX3CL1; fractalkine [KO:K05508]
111165747  ARG1; arginase-1 [KO:K01476] [EC:3.5.3.1]
111165859  XKR4; XK-related protein 4 [KO:K26811]
111165942  [KO:K05079]
111165956  [KO:K13302] [EC:2.7.11.1]
111165994  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
111166139  [KO:K05079]
111166267  RAB5C; ras-related protein Rab-5C [KO:K07889]
111166685  CALR; calreticulin [KO:K08057]
111167284  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
111167411  VPS11; vacuolar protein sorting-associated protein 11 homolog isoform X1 [KO:K20179]
111167579  CASP1; caspase-1 [KO:K01370] [EC:3.4.22.36]
111167957  PANX1; pannexin-1 [KO:K03443]
111168801  RAB7A; ras-related protein Rab-7a [KO:K07897]
111168952  [KO:K08530]
111169236  PBX1; pre-B-cell leukemia transcription factor 1 isoform X1 [KO:K09355]
111169447  CX3CR1; CX3C chemokine receptor 1 isoform X1 [KO:K04192]
111169670  MFGE8; lactadherin [KO:K17253]
111169763  ARNT; aryl hydrocarbon receptor nuclear translocator isoform X1 [KO:K09097]
111170198  ATP8A1; phospholipid-transporting ATPase IA isoform X1 [KO:K14802] [EC:7.6.2.1]
111170310  ANO9; LOW QUALITY PROTEIN: anoctamin-9 [KO:K19503]
111170311  DUSP8; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
111170495  BSG; basigin [KO:K06535]
111170949  AGER; advanced glycosylation end product-specific receptor isoform X1 [KO:K19722]
111171639  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
111171644  GULP1; PTB domain-containing engulfment adapter protein 1 isoform X1 [KO:K23285]
111171769  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
111171786  ITGB5; integrin beta-5 [KO:K06588]
111172114  RAB17; ras-related protein Rab-17 [KO:K07909]
111172195  DOCK1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
111172296  CASP7; caspase-7 [KO:K04397] [EC:3.4.22.60]
111172314  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
111172516  LIPA; lysosomal acid lipase/cholesteryl ester hydrolase [KO:K01052] [EC:3.1.1.13]
111172517  CH25H; cholesterol 25-hydroxylase [KO:K10223] [EC:1.14.99.38]
111172567  ALOX5; arachidonate 5-lipoxygenase [KO:K00461] [EC:1.13.11.34]
111173040  ARG2; arginase-2, mitochondrial [KO:K01476] [EC:3.5.3.1]
111173087  HIF1A; hypoxia-inducible factor 1-alpha isoform X1 [KO:K08268]
111173089  TMEM30B; cell cycle control protein 50B [KO:K26935]
111173156  PTGER2; prostaglandin E2 receptor EP2 subtype [KO:K04259]
111173401  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
111173470  DUSP4; dual specificity protein phosphatase 4 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
111173529  ADAM9; disintegrin and metalloproteinase domain-containing protein 9 isoform X1 [KO:K06834] [EC:3.4.24.-]
111173565  ATP11B; probable phospholipid-transporting ATPase IF isoform X1 [KO:K26934]
111173849  LRP1; prolow-density lipoprotein receptor-related protein 1 [KO:K04550]
111173894  RAB5B; ras-related protein Rab-5B [KO:K07888]
111174090  ANO6; anoctamin-6 isoform X1 [KO:K19500]
111174303  STAB1; stabilin-1 isoform X1 [KO:K19020]
111174324  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
111174651  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
111174996  DNMT3A; DNA (cytosine-5)-methyltransferase 3A isoform X1 [KO:K17398] [EC:2.1.1.37]
111175171  ATP8A2; phospholipid-transporting ATPase IB isoform X1 [KO:K14802] [EC:7.6.2.1]
111175474  [KO:K08057]
111175689  SLC2A1; solute carrier family 2, facilitated glucose transporter member 1 isoform X1 [KO:K07299]
111175999  GPR132; probable G-protein coupled receptor 132 [KO:K08426]
111176356  GAS6; growth arrest-specific protein 6 [KO:K05464]
111176371  ATP11A; probable phospholipid-transporting ATPase IH isoform X1 [KO:K26934]
111176702  PTPN6; tyrosine-protein phosphatase non-receptor type 6 isoform X1 [KO:K05697] [EC:3.1.3.48]
111176775  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
111177070  RXRA; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
111177220  [KO:K13302] [EC:2.7.11.1]
111177268  RAB14; ras-related protein Rab-14 [KO:K07881]
111177664  ADAM10; disintegrin and metalloproteinase domain-containing protein 10 [KO:K06704] [EC:3.4.24.81]
111177735  MEGF11; multiple epidermal growth factor-like domains protein 11 isoform X1 [KO:K24068]
111177745  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
111178503  PROS1; vitamin K-dependent protein S [KO:K03908]
111178514  CD24; signal transducer CD24 [KO:K06469]
111178721  PPARD; peroxisome proliferator-activated receptor delta isoform X1 [KO:K04504]
111178736  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
111178738  MAPK13; mitogen-activated protein kinase 13 isoform X2 [KO:K04441] [EC:2.7.11.24]
111179314  P2RY12; P2Y purinoceptor 12 [KO:K04298]
111179459  ELMO1; engulfment and cell motility protein 1 isoform X1 [KO:K12366]
111179506  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
111179608  PLA2G15; group XV phospholipase A2 isoform X1 [KO:K06129] [EC:3.1.1.5]
111179609  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
111179827  ANO3; anoctamin-3 isoform X1 [KO:K19498]
111179834  ANO5; anoctamin-5 isoform X1 [KO:K19480]
111180017  SLC16A1; monocarboxylate transporter 1 [KO:K08179]
111180020  [KO:K08179]
111180107  S1PR1; sphingosine 1-phosphate receptor 1 isoform X1 [KO:K04288]
111180605  CPT1C; carnitine O-palmitoyltransferase 1, brain isoform isoform X1 [KO:K19524] [EC:2.3.1.21]
111180657  SPHK2; sphingosine kinase 2 isoform X1 [KO:K04718] [EC:2.7.1.91]
111180824  TGFB1; transforming growth factor beta-1 proprotein isoform X1 [KO:K13375]
111180829  AXL; tyrosine-protein kinase receptor UFO [KO:K05115] [EC:2.7.10.1]
111180964  [KO:K00411] [EC:7.1.1.8]
111181068  SIGLEC10; sialic acid-binding Ig-like lectin 10 isoform X1 [KO:K06749]
111181092  NR1H2; oxysterols receptor LXR-beta isoform X1 [KO:K08535]
111181700  VPS39; vam6/Vps39-like protein isoform X1 [KO:K20183]
111181710  TYRO3; tyrosine-protein kinase receptor TYRO3 isoform X2 [KO:K05116] [EC:2.7.10.1]
111181727  VPS18; vacuolar protein sorting-associated protein 18 homolog [KO:K20181]
111181763  THBS1; thrombospondin-1 [KO:K16857]
111181869  [KO:K26935]
111181886  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
111182181  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
111182199  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
111182312  EPO; erythropoietin [KO:K05437]
111182383  MEGF10; multiple epidermal growth factor-like domains protein 10 [KO:K24068]
111182589  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
111182628  PECAM1; platelet endothelial cell adhesion molecule isoform X1 [KO:K06471]
111182791  SPHK1; sphingosine kinase 1 isoform X1 [KO:K04718] [EC:2.7.1.91]
111183091  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
111183151  TIMD4; T-cell immunoglobulin and mucin domain-containing protein 4 [KO:K26936]
111183152  [KO:K20413]
111183229  TMEM30A; cell cycle control protein 50A [KO:K26935]
111183434  SIRT1; NAD-dependent protein deacetylase sirtuin-1 isoform X1 [KO:K11411] [EC:2.3.1.286]
111183530  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
111183641  CPT1A; carnitine O-palmitoyltransferase 1, liver isoform [KO:K08765] [EC:2.3.1.21]
111183967  NR1H3; oxysterols receptor LXR-alpha isoform X1 [KO:K08536]
111184315  XKR7; XK-related protein 7 [KO:K26811]
111184361  [KO:K06551]
111184363  SIRPA; tyrosine-protein phosphatase non-receptor type substrate 1 isoform X1 [KO:K06551]
111184376  VPS16; vacuolar protein sorting-associated protein 16 homolog isoform X1 [KO:K20180]
111184485  VPS41; vacuolar protein sorting-associated protein 41 homolog isoform X1 [KO:K20184]
111184516  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
111184673  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
111184748  IL10; interleukin-10 [KO:K05443]
111184749  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
111184757  RAB7B; ras-related protein Rab-7b isoform X1 [KO:K07898]
111184829  P2RY2; P2Y purinoceptor 2 [KO:K04269]
111184832  P2RY6; P2Y purinoceptor 6 [KO:K04272]
111185376  XKR6; XK-related protein 6 [KO:K26811]
111185567  XKR9; XK-related protein 9 [KO:K26814]
111185654  SCARF1; scavenger receptor class F member 1 isoform X1 [KO:K24318]
111185687  CRK; adapter molecule crk isoform X1 [KO:K04438]
111185891  CD47; leukocyte surface antigen CD47 isoform X1 [KO:K06266]
111185895  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
111185975  ALOX15; LOW QUALITY PROTEIN: arachidonate 15-lipoxygenase [KO:K00460] [EC:1.13.11.33]
111186068  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
111186263  PLA2G6; 85/88 kDa calcium-independent phospholipase A2 isoform X1 [KO:K16343] [EC:3.1.1.4]
111186301  CPT1B; carnitine O-palmitoyltransferase 1, muscle isoform isoform X1 [KO:K19523] [EC:2.3.1.21]
111186351  VPS8; vacuolar protein sorting-associated protein 8 homolog [KO:K20178]
111186361  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
111186364  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
111186768  CEBPB; CCAAT/enhancer-binding protein beta [KO:K10048]
111186778  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
111186883  VPS33A; vacuolar protein sorting-associated protein 33A isoform X1 [KO:K20182]
111186914  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
111187198  [KO:K07293] [EC:3.1.3.48]
111187219  PTGER4; prostaglandin E2 receptor EP4 subtype [KO:K04261]
111187410  MERTK; tyrosine-protein kinase Mer isoform X1 [KO:K05117] [EC:2.7.10.1]
111187411  TGFBRAP1; transforming growth factor-beta receptor-associated protein 1 [KO:K20177]
111187508  DUSP2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
111187915  STAB2; stabilin-2 isoform X1 [KO:K19013]
111187922  ANO4; anoctamin-4 isoform X1 [KO:K19499]
111188018  ABCA1; phospholipid-transporting ATPase ABCA1 isoform X1 [KO:K05641]
111188123  PTPN11; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
115802126  ANO7; anoctamin-7 [KO:K19501]
Compound
C00002  ATP
C00003  NAD+
C00019  S-Adenosyl-L-methionine
C00031  D-Glucose
C00062  L-Arginine
C00073  L-Methionine
C00075  UTP
C00077  L-Ornithine
C00134  Putrescine
C00162  Fatty acid
C00186  (S)-Lactate
C00187  Cholesterol
C00584  Prostaglandin E2
C02530  Cholesterol ester
C02737  Phosphatidylserine
C04230  1-Acyl-sn-glycero-3-phosphocholine
C06124  Sphingosine 1-phosphate
C06314  Lipoxin A4
C15519  25-Hydroxycholesterol
C15610  Cholest-5-ene-3beta,26-diol
C18178  Resolvin D1
Reference
PMID:31822793
  Authors
Doran AC, Yurdagul A Jr, Tabas I
  Title
Efferocytosis in health and disease.
  Journal
Nat Rev Immunol 20:254-267 (2020)
DOI:10.1038/s41577-019-0240-6
Reference
PMID:36028471
  Authors
Zhang J, Ding W, Zhao M, Liu J, Xu Y, Wan J, Wang M
  Title
Mechanisms of efferocytosis in determining inflammation resolution: Therapeutic potential and the association with cardiovascular disease.
  Journal
Br J Pharmacol 179:5151-5171 (2022)
DOI:10.1111/bph.15939
Reference
PMID:30165442
  Authors
Kawano M, Nagata S
  Title
Efferocytosis and autoimmune disease.
  Journal
Int Immunol 30:551-558 (2018)
DOI:10.1093/intimm/dxy055
Reference
PMID:35650427
  Authors
Mehrotra P, Ravichandran KS
  Title
Drugging the efferocytosis process: concepts and opportunities.
  Journal
Nat Rev Drug Discov 21:601-620 (2022)
DOI:10.1038/s41573-022-00470-y
Reference
PMID:28496201
  Authors
Park SY, Kim IS
  Title
Engulfment signals and the phagocytic machinery for apoptotic cell clearance.
  Journal
Exp Mol Med 49:e331 (2017)
DOI:10.1038/emm.2017.52
Reference
PMID:28137963
  Authors
Kojima Y, Weissman IL, Leeper NJ
  Title
The Role of Efferocytosis in Atherosclerosis.
  Journal
Circulation 135:476-489 (2017)
DOI:10.1161/CIRCULATIONAHA.116.025684
Related
pathway
dle00010  Glycolysis / Gluconeogenesis
dle04140  Autophagy - animal
dle04145  Phagosome
KO pathway
ko04148   

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