Entry Name Cellular senescence - Microcebus murinus (gray mouse lemur)
Description Cellular senescence is a state of irreversible cellular arrest and can be triggered by a number of factors, such as telomere shortening, oncogene activation, irradiation, DNA damage and oxidative stress. It is characterized by enlarged flattened morphology, senescence-associated beta-galactosidase (SA-b-gal) activity, secretion of inflammatory cytokines, growth factors and matrix metalloproteinases, as part of the senescence-associated secretory phenotype (SASP). Cellular senescence is functionally associated with many biological processes including aging, tumor suppression, placental biology, embryonic development, and wound healing.
Class Cellular Processes; Cell growth and deathBRITE hierarchy
Pathway map Other DBs Organism Microcebus murinus (gray mouse lemur) [GN:
mmur ]
Gene 105855026 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
105855821 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
105857150 PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
105857276 ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959 ]
105857349 MRE11; double-strand break repair protein MRE11A isoform X1 [KO:K10865 ]
105857966 SMAD3; mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605 ]
105858914 NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333 ]
105860538 SMAD2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500 ]
105862660 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
105863295 PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
105866328 VDAC2; voltage-dependent anion-selective channel protein 2 isoform X1 [KO:K15040 ]
105866622 NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334 ]
105866954 TRPV4; transient receptor potential cation channel subfamily V member 4 isoform X1 [KO:K04973 ]
105868798 PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
105868994 RASSF5; ras association domain-containing protein 5 isoform X1 [KO:K08015 ]
105869384 ITPR1; LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958 ]
105869949 RAD50; DNA repair protein RAD50 isoform X1 [KO:K10866 ] [EC:3.6.-.-]
105869973 VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862 ]
105870389 EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205 ]
105871854 FBXW11; F-box/WD repeat-containing protein 11 isoform X1 [KO:K03362 ]
105872262 NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332 ]
105872856 GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402 ]
105873891 BTRC; F-box/WD repeat-containing protein 1A isoform X1 [KO:K03362 ]
105873984 GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402 ]
105874819 NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580 ]
105875072 CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851 ]
105876174 GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402 ]
105877483 PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649 ]
105877681 CALML6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183 ]
105878143 VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041 ]
105880256 ZFP36L1; mRNA decay activator protein ZFP36L1 isoform X2 [KO:K18753 ]
105880930 PPP1CC; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269 ] [EC:3.1.3.16 ]
105881219 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
105884723 NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446 ]
105886063 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
Compound C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference Authors Munoz-Espin D, Serrano M
Title Cellular senescence: from physiology to pathology.
Journal Reference Authors Childs BG, Durik M, Baker DJ, van Deursen JM
Title Cellular senescence in aging and age-related disease: from mechanisms to therapy.
Journal Reference Authors Sharpless NE, Sherr CJ
Title Forging a signature of in vivo senescence.
Journal Reference Authors Fridlyanskaya I, Alekseenko L, Nikolsky N
Title Senescence as a general cellular response to stress: A mini-review.
Journal Reference Authors Lujambio A
Title To clear, or not to clear (senescent cells)? That is the question.
Journal Reference Authors Di Mitri D, Alimonti A
Title Non-Cell-Autonomous Regulation of Cellular Senescence in Cancer.
Journal Reference Authors Francica P, Aebersold DM, Medova M
Title Senescence as biologic endpoint following pharmacological targeting of receptor tyrosine kinases in cancer.
Journal Reference Authors Bartling B
Title Cellular senescence in normal and premature lung aging.
Journal Reference Authors Munoz-Espin D, Canamero M, Maraver A, Gomez-Lopez G, Contreras J, Murillo-Cuesta S, Rodriguez-Baeza A, Varela-Nieto I, Ruberte J, Collado M, Serrano M
Title Programmed cell senescence during mammalian embryonic development.
Journal Reference Authors Herranz N, Gallage S, Gil J
Title TORn about SASP regulation.
Journal Reference Authors Martin N, Bernard D
Title Calcium signaling and cellular senescence.
Journal Reference Authors Farfariello V, Iamshanova O, Germain E, Fliniaux I, Prevarskaya N
Title Calcium homeostasis in cancer: A focus on senescence.
Journal Reference Authors McCarthy DA, Clark RR, Bartling TR, Trebak M, Melendez JA
Title Redox control of the senescence regulator interleukin-1alpha and the secretory phenotype.
Journal Reference Authors Donninger H, Schmidt ML, Mezzanotte J, Barnoud T, Clark GJ
Title Ras signaling through RASSF proteins.
Journal Reference Authors Barnoud T, Schmidt ML, Donninger H, Clark GJ
Title The role of the NORE1A tumor suppressor in Oncogene-Induced Senescence.
Journal Reference Authors Kang C, Xu Q, Martin TD, Li MZ, Demaria M, Aron L, Lu T, Yankner BA, Campisi J, Elledge SJ
Title The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4.
Journal Reference Authors Cao X, Li M
Title A New Pathway for Senescence Regulation.
Journal Reference Authors Gire V, Dulic V
Title Senescence from G2 arrest, revisited.
Journal Reference Authors Mowla SN, Lam EW, Jat PS
Title Cellular senescence and aging: the role of B-MYB.
Journal Reference Authors Yao H, Chung S, Hwang JW, Rajendrasozhan S, Sundar IK, Dean DA, McBurney MW, Guarente L, Gu W, Ronty M, Kinnula VL, Rahman I
Title SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice.
Journal Reference Authors Hwang JW, Yao H, Caito S, Sundar IK, Rahman I
Title Redox regulation of SIRT1 in inflammation and cellular senescence.
Journal Related KO pathway
