KEGG   PATHWAY: achc04810
Entry
achc04810                   Pathway                                
Name
Regulation of actin cytoskeleton - Aquila chrysaetos chrysaetos (golden eagle)
Class
Cellular Processes; Cell motility
Pathway map
achc04810  Regulation of actin cytoskeleton
achc04810

Other DBs
GO: 0030036
Organism
Aquila chrysaetos chrysaetos (golden eagle) [GN:achc]
Gene
115337166  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
115347899  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
115333831  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
115343885  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
115348274  CXCL12; stromal cell-derived factor 1 isoform X1 [KO:K10031]
115342992  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
115336537  F2; prothrombin [KO:K01313] [EC:3.4.21.5]
115337319  F2R; proteinase-activated receptor 1 isoform X1 [KO:K03914]
115352123  insulin [KO:K04526]
115344703  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
115334052  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
115343528  FGF2; fibroblast growth factor 2 [KO:K18497]
115349939  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
115337246  FGF10; fibroblast growth factor 10 [KO:K04358]
115351806  FGF3; fibroblast growth factor 3 [KO:K04358]
115351873  FGF4; fibroblast growth factor 4 [KO:K04358]
115352412  FGF6; fibroblast growth factor 6 [KO:K04358]
115353237  FGF9; fibroblast growth factor 9 [KO:K04358]
115347333  FGF5; LOW QUALITY PROTEIN: fibroblast growth factor 5 [KO:K04358]
115333915  FGF16; fibroblast growth factor 16 [KO:K04358]
115341210  FGF7; fibroblast growth factor 7 isoform X1 [KO:K04358]
121232827  fibroblast growth factor 10-like [KO:K04358]
115334399  FGF18; fibroblast growth factor 18 [KO:K04358]
115348494  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
115349017  FGF22; fibroblast growth factor 22 [KO:K04358]
115342720  FGF20; fibroblast growth factor 20 [KO:K04358]
115352222  FGF19; fibroblast growth factor 19 [KO:K22603]
115352405  FGF23; fibroblast growth factor 23 [KO:K22428]
115335808  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
115352795  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
115346275  PDGFC; platelet-derived growth factor C [KO:K05450]
115353500  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
115345961  INSRR; insulin receptor-related protein isoform X1 [KO:K05086] [EC:2.7.10.1]
115338920  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
115350076  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
115348147  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
115343423  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
115334290  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
115341064  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
115334242  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
115342628  FN1; fibronectin isoform X1 [KO:K05717]
115336652  ITGA1; integrin alpha-1 [KO:K06480]
115336494  ITGA2; integrin alpha-2 isoform X2 [KO:K06481]
115344825  ITGA2B; LOW QUALITY PROTEIN: integrin alpha-IIb [KO:K06476]
115344340  ITGA3; integrin alpha-3 [KO:K06482]
115342518  ITGA4; integrin alpha-4 [KO:K06483]
115342642  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
115350858  ITGA7; integrin alpha-7 [KO:K06583]
115339680  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
115339665  ITGA9; integrin alpha-9 isoform X1 [KO:K06585]
115345835  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
115341970  ITGA11; integrin alpha-11 isoform X1 [KO:K06587]
115343263  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
115346862  ITGAE; integrin alpha-E isoform X1 [KO:K06524]
115339345  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
115343262  ITGB2; integrin beta-2 [KO:K06464]
115345001  ITGB3; integrin beta-3 [KO:K06493]
115341344  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
115342811  ITGB5; LOW QUALITY PROTEIN: integrin beta-5 [KO:K06588]
115343304  ITGB6; integrin beta-6 [KO:K06589]
115351399  ITGB7; integrin beta-7 [KO:K06590]
115338779  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
115346711  KNG1; kininogen-1 isoform X1 [KO:K03898]
115334580  BDKRB1; B1 bradykinin receptor [KO:K03915]
115338673  BDKRB2; B2 bradykinin receptor [KO:K03916]
115352771  CHRM2; muscarinic acetylcholine receptor M2 isoform X1 [KO:K04130]
115350430  CHRM3; muscarinic acetylcholine receptor M3 isoform X1 [KO:K04131]
115336241  CHRM4; muscarinic acetylcholine receptor M4 isoform X1 [KO:K04132]
115334503  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
115335382  C5; complement C5 isoform X1 [KO:K03994]
115336744  C6; complement component C6 isoform X1 [KO:K03995]
115336745  C7; complement component C7 isoform X1 [KO:K03996]
115348777  C8A; complement component C8 alpha chain [KO:K03997]
115348778  C8B; complement component C8 beta chain [KO:K03998]
115335378  C8G; complement component C8 gamma chain [KO:K03999]
115337185  C9; LOW QUALITY PROTEIN: complement component C9 [KO:K04000]
115335761  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
115341158  GNA13; guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
115349510  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
115353708  FGD3; FYVE, RhoGEF and PH domain-containing protein 3 isoform X1 [KO:K05722]
115340288  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
115345831  BCAR1; LOW QUALITY PROTEIN: breast cancer anti-estrogen resistance protein 1 [KO:K05726]
115346006  CRKL; crk-like protein [KO:K04438]
115346773  CRK; adapter molecule crk isoform X2 [KO:K04438]
115347969  DOCK1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
115339513  SRC; proto-oncogene tyrosine-protein kinase Src isoform X3 [KO:K05704] [EC:2.7.10.2]
115351224  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
115352127  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
115351819  HRAS; GTPase HRas [KO:K02833]
115352540  KRAS; GTPase KRas isoform X2 [KO:K07827]
115335439  NRAS; GTPase NRas isoform X1 [KO:K07828]
115351885  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
115342940  MRAS; ras-related protein M-Ras [KO:K07831]
115333918  ARHGEF6; rho guanine nucleotide exchange factor 6 isoform X1 [KO:K05729]
115347173  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
115347305  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
115342450  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
115349575  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
115337134  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
121233034  phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1 [KO:K02649]
115348975  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
115335021  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
115348546  LOW QUALITY PROTEIN: proto-oncogene vav-like [KO:K05730]
115348976  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
115343736  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 isoform X1 [KO:K05731]
115352782  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
115353699  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
115340427  MOS; proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
115342153  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
115349300  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
115346261  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
115350251  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
115338049  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
115338050  RAC-beta serine/threonine-protein kinase-like isoform X1 [KO:K04456] [EC:2.7.11.1]
115347910  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
115350723  RGCC; regulator of cell cycle RGCC [KO:K26108]
115333858  regulator of cell cycle RGCC-like isoform X2 [KO:K26108]
115345091  ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X3 [KO:K07532]
115338290  rho GTPase-activating protein 35 [KO:K05732]
115338291  rho GTPase-activating protein 35-like [KO:K05732]
115353760  RHOA; transforming protein RhoA [KO:K04513]
115335619  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X2 [KO:K04392]
115352715  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
115340958  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
115342739  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
115353441  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
115346855  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
115333461  PAK3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
115338174  serine/threonine-protein kinase PAK 4 isoform X1 [KO:K05734] [EC:2.7.11.1]
115338183  serine/threonine-protein kinase PAK 4-like [KO:K05734] [EC:2.7.11.1]
115344239  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
115352095  serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
115334521  ARHGEF7; rho guanine nucleotide exchange factor 7 isoform X1 [KO:K13710]
115346844  GIT1; LOW QUALITY PROTEIN: ARF GTPase-activating protein GIT1 [KO:K05737]
115340145  ROCK1; rho-associated protein kinase 1 isoform X2 [KO:K04514] [EC:2.7.11.1]
115351142  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
115339138  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
115346654  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
115353120  MYLK4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
115342719  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
115345195  LOW QUALITY PROTEIN: myosin light chain kinase, smooth muscle-like [KO:K00907] [EC:2.7.11.18]
115350480  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
115337541  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
115346179  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
115336095  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
115334870  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X1 [KO:K12329]
115345956  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
115349922  MYL7; myosin regulatory light chain 2, atrial isoform isoform X1 [KO:K12754]
115339909  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
115347623  MYL10; myosin regulatory light chain 10 [KO:K12756]
115340208  myosin regulatory light chain 2, smooth muscle minor isoform [KO:K12757]
115352386  MYH9; myosin-9 [KO:K10352]
115340939  MYH10; myosin-10 isoform X1 [KO:K10352]
115335597  MYH11; myosin-11 isoform X1 [KO:K10352]
115333572  DIAPH2; protein diaphanous homolog 2 isoform X1 [KO:K05741]
115352135  SLC9A1; sodium/hydrogen exchanger 1 [KO:K05742]
115336472  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
115345542  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
115348832  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X2 [KO:K00889] [EC:2.7.1.68]
115344862  PIP4K2B; phosphatidylinositol 5-phosphate 4-kinase type-2 beta isoform X1 [KO:K00920] [EC:2.7.1.149]
115338527  PIP4K2C; phosphatidylinositol 5-phosphate 4-kinase type-2 gamma isoform X1 [KO:K00920] [EC:2.7.1.149]
115339349  PIP4K2A; phosphatidylinositol 5-phosphate 4-kinase type-2 alpha isoform X1 [KO:K00920] [EC:2.7.1.149]
115343421  PIKFYVE; 1-phosphatidylinositol 3-phosphate 5-kinase [KO:K00921] [EC:2.7.1.150]
115346840  LIMK1; LOW QUALITY PROTEIN: LIM domain kinase 1 [KO:K05743] [EC:2.7.11.1]
115346159  LIMK2; LIM domain kinase 2 isoform X1 [KO:K05744] [EC:2.7.11.1]
115350734  DIAPH3; protein diaphanous homolog 3 isoform X1 [KO:K05745]
115341035  BAIAP2; brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X1 [KO:K05627]
115350063  ENAH; protein enabled homolog isoform X2 [KO:K05746]
115342183  WASL; neural Wiskott-Aldrich syndrome protein isoform X2 [KO:K23612]
115351658  WASF2; wiskott-Aldrich syndrome protein family member 2 isoform X4 [KO:K05748]
115334045  CYFIP2; cytoplasmic FMR1-interacting protein 2 isoform X1 [KO:K05749]
115334479  CYFIP1; cytoplasmic FMR1-interacting protein 1 isoform X1 [KO:K05749]
115350954  NCKAP1L; nck-associated protein 1-like [KO:K05750]
115342778  NCKAP1; nck-associated protein 1 isoform X1 [KO:K05750]
115342405  ABI2; abl interactor 2 isoform X1 [KO:K05751]
115353777  BRK1; protein BRICK1 [KO:K05752]
115337365  WASF1; wiskott-Aldrich syndrome protein family member 1 isoform X1 [KO:K05753]
115344937  ACTR2; actin-related protein 2 isoform X1 [KO:K17260]
115339685  ACTR3B; actin-related protein 3B isoform X1 [KO:K18584]
115342867  ACTR3; actin-related protein 3 [KO:K18584]
115335690  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
115335785  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
115342627  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
115345332  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
121232467  ARPC4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
115334855  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
115349403  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
115336033  ACTB; actin, cytoplasmic 1 [KO:K05692]
115340949  ACTG1; actin, cytoplasmic 2 [KO:K05692]
115341775  actin, cytoplasmic type 5 [KO:K05692]
115350157  PFN3; profilin-3 [KO:K05759]
115338398  PFN1; profilin-1 [KO:K05759]
115347298  PFN2; profilin-2 isoform X1 [KO:K05759]
115346227  PXN; paxillin isoform X1 [KO:K05760]
115345160  EZR; ezrin isoform X1 [KO:K08007]
115353461  RDX; radixin isoform X2 [KO:K05762]
115333699  MSN; moesin isoform X1 [KO:K05763]
115334130  thymosin beta-12-like [KO:K05764]
115334602  TMSB4X; thymosin beta-4 [KO:K05764]
115335544  CFL2; cofilin-2 isoform X1 [KO:K05765]
115345916  SSH1; protein phosphatase Slingshot homolog 1 isoform X2 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
115346938  SSH2; protein phosphatase Slingshot homolog 2 isoform X2 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
115348369  VCL; vinculin isoform X1 [KO:K05700]
115341071  IQGAP1; ras GTPase-activating-like protein IQGAP1 isoform X1 [KO:K16848]
115336809  IQGAP2; ras GTPase-activating-like protein IQGAP2 isoform X1 [KO:K05767]
115346531  IQGAP3; ras GTPase-activating-like protein IQGAP3 [KO:K05767]
115339000  SCIN; adseverin [KO:K05768]
115334964  GSN; gelsolin isoform X1 [KO:K05768]
115338181  ACTN4; alpha-actinin-4 isoform X2 [KO:K05699]
115353066  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
115336672  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
121232399  LOW QUALITY PROTEIN: adenomatous polyposis coli protein-like [KO:K02085]
115348841  APC2; LOW QUALITY PROTEIN: adenomatous polyposis coli protein 2 [KO:K02085]
115347255  ARHGEF4; rho guanine nucleotide exchange factor 4 isoform X1 [KO:K05769]
115353495  SPATA13; spermatogenesis-associated protein 13 isoform X1 [KO:K05769]
Compound
C00681  1-Acyl-sn-glycerol 3-phosphate
C01996  Acetylcholine
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:11152757
  Authors
Takai Y, Sasaki T, Matozaki T.
  Title
Small GTP-binding proteins.
  Journal
Physiol Rev 81:153-208 (2001)
DOI:10.1152/physrev.2001.81.1.153
Reference
PMID:12700767
  Authors
Pollard TD.
  Title
The cytoskeleton, cellular motility and the reductionist agenda.
  Journal
Nature 422:741-5 (2003)
DOI:10.1038/nature01598
Reference
PMID:14657486
  Authors
Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR.
  Title
Cell migration: integrating signals from front to back.
  Journal
Science 302:1704-9 (2003)
DOI:10.1126/science.1092053
Reference
PMID:11082272
  Authors
Sastry SK, Burridge K.
  Title
Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics.
  Journal
Exp Cell Res 261:25-36 (2000)
DOI:10.1006/excr.2000.5043
Reference
PMID:10574699
  Authors
Fukata M, Nakagawa M, Kuroda S, Kaibuchi K.
  Title
Cell adhesion and Rho small GTPases.
  Journal
J Cell Sci 112 ( Pt 24):4491-500 (1999)
Related
pathway
achc04010  MAPK signaling pathway
achc04510  Focal adhesion
achc04520  Adherens junction
KO pathway
ko04810   
LinkDB

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