KEGG   PATHWAY: msam04144
Entry
msam04144                   Pathway                                
Name
Endocytosis - Micropterus salmoides (largemouth bass)
Description
Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.
Class
Cellular Processes; Transport and catabolism
Pathway map
msam04144  Endocytosis
msam04144

Other DBs
GO: 0006897
Organism
Micropterus salmoides (largemouth bass) [GN:msam]
Gene
119881860  [KO:K04646]
119882009  rab11fip4a; rab11 family-interacting protein 4A isoform X1 [KO:K12485]
119882034  [KO:K00909] [EC:2.7.11.14]
119882039  [KO:K04237]
119882414  vps35; vacuolar protein sorting-associated protein 35 [KO:K18468]
119882436  [KO:K18439]
119882557  zgc:162872; BAR_ACAPs and ArfGap_ACAP domain-containing protein [KO:K12489]
119882681  ap2s1; AP-2 complex subunit sigma [KO:K11827]
119882738  ehd2b; EH domain-containing protein 2b isoform X1 [KO:K12469]
119882772  [KO:K04646]
119882902  [KO:K11826]
119882924  spartb; spartin b isoform X1 [KO:K19366]
119883053  hspa8b; LOW QUALITY PROTEIN: heat shock protein family A (Hsp70) member 8b [KO:K03283]
119883158  [KO:K12185]
119883239  git1; ARF GTPase-activating protein GIT1 isoform X1 [KO:K05737]
119883283  [KO:K00909] [EC:2.7.11.14]
119883306  cbl; E3 ubiquitin-protein ligase CBL [KO:K04707] [EC:2.3.2.27]
119883315  [KO:K12469]
119883442  vps26b; vacuolar protein sorting-associated protein 26B [KO:K18466]
119883456  ldlra; low density lipoprotein receptor a isoform X1 [KO:K12473]
119883577  folr; folate receptor [KO:K13649]
119883599  arrb1; beta-arrestin-1 isoform X1 [KO:K04439]
119883833  [KO:K04678] [EC:2.3.2.26]
119884204  [KO:K12487]
119884242  [KO:K19475]
119884279  [KO:K06751]
119884280  [KO:K06751]
119884431  [KO:K00889] [EC:2.7.1.68]
119884573  [KO:K01115] [EC:3.1.4.4]
119884791  [KO:K18441]
119884900  snf8; vacuolar-sorting protein SNF8 [KO:K12188]
119884902  chmp2a; charged multivesicular body protein 2a [KO:K12191]
119884926  [KO:K07939]
119884985  [KO:K12474]
119885091  smurf1; E3 ubiquitin-protein ligase SMURF1 isoform X1 [KO:K04678] [EC:2.3.2.26]
119885295  il2rb; interleukin-2 receptor subunit beta [KO:K05069]
119885487  [KO:K04393]
119885543  [KO:K04513]
119885557  si:dkey-28n18.9; sorting nexin-6 [KO:K17920]
119885634  si:dkey-13a21.4; ras-related protein rab7 isoform X1 [KO:K07897]
119885658  [KO:K05755]
119885767  arpc4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
119885845  unm_sa1614; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K12488]
119885992  [KO:K07897]
119886019  epn2; epsin-2 isoform X1 [KO:K12471]
119886041  arfgap1; ADP-ribosylation factor GTPase-activating protein 1 [KO:K12492]
119886053  chmp4ba; charged multivesicular body protein 4b [KO:K12194]
119886114  iqsec1b; IQ motif and SEC7 domain-containing protein 1 isoform X1 [KO:K12495]
119886221  capzb; F-actin-capping protein subunit beta isoform X1 [KO:K10365]
119886229  [KO:K04513]
119886292  [KO:K05704] [EC:2.7.10.2]
119886410  itcha; itchy E3 ubiquitin protein ligase a [KO:K05632] [EC:2.3.2.26]
119886528  [KO:K06751]
119886581  [KO:K10364]
119886611  acap3b; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3b isoform X1 [KO:K12489]
119886776  [KO:K07939]
119886802  zgc:172270; caveolin-2 [KO:K12958]
119886812  [KO:K07938]
119886847  kif5ab; kinesin heavy chain isoform X1 [KO:K10396] [EC:5.6.1.3]
119886870  cav3; caveolin-3 [KO:K12959]
119886960  [KO:K17848]
119886975  [KO:K12958]
119886978  rab22a; ras-related protein Rab-22A [KO:K07891]
119886989  si:dkey-197j19.6; wiskott-Aldrich syndrome protein homolog [KO:K23612]
119886994  [KO:K07897]
119887120  [KO:K06503]
119887218  [KO:K23612]
119887268  acap2; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 [KO:K12489]
119887536  [KO:K12196]
119888368  [KO:K12484]
119888667  cltb; clathrin light chain B isoform X1 [KO:K04645]
119888686  arap3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 [KO:K12490]
119888690  ehd1a; EH domain-containing protein 1a [KO:K12483]
119888767  rufy1; RUN and FYVE domain-containing protein 1 isoform X1 [KO:K12482]
119888770  psd2; PH and SEC7 domain-containing protein 2 isoform X1 [KO:K12494]
119889003  [KO:K12197]
119889245  cyth3b; cytohesin-3 isoform X1 [KO:K18441]
119889561  [KO:K17920]
119889757  traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
119889758  [KO:K17917]
119889766  grk1a; rhodopsin kinase GRK1 [KO:K00909] [EC:2.7.11.14]
119889769  [KO:K11824]
119889834  vps26a; vacuolar protein sorting-associated protein 26A [KO:K18466]
119889848  igf1rb; insulin-like growth factor 1b receptor [KO:K05087] [EC:2.7.10.1]
119889861  [KO:K10591] [EC:2.3.2.26]
119889963  usp8; ubiquitin carboxyl-terminal hydrolase 8 [KO:K11839] [EC:3.4.19.12]
119889977  rab11a; ras-related protein Rab-11A [KO:K07904]
119890083  smad3a; mothers against decapentaplegic homolog 3a [KO:K23605]
119890097  rab4a; ras-related protein Rab-4A [KO:K07879]
119890182  rufy2; RUN and FYVE domain-containing protein 2 isoform X1 [KO:K12482]
119890197  sh3gl3a; endophilin-A3a [KO:K11247]
119890259  cyth1a; cytohesin-1a isoform X1 [KO:K18441]
119890457  ist1; IST1 homolog isoform X1 [KO:K19476]
119890469  arfgap2; ADP-ribosylation factor GTPase-activating protein 2 isoform X1 [KO:K12493]
119890645  [KO:K12195]
119890697  spg21; maspardin [KO:K19367]
119890831  epn3a; epsin-3 isoform X1 [KO:K12471]
119890923  hgs; hepatocyte growth factor-regulated tyrosine kinase substrate isoform X1 [KO:K12182]
119891297  cltcl1; clathrin heavy chain 1 isoform X1 [KO:K04646]
119891304  pip5k1bb; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
119891319  [KO:K19475]
119891328  mvb12bb; multivesicular body subunit 12Bb isoform X1 [KO:K12186]
119891398  rab11fip1a; rab11 family-interacting protein 1 isoform X1 [KO:K12484]
119891474  grk5l; G protein-coupled receptor kinase 5 isoform X1 [KO:K08291] [EC:2.7.11.16]
119891479  git2a; ARF GTPase-activating protein GIT2a isoform X1 [KO:K12487]
119891536  [KO:K01528] [EC:3.6.5.5]
119891647  [KO:K21269]
119891755  [KO:K04500]
119891793  [KO:K11866] [EC:3.4.19.12]
119891800  rab35b; ras-related protein Rab-35b [KO:K07876]
119891860  snx2; sorting nexin-2 isoform X1 [KO:K17917]
119891911  chmp7; charged multivesicular body protein 7 [KO:K15053]
119892092  arf2a; ADP-ribosylation factor 2a [KO:K07937]
119892408  rab5c; ras-related protein Rab-5C [KO:K07889]
119892414  vps37ba; VPS37B subunit of ESCRT-I a [KO:K12185]
119893057  sh3gl3b; endophilin-A3b [KO:K11247]
119893067  [KO:K06093]
119893260  washc4; WASH complex subunit 4 isoform X1 [KO:K18465]
119893311  vps4a; vacuolar protein sorting-associated protein 4A [KO:K12196]
119893313  [KO:K12194]
119893375  smad3b; mothers against decapentaplegic homolog 3b [KO:K23605]
119893491  [KO:K07939]
119893566  tsg101a; tumor susceptibility 101a [KO:K12183]
119893575  hrasb; HRas proto-oncogene, GTPase b [KO:K02833]
119893621  cav1; caveolin-1 [KO:K06278]
119893660  iqsec3b; IQ motif and SEC7 domain-containing protein 3 isoform X1 [KO:K12495]
119893662  wash1; WASH complex subunit 1 isoform X1 [KO:K18461]
119893692  chmp1a; charged multivesicular body protein 1a [KO:K12197]
119893726  snx1a; sorting nexin-1a [KO:K17917]
119893857  pard6a; partitioning defective 6 homolog alpha [KO:K06093]
119893875  wasla; WASP like actin nucleation promoting factor a isoform X1 [KO:K23612]
119893954  [KO:K10364]
119893964  [KO:K23612]
119894034  cav2; caveolin-2 [KO:K12958]
119894125  igf1ra; insulin-like growth factor 1a receptor [KO:K05087] [EC:2.7.10.1]
119894371  [KO:K18441]
119894452  eea1; early endosome antigen 1 isoform X1 [KO:K12478]
119894725  [KO:K07901]
119894854  grk1b; LOW QUALITY PROTEIN: rhodopsin kinase GRK1b [KO:K00909] [EC:2.7.11.14]
119894956  [KO:K05070]
119894958  snx12; sorting nexin-12 isoform X1 [KO:K17918]
119894978  [KO:K04707] [EC:2.3.2.27]
119894985  mdm2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
119895129  vps26bl; vacuolar protein sorting-associated protein 26B-like [KO:K18466]
119895152  fgfr4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
119895209  si:dkey-16l2.16; ras-related protein Rab-35 [KO:K07876]
119895242  rabep1; rab GTPase-binding effector protein 1 isoform X1 [KO:K12480]
119895260  vps37d; vacuolar protein sorting-associated protein 37D [KO:K12185]
119895269  [KO:K03283]
119895311  [KO:K03283]
119895319  [KO:K03283]
119895332  ap2b1; AP-2 complex subunit beta [KO:K11825]
119895353  grk6; G protein-coupled receptor kinase 6 [KO:K08291] [EC:2.7.11.16]
119895392  vps36; vacuolar protein-sorting-associated protein 36 [KO:K12190]
119895528  [KO:K07939]
119895627  [KO:K04439]
119895682  [KO:K03283]
119895688  [KO:K03283]
119895736  [KO:K12197]
119895767  [KO:K01115] [EC:3.1.4.4]
119895784  cblb; E3 ubiquitin-protein ligase CBL-B-B isoform X1 [KO:K22517] [EC:2.3.2.27]
119895824  [KO:K18439]
119895839  [KO:K06751]
119895865  sparta; spartin a isoform X1 [KO:K19366]
119895990  [KO:K06751]
119896417  [KO:K05050]
119896491  dnm2a; dynamin-3 isoform X1 [KO:K23484]
119896543  [KO:K03283]
119896596  pld1b; phospholipase D1 [KO:K01115] [EC:3.1.4.4]
119896807  [KO:K07876]
119896928  agap1; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 [KO:K12491]
119897085  rab5ab; RAB5A, member RAS oncogene family, b [KO:K07887]
119897134  rab11al; RAB11a, member RAS oncogene family, like [KO:K07904]
119897333  cblc; E3 ubiquitin-protein ligase CBL-C isoform X1 [KO:K22518] [EC:2.3.2.27]
119897425  cdc42l; cell division cycle 42, like [KO:K04393]
119897482  epn1; epsin-1 isoform X1 [KO:K12471]
119897530  [KO:K18584]
119897531  cyth2; cytohesin-2 [KO:K18441]
119897543  [KO:K18584]
119897616  [KO:K00889] [EC:2.7.1.68]
119897901  [KO:K04180]
119897920  washc5; WASH complex subunit 5 [KO:K18464]
119898112  tgfbr2b; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
119898114  [KO:K19475]
119898309  hsc70; heat shock cognate 71 kDa protein isoform X1 [KO:K03283]
119898607  cyth4b; cytohesin 4b [KO:K18441]
119898625  [KO:K05069]
119898735  arpc1a; actin-related protein 2/3 complex subunit 1A [KO:K05757]
119898739  arpc1b; actin-related protein 2/3 complex subunit 1B [KO:K05757]
119898898  sh3gl2a; SH3 domain containing GRB2 like 2a, endophilin A1 isoform X1 [KO:K11247]
119899188  ldlrb; low-density lipoprotein receptor isoform X1 [KO:K12473]
119899231  rab11fip4b; rab11 family-interacting protein 4B isoform X1 [KO:K12485]
119899331  [KO:K04678] [EC:2.3.2.26]
119899372  clta; clathrin light chain A isoform X1 [KO:K04644]
119899388  vps37a; vacuolar protein sorting-associated protein 37A isoform X1 [KO:K12185]
119899439  mvb12a; multivesicular body subunit 12A [KO:K12186]
119899452  [KO:K23484]
119899511  zfyve27; protrudin isoform X1 [KO:K19368]
119899572  [KO:K12486]
119899651  grk4; G protein-coupled receptor kinase 4 isoform X1 [KO:K08291] [EC:2.7.11.16]
119900146  [KO:K06751]
119900275  bin1b; myc box-dependent-interacting protein 1b isoform X1 [KO:K12562]
119900410  dnajc6; putative tyrosine-protein phosphatase auxilin isoform X1 [KO:K09526]
119900431  arpc5b; actin-related protein 2/3 complex subunit 5b [KO:K05754]
119900595  [KO:K12489]
119900723  eps15; epidermal growth factor receptor substrate 15 isoform X1 [KO:K12472]
119900748  [KO:K07901]
119900820  zfyve9b; zinc finger FYVE domain-containing protein 9 [KO:K04679]
119900844  sh3gl1b; SH3-domain GRB2-like 1b [KO:K11247]
119900947  pip5k1ca; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
119900948  [KO:K07905]
119900952  [KO:K07905]
119901018  dnm3a; dynamin 3a isoform X1 [KO:K01528] [EC:3.6.5.5]
119901047  [KO:K12196]
119901064  pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
119901282  eps15l1a; epidermal growth factor receptor substrate 15-like 1 [KO:K12472]
119901322  [KO:K12472]
119901327  [KO:K12472]
119901600  [KO:K12472]
119901711  pard3ab; par-3 family cell polarity regulator alpha, b isoform X1 [KO:K04237]
119901720  [KO:K10396] [EC:5.6.1.3]
119901819  rab31; ras-related protein Rab-31 [KO:K07891]
119901852  [KO:K07901]
119901858  [KO:K12472]
119901876  prkci; protein kinase C iota type isoform X1 [KO:K06069] [EC:2.7.11.13]
119901902  stam; signal transducing adapter molecule 1 [KO:K04705]
119901913  chmp5a; charged multivesicular body protein 5 [KO:K12198]
119901961  egfra; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
119901993  arf1; ADP-ribosylation factor 1 [KO:K07937]
119902002  agap3; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12491]
119902075  vps4b; vacuolar protein sorting-associated protein 4B isoform X1 [KO:K12196]
119902193  [KO:K00889] [EC:2.7.1.68]
119902210  [KO:K11826]
119902221  [KO:K07905]
119902401  dnm3b; dynamin-3 [KO:K01528] [EC:3.6.5.5]
119902413  tfr1a; transferrin receptor 1a [KO:K06503]
119902454  [KO:K04189]
119902632  [KO:K05754]
119902752  amph; amphiphysin isoform X1 [KO:K12562]
119902780  asap1a; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1a [KO:K12488]
119902840  zfyve9a; zinc finger FYVE domain-containing protein 9 isoform X1 [KO:K04679]
119902935  [KO:K11247]
119903020  grk7a; rhodopsin kinase grk7a [KO:K00909] [EC:2.7.11.14]
119903365  [KO:K11826]
119903457  [KO:K18584]
119903646  [KO:K05050]
119903714  arpc2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
119903766  tgfbr2l; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
119903849  [KO:K05050]
119903907  [KO:K04189]
119903943  chmp2ba; charged multivesicular body protein 2Ba [KO:K12192]
119903985  snx4; sorting nexin-4 [KO:K17919]
119904109  [KO:K10396] [EC:5.6.1.3]
119904271  [KO:K00909] [EC:2.7.11.14]
119904387  [KO:K05050]
119904439  stam2; signal transducing adapter molecule 2 [KO:K04705]
119904500  [KO:K12562]
119904573  rab5b; ras-related protein Rab-5B [KO:K07888]
119904789  [KO:K18584]
119904984  [KO:K04513]
119905108  agap2; LOW QUALITY PROTEIN: arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 [KO:K17848]
119905139  src; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
119905154  acap3a; LOW QUALITY PROTEIN: arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3 [KO:K12489]
119905195  rnf41; E3 ubiquitin-protein ligase NRDP1 [KO:K11981] [EC:2.3.2.27]
119905238  [KO:K04393]
119905292  [KO:K10396] [EC:5.6.1.3]
119905314  [KO:K12495]
119905342  [KO:K12481]
119905427  capza1b; F-actin-capping protein subunit alpha-1b [KO:K10364]
119905430  [KO:K04513]
119905440  [KO:K12495]
119905695  [KO:K12194]
119905729  rhoab; rho-related GTP-binding protein RhoA-B [KO:K04513]
119905806  arfgef2; brefeldin A-inhibited guanine nucleotide-exchange protein 2 [KO:K18442]
119905808  pard6b; partitioning defective 6 homolog beta [KO:K06093]
119905834  tgfbr1b; TGF-beta receptor type-1b [KO:K04674] [EC:2.7.11.30]
119905855  hspa1b; heat shock 70 kDa protein 1B [KO:K03283]
119905958  itchb; itchy E3 ubiquitin protein ligase b [KO:K05632] [EC:2.3.2.26]
119905992  prkcz; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
119906012  iqsec2b; IQ motif and SEC7 domain-containing protein 1 isoform X1 [KO:K12495]
119906035  arf3a; ADP-ribosylation factor 3a [KO:K07938]
119906186  kif5aa; kinesin family member 5Aa [KO:K10396] [EC:5.6.1.3]
119906255  [KO:K10396] [EC:5.6.1.3]
119906458  [KO:K04644]
119906669  [KO:K07887]
119906686  [KO:K04237]
119906801  smap2; stromal membrane-associated protein 2 [KO:K12486]
119906823  ldlrap1a; low density lipoprotein receptor adapter protein 1a isoform X1 [KO:K12474]
119906884  [KO:K05633] [EC:2.3.2.26]
119906903  vps45; vacuolar protein sorting-associated protein 45 [KO:K12479]
119907060  vps28; vacuolar protein sorting-associated protein 28 homolog [KO:K12184]
119907067  [KO:K12200]
119907070  [KO:K04393]
119907119  sh3glb1a; endophilin-B1a [KO:K11248]
119907257  [KO:K04388] [EC:2.7.11.30]
119907391  pard6gb; par-6 family cell polarity regulator gamma b [KO:K06093]
119907394  wipf3; WAS/WASL-interacting protein family member 3 [KO:K19475]
119907424  [KO:K06751]
119907713  [KO:K06751]
119907749  [KO:K06751]
119907863  [KO:K06751]
119907864  [KO:K06751]
119907865  [KO:K06751]
119907866  [KO:K06751]
119907889  [KO:K00889] [EC:2.7.1.68]
119907973  [KO:K06751]
119908016  [KO:K06751]
119908017  [KO:K06751]
119908018  [KO:K06751]
119908019  [KO:K06751]
119908020  [KO:K06751]
119908021  [KO:K06751]
119908022  [KO:K06751]
119908024  [KO:K06751]
119908110  [KO:K06751]
119908112  [KO:K06751]
119908113  [KO:K06751]
119908114  [KO:K06751]
119908778  ehd3; EH domain-containing protein 3 [KO:K12476]
119908813  vta1; vacuolar protein sorting-associated protein VTA1 homolog isoform X1 [KO:K12199]
119908843  si:dkey-71h2.2; low density lipoprotein receptor adapter protein 1 isoform X1 [KO:K12474]
119908924  rab10; ras-related protein Rab-10 [KO:K07903]
119909096  snx3; sorting nexin-3 [KO:K17918]
119909109  arf6a; ADP-ribosylation factor 6a [KO:K07941]
119909163  igf2r; cation-independent mannose-6-phosphate receptor [KO:K06564]
119909387  asap2b; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2b [KO:K12488]
119909428  arfgef1; brefeldin A-inhibited guanine nucleotide-exchange protein 1 isoform X1 [KO:K18442]
119909666  [KO:K12185]
119909676  [KO:K12474]
119909715  [KO:K06751]
119909809  snx6; LOW QUALITY PROTEIN: sorting nexin-6 [KO:K17920]
119909976  [KO:K18467]
119909992  ehd4; EH domain-containing protein 4 [KO:K12477]
119910021  ldlrap1b; low density lipoprotein receptor adapter protein 1b isoform X1 [KO:K12474]
119910042  chmp3; charged multivesicular body protein 3 [KO:K12193]
119910102  fgfr3; LOW QUALITY PROTEIN: fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
119910118  arf6b; ADP-ribosylation factor 6b [KO:K07941]
119910139  asap3; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12488]
119910183  pld1a; phospholipase D1a [KO:K01115] [EC:3.1.4.4]
119910409  asap2a; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2a [KO:K12488]
119910497  [KO:K07941]
119910562  [KO:K18467]
119910640  [KO:K11248]
119910863  rab11fip5a; rab11 family-interacting protein 1 isoform X1 [KO:K12484]
119910968  chmp4c; charged multivesicular body protein 4c [KO:K24782]
119911287  [KO:K12494]
119911316  [KO:K04439]
119911332  chmp5b; charged multivesicular body protein 5 [KO:K12198]
119911334  [KO:K12494]
119911510  asap1b; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12488]
119911746  acap1; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 [KO:K12489]
119911793  zmp:0000000660; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K18440]
119911826  si:dkey-19b23.8; low density lipoprotein receptor adapter protein 1 [KO:K12474]
119912484  tfr1b; LOW QUALITY PROTEIN: transferrin receptor 1b [KO:K06503]
119912491  sh3kbp1; SH3 domain-containing kinase-binding protein 1 isoform X1 [KO:K12470]
119912931  [KO:K04180]
119913004  [KO:K11247]
119913339  zgc:101810; actin-related protein 2 [KO:K17260]
119913984  [KO:K04361] [EC:2.7.10.1]
119914027  git2b; ARF GTPase-activating protein GIT2b isoform X1 [KO:K12487]
119914039  zfyve16; zinc finger FYVE domain-containing protein 16 isoform X1 [KO:K04679]
119914060  [KO:K12484]
119914088  nedd4l; E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K13305] [EC:2.3.2.26]
119914177  dnm1a; dynamin-1a isoform X1 [KO:K01528] [EC:3.6.5.5]
119914182  pip5kl1; phosphatidylinositol 4-phosphate 5-kinase-like protein 1 [KO:K13712] [EC:2.7.1.68]
119914201  arpc3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
119914207  [KO:K12494]
119914240  vps37c; vacuolar protein sorting-associated protein 37C isoform X1 [KO:K12185]
119914314  smad2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
119914358  dab2; disabled homolog 2 isoform X1 [KO:K12475]
119914379  mvb12ba; multivesicular body subunit 12Ba [KO:K12186]
119914502  grk5; G protein-coupled receptor kinase 5 isoform X1 [KO:K08291] [EC:2.7.11.16]
119914643  sh3glb2b; endophilin-B2b isoform X1 [KO:K21269]
119914686  grk3; beta-adrenergic receptor kinase 2 isoform X1 [KO:K00910] [EC:2.7.11.15]
119914911  pip5k1ba; phosphatidylinositol-4-phosphate 5-kinase, type I, beta a [KO:K00889] [EC:2.7.1.68]
119915126  actr2a; actin-related protein 2-A [KO:K17260]
119915418  [KO:K18441]
119915604  vps25; vacuolar protein-sorting-associated protein 25 [KO:K12189]
119915654  [KO:K18441]
119915688  arf2b; ADP-ribosylation factor 2b [KO:K07937]
119915848  [KO:K07889]
119915998  [KO:K12494]
119916067  [KO:K12195]
119916161  [KO:K06751]
119916181  rab11fip3; rab11 family-interacting protein 3 isoform X1 [KO:K12485]
119916749  [KO:K00909] [EC:2.7.11.14]
119916752  washc2c; WASH complex subunit 2 isoform X1 [KO:K18462]
119916902  fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
119916961  snx5; sorting nexin-5 [KO:K17920]
119917127  [KO:K17260]
119917193  [KO:K12484]
119917285  gbf1; Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X1 [KO:K18443]
119917299  wipf1b; WAS/WASL-interacting protein family member 1 [KO:K19475]
119917674  [KO:K12486]
119918042  waslb; WASP like actin nucleation promoting factor b isoform X1 [KO:K23612]
119918050  [KO:K17919]
119918160  washc3; WASH complex subunit 3 [KO:K18463]
119918189  [KO:K19475]
119918298  iqsec3a; IQ motif and SEC7 domain-containing protein 3 isoform X1 [KO:K12495]
119918482  arfgap3; ADP-ribosylation factor GTPase-activating protein 3 isoform X1 [KO:K12493]
119918727  zgc:86896; actin-related protein 2/3 complex subunit 1A-A [KO:K05757]
119919101  ap2a1; AP-2 complex subunit alpha-2 isoform X1 [KO:K11824]
119919148  [KO:K22518] [EC:2.3.2.27]
Compound
C00035  GDP
C00044  GTP
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
Reference
PMID:19007773
  Authors
Acconcia F, Sigismund S, Polo S
  Title
Ubiquitin in trafficking: the network at work.
  Journal
Exp Cell Res 315:1610-8 (2009)
DOI:10.1016/j.yexcr.2008.10.014
Reference
PMID:18647649
  Authors
Donaldson JG, Porat-Shliom N, Cohen LA
  Title
Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling.
  Journal
Cell Signal 21:1-6 (2009)
DOI:10.1016/j.cellsig.2008.06.020
Reference
PMID:15261671
  Authors
Sorkin A
  Title
Cargo recognition during clathrin-mediated endocytosis: a team effort.
  Journal
Curr Opin Cell Biol 16:392-9 (2004)
DOI:10.1016/j.ceb.2004.06.001
Reference
PMID:19325624
  Authors
Raiborg C, Stenmark H
  Title
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins.
  Journal
Nature 458:445-52 (2009)
DOI:10.1038/nature07961
Reference
PMID:20110990
  Authors
Scita G, Di Fiore PP
  Title
The endocytic matrix.
  Journal
Nature 463:464-73 (2010)
DOI:10.1038/nature08910
Reference
PMID:15687999
  Authors
Le Roy C, Wrana JL
  Title
Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling.
  Journal
Nat Rev Mol Cell Biol 6:112-26 (2005)
DOI:10.1038/nrm1571
Reference
PMID:19924646
  Authors
Jovic M, Sharma M, Rahajeng J, Caplan S
  Title
The early endosome: a busy sorting station for proteins at the crossroads.
  Journal
Histol Histopathol 25:99-112 (2010)
DOI:10.14670/HH-25.99
Reference
PMID:16203612
  Authors
Pietiainen VM, Marjomaki V, Heino J, Hyypia T
  Title
Viral entry, lipid rafts and caveosomes.
  Journal
Ann Med 37:394-403 (2005)
DOI:10.1080/07853890510011976
Reference
PMID:19696797
  Authors
Grant BD, Donaldson JG
  Title
Pathways and mechanisms of endocytic recycling.
  Journal
Nat Rev Mol Cell Biol 10:597-608 (2009)
DOI:10.1038/nrm2755
Reference
PMID:22193161
  Authors
Cullen PJ, Korswagen HC
  Title
Sorting nexins provide diversity for retromer-dependent trafficking events.
  Journal
Nat Cell Biol 14:29-37 (2012)
DOI:10.1038/ncb2374
Related
pathway
msam04060  Cytokine-cytokine receptor interaction
msam04070  Phosphatidylinositol signaling system
msam04130  SNARE interactions in vesicular transport
msam04142  Lysosome
msam04350  TGF-beta signaling pathway
KO pathway
ko04144   

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