KEGG   PATHWAY: bgar04510
Entry
bgar04510                   Pathway                                
Name
Focal adhesion - Bufo gargarizans (Asiatic toad)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
bgar04510  Focal adhesion
bgar04510

Other DBs
GO: 0005925
Organism
Bufo gargarizans (Asiatic toad) [GN:bgar]
Gene
122940020  COL1A1; collagen alpha-1(I) chain [KO:K06236]
122930405  COL2A1; collagen alpha-1(II) chain [KO:K19719]
122930649  COL4A2; LOW QUALITY PROTEIN: collagen alpha-2(IV) chain [KO:K06237]
122930650  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
122919426  COL4A6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
122946309  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
122937796  collagen alpha-6(VI) chain-like isoform X1 [KO:K06238]
122944801  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
122945163  COL6A2; collagen alpha-2(VI) chain [KO:K06238]
122945708  COL6A3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
122939368  collagen alpha-6(VI) chain-like [KO:K06238]
122935352  collagen alpha-1(IX) chain-like [KO:K08131]
122931555  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
122941569  COL9A3; collagen alpha-3(IX) chain isoform X1 [KO:K08131]
122935397  LAMA2; laminin subunit alpha-2 [KO:K05637]
122938098  LAMA1; laminin subunit alpha-1 [KO:K05637]
122939563  LAMA3; LOW QUALITY PROTEIN: laminin subunit alpha-3 [KO:K06240]
122939996  LAMA5; LOW QUALITY PROTEIN: laminin subunit alpha-5 [KO:K06240]
122934724  LAMA4; laminin subunit alpha-4 [KO:K06241]
122927890  LAMB1; laminin subunit beta-1 [KO:K05636]
122944030  LOW QUALITY PROTEIN: laminin subunit beta-2-like [KO:K06243]
122944031  LAMB2; laminin subunit beta-2 isoform X1 [KO:K06243]
122944126  laminin subunit beta-2-like [KO:K06243]
122933367  LAMB3; laminin subunit beta-3 [KO:K06244]
122925819  LAMB4; laminin subunit beta-4 [KO:K06245]
122943241  LAMC1; laminin subunit gamma-1 [KO:K05635]
122943242  LAMC2; laminin subunit gamma-2 [KO:K06246]
122942486  CHAD; chondroadherin isoform X1 [KO:K06248]
122927871  RELN; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
122922235  THBS1; thrombospondin-1 [KO:K16857]
122936138  THBS4; thrombospondin-4 [KO:K04659]
122929708  cartilage oligomeric matrix protein [KO:K04659]
122933981  THBS2; thrombospondin-2 [KO:K04659]
122944776  FN1; LOW QUALITY PROTEIN: fibronectin [KO:K05717]
122930472  VTN; vitronectin [KO:K06251]
122943865  TNR; tenascin-R [KO:K06252]
122944155  LOW QUALITY PROTEIN: tenascin-like [KO:K06252]
122946086  TNC; tenascin isoform X1 [KO:K06252]
122919566  TNXB; tenascin-X [KO:K06252]
122928319  VWF; von Willebrand factor [KO:K03900]
122925890  bone sialoprotein 2 [KO:K06253]
122924791  ITGA1; integrin alpha-1 [KO:K06480]
122924792  ITGA2; integrin alpha-2 [KO:K06481]
122940098  ITGA2B; integrin alpha-IIb [KO:K06476]
122940317  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
122944389  ITGA4; integrin alpha-4 [KO:K06483]
122931413  ITGA5; integrin alpha-5 [KO:K06484]
122944564  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
122933339  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
122937824  ITGA8; integrin alpha-8 [KO:K06584]
122938035  ITGA9; integrin alpha-9 isoform X1 [KO:K06585]
122921379  ITGA10; integrin alpha-10 [KO:K06586]
122929534  ITGA11; integrin alpha-11 isoform X1 [KO:K06587]
122946190  ITGAV; integrin alpha-V [KO:K06487]
122937735  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
122940129  ITGB3; integrin beta-3 [KO:K06493]
122942615  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
122942561  ITGB5; integrin beta-5 [KO:K06588]
122945583  ITGB6; integrin beta-6 [KO:K06589]
122931006  ITGB7; integrin beta-7 [KO:K06590]
122937964  ITGB8; integrin beta-8 [KO:K06591]
122944898  EMP2; epithelial membrane protein 2 [KO:K26256]
122938815  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
122943591  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
122942494  PDGFC; platelet-derived growth factor C [KO:K05450]
122931035  PDGFD; platelet-derived growth factor D [KO:K05450]
122946843  EGF; pro-epidermal growth factor [KO:K04357]
122928101  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
122923368  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
122932382  VEGFD; vascular endothelial growth factor D [KO:K05449]
122940632  VEGFC; vascular endothelial growth factor C [KO:K05449]
122927846  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
122941740  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
122928360  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
122927524  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
122941781  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
122939241  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
122930927  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
122946033  vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
122928355  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
122927947  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
122940045  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
122943711  EMP1; epithelial membrane protein 1 [KO:K26255]
122922328  tyrosine-protein kinase Src-2 [KO:K05704] [EC:2.7.10.2]
122940461  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
122923868  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
122922025  ARHGAP5; rho GTPase-activating protein 5 [KO:K13709]
122929097  transforming protein RhoA-like [KO:K04513]
122930262  rho-related GTP-binding protein RhoC [KO:K04513]
122923919  transforming protein RhoA [KO:K04513]
122946509  transforming protein RhoA-like [KO:K04513]
122934090  rho-related GTP-binding protein RhoB-like [KO:K04513]
122928298  DIAPH1; protein diaphanous homolog 1 isoform X1 [KO:K05740]
122938923  ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.1]
122933631  rho-associated protein kinase 2-like [KO:K17388] [EC:2.7.11.1]
122934995  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
122927385  MYL7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
122941730  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
122922782  MYL10; myosin regulatory light chain 10 [KO:K12756]
122937769  myosin regulatory light chain RLC-A [KO:K12757]
122944949  serine/threonine-protein phosphatase PP1-gamma catalytic subunit A-like [KO:K06269] [EC:3.1.3.16]
122924555  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
122933978  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
122927987  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
122920592  protein phosphatase 1 regulatory subunit 12A-like isoform X1 [KO:K06270]
122928652  PPP1R12C; protein phosphatase 1 regulatory subunit 12C isoform X1 [KO:K17457]
122941810  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
122942078  MYLK; myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
122939426  MYLK4; LOW QUALITY PROTEIN: myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
122940368  myosin light chain kinase, smooth muscle-like isoform X1 [KO:K00907] [EC:2.7.11.18]
122920471  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
122922187  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
122922211  phosphatidylinositol 4-phosphate 5-kinase type-1 beta-like [KO:K00889] [EC:2.7.1.68]
122938158  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha-like isoform X1 [KO:K00889] [EC:2.7.1.68]
122919579  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
122944482  ACTB; actin, cytoplasmic 1 [KO:K05692]
122939974  ACTG1; actin, cytoplasmic 2 [KO:K05692]
122929530  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
122934009  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
122921807  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
122946045  ACTN4; alpha-actinin-4 [KO:K05699]
122922490  talin-1 isoform X1 [KO:K06271]
122927709  TLN2; talin-2 isoform X1 [KO:K06271]
122919600  FLNA; filamin-A isoform X1 [KO:K04437]
122943041  filamin-B-like [KO:K27392]
122944052  FLNB; filamin-B isoform X1 [KO:K27392]
122924392  PXN; paxillin isoform X1 [KO:K05760]
122932397  ILK; integrin-linked protein kinase [KO:K06272] [EC:2.7.11.1]
122939984  ZYX; zyxin isoform X1 [KO:K06273]
122922928  vasodilator-stimulated phosphoprotein-like [KO:K06274]
122923105  vasodilator-stimulated phosphoprotein-like [KO:K06274]
122942597  VCL; vinculin isoform X1 [KO:K05700]
122928338  PARVB; beta-parvin isoform X1 [KO:K06275]
122928340  PARVG; gamma-parvin [KO:K06275]
122920260  alpha-parvin [KO:K06275]
122920883  PARVA; alpha-parvin [KO:K06275]
122944762  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
122921719  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
122946254  RAC-beta serine/threonine-protein kinase A [KO:K04456] [EC:2.7.11.1]
122923432  glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
122937904  CTNNB1; catenin beta-1 [KO:K02105]
122923186  protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
122945749  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
122926643  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
122937761  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
122934155  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
122928806  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
122934079  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
122924744  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
122946211  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
122941293  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
122943988  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
122923296  guanine nucleotide exchange factor VAV2-like [KO:K05730]
122932157  VAV1; proto-oncogene vav isoform X1 [KO:K05730]
122944424  ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
122944817  ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
122944818  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
122943080  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
122940270  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
122931346  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
122933991  PAK2; serine/threonine-protein kinase PAK 2 isoform X1 [KO:K04410] [EC:2.7.11.1]
122919698  PAK3; serine/threonine-protein kinase PAK 3 [KO:K05733] [EC:2.7.11.1]
122946242  PAK4; serine/threonine-protein kinase PAK 4 isoform X1 [KO:K05734] [EC:2.7.11.1]
122934429  PAK5; serine/threonine-protein kinase PAK 5 isoform X1 [KO:K05736] [EC:2.7.11.1]
122922031  serine/threonine-protein kinase PAK 6-like [KO:K05735] [EC:2.7.11.1]
122920389  BCAR1; breast cancer anti-estrogen resistance protein 1 [KO:K05726]
122934259  CRKL; crk-like protein [KO:K04438]
122922790  CRK; adapter molecule crk isoform X1 [KO:K04438]
122939903  DOCK1; dedicator of cytokinesis protein 1 [KO:K13708]
122946078  RAPGEF1; rap guanine nucleotide exchange factor 1 isoform X1 [KO:K06277]
122919953  LOW QUALITY PROTEIN: rap guanine nucleotide exchange factor 1-like [KO:K06277]
122930275  ras-related protein Rap-1A [KO:K04353]
122930276  ras-related protein Rap-1A-like [KO:K04353]
122928017  RAP1B; ras-related protein Rap-1b [KO:K07836]
122942594  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
122926653  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
122943208  JUN; transcription factor AP-1 [KO:K04448]
122921602  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
122927948  CAV1; caveolin-1 [KO:K06278]
122927949  CAV2; caveolin-2 [KO:K12958]
122919509  caveolin-2-like [KO:K12958]
122943570  CAV3; caveolin-3 [KO:K12959]
122919521  caveolin-3-like [KO:K12959]
122933715  FYN; tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
122930875  SHC2; SHC-transforming protein 2 [KO:K17447]
122932862  SHC3; SHC-transforming protein 3 [KO:K17448]
122927622  SHC4; SHC-transforming protein 4 [KO:K17449]
122941198  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
122934359  SOS1; son of sevenless homolog 1 [KO:K03099]
122922238  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
122920728  HRAS; GTPase HRas isoform X1 [KO:K02833]
122943150  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
122929542  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
122930454  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
122924457  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
122946082  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
122920343  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
122926689  G1/S-specific cyclin-D1-like [KO:K04503]
122928449  CCND2; G1/S-specific cyclin-D2 isoform X1 [KO:K10151]
122931187  BIRC2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
122946169  E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
122921928  bcl2-associated agonist of cell death-like [KO:K02158]
122920050  BAD; bcl2-associated agonist of cell death [KO:K02158]
122937918  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
PMID:11573199
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
PMID:15459662
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
  Journal
Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
PMID:11229600
  Authors
Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
  Journal
Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
PMID:12235283
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
PMID:12640026
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
PMID:15688067
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
Reference
PMID:14519391
  Authors
Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
PMID:15108811
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:10698680
  Authors
Vanhaesebroeck B, Alessi DR.
  Title
The PI3K-PDK1 connection: more than just a road to PKB.
  Journal
Biochem J 346 Pt 3:561-76 (2000)
DOI:10.1042/bj3460561
Reference
PMID:11882383
  Authors
Nicholson KM, Anderson NG.
  Title
The protein kinase B/Akt signalling pathway in human malignancy.
  Journal
Cell Signal 14:381-95 (2002)
DOI:10.1016/S0898-6568(01)00271-6
Reference
PMID:15053919
  Authors
Oloumi A, McPhee T, Dedhar S.
  Title
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
  Journal
Biochim Biophys Acta 1691:1-15 (2004)
DOI:10.1016/j.bbamcr.2003.12.002
Reference
PMID:11146675
  Authors
Turner CE.
  Title
Paxillin and focal adhesion signalling.
  Journal
Nat Cell Biol 2:E231-6 (2000)
DOI:10.1038/35046659
Reference
PMID:15034601
  Authors
Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
  Title
The mechanism of action of the tumour suppressor gene PTEN.
  Journal
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
bgar04010  MAPK signaling pathway
bgar04060  Cytokine-cytokine receptor interaction
bgar04070  Phosphatidylinositol signaling system
bgar04110  Cell cycle
bgar04310  Wnt signaling pathway
bgar04512  ECM-receptor interaction
bgar04810  Regulation of actin cytoskeleton
KO pathway
ko04510   
LinkDB

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