KEGG   PATHWAY: hsa05213
Entry
hsa05213                    Pathway                                
Name
Endometrial cancer - Homo sapiens (human)
Description
Endometrial cancer (EC) is the most common gynaecological malignancy and the fourth most common malignancy in women in the developed world after breast, colorectal and lung cancer. Two types of endometrial carcinoma are distinguished with respect to biology and clinical course. Type-I carcinoma is related to hyperestrogenism by association with endometrial hyperplasia, frequent expression of estrogen and progesterone receptors and younger age, whereas type-II carcinoma is unrelated to estrogen, associated with atrophic endometrium, frequent lack of estrogen and progesterone receptors and older age. The morphologic differences in these cancers are mirrored in their molecular genetic profile with type I showing defects in DNA-mismatch repair and mutations in PTEN, K-ras, and beta-catenin, and type II showing aneuploidy, p53 mutations, and her2/neu amplification.
Class
Human Diseases; Cancer: specific types
Pathway map
hsa05213  Endometrial cancer
hsa05213

Network
nt06210  ERK signaling (cancer)
nt06214  PI3K signaling (cancer)
nt06215  WNT signaling (cancer)
nt06240  Transcription (cancer)
nt06260  Colorectal cancer
nt06261  Gastric cancer
nt06262  Pancreatic cancer
nt06263  Hepatocellular carcinoma
nt06265  Bladder cancer
nt06266  Non-small cell lung cancer
nt06267  Small cell lung cancer
nt06268  Melanoma
nt06269  Basal cell carcinoma
nt06270  Breast cancer
nt06271  Endometrial cancer
nt06272  Prostate cancer
nt06273  Glioma
nt06274  Thyroid cancer
nt06275  Acute myeloid leukemia
nt06276  Chronic myeloid leukemia
  Element
N00012  Mutation-activated KRAS/NRAS to ERK signaling pathway
N00052  Mutation-inactivated PTEN to PI3K signaling pathway
N00058  Mutation-activated CTNNB1 to Wnt signaling pathway
N00115  Mutation-inactivated TP53 to transcription
Disease
H00026  Endometrial cancer
Organism
Homo sapiens (human) [GN:hsa]
Gene
10000  AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
1026  CDKN1A; cyclin dependent kinase inhibitor 1A [KO:K06625]
10297  APC2; APC regulator of WNT signaling pathway 2 [KO:K02085]
10912  GADD45G; growth arrest and DNA damage inducible gamma [KO:K04402]
110117499  P3R3URF-PIK3R3; P3R3URF-PIK3R3 readthrough [KO:K02649]
1495  CTNNA1; catenin alpha 1 [KO:K05691]
1496  CTNNA2; catenin alpha 2 [KO:K05691]
1499  CTNNB1; catenin beta 1 [KO:K02105]
1643  DDB2; damage specific DNA binding protein 2 [KO:K10140]
1647  GADD45A; growth arrest and DNA damage inducible alpha [KO:K04402]
1950  EGF; epidermal growth factor [KO:K04357]
1956  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
2002  ELK1; ETS transcription factor ELK1 [KO:K04375]
2064  ERBB2; erb-b2 receptor tyrosine kinase 2 [KO:K05083] [EC:2.7.10.1]
207  AKT1; AKT serine/threonine kinase 1 [KO:K04456] [EC:2.7.11.1]
208  AKT2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
2309  FOXO3; forkhead box O3 [KO:K09408]
2885  GRB2; growth factor receptor bound protein 2 [KO:K04364]
29119  CTNNA3; catenin alpha 3 [KO:K05691]
2932  GSK3B; glycogen synthase kinase 3 beta [KO:K03083] [EC:2.7.11.26]
324  APC; APC regulator of WNT signaling pathway [KO:K02085]
3265  HRAS; HRas proto-oncogene, GTPase [KO:K02833]
3611  ILK; integrin linked kinase [KO:K06272] [EC:2.7.11.1]
369  ARAF; A-Raf proto-oncogene, serine/threonine kinase [KO:K08845] [EC:2.7.11.1]
3845  KRAS; KRAS proto-oncogene, GTPase [KO:K07827]
4292  MLH1; mutL homolog 1 [KO:K08734]
4609  MYC; MYC proto-oncogene, bHLH transcription factor [KO:K04377]
4616  GADD45B; growth arrest and DNA damage inducible beta [KO:K04402]
4893  NRAS; NRAS proto-oncogene, GTPase [KO:K07828]
51176  LEF1; lymphoid enhancer binding factor 1 [KO:K04492]
51426  POLK; DNA polymerase kappa [KO:K03511] [EC:2.7.7.7]
5170  PDPK1; 3-phosphoinositide dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
5290  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
5291  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
5293  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
5295  PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
5296  PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
5594  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
5595  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
5604  MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
5605  MAP2K2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
572  BAD; BCL2 associated agonist of cell death [KO:K02158]
5728  PTEN; phosphatase and tensin homolog [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
578  BAK1; BCL2 antagonist/killer 1 [KO:K14021]
581  BAX; BCL2 associated X, apoptosis regulator [KO:K02159]
5894  RAF1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
595  CCND1; cyclin D1 [KO:K04503]
6654  SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1 [KO:K03099]
6655  SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2 [KO:K03099]
673  BRAF; B-Raf proto-oncogene, serine/threonine kinase [KO:K04365] [EC:2.7.11.1]
6932  TCF7; transcription factor 7 [KO:K02620]
6934  TCF7L2; transcription factor 7 like 2 [KO:K04491]
7157  TP53; tumor protein p53 [KO:K04451]
8312  AXIN1; axin 1 [KO:K02157]
8313  AXIN2; axin 2 [KO:K04385]
83439  TCF7L1; transcription factor 7 like 1 [KO:K04490]
842  CASP9; caspase 9 [KO:K04399] [EC:3.4.22.62]
8503  PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
999  CDH1; cadherin 1 [KO:K05689]
Compound
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:15947972
  Authors
Ryan AJ, Susil B, Jobling TW, Oehler MK.
  Title
Endometrial cancer.
  Journal
Cell Tissue Res 322:53-61 (2005)
DOI:10.1007/s00441-005-1109-5
Reference
PMID:14747944
  Authors
Lax SF.
  Title
Molecular genetic pathways in various types of endometrial carcinoma: from a phenotypical to a molecular-based classification.
  Journal
Virchows Arch 444:213-23 (2004)
DOI:10.1007/s00428-003-0947-3
Reference
PMID:16508724
  Authors
Shiozawa T, Konishi I.
  Title
Early endometrial carcinoma: clinicopathology, hormonal aspects, molecular genetics, diagnosis, and treatment.
  Journal
Int J Clin Oncol 11:13-21 (2006)
DOI:10.1007/s10147-005-0546-1
Reference
PMID:17028294
  Authors
Hecht JL, Mutter GL.
  Title
Molecular and pathologic aspects of endometrial carcinogenesis.
  Journal
J Clin Oncol 24:4783-91 (2006)
DOI:10.1200/JCO.2006.06.7173
Reference
PMID:11431710
  Authors
Matias-Guiu X, Catasus L, Bussaglia E, Lagarda H, Garcia A, Pons C, Munoz J, Arguelles R, Machin P, Prat J.
  Title
Molecular pathology of endometrial hyperplasia and carcinoma.
  Journal
Hum Pathol 32:569-77 (2001)
DOI:10.1053/hupa.2001.25929
Reference
PMID:15284264
  Authors
Slomovitz BM, Broaddus RR, Burke TW, Sneige N, Soliman PT, Wu W, Sun CC, Munsell MF, Gershenson DM, Lu KH.
  Title
Her-2/neu overexpression and amplification in uterine papillary serous carcinoma.
  Journal
J Clin Oncol 22:3126-32 (2004)
DOI:10.1200/JCO.2004.11.154
Reference
PMID:7585656
  Authors
Saffari B, Jones LA, el-Naggar A, Felix JC, George J, Press MF.
  Title
Amplification and overexpression of HER-2/neu (c-erbB2) in endometrial cancers: correlation with overall survival.
  Journal
Cancer Res 55:5693-8 (1995)
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Related
pathway
hsa04010  MAPK signaling pathway
hsa04012  ErbB signaling pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04110  Cell cycle
hsa04115  p53 signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa04310  Wnt signaling pathway
hsa04520  Adherens junction
KO pathway
ko05213   

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