KEGG   PATHWAY: mcep04210
Entry
mcep04210                   Pathway                                
Name
Apoptosis - Mugil cephalus (flathead mullet)
Description
Apoptosis is a genetically programmed process for the elimination of damaged or redundant cells by activation of caspases (aspartate-specific cysteine proteases). The onset of apoptosis is controlled by numerous interrelating processes. The 'extrinsic' pathway involves stimulation of members of the tumor necrosis factor (TNF) receptor subfamily, such as TNFRI, CD95/Fas or TRAILR (death receptors), located at the cell surface, by their specific ligands, such as TNF-alpha, FasL or TRAIL, respectively. The 'intrinsic' pathway is activated mainly by non-receptor stimuli, such as DNA damage, ER stress, metabolic stress, UV radiation or growth-factor deprivation. The central event in the 'intrinsic' pathway is the mitochondrial outer membrane permeabilization (MOMP), which leads to the release of cytochrome c. These two pathways converge at the level of effector caspases, such as caspase-3 and caspase-7. The third major pathway is initiated by the constituents of cytotoxic granules (e.g. Perforin and Granzyme B) that are released by CTLs (cytotoxic T-cells) and NK (natural killer) cells. Granzyme B, similarly to the caspases, cleaves its substrates after aspartic acid residues, suggesting that this protease has the ability to activate members of the caspase family directly. It is the balance between the pro-apoptotic and anti-apoptotic signals that eventually determines whether cells will undergo apoptosis, survive or proliferate. TNF family of ligands activates anti-apoptotic or cell-survival signals as well as apoptotic signals. NGF and Interleukin-3 promotes the survival, proliferation and differentiation of neurons or hematopoietic cells, respectively. Withdrawal of these growth factors leads to cell death, as described above.
Class
Cellular Processes; Cell growth and death
Pathway map
mcep04210  Apoptosis
mcep04210

Other DBs
GO: 0006915
Organism
Mugil cephalus (flathead mullet) [GN:mcep]
Gene
124995540  [KO:K04721]
124996387  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
124996412  lmnb1; lamin-B1 [KO:K07611]
124996426  traf2b; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
124996570  sptan1; spectrin alpha chain, non-erythrocytic 1 isoform X1 [KO:K06114]
124996629  [KO:K04722]
124996647  ptpn13; tyrosine-protein phosphatase non-receptor type 13 isoform X1 [KO:K02374]
124996730  casp17; caspase-7 [KO:K04397] [EC:3.4.22.60]
124996760  [KO:K04402]
124996826  junE; JunE proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
124997018  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
124997051  [KO:K19901]
124997108  tuba1a; tubulin alpha-1A chain [KO:K07374]
124997119  [KO:K07374]
124997127  [KO:K07374]
124997156  gadd45gb.1; growth arrest and DNA-damage-inducible, gamma b, tandem duplicate 1 [KO:K04402]
124997163  [KO:K03173] [EC:2.3.2.27]
124997358  csf2rb; cytokine receptor common subunit beta [KO:K04738]
124997473  map3k14a; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
124997474  [KO:K02159]
124997478  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
124997541  zgc:55558; GTPase KRas [KO:K07827]
124997650  prf1.3; perforin-1.3 [KO:K07818]
124997994  [KO:K08852] [EC:2.7.11.1 3.1.26.-]
124998024  [KO:K07818]
124998067  napsa; napsin-A [KO:K01379] [EC:3.4.23.5]
124998068  atf4b; activating transcription factor 4b [KO:K04374]
124998080  actb2; actin, cytoplasmic 2 [KO:K05692]
124998318  [KO:K07818]
124998774  eif2s1b; eukaryotic translation initiation factor 2 subunit 1b [KO:K03237]
124999028  parp1; poly [ADP-ribose] polymerase 1 [KO:K24070]
124999107  raf1a; raf-1 proto-oncogene, serine/threonine kinase A isoform X1 [KO:K04366] [EC:2.7.11.1]
124999159  [KO:K04379]
124999160  [KO:K04379]
124999414  [KO:K01363] [EC:3.4.22.1]
124999499  [KO:K04734]
125000209  apaf1; apoptotic protease-activating factor 1 [KO:K02084]
125000661  [KO:K07374]
125000662  [KO:K07374]
125000663  [KO:K07374]
125001542  [KO:K07818]
125003405  [KO:K07818]
125003446  [KO:K07818]
125003474  [KO:K07818]
125003771  [KO:K04396] [EC:3.4.22.59]
125003859  atf4a; cyclic AMP-dependent transcription factor ATF-4 isoform X1 [KO:K04374]
125003914  [KO:K05692]
125004162  ern2; serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
125004330  [KO:K07818]
125004369  tuba5; tubulin alpha 5 [KO:K07374]
125004376  casp3a; caspase-3a [KO:K02187] [EC:3.4.22.56]
125004441  [KO:K07818]
125004515  [KO:K07818]
125004516  [KO:K07818]
125004517  [KO:K07818]
125004518  [KO:K07818]
125004579  capn8; calpain-8 isoform X1 [KO:K03853] [EC:3.4.22.53]
125004580  capn2l; calpain 2, (m/II) large subunit, like [KO:K03853] [EC:3.4.22.53]
125004581  capn2b; calpain 2, (m/II) large subunit B [KO:K03853] [EC:3.4.22.53]
125004613  akt3b; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
125005173  fadD; protein FADD [KO:K02373]
125005746  tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
125005753  ctsD; cathepsin D [KO:K01379] [EC:3.4.23.5]
125005757  [KO:K01366] [EC:3.4.22.16]
125005918  zgc:153993; apoptosis regulator BAX isoform X1 [KO:K02159]
125005924  ctsba; cathepsin B [KO:K01363] [EC:3.4.22.1]
125005975  lmnl3; lamin L3 isoform X1 [KO:K07611]
125006285  [KO:K04958]
125006288  parp3; protein mono-ADP-ribosyltransferase PARP3 [KO:K10798] [EC:2.4.2.-]
125006406  ddit3; DNA damage-inducible transcript 3 protein [KO:K04452]
125007148  ctsZ; cathepsin Z [KO:K08568] [EC:3.4.18.1]
125007204  [KO:K04958]
125007264  ngfB; nerve growth factor [KO:K02582]
125007337  [KO:K04570]
125007804  nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
125007842  [KO:K02187] [EC:3.4.22.56]
125007881  cd40lg; CD40 ligand [KO:K04389]
125007958  [KO:K04725] [EC:2.3.2.27]
125008233  [KO:K08568] [EC:3.4.18.1]
125008315  itpr3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
125008335  ctsF; cathepsin F isoform X1 [KO:K01373] [EC:3.4.22.41]
125008512  ctsO; cathepsin O isoform X1 [KO:K01374] [EC:3.4.22.42]
125008712  mapk9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
125008925  [KO:K01353] [EC:3.4.21.79]
125008926  [KO:K01353] [EC:3.4.21.79]
125009173  faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
125009281  pik3r3b; phosphoinositide-3-kinase, regulatory subunit 3b (gamma) [KO:K02649]
125009384  [KO:K00922] [EC:2.7.1.153]
125009453  jun; transcription factor AP-1 [KO:K04448]
125009454  map2k2a; dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
125009487  [KO:K01353] [EC:3.4.21.79]
125009673  lmnb2; lamin-B2 [KO:K07611]
125009744  [KO:K02649]
125009799  [KO:K04402]
125009947  cts12; procathepsin L [KO:K01365] [EC:3.4.22.15]
125009995  gadd45ab; growth arrest and DNA-damage-inducible, alpha, B [KO:K04402]
125010117  [KO:K08568] [EC:3.4.18.1]
125010254  [KO:K04451]
125010340  [KO:K04448]
125010408  bcl2b; apoptosis regulator Bcl-2 [KO:K02161]
125010445  pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
125010642  [KO:K28005]
125010654  map2k2b; LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 2b [KO:K04369] [EC:2.7.12.2]
125010793  [KO:K00922] [EC:2.7.1.153]
125010912  relA; transcription factor P65 [KO:K04735]
125011199  [KO:K02649]
125011224  ripk1l; receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861] [EC:2.7.11.1]
125011288  parp2; poly [ADP-ribose] polymerase 2 isoform X1 [KO:K28005]
125011438  [KO:K07374]
125011470  gadd45aa; growth arrest and DNA-damage-inducible, alpha, A [KO:K04402]
125011841  ngfA; neurotrophin-7 [KO:K02582]
125011866  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
125012012  [KO:K05692]
125012076  [KO:K19901]
125012092  ctsla; cathepsin La [KO:K01365] [EC:3.4.22.15]
125012106  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
125012290  prf1.5; perforin 1.5 isoform X1 [KO:K07818]
125012733  [KO:K03173] [EC:2.3.2.27]
125012779  [KO:K02649]
125012801  [KO:K05692]
125012829  [KO:K05692]
125012876  badB; BCL2 associated agonist of cell death b isoform X1 [KO:K02158]
125012907  gadd45ga; growth arrest and DNA-damage-inducible, gamma A [KO:K04402]
125012978  ctsC; dipeptidyl peptidase 1 [KO:K01275] [EC:3.4.14.1]
125013120  septin4b; septin 4b isoform X1 [KO:K16943]
125013280  atm; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
125013336  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
125013339  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
125013603  [KO:K10522]
125013694  [KO:K07374]
125014099  [KO:K10522]
125014320  ctsH; pro-cathepsin H [KO:K01366] [EC:3.4.22.16]
125014526  pidd1; p53-induced death domain-containing protein 1 [KO:K10130]
125014660  kraS; GTPase KRas [KO:K07827]
125014864  bidA; BH3 interacting domain death agonist isoform X1 [KO:K04726]
125015016  [KO:K02833]
125015051  itpr2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
125015166  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
125015712  ntrk1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
125015976  lmnA; lamin [KO:K12641]
125016156  ctss2.1; cathepsin S, ortholog2, tandem duplicate 1 [KO:K01368] [EC:3.4.22.27]
125016158  ctsK; cathepsin K [KO:K01371] [EC:3.4.22.38]
125016180  tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
125016415  mcl1b; induced myeloid leukemia cell differentiation protein Mcl-1b [KO:K02539]
125016978  si:ch211-1i11.3; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
125017067  casp2; caspase-2 isoform X1 [KO:K02186] [EC:3.4.22.55]
125017234  [KO:K04724]
125017250  [KO:K07374]
125017251  [KO:K07374]
125017328  casp9; caspase-9 [KO:K04399] [EC:3.4.22.62]
125017452  [KO:K07374]
125017759  [KO:K01353] [EC:3.4.21.79]
125018020  [KO:K08738]
125018039  parp4; protein mono-ADP-ribosyltransferase PARP4 isoform X1 [KO:K10798] [EC:2.4.2.-]
125018228  casp10; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
125018283  [KO:K01353] [EC:3.4.21.79]
125018358  [KO:K04467] [EC:2.7.11.10]
125018547  akt3a; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
125018834  capn1a; calpain 1, (mu/I) large subunit A [KO:K01367] [EC:3.4.22.52]
125018956  [KO:K08738]
125019044  bcl2l1; bcl-2-like protein 1 [KO:K04570]
125019146  [KO:K03853] [EC:3.4.22.53]
125019147  [KO:K03853] [EC:3.4.22.53]
125019152  bcl2l11; bcl-2-like protein 11 [KO:K16341]
125019343  mapk8a; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
125019489  daxX; death domain-associated protein 6 [KO:K02308]
125019542  [KO:K04451]
125019568  [KO:K04451]
125019584  [KO:K04451]
125019929  capn1; calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
125019961  [KO:K12641]
125020121  [KO:K08738]
125020172  tnfA; tumor necrosis factor a (TNF superfamily, member 2) [KO:K03156]
125020404  [KO:K01371] [EC:3.4.22.38]
125020405  [KO:K01368] [EC:3.4.22.27]
125020749  [KO:K01367] [EC:3.4.22.52]
125020875  [KO:K04456] [EC:2.7.11.1]
125021103  aifm1; apoptosis-inducing factor 1, mitochondrial isoform X1 [KO:K04727] [EC:1.-.-.-]
125021136  [KO:K01367] [EC:3.4.22.52]
125021342  birc2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
125021401  septin4a; septin 4a isoform X1 [KO:K16943]
125021757  [KO:K02159]
125021891  dffB; DNA fragmentation factor subunit beta [KO:K02311] [EC:3.-.-.-]
125021920  [KO:K04466] [EC:2.7.11.25]
125022122  mapk8b; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
125022245  pdpk1b; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
125022415  ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
125022650  [KO:K04467] [EC:2.7.11.10]
125022738  casp7; caspase-7 isoform X1 [KO:K04397] [EC:3.4.22.60]
125022987  birc5a; baculoviral IAP repeat-containing protein 5A [KO:K08731]
125023193  fosaa; protein C-Fos [KO:K04379]
125023264  [KO:K08669] [EC:3.4.21.108]
125023316  [KO:K04402]
125023607  dffA; DNA fragmentation factor subunit alpha isoform X1 [KO:K02310]
125023675  akt1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
125023797  eif2ak3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
125023991  ctsl.1; cathepsin L.1 [KO:K01365] [EC:3.4.22.15]
125024054  [KO:K04734]
125024079  [KO:K04721]
125024190  [KO:K01367] [EC:3.4.22.52]
125024213  [KO:K01367] [EC:3.4.22.52]
125024403  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00319  Sphingosine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:26615431
  Authors
Savitskaya MA, Onishchenko GE
  Title
Mechanisms of Apoptosis.
  Journal
Biochemistry (Mosc) 80:1393-417 (2015)
DOI:10.1134/S0006297915110012
Reference
PMID:23803157
  Authors
Schleich K, Lavrik IN
  Title
Mathematical modeling of apoptosis.
  Journal
Cell Commun Signal 11:44 (2013)
DOI:10.1186/1478-811X-11-44
Reference
PMID:15654015
  Authors
Lavrik I, Golks A, Krammer PH
  Title
Death receptor signaling.
  Journal
J Cell Sci 118:265-7 (2005)
DOI:10.1242/jcs.01610
Reference
PMID:15725726
  Authors
Jin Z, El-Deiry WS
  Title
Overview of cell death signaling pathways.
  Journal
Cancer Biol Ther 4:139-63 (2005)
DOI:10.4161/cbt.4.2.1508
Reference
PMID:15322527
  Authors
Benn SC, Woolf CJ
  Title
Adult neuron survival strategies--slamming on the brakes.
  Journal
Nat Rev Neurosci 5:686-700 (2004)
DOI:10.1038/nrn1477
Reference
PMID:12838338
  Authors
Orrenius S, Zhivotovsky B, Nicotera P
  Title
Regulation of cell death: the calcium-apoptosis link.
  Journal
Nat Rev Mol Cell Biol 4:552-65 (2003)
DOI:10.1038/nrm1150
Reference
PMID:19148180
  Authors
Clarke P, Tyler KL
  Title
Apoptosis in animal models of virus-induced disease.
  Journal
Nat Rev Microbiol 7:144-55 (2009)
DOI:10.1038/nrmicro2071
Reference
PMID:22429822
  Authors
Wen X, Lin ZQ, Liu B, Wei YQ
  Title
Caspase-mediated programmed cell death pathways as potential therapeutic targets in cancer.
  Journal
Cell Prolif 45:217-24 (2012)
DOI:10.1111/j.1365-2184.2012.00814.x
Reference
PMID:25526085
  Authors
Shalini S, Dorstyn L, Dawar S, Kumar S
  Title
Old, new and emerging functions of caspases.
  Journal
Cell Death Differ 22:526-39 (2015)
DOI:10.1038/cdd.2014.216
Reference
PMID:15601572
  Authors
Philchenkov A
  Title
Caspases: potential targets for regulating cell death.
  Journal
J Cell Mol Med 8:432-44 (2004)
DOI:10.1111/j.1582-4934.2004.tb00468.x
Reference
PMID:9894605
  Authors
Stroh C, Schulze-Osthoff K
  Title
Death by a thousand cuts: an ever increasing list of caspase substrates.
  Journal
Cell Death Differ 5:997-1000 (1998)
DOI:10.1038/sj.cdd.4400451
Reference
PMID:23070002
  Authors
Safa AR
  Title
c-FLIP, a master anti-apoptotic regulator.
  Journal
Exp Oncol 34:176-84 (2012)
Reference
PMID:18304445
  Authors
Jeong SY, Seol DW
  Title
The role of mitochondria in apoptosis.
  Journal
BMB Rep 41:11-22 (2008)
DOI:10.5483/bmbrep.2008.41.1.011
Reference
PMID:20533903
  Authors
Parsons MJ, Green DR
  Title
Mitochondria in cell death.
  Journal
Essays Biochem 47:99-114 (2010)
DOI:10.1042/bse0470099
Reference
PMID:15719025
  Authors
Strasser A
  Title
The role of BH3-only proteins in the immune system.
  Journal
Nat Rev Immunol 5:189-200 (2005)
DOI:10.1038/nri1568
Reference
PMID:24278747
  Authors
Schonthal AH
  Title
Endoplasmic reticulum stress: its role in disease and novel prospects for therapy.
  Journal
Scientifica (Cairo) 2012:857516 (2012)
DOI:10.6064/2012/857516
Reference
PMID:21145844
  Authors
Malhi H, Kaufman RJ
  Title
Endoplasmic reticulum stress in liver disease.
  Journal
J Hepatol 54:795-809 (2011)
DOI:10.1016/j.jhep.2010.11.005
Reference
PMID:18023214
  Authors
Malhotra JD, Kaufman RJ
  Title
The endoplasmic reticulum and the unfolded protein response.
  Journal
Semin Cell Dev Biol 18:716-31 (2007)
DOI:10.1016/j.semcdb.2007.09.003
Reference
PMID:16397578
  Authors
Wu J, Kaufman RJ
  Title
From acute ER stress to physiological roles of the Unfolded Protein Response.
  Journal
Cell Death Differ 13:374-84 (2006)
DOI:10.1038/sj.cdd.4401840
Reference
PMID:21914490
  Authors
Repnik U, Stoka V, Turk V, Turk B
  Title
Lysosomes and lysosomal cathepsins in cell death.
  Journal
Biochim Biophys Acta 1824:22-33 (2012)
DOI:10.1016/j.bbapap.2011.08.016
Reference
PMID:22465226
  Authors
Cesen MH, Pegan K, Spes A, Turk B
  Title
Lysosomal pathways to cell death and their therapeutic applications.
  Journal
Exp Cell Res 318:1245-51 (2012)
DOI:10.1016/j.yexcr.2012.03.005
Reference
PMID:26231733
  Authors
Dashzeveg N, Yoshida K
  Title
Cell death decision by p53 via control of the mitochondrial membrane.
  Journal
Cancer Lett 367:108-12 (2015)
DOI:10.1016/j.canlet.2015.07.019
Reference
PMID:22075987
  Authors
Bouchier-Hayes L, Green DR
  Title
Caspase-2: the orphan caspase.
  Journal
Cell Death Differ 19:51-7 (2012)
DOI:10.1038/cdd.2011.157
Reference
PMID:18238895
  Authors
Baptiste-Okoh N, Barsotti AM, Prives C
  Title
A role for caspase 2 and PIDD in the process of p53-mediated apoptosis.
  Journal
Proc Natl Acad Sci U S A 105:1937-42 (2008)
DOI:10.1073/pnas.0711800105
Reference
PMID:12949498
  Authors
Aggarwal BB
  Title
Signalling pathways of the TNF superfamily: a double-edged sword.
  Journal
Nat Rev Immunol 3:745-56 (2003)
DOI:10.1038/nri1184
Reference
PMID:14737178
  Authors
Steelman LS, Pohnert SC, Shelton JG, Franklin RA, Bertrand FE, McCubrey JA.
  Title
JAK/STAT, Raf/MEK/ERK, PI3K/Akt and BCR-ABL in cell cycle progression and leukemogenesis.
  Journal
Leukemia 18:189-218 (2004)
DOI:10.1038/sj.leu.2403241
Reference
PMID:9916983
  Authors
Dragovich T, Rudin CM, Thompson CB
  Title
Signal transduction pathways that regulate cell survival and cell death.
  Journal
Oncogene 17:3207-13 (1998)
DOI:10.1038/sj.onc.1202587
Reference
PMID:11520933
  Authors
Sofroniew MV, Howe CL, Mobley WC
  Title
Nerve growth factor signaling, neuroprotection, and neural repair.
  Journal
Annu Rev Neurosci 24:1217-81 (2001)
DOI:10.1146/annurev.neuro.24.1.1217
Reference
PMID:24769728
  Authors
Kristiansen M, Ham J
  Title
Programmed cell death during neuronal development: the sympathetic neuron model.
  Journal
Cell Death Differ 21:1025-35 (2014)
DOI:10.1038/cdd.2014.47
Reference
PMID:18208375
  Authors
Logue SE, Martin SJ
  Title
Caspase activation cascades in apoptosis.
  Journal
Biochem Soc Trans 36:1-9 (2008)
DOI:10.1042/BST0360001
Reference
PMID:19770840
  Authors
Boivin WA, Cooper DM, Hiebert PR, Granville DJ
  Title
Intracellular versus extracellular granzyme B in immunity and disease: challenging the dogma.
  Journal
Lab Invest 89:1195-220 (2009)
DOI:10.1038/labinvest.2009.91
Reference
PMID:20075940
  Authors
Cullen SP, Brunet M, Martin SJ
  Title
Granzymes in cancer and immunity.
  Journal
Cell Death Differ 17:616-23 (2010)
DOI:10.1038/cdd.2009.206
Reference
PMID:36652128
  Authors
Liu K, Lan D, Li C, Liu S, Dai X, Song T, Wang X, Kong Q, He Z, Tan J, Zhang J
  Title
A double-edged sword: role of apoptosis repressor with caspase recruitment domain (ARC) in tumorigenesis and ischaemia/reperfusion (I/R) injury.
  Journal
Apoptosis 28:313-325 (2023)
DOI:10.1007/s10495-022-01802-4
Related
pathway
mcep04010  MAPK signaling pathway
mcep04020  Calcium signaling pathway
mcep04115  p53 signaling pathway
mcep04141  Protein processing in endoplasmic reticulum
KO pathway
ko04210   

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