KEGG   PATHWAY: ats03040
Entry
ats03040                    Pathway                                
Name
Spliceosome - Aegilops tauschii (wheat D)
Description
After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified.
Class
Genetic Information Processing; Transcription
Pathway map
ats03040  Spliceosome
ats03040

Other DBs
GO: 0005681
Organism
Aegilops tauschii (wheat D) [GN:ats]
Gene
109744095  DEAD-box ATP-dependent RNA helicase 42-like [KO:K12811] [EC:5.6.2.7]
109784058  DEAD-box ATP-dependent RNA helicase 15 isoform X1 [KO:K12812] [EC:5.6.2.7]
109769288  DEAD-box ATP-dependent RNA helicase 15-like isoform X1 [KO:K12812] [EC:5.6.2.7]
109771754  pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH1-like isoform X1 [KO:K12813] [EC:5.6.2.6]
109780101  pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH1-like [KO:K12813] [EC:5.6.2.6]
109744394  pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH7 [KO:K12815] [EC:5.6.2.6]
109779592  pre-mRNA-processing factor 17 [KO:K12816]
109752047  pre-mRNA-splicing factor 18 [KO:K12817]
109764545  pre-mRNA-splicing factor 18-like [KO:K12817]
109738466  ATP-dependent RNA helicase DEAH12, chloroplastic-like [KO:K12818] [EC:5.6.2.6]
109787073  ATP-dependent RNA helicase DEAH11, chloroplastic-like [KO:K12818] [EC:5.6.2.6]
109781846  pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH10 [KO:K12818] [EC:5.6.2.6]
109757866  probable pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH4 [KO:K12818] [EC:5.6.2.6]
109771825  probable pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH5 [KO:K12818] [EC:5.6.2.6]
109732673  probable pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH5 [KO:K12818] [EC:5.6.2.6]
109732912  pre-mRNA-splicing factor SLU7 [KO:K12819]
109778379  probable pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH3 isoform X1 [KO:K12820] [EC:5.6.2.6]
109741594  small nuclear ribonucleoprotein-associated protein B'-like [KO:K11086]
109734227  small nuclear ribonucleoprotein Sm D1-like [KO:K11087]
109757661  small nuclear ribonucleoprotein Sm D1-like isoform X1 [KO:K11087]
109763304  small nuclear ribonucleoprotein Sm D2-like isoform X1 [KO:K11096]
109769660  small nuclear ribonucleoprotein Sm D2-like [KO:K11096]
109785151  small nuclear ribonucleoprotein Sm D2-like [KO:K11096]
109783081  small nuclear ribonucleoprotein SmD3b [KO:K11088]
109738284  small nuclear ribonucleoprotein E-like [KO:K11097]
109738274  small nuclear ribonucleoprotein E-like [KO:K11097]
109779153  small nuclear ribonucleoprotein E-like [KO:K11097]
109785635  small nuclear ribonucleoprotein E-like [KO:K11097]
109769192  probable small nuclear ribonucleoprotein F [KO:K11098]
109734301  probable small nuclear ribonucleoprotein F [KO:K11098]
109770622  probable small nuclear ribonucleoprotein G [KO:K11099]
109745705  U1 small nuclear ribonucleoprotein 70 kDa-like [KO:K11093]
109743642  U1 small nuclear ribonucleoprotein 70 kDa-like [KO:K11093]
109785811  U1 small nuclear ribonucleoprotein A [KO:K11091]
109779738  U1 small nuclear ribonucleoprotein C-1-like [KO:K11095]
109784689  pre-mRNA-processing protein 40A isoform X1 [KO:K12821]
109735093  RNA-binding protein 25 isoform X1 [KO:K12822]
109776680  DEAD-box ATP-dependent RNA helicase 40-like isoform X1 [KO:K12823] [EC:5.6.2.7]
109740785  DEAD-box ATP-dependent RNA helicase 30-like [KO:K12823] [EC:5.6.2.7]
109738726  DEAD-box ATP-dependent RNA helicase 40-like [KO:K12823] [EC:5.6.2.7]
109756743  DEAD-box ATP-dependent RNA helicase 14-like isoform X1 [KO:K12823] [EC:5.6.2.7]
109756807  DEAD-box ATP-dependent RNA helicase 20 [KO:K12823] [EC:5.6.2.7]
109741842  pre-mRNA-processing protein 40C isoform X1 [KO:K12824]
109772368  transcription initiation factor TFIID subunit 15b [KO:K13098]
109769645  U2 small nuclear ribonucleoprotein A' [KO:K11092]
109775448  U2 small nuclear ribonucleoprotein A'-like [KO:K11092]
109755988  U2 small nuclear ribonucleoprotein A'-like [KO:K11092]
109740988  U2 small nuclear ribonucleoprotein B''-like [KO:K11094]
109763147  probable splicing factor 3A subunit 1 [KO:K12825]
109763417  splicing factor 3A subunit 2 isoform X1 [KO:K12826]
109785936  splicing factor SF3a60 homolog [KO:K12827]
109760505  splicing factor SF3a60 homolog [KO:K12827]
109743206  splicing factor SF3a60 homolog isoform X1 [KO:K12827]
109753399  splicing factor 3B subunit 1-like [KO:K12828]
109781233  splicing factor 3B subunit 1 [KO:K12828]
109758912  splicing factor 3B subunit 2 [KO:K12829]
109736416  splicing factor 3B subunit 2-like [KO:K12829]
109747149  splicing factor 3B subunit 2-like [KO:K12829]
109735663  splicing factor 3B subunit 3-like [KO:K12830]
109733158  splicing factor 3B subunit 3 isoform X1 [KO:K12830]
109776698  splicing factor 3B subunit 4 [KO:K12831]
109752781  RNA-binding protein 7 [KO:K12831]
109752937  splicing regulator RBM11-like [KO:K12831]
109749337  uncharacterized protein At4g14342-like [KO:K12832]
109749346  uncharacterized protein At4g14342 [KO:K12832]
109781463  uncharacterized protein At4g14342-like [KO:K12832]
109786547  splicing factor 3B subunit 6-like protein [KO:K12833]
109746155  PHD finger-like domain-containing protein 5B [KO:K12834]
109784567  PHD finger-like domain-containing protein 5B [KO:K12834]
109758410  DEAD-box ATP-dependent RNA helicase 24 isoform X1 [KO:K12835] [EC:5.6.2.7]
109767752  splicing factor U2af small subunit B-like [KO:K12836]
109773716  splicing factor U2af small subunit A-like isoform X1 [KO:K12836]
109771533  splicing factor U2af small subunit B isoform X1 [KO:K12836]
109741716  splicing factor U2af large subunit B isoform X1 [KO:K12837]
109733611  splicing factor U2af large subunit A-like isoform X1 [KO:K12837]
109773246  splicing factor U2af large subunit A-like isoform X1 [KO:K12837]
109752475  uncharacterized protein LOC109752475 isoform X1 [KO:K12837]
109743347  survival of motor neuron-related-splicing factor 30 [KO:K12839]
109773310  DNA-damage-repair/toleration protein DRT111, chloroplastic [KO:K12840]
109745122  protein RRC1-like isoform X1 [KO:K12842]
109783433  protein RRC1-like isoform X1 [KO:K12842]
109762555  sm-like protein LSM2 [KO:K12621]
109750384  sm-like protein LSM3A [KO:K12622]
109753143  sm-like protein LSM3A [KO:K12622]
109739341  probable U6 snRNA-associated Sm-like protein LSm4 [KO:K12623]
109782122  sm-like protein LSM5 [KO:K12624]
109731843  U6 snRNA-associated Sm-like protein LSm6 isoform X1 [KO:K12625]
109734399  sm-like protein LSM7 [KO:K12626]
109736943  uncharacterized protein LOC109736943 isoform X1 [KO:K12626]
109748116  sm-like protein LSM7 [KO:K12626]
109763635  uncharacterized protein LOC109763635 [KO:K12626]
109784060  sm-like protein LSM8 [KO:K12627]
109762796  protein RDM16 isoform X1 [KO:K12843]
109736560  protein RDM16-like [KO:K12843]
109786473  U4/U6 small nuclear ribonucleoprotein PRP4-like protein [KO:K12662]
109786569  U4/U6 small nuclear ribonucleoprotein PRP4-like protein isoform X1 [KO:K12662]
109786546  peptidyl-prolyl cis-trans isomerase CYP22 [KO:K09567] [EC:5.2.1.8]
109732575  U4/U6 small nuclear ribonucleoprotein Prp31 homolog [KO:K12844]
109740262  NHP2-like protein 1 [KO:K12845]
109755764  U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein [KO:K12846]
109763907  uncharacterized protein LOC109763907 [KO:K12846]
109768378  U4/U6.U5 tri-snRNP-associated protein 2-like [KO:K12847]
109763337  SART-1 family protein DOT2 [KO:K11984]
109783313  zinc finger matrin-type protein 2 [KO:K12848]
109761978  pre-mRNA-splicing factor 38-like [KO:K12849]
109787651  pre-mRNA-splicing factor 38 [KO:K12849]
109745850  pre-mRNA splicing factor SR-like 1 isoform X1 [KO:K12850]
109761209  pre-mRNA splicing factor SR-like 1 isoform X1 [KO:K12850]
109781804  110 kDa U5 small nuclear ribonucleoprotein component CLO-like [KO:K12852]
109762882  DExH-box ATP-dependent RNA helicase DExH12 [KO:K12854] [EC:5.6.2.6]
109744367  protein STABILIZED1-like [KO:K12855]
109744313  pre-mRNA-processing-splicing factor 8A-like [KO:K12856]
109763000  pre-mRNA-processing-splicing factor 8A [KO:K12856]
109749438  U5 small nuclear ribonucleoprotein 40 kDa protein-like [KO:K12857]
109780750  DEAD-box ATP-dependent RNA helicase 21 [KO:K12858] [EC:5.6.2.7]
109760116  DEAD-box ATP-dependent RNA helicase 21-like [KO:K12858] [EC:5.6.2.7]
109772928  thioredoxin-like protein YLS8 [KO:K12859]
109773417  thioredoxin-like protein YLS8 [KO:K12859]
109755429  pre-mRNA-processing factor 19-like [KO:K10599] [EC:2.3.2.27]
109771913  pre-mRNA-processing factor 19 isoform X1 [KO:K10599] [EC:2.3.2.27]
109784299  cell division cycle 5-like protein isoform X1 [KO:K12860]
109763172  cell division cycle 5-like protein [KO:K12860]
109766928  pre-mRNA-splicing factor SPF27 homolog [KO:K12861]
109776823  protein pleiotropic regulatory locus 1-like [KO:K12862]
109771859  protein CWC15 homolog [KO:K12863]
109758245  protein CWC15 homolog [KO:K12863]
109786641  beta-catenin-like protein 1 [KO:K12864]
109741152  heat shock cognate 70 kDa protein 2 [KO:K03283]
109761115  heat shock cognate 70 kDa protein 2-like [KO:K03283]
109756071  heat shock cognate 70 kDa protein 2-like [KO:K03283]
109763346  heat shock cognate 70 kDa protein 2-like [KO:K03283]
109747067  heat shock cognate 70 kDa protein-like [KO:K03283]
109751353  heat shock cognate 70 kDa protein 2-like [KO:K03283]
109768748  heat shock cognate 70 kDa protein-like [KO:K03283]
109745079  probable mediator of RNA polymerase II transcription subunit 37c [KO:K03283]
109751487  heat shock cognate 70 kDa protein [KO:K03283]
109736734  heat shock cognate 70 kDa protein-like [KO:K03283]
109787241  heat shock 70 kDa protein 6, chloroplastic-like [KO:K03283]
109787315  heat shock cognate 70 kDa protein-like [KO:K03283]
109786458  heat shock cognate 70 kDa protein 2-like [KO:K03283]
109782177  stromal 70 kDa heat shock-related protein, chloroplastic-like [KO:K03283]
109738129  uncharacterized protein LOC109738129 [KO:K12865]
109774263  uncharacterized protein LOC109774263 [KO:K12865]
109763105  SNW/SKI-interacting protein-like [KO:K06063]
109732048  SNW/SKI-interacting protein [KO:K06063]
109734331  pre-mRNA-splicing factor SYF1 [KO:K12867]
109778761  pre-mRNA-splicing factor syf2 [KO:K12868]
109782302  crooked neck-like protein 1 [KO:K12869]
109740255  pre-mRNA-splicing factor ISY1 homolog [KO:K12870]
109765557  peptidyl-prolyl cis-trans isomerase CYP18-2 [KO:K12733] [EC:5.2.1.8]
109747145  coiled-coil domain-containing protein 12 [KO:K12871]
109759602  zinc finger CCCH domain-containing protein 40 [KO:K12872]
109734599  protein BUD31 homolog 1 [KO:K12873]
109770725  protein BUD31 homolog 2 [KO:K12873]
109771971  intron-binding protein aquarius [KO:K12874]
109781791  apoptotic chromatin condensation inducer in the nucleus [KO:K12875]
109756890  apoptotic chromatin condensation inducer in the nucleus-like [KO:K12875]
109787314  DEAD-box ATP-dependent RNA helicase 2-like [KO:K13025] [EC:5.6.2.7]
109775412  DEAD-box ATP-dependent RNA helicase 34 isoform X1 [KO:K13025] [EC:5.6.2.7]
109746557  DEAD-box ATP-dependent RNA helicase 34-like [KO:K13025] [EC:5.6.2.7]
109785532  RNA-binding protein 8A-like isoform X1 [KO:K12876]
109774414  RNA-binding protein 8A [KO:K12876]
109761680  protein mago nashi homolog [KO:K12877]
109787591  THO complex subunit 1 [KO:K12878]
109741139  THO complex subunit 2-like [KO:K12879]
109762678  THO complex subunit 2-like isoform X1 [KO:K12879]
109779000  THO complex subunit 3 isoform X1 [KO:K12880]
109755644  THO complex subunit 4B-like [KO:K12881]
109757782  THO complex subunit 4B-like [KO:K12881]
109745291  THO complex subunit 4A-like [KO:K12881]
109787643  THO complex subunit 4B-like [KO:K12881]
109769408  THO complex subunit 4D-like [KO:K12881]
109767624  THO complex subunit 4D-like [KO:K12881]
109773130  nuclear cap-binding protein subunit 1 [KO:K12882]
109736194  nuclear cap-binding protein subunit 2 [KO:K12883]
109740998  heterogeneous nuclear ribonucleoprotein 1-like [KO:K12741]
109738089  UBP1-associated protein 2A-like [KO:K12741]
109738399  heterogeneous nuclear ribonucleoprotein 27C-like isoform X1 [KO:K12741]
109760925  heterogeneous nuclear ribonucleoprotein 27C-like isoform X1 [KO:K12741]
109737811  heterogeneous nuclear ribonucleoproteins A2/B1-like [KO:K12741]
109761389  glycine-rich RNA-binding protein 10-like [KO:K12741]
109751556  UBP1-associated protein 2B-like [KO:K12741]
109770147  heterogeneous nuclear ribonucleoprotein A/B-like [KO:K12741]
109778658  glycine-rich RNA-binding protein 2, mitochondrial-like [KO:K12741]
109756506  UBP1-associated protein 2C-like [KO:K12741]
109764094  UBP1-associated protein 2C-like [KO:K12741]
109738290  serine/arginine-rich-splicing factor SR34 isoform X1 [KO:K12890]
109733583  serine/arginine-rich splicing factor SR30-like isoform X1 [KO:K12890]
109750273  serine/arginine-rich-splicing factor SR34-like isoform X1 [KO:K12890]
109768134  serine/arginine-rich-splicing factor SR34-like [KO:K12890]
109740922  serine/arginine-rich splicing factor SC35 isoform X1 [KO:K12891]
109786429  serine/arginine-rich splicing factor RS41 isoform X1 [KO:K12893]
109786837  serine/arginine-rich splicing factor RS31-like [KO:K12893]
109733832  serine/arginine-rich splicing factor RS31 [KO:K12893]
109734964  serine/arginine-rich splicing factor RSZ21-like [KO:K12896]
109782769  serine/arginine-rich splicing factor RS2Z33-like isoform X1 [KO:K12896]
109744679  serine/arginine-rich splicing factor RSZ21A isoform X1 [KO:K12896]
109783005  serine/arginine-rich splicing factor RS2Z32-like isoform X1 [KO:K12896]
109779951  serine/arginine-rich splicing factor RSZ23-like [KO:K12896]
109736689  serine/arginine-rich splicing factor RS2Z32-like [KO:K12896]
109737557  serine/arginine-rich splicing factor SR45a-like [KO:K12897]
109765710  serine/arginine-rich splicing factor SR45a-like [KO:K12897]
109762741  serine/arginine-rich splicing factor SR45a-like [KO:K12897]
109784408  serine/arginine-rich SC35-like splicing factor SCL30 isoform X1 [KO:K12900]
109755881  serine/arginine-rich SC35-like splicing factor SCL28 [KO:K12900]
109734867  serine/arginine-rich SC35-like splicing factor SCL30 isoform X1 [KO:K12900]
109756113  serine/arginine-rich SC35-like splicing factor SCL33 [KO:K12900]
Reference
PMID:19239890
  Authors
Wahl MC, Will CL, Luhrmann R
  Title
The spliceosome: design principles of a dynamic RNP machine.
  Journal
Cell 136:701-18 (2009)
DOI:10.1016/j.cell.2009.02.009
Reference
PMID:10978320
  Authors
Morris DP, Greenleaf AL
  Title
The splicing factor, Prp40, binds the phosphorylated carboxyl-terminal domain of RNA polymerase II.
  Journal
J Biol Chem 275:39935-43 (2000)
DOI:10.1074/jbc.M004118200
Reference
PMID:17537823
  Authors
Chen YI, Moore RE, Ge HY, Young MK, Lee TD, Stevens SW
  Title
Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors.
  Journal
Nucleic Acids Res 35:3928-44 (2007)
DOI:10.1093/nar/gkm347
Reference
PMID:19733268
  Authors
Ritchie DB, Schellenberg MJ, MacMillan AM
  Title
Spliceosome structure: piece by piece.
  Journal
Biochim Biophys Acta 1789:624-33 (2009)
DOI:10.1016/j.bbagrm.2009.08.010
KO pathway
ko03040   
LinkDB

DBGET integrated database retrieval system