KEGG   PATHWAY: loc04060
Entry
loc04060                    Pathway                                
Name
Cytokine-cytokine receptor interaction - Lepisosteus oculatus (spotted gar)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
loc04060  Cytokine-cytokine receptor interaction
loc04060

Organism
Lepisosteus oculatus (spotted gar) [GN:loc]
Gene
102682152  [KO:K05058]
102682171  eda; ectodysplasin-A isoform X1 [KO:K05480]
102682204  [KO:K04188]
102682373  [KO:K05476]
102682400  tnfsf13b; tumor necrosis factor ligand superfamily member 13B [KO:K05476]
102682723  tgfbr2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
102682751  bmp2; bone morphogenetic protein 2 isoform X1 [KO:K21283]
102682814  [KO:K13376]
102682852  faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
102682956  gdf3; growth/differentiation factor 3 [KO:K22672]
102683026  prlr; prolactin receptor isoform X1 [KO:K05081]
102683167  relt; tumor necrosis factor receptor superfamily member 19L isoform X1 [KO:K05156]
102683276  [KO:K22629]
102683355  [KO:K05160]
102683404  ngfr; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
102683440  acvr1b; activin receptor type-1B [KO:K13567] [EC:2.7.11.30]
102683479  [KO:K22629]
102683493  tgfb2; transforming growth factor beta-2 [KO:K13376]
102683870  acvr2b; activin receptor type-2B [KO:K13596] [EC:2.7.11.30]
102683981  [KO:K04722]
102684136  bmp4; bone morphogenetic protein 4 [KO:K04662]
102684223  cxcr4; C-X-C chemokine receptor type 4 [KO:K04189]
102684262  [KO:K05477]
102684371  [KO:K10032]
102684456  [KO:K05477]
102684564  il17d; interleukin-17D [KO:K05492]
102684715  [KO:K10030]
102684777  [KO:K05136]
102684846  [KO:K05477]
102684901  [KO:K05489]
102685062  acvr2a; activin receptor type-2A isoform X2 [KO:K04670] [EC:2.7.11.30]
102685166  [KO:K06454]
102685239  [KO:K22687]
102685649  gdf11; growth/differentiation factor 11 [KO:K22679]
102685666  [KO:K04179]
102686164  ccr7; C-C chemokine receptor type 7 isoform X1 [KO:K04182]
102686269  cxcl14; C-X-C motif chemokine 14 [KO:K10033]
102686273  [KO:K05439]
102686346  [KO:K05070]
102686658  gdf7; growth/differentiation factor 7 [KO:K20013]
102686806  bmpr1b; bone morphogenetic protein receptor type-1B isoform X1 [KO:K13578] [EC:2.7.11.30]
102686972  [KO:K05143]
102687172  tnfrsf11b; tumor necrosis factor receptor superfamily member 11B [KO:K05148]
102687451  [KO:K04675] [EC:2.7.11.30]
102687457  tnfrsf6b; tumor necrosis factor receptor superfamily member 6B [KO:K05143]
102687508  bmp5; bone morphogenetic protein 5 [KO:K04663]
102687524  [KO:K05438]
102687545  rell1; RELT-like protein 1 [KO:K26541]
102687575  gdf6; growth/differentiation factor 6 [KO:K20012]
102687741  epo; erythropoietin isoform X1 [KO:K05437]
102687795  tnfsf15; tumor necrosis factor ligand superfamily member 15 [KO:K05478]
102687890  gdf2; growth/differentiation factor 2 [KO:K22670]
102688021  bmp3; bone morphogenetic protein 3 [KO:K05496]
102688054  inhbb; inhibin beta B chain [KO:K22687]
102688095  gdf10; growth/differentiation factor 10 isoform X1 [KO:K22674]
102688112  il2rb; interleukin-2 receptor subunit beta isoform X1 [KO:K05069]
102688423  bmp10; bone morphogenetic protein 10 [KO:K22670]
102688432  tnfrsf19; tumor necrosis factor receptor superfamily member 19 [KO:K05155]
102688466  bmpr2; bone morphogenetic protein receptor type-2 isoform X3 [KO:K04671] [EC:2.7.11.30]
102688552  [KO:K04666]
102688604  ackr3; atypical chemokine receptor 3 [KO:K04304]
102688755  [KO:K04666]
102688763  [KO:K21283]
102688795  tgfbr1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
102688796  ackr4; atypical chemokine receptor 4 [KO:K04186]
102688917  [KO:K04179]
102688952  [KO:K04666]
102689112  [KO:K21283]
102689122  [KO:K04193]
102689133  edar; tumor necrosis factor receptor superfamily member EDAR [KO:K05162]
102689437  [KO:K05152]
102689641  [KO:K05152]
102689804  il17ra; interleukin-17 receptor A [KO:K05164]
102690193  il17rc; interleukin-17 receptor C isoform X1 [KO:K05166]
102690416  bmp6; bone morphogenetic protein 6 [KO:K16620]
102690527  [KO:K05453]
102690613  cntf; ciliary neurotrophic factor [KO:K05420]
102690765  [KO:K21283]
102690935  bmpr1a; bone morphogenetic protein receptor type-1A [KO:K04673] [EC:2.7.11.30]
102691298  il21r; interleukin-21 receptor [KO:K05075]
102691307  amh; muellerian-inhibiting factor [KO:K04665]
102691365  [KO:K13072]
102691380  [KO:K05468]
102691411  [KO:K04687]
102691421  mpl; thrombopoietin receptor [KO:K05082]
102691429  acvr1c; activin receptor type-1C isoform X1 [KO:K13568] [EC:2.7.11.30]
102691462  [KO:K05504]
102691463  [KO:K05056]
102691663  [KO:K05059]
102691880  tgfb3; transforming growth factor beta-3 [KO:K13377]
102692089  [KO:K04179]
102692092  [KO:K04388] [EC:2.7.11.30]
102692225  [KO:K02583]
102692258  ccr6; C-C chemokine receptor type 6 [KO:K04181]
102692294  [KO:K05050]
102692492  [KO:K04179]
102692498  [KO:K05050]
102692607  epor; erythropoietin receptor [KO:K05079]
102692695  [KO:K04179]
102692738  ngf; beta-nerve growth factor [KO:K02582]
102692739  il10; interleukin-10 [KO:K05443]
102692828  clcf1; cardiotrophin-like cytokine factor 1 [KO:K05421]
102692870  ghr; growth hormone receptor isoform X1 [KO:K05080]
102692937  il20; interleukin-20 isoform X1 [KO:K22667]
102692951  bmp15; bone morphogenetic protein 15 [KO:K05498]
102693027  inhba; inhibin beta A chain [KO:K04667]
102693200  tnfsf12; tumor necrosis factor ligand superfamily member 12 [KO:K05474]
102693230  [KO:K04184]
102693349  cxcl12; stromal cell-derived factor 1 isoform X1 [KO:K10031]
102693519  ccr10; C-C chemokine receptor type 10 isoform X3 [KO:K04182]
102693576  [KO:K05135]
102693617  gdf9; growth/differentiation factor 9 [KO:K22673]
102693774  [KO:K05414]
102693776  [KO:K05135]
102693969  [KO:K05131]
102694171  [KO:K05438]
102694321  ebi3; interleukin-27 subunit beta [KO:K24476]
102694353  csf3r; granulocyte colony-stimulating factor receptor [KO:K05061]
102694711  il17c; interleukin-17C [KO:K05491]
102694740  nodal; nodal homolog [KO:K04666]
102694985  [KO:K05475]
102695018  lepr; leptin receptor [KO:K05062]
102695113  il18rap; interleukin-18 receptor accessory protein isoform X1 [KO:K05174]
102695221  il1rap; interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
102695309  [KO:K05173]
102695320  il6st; interleukin-6 receptor subunit beta [KO:K05060]
102695324  il16; pro-interleukin-16 [KO:K22628]
102695414  tnfsf10; tumor necrosis factor ligand superfamily member 10 [KO:K04721]
102695590  il13ra2; interleukin-13 receptor subunit alpha-2 [KO:K05077]
102695605  mstn; growth/differentiation factor 8 isoform X1 [KO:K05497]
102695624  cxcr5; C-X-C chemokine receptor type 5 [KO:K04190]
102696196  il12rb2; interleukin-12 receptor subunit beta-2 [KO:K05064]
102696720  tnfrsf11a; tumor necrosis factor receptor superfamily member 11A [KO:K05147]
102696844  csf1r; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
102697185  [KO:K05504]
102697617  il12b; interleukin-12 subunit beta [KO:K05425]
102697648  gdf5; growth/differentiation factor 5 [KO:K04664]
102697660  [KO:K03160]
102698143  cd40lg; CD40 ligand [KO:K03161]
102698487  [KO:K05424]
102698499  inha; inhibin alpha chain [KO:K05500]
102698573  bmp7; bone morphogenetic protein 7 [KO:K16621]
102698641  acvr1; activin receptor type-1 [KO:K04675] [EC:2.7.11.30]
102698656  il1r2; interleukin-1 receptor type 2 [KO:K04387]
102698805  tnfrsf21; tumor necrosis factor receptor superfamily member 21 [KO:K05157]
102698856  [KO:K04386]
102698936  tgfb1; transforming growth factor beta-1 [KO:K13375]
102699051  [KO:K04386]
102699113  [KO:K04179]
102699141  bmp8a; bone morphogenetic protein 8A [KO:K16622]
102699198  [KO:K05425]
107075521  [KO:K05142]
107075569  [KO:K05146]
107075582  [KO:K05152]
107075583  [KO:K05141]
107075592  [KO:K05141]
107075665  [KO:K22630]
107075710  [KO:K05134]
107075740  [KO:K03159]
107075821  [KO:K22630]
107075913  [KO:K05173]
107076357  [KO:K05414]
107076369  [KO:K03160]
107076525  [KO:K05058]
107076551  il7r; interleukin-7 receptor subunit alpha [KO:K05072]
107077008  [KO:K05426]
107077068  [KO:K05512]
107077081  [KO:K05433]
107077132  [KO:K10030]
107077137  [KO:K10030]
107077138  [KO:K10030]
107077281  tnfrsf12a; tumor necrosis factor receptor superfamily member 12A isoform X1 [KO:K05149]
107077336  fas; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
107077437  il17rb; interleukin-17 receptor B [KO:K05165]
107077441  [KO:K05168]
107077550  [KO:K05136]
107077552  [KO:K04721]
107077645  [KO:K12672]
107077703  rell2; RELT-like protein 2 [KO:K26541]
107077857  eda2r; tumor necrosis factor receptor superfamily member 27 [KO:K05163]
107077872  [KO:K05076]
107077891  [KO:K05070]
107077892  [KO:K05163]
107078291  [KO:K04178]
107078304  [KO:K04186]
107078386  il23r; interleukin-23 receptor isoform X1 [KO:K05064]
107078662  il6; interleukin-6 [KO:K05405]
107078934  tnfrsf13b; tumor necrosis factor receptor superfamily member 13B [KO:K05150]
107078986  [KO:K05071]
107078987  [KO:K05075]
107079022  tnfrsf17; tumor necrosis factor receptor superfamily member 17 isoform X1 [KO:K05153]
107079109  il12a; interleukin-12 subunit alpha [KO:K05406]
107079119  [KO:K14625]
107079120  [KO:K14625]
107079123  [KO:K14625]
107079136  [KO:K14625]
107079194  [KO:K05137]
107079271  [KO:K05414]
107079272  [KO:K05414]
107079327  [KO:K05132]
107079411  [KO:K05078]
107079424  [KO:K05133]
107079425  [KO:K05135]
107079496  [KO:K05171]
107079633  il12rb1; interleukin-12 receptor subunit beta-1 [KO:K05063]
107079649  [KO:K05060]
107079691  [KO:K21083]
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Reference
PMID:21106488
  Authors
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V
  Title
Evolutionary divergence and functions of the human interleukin (IL) gene family.
  Journal
Hum Genomics 5:30-55 (2010)
DOI:10.1186/1479-7364-5-1-30
Reference
PMID:27577879
  Authors
Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA
  Title
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases.
  Journal
J Allergy Clin Immunol 138:984-1010 (2016)
DOI:10.1016/j.jaci.2016.06.033
Reference
PMID:15500860
  Authors
Boulanger MJ, Garcia KC
  Title
Shared cytokine signaling receptors: structural insights from the gp130 system.
  Journal
Adv Protein Chem 68:107-46 (2004)
DOI:10.1016/S0065-3233(04)68004-1
Reference
PMID:16034365
  Authors
Allan SM, Tyrrell PJ, Rothwell NJ
  Title
Interleukin-1 and neuronal injury.
  Journal
Nat Rev Immunol 5:629-40 (2005)
DOI:10.1038/nri1664
Reference
PMID:23847622
  Authors
Lopetuso LR, Chowdhry S, Pizarro TT
  Title
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
  Journal
Front Immunol 4:181 (2013)
DOI:10.3389/fimmu.2013.00181
Reference
PMID:21349428
  Authors
Iwakura Y, Ishigame H, Saijo S, Nakae S
  Title
Functional specialization of interleukin-17 family members.
  Journal
Immunity 34:149-62 (2011)
DOI:10.1016/j.immuni.2011.02.012
Reference
PMID:17530315
  Authors
Fischer P, Hilfiker-Kleiner D
  Title
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
  Journal
Basic Res Cardiol 102:279-97 (2007)
DOI:10.1007/s00395-007-0658-z
Reference
PMID:24381786
  Authors
Richards CD
  Title
The enigmatic cytokine oncostatin m and roles in disease.
  Journal
ISRN Inflamm 2013:512103 (2013)
DOI:10.1155/2013/512103
Reference
PMID:18926762
  Authors
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W
  Title
Structures and biological functions of IL-31 and IL-31 receptors.
  Journal
Cytokine Growth Factor Rev 19:347-56 (2008)
DOI:10.1016/j.cytogfr.2008.08.003
Reference
PMID:21155715
  Authors
Meenhuis A, Verwijmeren C, Roovers O, Touw IP
  Title
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.
  Journal
Biochem J 434:343-51 (2011)
DOI:10.1042/BJ20101628
Reference
PMID:22410872
  Authors
de Weerd NA, Nguyen T
  Title
The interferons and their receptors--distribution and regulation.
  Journal
Immunol Cell Biol 90:483-91 (2012)
DOI:10.1038/icb.2012.9
Reference
PMID:12949498
  Authors
Aggarwal BB
  Title
Signalling pathways of the TNF superfamily: a double-edged sword.
  Journal
Nat Rev Immunol 3:745-56 (2003)
DOI:10.1038/nri1184
Reference
PMID:12189384
  Authors
Ashkenazi A
  Title
Targeting death and decoy receptors of the tumour-necrosis factor superfamily.
  Journal
Nat Rev Cancer 2:420-30 (2002)
DOI:10.1038/nrc821
Reference
PMID:26115564
  Authors
Seeger P, Musso T, Sozzani S
  Title
The TGF-beta superfamily in dendritic cell biology.
  Journal
Cytokine Growth Factor Rev 26:647-57 (2015)
DOI:10.1016/j.cytogfr.2015.06.002
Reference
PMID:23612460
  Authors
Wakefield LM, Hill CS
  Title
Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer.
  Journal
Nat Rev Cancer 13:328-41 (2013)
DOI:10.1038/nrc3500
Reference
PMID:22710174
  Authors
Mueller TD, Nickel J
  Title
Promiscuity and specificity in BMP receptor activation.
  Journal
FEBS Lett 586:1846-59 (2012)
DOI:10.1016/j.febslet.2012.02.043
KO pathway
ko04060   

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