KEGG   PATHWAY: nni04020
Entry
nni04020                    Pathway                                
Name
Calcium signaling pathway - Nipponia nippon (crested ibis)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
nni04020  Calcium signaling pathway
nni04020

Other DBs
GO: 0019722
Organism
Nipponia nippon (crested ibis) [GN:nni]
Gene
104008636  CASQ2; calsequestrin-2 [KO:K23445]
104008698  TNNC1; troponin C, slow skeletal and cardiac muscles isoform X1 [KO:K05865]
104008915  TRDN; triadin [KO:K23449]
104009116  [KO:K04851]
104009233  PTGER3; prostaglandin E2 receptor EP3 subtype [KO:K04260]
104009490  FGF3; fibroblast growth factor 3 [KO:K04358]
104009491  FGF4; fibroblast growth factor 4 [KO:K04358]
104009492  FGF19; fibroblast growth factor 19 [KO:K22603]
104009494  TPCN2; two pore calcium channel protein 2 [KO:K14077]
104009581  NTSR1; neurotensin receptor type 1 [KO:K04211]
104009589  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
104009780  [KO:K04161]
104009787  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
104009846  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
104009954  PLN; cardiac phospholamban [KO:K05852]
104010071  PLCD4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 [KO:K05857] [EC:3.1.4.11]
104010094  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
104010226  PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
104010307  CAMK1G; calcium/calmodulin-dependent protein kinase type 1G [KO:K08794] [EC:2.7.11.17]
104010337  NGF; beta-nerve growth factor [KO:K02582]
104010425  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
104010482  CALML3; calmodulin-like protein 3 [KO:K02183]
104010553  NOS1; nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
104010605  P2RX6; P2X purinoceptor 6 [KO:K05221]
104010752  HGF; hepatocyte growth factor [KO:K05460]
104010763  CD38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
104010825  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
104010904  HTR2A; 5-hydroxytryptamine receptor 2A [KO:K04157]
104010953  CYSLTR2; cysteinyl leukotriene receptor 2 [KO:K04323]
104011070  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
104011176  HTR6; 5-hydroxytryptamine receptor 6 [KO:K04162]
104011276  PHKB; phosphorylase b kinase regulatory subunit beta isoform X1 [KO:K07190]
104011279  MYLK3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
104011289  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
104011369  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
104011470  TPCN1; two pore calcium channel protein 1 [KO:K16896]
104011488  ADORA2A; adenosine receptor A2a [KO:K04266]
104011528  AVPR1A; vasopressin V1a receptor [KO:K04226]
104011583  RYR2; ryanodine receptor 2 [KO:K04962]
104011641  ATP2B1; plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
104011761  NTRK2; BDNF/NT-3 growth factors receptor [KO:K04360] [EC:2.7.10.1]
104011816  [KO:K02183]
104011962  PDE1B; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B [KO:K13755] [EC:3.1.4.17]
104012024  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
104012048  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
104012135  PDE1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C [KO:K13755] [EC:3.1.4.17]
104012180  P2RX5; P2X purinoceptor 5 [KO:K05219]
104012188  ADORA2B; adenosine receptor A2b [KO:K04267]
104012391  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
104012443  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
104012501  [KO:K05212]
104012629  PHKA1; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform [KO:K07190]
104012694  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
104012894  HTR2C; 5-hydroxytryptamine receptor 2C isoform X1 [KO:K04157]
104012930  CYSLTR1; cysteinyl leukotriene receptor 1 [KO:K04322]
104013033  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
104013042  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632]
104013073  HTR7; 5-hydroxytryptamine receptor 7 [KO:K04163]
104013097  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332]
104013121  AVPR1B; vasopressin V1b receptor [KO:K04227]
104013141  ATP2B4; plasma membrane calcium-transporting ATPase 4 [KO:K05850] [EC:7.2.2.10]
104013156  TFEB; transcription factor EB isoform X1 [KO:K15590]
104013165  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
104013343  F2R; proteinase-activated receptor 1 [KO:K03914]
104013543  TACR2; substance-K receptor [KO:K04223]
104013554  FGF8; fibroblast growth factor 8 [KO:K04358]
104013561  MCU; calcium uniporter protein, mitochondrial [KO:K20858]
104013588  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
104013781  GRM1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
104013813  [KO:K04360] [EC:2.7.10.1]
104013874  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
104013912  [KO:K05840]
104014191  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
104014196  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
104014199  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
104014361  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
104014569  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
104014633  CAMK1D; calcium/calmodulin-dependent protein kinase type 1D [KO:K08794] [EC:2.7.11.17]
104014715  PTK2B; protein-tyrosine kinase 2-beta [KO:K05871] [EC:2.7.10.2]
104014763  ADCY3; LOW QUALITY PROTEIN: adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
104014808  BDKRB2; B2 bradykinin receptor [KO:K03916]
104014829  BDKRB1; B1 bradykinin receptor [KO:K03915]
104014855  TRHR; thyrotropin-releasing hormone receptor [KO:K04282]
104014872  STIM1; stromal interaction molecule 1 [KO:K16059]
104014907  HTR5A; 5-hydroxytryptamine receptor 5A [KO:K04161]
104014973  MCOLN1; mucolipin-1 [KO:K04992]
104015011  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
104015206  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
104015248  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
104015276  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
104015394  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
104015433  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
104015456  PTGFR; LOW QUALITY PROTEIN: prostaglandin F2-alpha receptor [KO:K04262]
104015461  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
104015468  PPIF; LOW QUALITY PROTEIN: peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
104015470  MCOLN2; mucolipin-2 [KO:K04993]
104015471  MCOLN3; mucolipin-3 [KO:K04994]
104015570  PTAFR; platelet-activating factor receptor [KO:K04279]
104015655  HTR2B; 5-hydroxytryptamine receptor 2B [KO:K04157]
104015689  AGTR1; type-1 angiotensin II receptor [KO:K04166]
104015868  FGF5; fibroblast growth factor 5 [KO:K04358]
104015955  VDAC2; voltage-dependent anion-selective channel protein 2 isoform X1 [KO:K15040]
104015964  EDNRA; endothelin-1 receptor isoform X1 [KO:K04197]
104015971  SLC25A31; LOW QUALITY PROTEIN: ADP/ATP translocase 4 [KO:K05863]
104016019  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
104016030  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
104016039  FGF17; fibroblast growth factor 17 [KO:K04358]
104016059  ADRB3; beta-3 adrenergic receptor [KO:K04143]
104016101  PHKG1; phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform isoform X1 [KO:K00871] [EC:2.7.11.19]
104016104  ORAI2; protein orai-2 [KO:K16057]
104016114  P2RX1; P2X purinoceptor 1 [KO:K05215]
104016115  ATP2A3; LOW QUALITY PROTEIN: sarcoplasmic/endoplasmic reticulum calcium ATPase 3 [KO:K05853] [EC:7.2.2.10]
104016248  NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
104016271  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
104016286  [KO:K05869] [EC:2.7.11.17]
104016305  GRIN3B; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 3B [KO:K05214]
104016313  FGF22; LOW QUALITY PROTEIN: fibroblast growth factor 22 [KO:K04358]
104016462  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
104016558  FGF18; fibroblast growth factor 18 [KO:K04358]
104016581  ADRA1B; alpha-1B adrenergic receptor [KO:K04136]
104016767  CHRFAM7A; CHRNA7-FAM7A fusion protein [KO:K04809]
104016868  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
104016939  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma [KO:K04515] [EC:2.7.11.17]
104016945  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
104016952  OXTR; oxytocin receptor [KO:K04229]
104017079  NTRK3; NT-3 growth factor receptor isoform X1 [KO:K05101] [EC:2.7.10.1]
104017125  FGF7; fibroblast growth factor 7 [KO:K04358]
104017200  CALML4; calmodulin-like protein 4 [KO:K02183]
104017356  GRM5; metabotropic glutamate receptor 5 [KO:K04604]
104017527  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
104017557  [KO:K04809]
104017593  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
104017660  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha isoform X1 [KO:K04633]
104017952  PLCZ1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 [KO:K05861] [EC:3.1.4.11]
104017979  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
104018076  DRD5; D(1B) dopamine receptor [KO:K05840]
104018093  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
104018120  LHCGR; lutropin-choriogonadotropic hormone receptor [KO:K04248]
104018338  TNNC2; troponin C, skeletal muscle [KO:K12042]
104018366  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
104018518  [KO:K04163]
104018527  ADRA1D; alpha-1D adrenergic receptor [KO:K04137]
104018562  [KO:K04150]
104018695  VEGFA; vascular endothelial growth factor A [KO:K05448]
104018798  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
104018826  EDNRB; endothelin B receptor [KO:K04198]
104018888  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
104018910  PLCD3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 [KO:K05857] [EC:3.1.4.11]
104018914  [KO:K00907] [EC:2.7.11.18]
104018925  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
104018958  DRD1; D(1A) dopamine receptor [KO:K04144]
104018980  HRH2; histamine H2 receptor [KO:K04150]
104018994  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
104019019  ADRB2; beta-2 adrenergic receptor [KO:K04142]
104019030  HTR4; 5-hydroxytryptamine receptor 4 [KO:K04160]
104019084  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
104019154  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta [KO:K04515] [EC:2.7.11.17]
104019288  ITPKB; inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
104019483  ORAI1; calcium release-activated calcium channel protein 1 [KO:K16056]
104019516  ADRA1A; alpha-1A adrenergic receptor [KO:K04135]
104019537  ATP2A2; LOW QUALITY PROTEIN: sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
104019540  [KO:K05840]
104019551  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348] [EC:3.1.3.16]
104019630  TBXA2R; thromboxane A2 receptor [KO:K04264]
104019734  ASPH; aspartyl/asparaginyl beta-hydroxylase [KO:K00476] [EC:1.14.11.16]
104019863  GRIN3A; glutamate receptor ionotropic, NMDA 3A [KO:K05213]
104019988  [KO:K04282]
104020209  CACNA1C; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
104020290  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
104020318  SLC8A3; sodium/calcium exchanger 3 isoform X1 [KO:K05849]
104020355  ITPKA; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
104020404  RYR3; ryanodine receptor 3 [KO:K04963]
104020525  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
104020574  FGFR2; LOW QUALITY PROTEIN: fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
104020599  [KO:K01116] [EC:3.1.4.11]
104020687  CACNA1G; LOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1G [KO:K04854]
104020724  GRIN2C; glutamate receptor ionotropic, NMDA 2C [KO:K05211]
104020776  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
104020821  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
104020830  P2RX4; P2X purinoceptor 4 [KO:K05218]
104020832  FGF20; fibroblast growth factor 20 [KO:K04358]
104020841  P2RX7; LOW QUALITY PROTEIN: P2X purinoceptor 7 [KO:K05220]
104020875  GNAQ; LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
104020876  GNA14; guanine nucleotide-binding protein subunit alpha-14 [KO:K04636]
104021067  CCKAR; cholecystokinin receptor type A [KO:K04194]
104021068  STIM2; stromal interaction molecule 2 [KO:K18196]
104021082  [KO:K05096] [EC:2.7.10.1]
104021100  [KO:K04198]
104021157  EGF; pro-epidermal growth factor [KO:K04357]
104021177  TACR3; neuromedin-K receptor [KO:K04224]
104021276  VEGFC; vascular endothelial growth factor C isoform X1 [KO:K05449]
104021290  SLC25A4; LOW QUALITY PROTEIN: ADP/ATP translocase 1 [KO:K05863]
104021326  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
104021357  PDGFC; platelet-derived growth factor C [KO:K05450]
104021521  CALM2; calmodulin [KO:K02183]
104021619  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
104021666  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
104021698  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
104021751  PLCD1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 [KO:K05857] [EC:3.1.4.11]
104021845  MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
104021846  FGF23; fibroblast growth factor 23 [KO:K22428]
104021856  FGF6; fibroblast growth factor 6 [KO:K04358]
104021875  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
104022117  SLC8A1; sodium/calcium exchanger 1 isoform X1 [KO:K05849]
104022203  CAMK4; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
104022209  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
104022221  CALM1; LOW QUALITY PROTEIN: calmodulin [KO:K02183]
104022377  ADRB1; beta-1 adrenergic receptor [KO:K04141]
104022433  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
104022482  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
104022518  PHKA2; phosphorylase b kinase regulatory subunit alpha, liver isoform [KO:K07190]
104022528  GRPR; gastrin-releasing peptide receptor [KO:K04169]
104022532  FIGF; vascular endothelial growth factor D [KO:K05449]
104022609  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta [KO:K04515] [EC:2.7.11.17]
104022714  GRIN1; glutamate receptor ionotropic, NMDA 1 [KO:K05208]
104022808  [KO:K05849]
104022872  SPHK1; sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
104022917  MST1; hepatocyte growth factor-like protein [KO:K23441]
104022937  HRH1; histamine H1 receptor [KO:K04149]
104022940  ATP2B2; LOW QUALITY PROTEIN: plasma membrane calcium-transporting ATPase 2 [KO:K05850] [EC:7.2.2.10]
104023019  FLT1; LOW QUALITY PROTEIN: vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
104023031  MST1R; macrophage-stimulating protein receptor [KO:K05100] [EC:2.7.10.1]
104023035  FGF9; fibroblast growth factor 9 [KO:K04358]
104023056  SLN; sarcolipin [KO:K22642]
104023065  PDGFD; platelet-derived growth factor D [KO:K05450]
104023444  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
104023465  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
104023557  FGF16; fibroblast growth factor 16 [KO:K04358]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
  Authors
Berridge MJ, Bootman MD, Roderick HL.
  Title
Calcium signalling: dynamics, homeostasis and remodelling.
  Journal
Nat Rev Mol Cell Biol 4:517-29 (2003)
DOI:10.1038/nrm1155
Reference
PMID:11413485
  Authors
Berridge MJ, Lipp P, Bootman MD.
  Title
The versatility and universality of calcium signalling.
  Journal
Nat Rev Mol Cell Biol 1:11-21 (2000)
DOI:10.1038/35036035
Reference
PMID:15111104
  Authors
Wang MC, Dolphin A, Kitmitto A.
  Title
L-type voltage-gated calcium channels: understanding function through structure.
  Journal
FEBS Lett 564:245-50 (2004)
DOI:10.1016/S0014-5793(04)00253-4
Reference
PMID:11299192
  Authors
Ferrier GR, Howlett SE.
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Related
pathway
nni04010  MAPK signaling pathway
nni04070  Phosphatidylinositol signaling system
nni04210  Apoptosis
KO pathway
ko04020   

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