KEGG   PATHWAY: panu04218
Entry
panu04218                   Pathway                                
Name
Cellular senescence - Papio anubis (olive baboon)
Description
Cellular senescence is a state of irreversible cellular arrest and can be triggered by a number of factors, such as telomere shortening, oncogene activation, irradiation, DNA damage and oxidative stress. It is characterized by enlarged flattened morphology, senescence-associated beta-galactosidase (SA-b-gal) activity, secretion of inflammatory cytokines, growth factors and matrix metalloproteinases, as part of the senescence-associated secretory phenotype (SASP). Cellular senescence is functionally associated with many biological processes including aging, tumor suppression, placental biology, embryonic development, and wound healing.
Class
Cellular Processes; Cell growth and death
Pathway map
panu04218  Cellular senescence
panu04218

Other DBs
GO: 0090398
Organism
Papio anubis (olive baboon) [GN:panu]
Gene
100126713  PACA-F; major histocompatibility complex, class I, F precursor [KO:K06751]
100137215  CCND3; G1/S-specific cyclin-D3 [KO:K10152]
100137539  RAD50; DNA repair protein RAD50 [KO:K10866] [EC:3.6.-.-]
100381179  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100381195  IL6; interleukin-6 precursor [KO:K05405]
100381196  CXCL8; interleukin-8 precursor [KO:K10030]
100510873  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X4 [KO:K02649]
100526779  NBN; nibrin isoform X2 [KO:K10867]
100997036  CALM2; calmodulin-2 [KO:K02183]
100997116  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
100997308  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
100997330  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
100997355  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
100997583  [KO:K06751]
100997634  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100997835  CALML5; calmodulin-like protein 5 [KO:K02183]
100998071  RBL1; retinoblastoma-like protein 1 isoform X3 [KO:K04681]
100998530  CALML3; calmodulin-like protein 3 [KO:K02183]
100998866  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
100998956  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
100999197  CCNA2; cyclin-A2 [KO:K06627]
100999911  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
101000384  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X3 [KO:K17333]
101000402  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101000533  E2F1; transcription factor E2F1 [KO:K17454]
101000568  ETS1; protein C-ets-1 isoform X1 [KO:K02678]
101000606  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
101000631  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
101000645  MYC; myc proto-oncogene protein [KO:K04377]
101001103  MAPK12; mitogen-activated protein kinase 12 isoform X2 [KO:K04441] [EC:2.7.11.24]
101001272  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
101001515  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X4 [KO:K04433] [EC:2.7.12.2]
101001746  PPID; peptidyl-prolyl cis-trans isomerase D [KO:K05864] [EC:5.2.1.8]
101002070  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X6 [KO:K04851]
101002124  ZFP36L1; mRNA decay activator protein ZFP36L1 [KO:K18753]
101002278  PIK3CD; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
101002393  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
101002482  [KO:K06751]
101002848  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X2 [KO:K17332]
101002958  MCU; calcium uniporter protein, mitochondrial isoform X2 [KO:K20858]
101002971  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
101002992  HRAS; GTPase HRas isoform X2 [KO:K02833]
101003301  MYBL2; myb-related protein B isoform X1 [KO:K21769]
101003474  CCNA1; cyclin-A1 isoform X1 [KO:K06627]
101003522  [KO:K06751]
101004074  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
101004371  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
101004763  RHEB; GTP-binding protein Rheb isoform X1 [KO:K07208]
101004882  SMAD2; mothers against decapentaplegic homolog 2 isoform X2 [KO:K04500]
101004976  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101004981  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
101006198  [KO:K06751]
101006608  TP53; cellular tumor antigen p53 [KO:K04451]
101006627  TGFB1; transforming growth factor beta-1 proprotein isoform X1 [KO:K13375]
101006670  SIRT1; NAD-dependent protein deacetylase sirtuin-1 isoform X1 [KO:K11411] [EC:2.3.1.286]
101006756  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
101007101  CALM1; calmodulin-1 isoform X1 [KO:K02183]
101007301  [KO:K24231]
101007608  LIN9; protein lin-9 homolog isoform X1 [KO:K21773]
101007622  MRE11; double-strand break repair protein MRE11 isoform X3 [KO:K10865]
101007909  CCNB1; G2/mitotic-specific cyclin-B1 [KO:K05868]
101007932  [KO:K06751]
101008150  RBL2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
101008204  ZFP36L2; mRNA decay activator protein ZFP36L2 [KO:K18753]
101008394  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
101008699  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101009029  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
101009212  GATA4; transcription factor GATA-4 isoform X1 [KO:K09183]
101009253  TGFB2; transforming growth factor beta-2 proprotein isoform X2 [KO:K13376]
101009503  [KO:K06751]
101009552  VDAC2; voltage-dependent anion-selective channel protein 2 isoform X1 [KO:K15040]
101009750  SLC25A31; ADP/ATP translocase 4 isoform X1 [KO:K05863]
101009868  E2F4; transcription factor E2F4 isoform X1 [KO:K04682]
101009948  MRAS; ras-related protein M-Ras isoform X1 [KO:K07831]
101009981  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101010700  TRAF3IP2; adapter protein CIKS isoform X1 [KO:K21124]
101010979  LIN52; protein lin-52 homolog isoform X3 [KO:K21775]
101010993  BTRC; F-box/WD repeat-containing protein 1A isoform X7 [KO:K03362]
101011004  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
101011281  LIN54; protein lin-54 homolog isoform X2 [KO:K21776]
101011767  CALM3; calmodulin-3 isoform X2 [KO:K02183]
101012041  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101012106  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta isoform X2 [KO:K04402]
101012111  LIN37; protein lin-37 homolog isoform X1 [KO:K21774]
101012583  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X2 [KO:K04432] [EC:2.7.12.2]
101012607  RRAS; ras-related protein R-Ras [KO:K07829]
101012738  [KO:K06751]
101013089  SMAD3; mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
101013902  CDK6; cyclin-dependent kinase 6 isoform X1 [KO:K02091] [EC:2.7.11.22]
101013999  RAD9A; cell cycle checkpoint control protein RAD9A isoform X2 [KO:K10994] [EC:3.1.11.2]
101014127  CDKN2B; cyclin-dependent kinase 4 inhibitor B [KO:K04685]
101014342  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
101014806  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
101015041  MTOR; serine/threonine-protein kinase mTOR isoform X2 [KO:K07203] [EC:2.7.11.1]
101015078  [KO:K06621]
101015220  [KO:K06751]
101015280  CHEK2; serine/threonine-protein kinase Chk2 [KO:K06641] [EC:2.7.11.1]
101015622  TRPV4; transient receptor potential cation channel subfamily V member 4 isoform X2 [KO:K04973]
101015623  E2F2; transcription factor E2F2 isoform X1 [KO:K09389]
101016118  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform X2 [KO:K06269] [EC:3.1.3.16]
101016512  TGFBR1; TGF-beta receptor type-1 isoform X2 [KO:K04674] [EC:2.7.11.30]
101016586  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
101016712  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
101017005  RB1; retinoblastoma-associated protein [KO:K06618]
101017078  RELA; transcription factor p65 isoform X1 [KO:K04735]
101017109  FOXO1; forkhead box protein O1 [KO:K07201]
101017208  [KO:K06621]
101017317  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
101017438  CDC25A; M-phase inducer phosphatase 1 isoform X1 [KO:K06645] [EC:3.1.3.48]
101017442  ATR; serine/threonine-protein kinase ATR isoform X1 [KO:K06640] [EC:2.7.11.1]
101017528  KRAS; GTPase KRas isoform X2 [KO:K07827]
101017532  CALML6; calmodulin-like protein 6 [KO:K02183]
101018296  HIPK2; homeodomain-interacting protein kinase 2 isoform X1 [KO:K08826] [EC:2.7.11.1]
101018581  SQSTM1; sequestosome-1 [KO:K14381]
101018753  HIPK3; homeodomain-interacting protein kinase 3 isoform X2 [KO:K08826] [EC:2.7.11.1]
101018874  SERPINE1; plasminogen activator inhibitor 1 [KO:K03982]
101018977  HIPK1; homeodomain-interacting protein kinase 1 isoform X5 [KO:K08826] [EC:2.7.11.1]
101019344  RBBP4; histone-binding protein RBBP4 [KO:K10752]
101019427  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X2 [KO:K15041]
101019580  CHEK1; LOW QUALITY PROTEIN: serine/threonine-protein kinase Chk1 [KO:K02216] [EC:2.7.11.1]
101019754  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
101019755  [KO:K06751]
101019923  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
101020363  [KO:K06751]
101020566  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
101021052  [KO:K06751]
101021250  HIPK4; homeodomain-interacting protein kinase 4 [KO:K08826] [EC:2.7.11.1]
101021633  [KO:K06751]
101021694  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
101021695  ATM; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
101021987  [KO:K06751]
101022030  CAPN2; calpain-2 catalytic subunit isoform X1 [KO:K03853] [EC:3.4.22.53]
101022333  [KO:K06751]
101022360  RAD9B; cell cycle checkpoint control protein RAD9B isoform X1 [KO:K10995]
101022550  FOXO3; LOW QUALITY PROTEIN: forkhead box protein O3 [KO:K09408]
101022836  [KO:K24231]
101023088  IL1A; interleukin-1 alpha isoform X1 [KO:K04383]
101023107  TGFBR2; TGF-beta receptor type-2 isoform X2 [KO:K04388] [EC:2.7.11.30]
101023200  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
101023767  E2F5; transcription factor E2F5 isoform X3 [KO:K04682]
101024059  [KO:K06751]
101024169  TSC1; hamartin isoform X4 [KO:K07206]
101024189  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
101024315  RAD1; cell cycle checkpoint protein RAD1 [KO:K02830] [EC:3.1.11.2]
101024625  MAPKAPK2; MAP kinase-activated protein kinase 2 isoform X4 [KO:K04443] [EC:2.7.11.1]
101024771  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
101024785  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101024929  CCNB3; G2/mitotic-specific cyclin-B3 isoform X1 [KO:K21771]
101025020  TSC2; tuberin isoform X12 [KO:K07207]
101025041  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
101025045  [KO:K06751]
101025116  E2F3; transcription factor E2F3 isoform X3 [KO:K06620]
101025156  FBXW11; F-box/WD repeat-containing protein 11 isoform X1 [KO:K03362]
101025161  [KO:K04982] [EC:2.7.11.1]
101025307  CCNE2; G1/S-specific cyclin-E2 isoform X3 [KO:K06626]
101025310  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X4 [KO:K04348] [EC:3.1.3.16]
101025437  CAPN1; calpain-1 catalytic subunit isoform X1 [KO:K01367] [EC:3.4.22.52]
101025662  FOXM1; forkhead box protein M1 isoform X1 [KO:K09406]
101025668  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
101025881  CDK1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
101025892  CDK2; cyclin-dependent kinase 2 isoform X2 [KO:K02206] [EC:2.7.11.22]
101025984  [KO:K21770]
101026054  IGFBP3; insulin-like growth factor-binding protein 3 [KO:K10138]
101026217  [KO:K06751]
101026253  NRAS; GTPase NRas isoform X2 [KO:K07828]
101026375  RASSF5; ras association domain-containing protein 5 isoform X1 [KO:K08015]
101026693  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X4 [KO:K04348] [EC:3.1.3.16]
101026781  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X6 [KO:K02580]
103877032  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
110741963  [KO:K24231]
116268503  [KO:K04982] [EC:2.7.11.1]
116268672  [KO:K24231]
116268677  [KO:K06751]
116271990  [KO:K05864] [EC:5.2.1.8]
116272568  [KO:K21770]
116272574  [KO:K06751]
116272784  [KO:K06751]
116272937  [KO:K06751]
116273056  [KO:K06751]
116273133  [KO:K06751]
116273134  [KO:K06751]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C07909  Sirolimus
C16844  Hydroxyl radical
Reference
PMID:24954210
  Authors
Munoz-Espin D, Serrano M
  Title
Cellular senescence: from physiology to pathology.
  Journal
Nat Rev Mol Cell Biol 15:482-96 (2014)
DOI:10.1038/nrm3823
Reference
PMID:26646499
  Authors
Childs BG, Durik M, Baker DJ, van Deursen JM
  Title
Cellular senescence in aging and age-related disease: from mechanisms to therapy.
  Journal
Nat Med 21:1424-35 (2015)
DOI:10.1038/nm.4000
Reference
PMID:26105537
  Authors
Sharpless NE, Sherr CJ
  Title
Forging a signature of in vivo senescence.
  Journal
Nat Rev Cancer 15:397-408 (2015)
DOI:10.1038/nrc3960
Reference
PMID:26435346
  Authors
Fridlyanskaya I, Alekseenko L, Nikolsky N
  Title
Senescence as a general cellular response to stress: A mini-review.
  Journal
Exp Gerontol 72:124-8 (2015)
DOI:10.1016/j.exger.2015.09.021
Reference
PMID:27417123
  Authors
Lujambio A
  Title
To clear, or not to clear (senescent cells)? That is the question.
  Journal
Bioessays 38 Suppl 1:S56-64 (2016)
DOI:10.1002/bies.201670910
Reference
PMID:26564316
  Authors
Di Mitri D, Alimonti A
  Title
Non-Cell-Autonomous Regulation of Cellular Senescence in Cancer.
  Journal
Trends Cell Biol 26:215-26 (2016)
DOI:10.1016/j.tcb.2015.10.005
Reference
PMID:27574725
  Authors
Francica P, Aebersold DM, Medova M
  Title
Senescence as biologic endpoint following pharmacological targeting of receptor tyrosine kinases in cancer.
  Journal
Biochem Pharmacol 126:1-12 (2017)
DOI:10.1016/j.bcp.2016.08.022
Reference
PMID:23982440
  Authors
Bartling B
  Title
Cellular senescence in normal and premature lung aging.
  Journal
Z Gerontol Geriatr 46:613-22 (2013)
DOI:10.1007/s00391-013-0543-3
Reference
PMID:24238962
  Authors
Munoz-Espin D, Canamero M, Maraver A, Gomez-Lopez G, Contreras J, Murillo-Cuesta S, Rodriguez-Baeza A, Varela-Nieto I, Ruberte J, Collado M, Serrano M
  Title
Programmed cell senescence during mammalian embryonic development.
  Journal
Cell 155:1104-18 (2013)
DOI:10.1016/j.cell.2013.10.019
Reference
PMID:26697828
  Authors
Herranz N, Gallage S, Gil J
  Title
TORn about SASP regulation.
  Journal
Cell Cycle 14:3771-2 (2015)
DOI:10.1080/15384101.2015.1105694
Reference
PMID:28410770
  Authors
Martin N, Bernard D
  Title
Calcium signaling and cellular senescence.
  Journal
Cell Calcium S0143-4160(17)30049-0 (2017)
DOI:10.1016/j.ceca.2017.04.001
Reference
PMID:25764980
  Authors
Farfariello V, Iamshanova O, Germain E, Fliniaux I, Prevarskaya N
  Title
Calcium homeostasis in cancer: A focus on senescence.
  Journal
Biochim Biophys Acta 1853:1974-9 (2015)
DOI:10.1016/j.bbamcr.2015.03.005
Reference
PMID:24062309
  Authors
McCarthy DA, Clark RR, Bartling TR, Trebak M, Melendez JA
  Title
Redox control of the senescence regulator interleukin-1alpha and the secretory phenotype.
  Journal
J Biol Chem 288:32149-59 (2013)
DOI:10.1074/jbc.M113.493841
Reference
PMID:27288568
  Authors
Donninger H, Schmidt ML, Mezzanotte J, Barnoud T, Clark GJ
  Title
Ras signaling through RASSF proteins.
  Journal
Semin Cell Dev Biol 58:86-95 (2016)
DOI:10.1016/j.semcdb.2016.06.007
Reference
PMID:28455242
  Authors
Barnoud T, Schmidt ML, Donninger H, Clark GJ
  Title
The role of the NORE1A tumor suppressor in Oncogene-Induced Senescence.
  Journal
Cancer Lett 400:30-36 (2017)
DOI:10.1016/j.canlet.2017.04.030
Reference
PMID:26404840
  Authors
Kang C, Xu Q, Martin TD, Li MZ, Demaria M, Aron L, Lu T, Yankner BA, Campisi J, Elledge SJ
  Title
The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4.
  Journal
Science 349:aaa5612 (2015)
DOI:10.1126/science.aaa5612
Reference
PMID:26777575
  Authors
Cao X, Li M
  Title
A New Pathway for Senescence Regulation.
  Journal
Genomics Proteomics Bioinformatics 13:333-5 (2015)
DOI:10.1016/j.gpb.2015.11.002
Reference
PMID:25564883
  Authors
Gire V, Dulic V
  Title
Senescence from G2 arrest, revisited.
  Journal
Cell Cycle 14:297-304 (2015)
DOI:10.1080/15384101.2014.1000134
Reference
PMID:24981831
  Authors
Mowla SN, Lam EW, Jat PS
  Title
Cellular senescence and aging: the role of B-MYB.
  Journal
Aging Cell 13:773-9 (2014)
DOI:10.1111/acel.12242
Reference
PMID:22546858
  Authors
Yao H, Chung S, Hwang JW, Rajendrasozhan S, Sundar IK, Dean DA, McBurney MW, Guarente L, Gu W, Ronty M, Kinnula VL, Rahman I
  Title
SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice.
  Journal
J Clin Invest 122:2032-45 (2012)
DOI:10.1172/JCI60132
Reference
PMID:23542362
  Authors
Hwang JW, Yao H, Caito S, Sundar IK, Rahman I
  Title
Redox regulation of SIRT1 in inflammation and cellular senescence.
  Journal
Free Radic Biol Med 61:95-110 (2013)
DOI:10.1016/j.freeradbiomed.2013.03.015
Related
pathway
panu04020  Calcium signaling pathway
panu04068  FoxO signaling pathway
panu04110  Cell cycle
panu04115  p53 signaling pathway
panu04150  mTOR signaling pathway
KO pathway
ko04218   

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