KEGG PATHWAY: ko05207

PATHWAY: ko05207

Entry

ko05207                     Pathway

Name

Chemical carcinogenesis - receptor activation

Description

Carcinogenesis is a multistage process that consists of initiation, promotion, and progression stages. Chemicals or environmental factors may act at any of these stages to induce and/or enhance the carcinogenic process. Based on their mode-of-action, carcinogens can be classified as genotoxic or non-genotoxic. Genotoxic agent begins their action at the deoxyribonucleic acid (DNA) level, causing DNA damage through several mechanisms. Non-genotoxic carcinogens are chemicals that cause the development of tumors through multiple non-genotoxic events and epigenetic alterations without direct interaction with DNA. One non-genotoxic mechanism involves receptor activation. Biological mechanisms involving receptor activation fall into two broad categories: (i) those that involve cell surface receptors and some intracellular receptors that activate signal transduction pathways, resulting in biological responses, including gene transcription, and (ii) those that involve intracellular receptors that translocate into the nucleus and act as transcription factors regulating gene expression. Both classes of receptors can be involved in mechanisms of carcinogenesis.

Class

Human Diseases; Cancer: overview

Pathway map

ko05207

Chemical carcinogenesis - receptor activation

Orthology

K00699

UGT; glucuronosyltransferase [EC:2.4.1.17]

K00799

GST; glutathione S-transferase [EC:2.5.1.18]

K00922

PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]

K01253

EPHX1; microsomal epoxide hydrolase [EC:3.3.2.9]

K02158

BAD; Bcl-2-antagonist of cell death

K02161

BCL2; apoptosis regulator Bcl-2

K02213

CDC6; cell division control protein 6

K02580

NFKB1; nuclear factor NF-kappa-B p105 subunit

K02649

PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta

K02677

PRKCA; classical protein kinase C alpha type [EC:2.7.11.13]

K02833

HRAS; GTPase HRas

K03099

SOS; son of sevenless

K03209

WNT1; wingless-type MMTV integration site family, member 1

K04079

HSP90A, htpG; molecular chaperone HtpG

K04141

ADRB1; adrenergic receptor beta-1

K04142

ADRB2; adrenergic receptor beta-2

K04143

ADRB3; adrenergic receptor beta-3

K04344

CACNA1A, CAV2.1; voltage-dependent calcium channel P/Q type alpha-1A

K04345

PKA; protein kinase A [EC:2.7.11.11]

K04357

EGF; epidermal growth factor

K04358

FGF; fibroblast growth factor

K04361

EGFR, ERBB1; epidermal growth factor receptor [EC:2.7.10.1]

K04364

GRB2; growth factor receptor-bound protein 2

K04366

RAF1; RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]

K04368

MAP2K1, MEK1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]

K04369

MAP2K2, MEK2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]

K04371

ERK, MAPK1_3; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]

K04373

RPS6KA; ribosomal protein S6 kinase alpha-1/2/3/6 [EC:2.7.11.1]

K04374

ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4

K04377

MYC; Myc proto-oncogene protein

K04379

FOS; proto-oncogene protein c-fos

K04439

ARRB; beta-arrestin

K04447

JAK2; Janus kinase 2 [EC:2.7.10.2]

K04448

JUN; transcription factor AP-1

K04450

ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2

K04456

AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]

K04503

CCND1; G1/S-specific cyclin-D1

K04630

GNAI; guanine nucleotide-binding protein G(i) subunit alpha

K04632

GNAS; guanine nucleotide-binding protein G(s) subunit alpha

K04688

RPS6KB; ribosomal protein S6 kinase beta [EC:2.7.11.1]

K04692

STAT3; signal transducer and activator of transcription 3

K04725

XIAP, BIRC4; E3 ubiquitin-protein ligase XIAP [EC:2.3.2.27]

K04735

RELA; transcription factor p65

K04805

CHRNA3; nicotinic acetylcholine receptor alpha-3

K04806

CHRNA4; nicotinic acetylcholine receptor alpha-4

K04809

CHRNA7; nicotinic acetylcholine receptor alpha-7

K04810

CHRNA9; nicotinic acetylcholine receptor alpha-9

K04813

CHRNB2; nicotinic acetylcholine receptor beta-2

K04815

CHRNB4; nicotinic acetylcholine receptor beta-4

K04849

CACNA1B, CAV2.2; voltage-dependent calcium channel N type alpha-1B

K04850

CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C

K04851

CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D

K04853

CACNA1F, CAV1.4; voltage-dependent calcium channel L type alpha-1F

K04857

CACNA1S, CAV1.1; voltage-dependent calcium channel L type alpha-1S

K05448

VEGFA; vascular endothelial growth factor A

K05473

TNFSF11, RANKL, CD254; tumor necrosis factor ligand superfamily member 11

K05704

SRC; tyrosine-protein kinase Src [EC:2.7.10.2]

K05870

CREB1; cyclic AMP-responsive element-binding protein 1

K06051

DLL; delta

K06052

JAG1, CD339; jagged-1

K06618

RB1; retinoblastoma-associated protein

K06645

CDC25A; M-phase inducer phosphatase 1 [EC:3.1.3.48]

K07203

MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1]

K07205

EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1

K07211

IKBKE, IKKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon [EC:2.7.11.10]

K07294

NR1C1, PPARA; peroxisome proliferator-activated receptor alpha

K07408

CYP1A1; cytochrome P450 family 1 subfamily A1 [EC:1.14.14.1]

K07409

CYP1A2; cytochrome P450 family 1 subfamily A2 [EC:1.14.14.1]

K07410

CYP1B1; cytochrome P450 family 1 subfamily B1 [EC:1.14.14.1]

K07412

CYP2B; cytochrome P450 family 2 subfamily B [EC:1.14.14.1]

K07424

CYP3A; cytochrome P450 family 3 subfamily A [EC:1.14.14.1]

K07827

KRAS, KRAS2; GTPase KRas

K07828

NRAS; GTPase NRas

K08041

ADCY1; adenylate cyclase 1 [EC:4.6.1.1]

K08042

ADCY2; adenylate cyclase 2 [EC:4.6.1.1]

K08043

ADCY3; adenylate cyclase 3 [EC:4.6.1.1]

K08044

ADCY4; adenylate cyclase 4 [EC:4.6.1.1]

K08045

ADCY5; adenylate cyclase 5 [EC:4.6.1.1]

K08046

ADCY6; adenylate cyclase 6 [EC:4.6.1.1]

K08047

ADCY7; adenylate cyclase 7 [EC:4.6.1.1]

K08048

ADCY8; adenylate cyclase 8 [EC:4.6.1.1]

K08049

ADCY9; adenylate cyclase 9 [EC:4.6.1.1]

K08524

RXRA, NR2B1; retinoid X receptor alpha

K08525

RXRB, NR2B2; retinoid X receptor beta

K08526

RXRG, NR2B3; retinoid X receptor gamma

K08539

VDR, NR1I1; vitamin D3 receptor

K08541

NR1I3, CAR; constitutive androstane receptor

K08550

ESR1, NR3A1; estrogen receptor alpha

K08551

ESR2, NR3A2; estrogen receptor beta

K08556

PGR, NR3C3; progesterone receptor

K08557

AR, NR3C4; androgen receptor

K08726

EPHX2; soluble epoxide hydrolase / lipid-phosphate phosphatase [EC:3.3.2.10 3.1.3.76]

K08731

BIRC5; baculoviral IAP repeat-containing protein 5

K09047

CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5

K09048

CREB3; cyclic AMP-responsive element-binding protein 3

K09049

ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta

K09093

AHR; aryl hydrocarbon receptor

K09097

ARNT; aryl hydrocarbon receptor nuclear translocator

K09206

KLF5; krueppel-like factor 5

K09487

HSP90B, TRA1; heat shock protein 90kDa beta

K10152

CCND3; G1/S-specific cyclin-D3

K11223

STAT5A; signal transducer and activator of transcription 5A

K11224

STAT5B; signal transducer and activator of transcription 5B

K14293

KPNB1, IPO1; importin subunit beta-1

K15042

KPNA5_6; importin subunit alpha-6/7

K15043

KPNA2_7; importin subunit alpha-1/8

K15618

BCL6; B-cell lymphoma 6 protein

K15730

PTGES3; cytosolic prostaglandin-E synthase [EC:5.3.99.3]

K16980

MIRLET7; microRNA let-7

K16995

MIR29; microRNA 29

K17018

MIR141; microRNA 141

K17454

E2F1; transcription factor E2F1

K17689

CYP3A4; cytochrome P450 family 3 subfamily A4 [EC:1.14.13.32 1.14.14.55 1.14.14.56 1.14.14.57 1.14.14.73 1.14.14.-]

K17709

CYP2B6; cytochrome P450 family 2 subfamily B6 [EC:1.14.14.-]

K17767

AIP, XAP2; AH receptor-interacting protein

K17846

KLF4; krueppel-like factor 4

K18497

FGF2; fibroblast growth factor 2

K19662

PRKCB; classical protein kinase C beta type [EC:2.7.11.13]

K19663

PRKCG; classical protein kinase C gamma type [EC:2.7.11.13]

K20994

NOTCH2; Notch 2

K22368

EPHX3; epoxide hydrolase 3 [EC:3.3.2.10]

K22369

EPHX4; epoxide hydrolase 4 [EC:3.3.-.-]

K23583

KPNA3_4; importin subunit alpha-4/3

K23940

KPNA1; importin subunit alpha-5

K25039

PAQR7, MPRA; membrane progestin receptor alpha

K25040

PAQR8, MPRB; membrane progestin receptor beta

K25041

PAQR5, MPRG; membrane progestin receptor gamma

Compound

C00076

Calcium cation

C00410

Progesterone

C00547

L-Noradrenaline

C00575

3',5'-Cyclic AMP

C00745

Nicotine

C00780

Serotonin

C00788

L-Adrenaline

C00951

Estradiol-17beta

C03690

Bis(2-ethylhexyl)phthalate

C04623

DDT

C05981

Phosphatidylinositol-3,4,5-trisphosphate

C06697

Arsenite

C06790

Trichloroethene

C06916

Clofibrate

C07020

Gemfibrozil

C07434

Phenobarbital

C07535

Benzo[a]pyrene

C07557

2,3,7,8-Tetrachlorodibenzodioxin

C08150

Medroxyprogesterone acetate

C11042

Hexachlorobenzene

C11150

Trichloroacetate

C11371

Nafenopin

C11906

Sodium arsenite

C13624

Bisphenol A

C14240

Di(2-ethylhexyl) adipate

C14573

3,3',4,4',5-Pentachlorobiphenyl

C15995

Bombesin

C16452

N'-Nitrosonornicotine

C16453

4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone

Reference

PMID:15660110

Authors

Luch A.

Title

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Journal

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Reference

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Authors

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Title

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Journal

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Reference

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Title

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Journal

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Reference

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Authors

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Title

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Journal

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Reference

PMID:21541211

Authors

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Title

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Journal

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DOI:10.1155/2011/456743

Reference

PMID:31956359

Authors

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Title

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Journal

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Reference

PMID:24827506

Authors

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Title

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Journal

Nat Rev Cancer 14:419-29 (2014)
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Reference

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Authors

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Title

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Journal

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Reference

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Authors

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Title

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Journal

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Reference

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Authors

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Title

Nicotinic acetylcholine receptors in cancer: multiple roles in proliferation and inhibition of apoptosis.

Journal

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Reference

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Title

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Journal

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Reference

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Title

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Journal

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Title

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Journal

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Reference

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Authors

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Title

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Journal

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Reference

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Authors

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Title

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Journal

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Reference

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Authors

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Title

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Journal

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Reference

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Authors

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Title

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Journal

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Reference

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Authors

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Title

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Journal

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Reference

PMID:28251049

Authors

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Title

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Journal

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Reference

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Authors

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Title

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Journal

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Reference

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Authors

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Title

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Journal

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Reference

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Authors

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Title

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Journal

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Reference

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Title

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Reference

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Authors

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Title

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Journal

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Reference

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Authors

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Title

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Journal

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Authors

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Title

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Journal

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Title

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Journal

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Reference

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Authors

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Title

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Title

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Journal

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Title

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Title

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Title

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Title

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Title

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Title

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Journal

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Title

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Journal

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Authors

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Title

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Journal

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Title

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Journal

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Reference

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