KEGG   PATHWAY: biu04217
Entry
biu04217                    Pathway                                
Name
Necroptosis - Bos indicus (zebu cattle)
Description
Necroptosis is a programmed form of necrosis. It can be initiated by different stimuli, such as tumor necrosis factor (TNF), TNF-related apoptosis-inducing ligand (TRAIL), Fas ligand (FasL), interferon (IFN), LPS, viral DNA or RNA, DNA-damage agent and requires the kinase activity of receptor-interacting protein 1 (RIPK1) and RIPK3. Its execution involves ROS generation, calcium overload, the opening of the mitochondrial permeability transition pore, mitochondrial fission, inflammatory response and chromatinolysis. Necroptosis participates in many pathogenesis of diseases, including neurological diseases, retinal disorders, acute kidney injury, inflammatory diseases and microbial infections.
Class
Cellular Processes; Cell growth and death
Pathway map
biu04217  Necroptosis
biu04217

Organism
Bos indicus (zebu cattle) [GN:biu]
Gene
109577428  TNF; tumor necrosis factor [KO:K03156]
109559729  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
109572519  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
109566626  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
109570606  TRAF5; TNF receptor-associated factor 5 [KO:K09849]
109577264  RIPK1; receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
109555878  baculoviral IAP repeat-containing protein 2 isoform X1 [KO:K16060]
109568764  BIRC3; baculoviral IAP repeat-containing protein 3 [KO:K16060]
109569840  BIRC2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
109567335  RBCK1; ranBP-type and C3HC4-type zinc finger-containing protein 1 isoform X1 [KO:K10630] [EC:2.3.2.31]
109564780  RNF31; E3 ubiquitin-protein ligase RNF31 isoform X1 [KO:K11974] [EC:2.3.2.31]
109568382  sharpin [KO:K20894]
109572603  uncharacterized protein LOC109572603 [KO:K17595]
109571637  spermatogenesis-associated protein 2-like protein [KO:K17595]
109572818  SPATA2L; spermatogenesis-associated protein 2-like protein [KO:K17595]
109567540  SPATA2; spermatogenesis-associated protein 2 [KO:K17595]
109572313  CYLD; ubiquitin carboxyl-terminal hydrolase CYLD isoform X1 [KO:K08601] [EC:3.4.19.12]
109554562  FADD; FAS-associated death domain protein [KO:K02373]
109569521  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
109569493  CFLAR; CASP8 and FADD-like apoptosis regulator isoform X1 [KO:K04724]
109564762  RIPK3; receptor-interacting serine/threonine-protein kinase 3 isoform X1 [KO:K08847] [EC:2.7.11.1]
109553698  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
109560236  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
109557541  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
109562200  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515] [EC:2.7.11.17]
109561148  ADP/ATP translocase 1-like [KO:K05863]
109571027  SLC25A31; ADP/ATP translocase 4 isoform X1 [KO:K05863]
109553455  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
109571170  PPID; peptidyl-prolyl cis-trans isomerase D [KO:K05864] [EC:5.2.1.8]
109562011  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
109553821  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
109553397  VDAC3; voltage-dependent anion-selective channel protein 3 [KO:K15041]
109553786  GLUD1; glutamate dehydrogenase 1, mitochondrial [KO:K00261] [EC:1.4.1.3]
109570357  GLUL; glutamine synthetase [KO:K01915] [EC:6.3.1.2]
109567623  PYGB; glycogen phosphorylase, brain form [KO:K00688] [EC:2.4.1.1]
109554068  glycogen phosphorylase, muscle form [KO:K00688] [EC:2.4.1.1]
109554069  glycogen phosphorylase, muscle form-like [KO:K00688] [EC:2.4.1.1]
109565026  PYGL; glycogen phosphorylase, liver form isoform X1 [KO:K00688] [EC:2.4.1.1]
109561331  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
109560650  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
109553773  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
109554491  FTH1; ferritin heavy chain [KO:K00522] [EC:1.16.3.1]
109571972  ferritin light chain [KO:K13625]
109577299  ferritin light chain [KO:K13625]
109572215  FTL; ferritin light chain [KO:K13625]
109570696  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
109564977  PLA2G4B; cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
109564980  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
109564981  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
109564982  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
109574003  arachidonate 15-lipoxygenase isoform X1 [KO:K00460] [EC:1.13.11.33]
109554508  CAPN1; calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
109570370  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
109569729  SMPD1; sphingomyelin phosphodiesterase [KO:K12350] [EC:3.1.4.12]
109573003  MLKL; mixed lineage kinase domain-like protein [KO:K08849] [EC:2.7.11.1]
109571145  PGAM5; serine/threonine-protein phosphatase PGAM5, mitochondrial isoform X1 [KO:K15637] [EC:3.1.3.16]
109559542  DNM1L; dynamin-1-like protein [KO:K17065] [EC:3.6.5.5]
109561926  NLRP3; NACHT, LRR and PYD domains-containing protein 3 isoform X1 [KO:K12800]
109578833  apoptosis-associated speck-like protein containing a CARD [KO:K12799]
109570010  CASP1; caspase-1 [KO:K01370] [EC:3.4.22.36]
109566133  IL1B; interleukin-1 beta [KO:K04519]
109571628  CHMP2A; charged multivesicular body protein 2a [KO:K12191]
109562036  CHMP2B; charged multivesicular body protein 2b [KO:K12192]
109566154  CHMP3; charged multivesicular body protein 3 [KO:K12193]
109564774  CHMP4A; charged multivesicular body protein 4a [KO:K12194]
109567684  CHMP4B; charged multivesicular body protein 4b [KO:K12194]
109568621  CHMP4C; charged multivesicular body protein 4c [KO:K24782]
109573754  CHMP6; charged multivesicular body protein 6 [KO:K12195]
109571987  VPS4A; vacuolar protein sorting-associated protein 4A isoform X1 [KO:K12196]
109577861  VPS4B; vacuolar protein sorting-associated protein 4B [KO:K12196]
109577814  CHMP1B; charged multivesicular body protein 1b [KO:K12197]
109571639  charged multivesicular body protein 1a-like [KO:K12197]
109572807  CHMP1A; charged multivesicular body protein 1a [KO:K12197]
109563172  CHMP5; charged multivesicular body protein 5 [KO:K12198]
109563122  CHMP7; charged multivesicular body protein 7 [KO:K15053]
109565130  TRPM7; transient receptor potential cation channel subfamily M member 7 isoform X1 [KO:K04982] [EC:2.7.11.1]
109566132  IL1A; interleukin-1 alpha [KO:K04383]
109562893  IL33; interleukin-33 [KO:K12967]
109566810  HMGB1; high mobility group protein B1 [KO:K10802]
109570634  high mobility group protein B1-like [KO:K10802]
109558018  TNFSF10; tumor necrosis factor ligand superfamily member 10 isoform X1 [KO:K04721]
109563119  tumor necrosis factor receptor superfamily member 10B-like isoform X1 [KO:K04722]
109570480  tumor necrosis factor ligand superfamily member 6 [KO:K04389]
109570785  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
109579171  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
109562847  interferon alpha-H [KO:K05414]
109562638  interferon alpha-G-like [KO:K05414]
109562641  LOW QUALITY PROTEIN: interferon alpha-1-like [KO:K05414]
109562644  interferon alpha-F [KO:K05414]
109562652  interferon alpha-A [KO:K05414]
109562656  interferon alpha-H-like [KO:K05414]
109562659  interferon alpha-H-like [KO:K05414]
109562660  interferon alpha-H-like [KO:K05414]
109562665  interferon alpha-B-like [KO:K05414]
109562668  interferon alpha-2-like [KO:K05414]
109562670  interferon alpha-2-like [KO:K05414]
109562673  interferon alpha-3-like [KO:K05414]
109562852  interferon beta-2-like [KO:K05415]
109562853  interferon beta-1-like [KO:K05415]
109562855  interferon beta-1 [KO:K05415]
109562667  LOW QUALITY PROTEIN: interferon beta-3-like [KO:K05415]
109562671  interferon beta-2-like [KO:K05415]
109562674  interferon beta-2 [KO:K05415]
109562675  interferon beta-2-like [KO:K05415]
109558719  IFNG; interferon gamma [KO:K04687]
109570535  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
109572614  interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
109563984  IFNGR1; interferon gamma receptor 1 [KO:K05132]
109569763  IFNGR2; interferon gamma receptor 2 [KO:K05133]
109556202  JAK1; LOW QUALITY PROTEIN: tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
109562906  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
109561426  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
109561587  TYK2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
109568771  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
109559357  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
109573817  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
109575487  STAT4; signal transducer and activator of transcription 4 [KO:K11222]
109574089  signal transducer and activator of transcription 5A-like [KO:K11223]
109573773  STAT5B; signal transducer and activator of transcription 5B isoform X1 [KO:K11224]
109559334  STAT6; signal transducer and activator of transcription 6 [KO:K11225]
109564781  IRF9; interferon regulatory factor 9 isoform X1 [KO:K04693]
109565977  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
109563399  TLR4; toll-like receptor 4 isoform X1 [KO:K10160]
109564619  TICAM2; TIR domain-containing adapter molecule 2 [KO:K05409]
109561728  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
109553388  TLR3; toll-like receptor 3 isoform X1 [KO:K05401]
109567302  ZBP1; Z-DNA-binding protein 1 isoform X1 [KO:K12965]
109578319  USP21; ubiquitin carboxyl-terminal hydrolase 21 isoform X1 [KO:K21634] [EC:3.4.19.12]
109561336  SQSTM1; sequestosome-1 [KO:K14381]
109575457  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
109577125  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
109563985  TNFAIP3; tumor necrosis factor alpha-induced protein 3 [KO:K11859] [EC:3.4.19.12]
109570525  PARP1; poly [ADP-ribose] polymerase 1 isoform X1 [KO:K24070] [EC:2.4.2.30]
109559782  BH3-interacting domain death agonist-like isoform X1 [KO:K04726]
109559783  BH3-interacting domain death agonist-like isoform X1 [KO:K04726]
109571977  apoptosis regulator BAX [KO:K02159]
109571778  BAX; apoptosis regulator BAX [KO:K02159]
109555268  AIFM1; apoptosis-inducing factor 1, mitochondrial [KO:K04727] [EC:1.-.-.-]
109553840  core histone macro-H2A.2 [KO:K11251]
109561360  histone H2A type 3 [KO:K11251]
109555711  histone H2A type 2-B [KO:K11251]
109555722  histone H2A type 2-C [KO:K11251]
109555755  histone H2A type 2-A [KO:K11251]
109576633  histone H2A type 1 [KO:K11251]
109576634  histone H2A type 1-D [KO:K11251]
109576635  histone H2A type 1-like [KO:K11251]
109576636  histone H2A type 1 [KO:K11251]
109576637  histone H2A type 1-H [KO:K11251]
109576638  histone H2A type 1-J [KO:K11251]
109562035  core histone macro-H2A.1 isoform X1 [KO:K11251]
109557533  histone H2A.V [KO:K11251]
109560306  histone H2A.Z [KO:K11251]
109570995  histone H2A type 3-like [KO:K11251]
109560108  histone H2A type 2-A-like [KO:K11251]
109555846  histone H2A type 2-A-like [KO:K11251]
109576288  histone H2A type 1-like [KO:K11251]
109576898  histone H2A type 1-C [KO:K11251]
109576899  histone H2A type 1 [KO:K11251]
109576900  histone H2A type 1 [KO:K11251]
109576901  histone H2A type 1-like [KO:K11251]
109559626  histone H2A.J [KO:K11251]
109577385  histone H2A type 1-like [KO:K11251]
109567444  histone H2A type 1-like [KO:K11251]
109577130  histone H2A type 1-A [KO:K11251]
109569701  histone H2AX [KO:K11251]
109573149  peptidyl-prolyl cis-trans isomerase A-like [KO:K03767] [EC:5.2.1.8]
109557534  PPIA; peptidyl-prolyl cis-trans isomerase A isoform X1 [KO:K03767] [EC:5.2.1.8]
109577782  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
Compound
C00002  ATP
C00027  Hydrogen peroxide
C00076  Calcium cation
C00195  N-Acylsphingosine
C00219  Arachidonate
C00305  Magnesium cation
C00319  Sphingosine
C00550  Sphingomyelin
C14592  N-Methyl-N'-nitro-N-nitrosoguanidine
C16844  Hydroxyl radical
Reference
PMID:20823910
  Authors
Vandenabeele P, Galluzzi L, Vanden Berghe T, Kroemer G
  Title
Molecular mechanisms of necroptosis: an ordered cellular explosion.
  Journal
Nat Rev Mol Cell Biol 11:700-14 (2010)
DOI:10.1038/nrm2970
Reference
PMID:26008591
  Authors
Brenner D, Blaser H, Mak TW
  Title
Regulation of tumour necrosis factor signalling: live or let die.
  Journal
Nat Rev Immunol 15:362-74 (2015)
DOI:10.1038/nri3834
Reference
PMID:26775689
  Authors
Conrad M, Angeli JP, Vandenabeele P, Stockwell BR
  Title
Regulated necrosis: disease relevance and therapeutic opportunities.
  Journal
Nat Rev Drug Discov 15:348-66 (2016)
DOI:10.1038/nrd.2015.6
Reference
PMID:24129419
  Authors
Ofengeim D, Yuan J
  Title
Regulation of RIP1 kinase signalling at the crossroads of inflammation and cell death.
  Journal
Nat Rev Mol Cell Biol 14:727-36 (2013)
DOI:10.1038/nrm3683
Reference
PMID:27158445
  Authors
Murphy JM, Vince JE
  Title
Post-translational control of RIPK3 and MLKL mediated necroptotic cell death.
  Journal
F1000Res 4:F1000 Faculty Rev-1297 (2015)
DOI:10.12688/f1000research.7046.1
Reference
PMID:24452471
  Authors
Vanden Berghe T, Linkermann A, Jouan-Lanhouet S, Walczak H, Vandenabeele P
  Title
Regulated necrosis: the expanding network of non-apoptotic cell death pathways.
  Journal
Nat Rev Mol Cell Biol 15:135-47 (2014)
DOI:10.1038/nrm3737
Reference
PMID:27368376
  Authors
Dondelinger Y, Hulpiau P, Saeys Y, Bertrand MJ, Vandenabeele P
  Title
An evolutionary perspective on the necroptotic pathway.
  Journal
Trends Cell Biol 26:721-32 (2016)
DOI:10.1016/j.tcb.2016.06.004
Reference
PMID:27746097
  Authors
Thapa RJ, Ingram JP, Ragan KB, Nogusa S, Boyd DF, Benitez AA, Sridharan H, Kosoff R, Shubina M, Landsteiner VJ, Andrake M, Vogel P, Sigal LJ, tenOever BR, Thomas PG, Upton JW, Balachandran S
  Title
DAI Senses Influenza A Virus Genomic RNA and Activates RIPK3-Dependent Cell Death.
  Journal
Cell Host Microbe 20:674-681 (2016)
DOI:10.1016/j.chom.2016.09.014
Reference
PMID:27984721
  Authors
Yuan J, Najafov A, Py BF
  Title
Roles of Caspases in Necrotic Cell Death.
  Journal
Cell 167:1693-1704 (2016)
DOI:10.1016/j.cell.2016.11.047
Reference
PMID:28138137
  Authors
Jorgensen I, Rayamajhi M, Miao EA
  Title
Programmed cell death as a defence against infection.
  Journal
Nat Rev Immunol 17:151-164 (2017)
DOI:10.1038/nri.2016.147
Reference
PMID:20354226
  Authors
Vandenabeele P, Declercq W, Van Herreweghe F, Vanden Berghe T
  Title
The role of the kinases RIP1 and RIP3 in TNF-induced necrosis.
  Journal
Sci Signal 3:re4 (2010)
DOI:10.1126/scisignal.3115re4
Reference
PMID:22075985
  Authors
Vanlangenakker N, Vanden Berghe T, Vandenabeele P
  Title
Many stimuli pull the necrotic trigger, an overview.
  Journal
Cell Death Differ 19:75-86 (2012)
DOI:10.1038/cdd.2011.164
Reference
PMID:23913919
  Authors
Moriwaki K, Chan FK
  Title
RIP3: a molecular switch for necrosis and inflammation.
  Journal
Genes Dev 27:1640-9 (2013)
DOI:10.1101/gad.223321.113
Reference
PMID:25146926
  Authors
Humphries F, Yang S, Wang B, Moynagh PN
  Title
RIP kinases: key decision makers in cell death and innate immunity.
  Journal
Cell Death Differ 22:225-36 (2015)
DOI:10.1038/cdd.2014.126
Reference
PMID:28126382
  Authors
Wegner KW, Saleh D, Degterev A
  Title
Complex Pathologic Roles of RIPK1 and RIPK3: Moving Beyond Necroptosis.
  Journal
Trends Pharmacol Sci 38:202-225 (2017)
DOI:10.1016/j.tips.2016.12.005
Reference
PMID:27545878
  Authors
Kupka S, De Miguel D, Draber P, Martino L, Surinova S, Rittinger K, Walczak H
  Title
SPATA2-Mediated Binding of CYLD to HOIP Enables CYLD Recruitment to Signaling Complexes.
  Journal
Cell Rep 16:2271-80 (2016)
DOI:10.1016/j.celrep.2016.07.086
Reference
PMID:27219062
  Authors
Goodall ML, Fitzwalter BE, Zahedi S, Wu M, Rodriguez D, Mulcahy-Levy JM, Green DR, Morgan M, Cramer SD, Thorburn A
  Title
The Autophagy Machinery Controls Cell Death Switching between Apoptosis and Necroptosis.
  Journal
Dev Cell 37:337-49 (2016)
DOI:10.1016/j.devcel.2016.04.018
Reference
PMID:19910467
  Authors
Xu G, Tan X, Wang H, Sun W, Shi Y, Burlingame S, Gu X, Cao G, Zhang T, Qin J, Yang J
  Title
Ubiquitin-specific peptidase 21 inhibits tumor necrosis factor alpha-induced nuclear factor kappaB activation via binding to and deubiquitinating receptor-interacting protein 1.
  Journal
J Biol Chem 285:969-78 (2010)
DOI:10.1074/jbc.M109.042689
Reference
PMID:26971869
  Authors
Jacobsen AV, Silke J
  Title
The importance of being chaperoned: HSP90 and necroptosis.
  Journal
Cell Chem Biol 23:205-7 (2016)
DOI:10.1016/j.chembiol.2016.02.003
Reference
PMID:25988900
  Authors
Gurung P, Man SM, Kanneganti TD
  Title
A20 is a regulator of necroptosis.
  Journal
Nat Immunol 16:596-7 (2015)
DOI:10.1038/ni.3174
Reference
PMID:28025046
  Authors
Feng N, Anderson ME
  Title
CaMKII is a nodal signal for multiple programmed cell death pathways in heart.
  Journal
J Mol Cell Cardiol 103:102-109 (2017)
DOI:10.1016/j.yjmcc.2016.12.007
Reference
PMID:19696789
  Authors
Zhivotovsky B, Galluzzi L, Kepp O, Kroemer G
  Title
Adenine nucleotide translocase: a component of the phylogenetically conserved cell death machinery.
  Journal
Cell Death Differ 16:1419-25 (2009)
DOI:10.1038/cdd.2009.118
Reference
PMID:23898178
  Authors
Thapa RJ, Nogusa S, Chen P, Maki JL, Lerro A, Andrake M, Rall GF, Degterev A, Balachandran S
  Title
Interferon-induced RIP1/RIP3-mediated necrosis requires PKR and is licensed by FADD and caspases.
  Journal
Proc Natl Acad Sci U S A 110:E3109-18 (2013)
DOI:10.1073/pnas.1301218110
Reference
PMID:21576359
  Authors
Thapa RJ, Basagoudanavar SH, Nogusa S, Irrinki K, Mallilankaraman K, Slifker MJ, Beg AA, Madesh M, Balachandran S
  Title
NF-kappaB protects cells from gamma interferon-induced RIP1-dependent necroptosis.
  Journal
Mol Cell Biol 31:2934-46 (2011)
DOI:10.1128/MCB.05445-11
Reference
PMID:24565922
  Authors
Sridharan H, Upton JW
  Title
Programmed necrosis in microbial pathogenesis.
  Journal
Trends Microbiol 22:199-207 (2014)
DOI:10.1016/j.tim.2014.01.005
Reference
PMID:21738214
  Authors
Cabon L, Galan-Malo P, Bouharrour A, Delavallee L, Brunelle-Navas MN, Lorenzo HK, Gross A, Susin SA
  Title
BID regulates AIF-mediated caspase-independent necroptosis by promoting BAX activation.
  Journal
Cell Death Differ 19:245-56 (2012)
DOI:10.1038/cdd.2011.91
Reference
PMID:20697198
  Authors
Baritaud M, Boujrad H, Lorenzo HK, Krantic S, Susin SA
  Title
Histone H2AX: The missing link in AIF-mediated caspase-independent programmed necrosis.
  Journal
Cell Cycle 9:3166-73 (2010)
DOI:10.4161/cc.9.16.12887
Reference
PMID:28279333
  Authors
Upton JW, Kaiser WJ
  Title
DAI Another Way: Necroptotic Control of Viral Infection.
  Journal
Cell Host Microbe 21:290-293 (2017)
DOI:10.1016/j.chom.2017.01.016
Reference
PMID:26086143
  Authors
Silke J, Rickard JA, Gerlic M
  Title
The diverse role of RIP kinases in necroptosis and inflammation.
  Journal
Nat Immunol 16:689-97 (2015)
DOI:10.1038/ni.3206
Reference
PMID:28388403
  Authors
Guo H, Kaiser WJ
  Title
ESCRTing Necroptosis.
  Journal
Cell 169:186-187 (2017)
DOI:10.1016/j.cell.2017.03.030
Reference
PMID:28388412
  Authors
Gong YN, Guy C, Olauson H, Becker JU, Yang M, Fitzgerald P, Linkermann A, Green DR
  Title
ESCRT-III Acts Downstream of MLKL to Regulate Necroptotic Cell Death and Its Consequences.
  Journal
Cell 169:286-300.e16 (2017)
DOI:10.1016/j.cell.2017.03.020
Reference
PMID:27999433
  Authors
Petrie EJ, Hildebrand JM, Murphy JM
  Title
Insane in the membrane: a structural perspective of MLKL function in necroptosis.
  Journal
Immunol Cell Biol 95:152-159 (2017)
DOI:10.1038/icb.2016.125
Reference
PMID:24316671
  Authors
Cai Z, Jitkaew S, Zhao J, Chiang HC, Choksi S, Liu J, Ward Y, Wu LG, Liu ZG
  Title
Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis.
  Journal
Nat Cell Biol 16:55-65 (2014)
DOI:10.1038/ncb2883
Reference
PMID:25693118
  Authors
Lawlor KE, Khan N, Mildenhall A, Gerlic M, Croker BA, D'Cruz AA, Hall C, Kaur Spall S, Anderton H, Masters SL, Rashidi M, Wicks IP, Alexander WS, Mitsuuchi Y, Benetatos CA, Condon SM, Wong WW, Silke J, Vaux DL, Vince JE
  Title
RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL.
  Journal
Nat Commun 6:6282 (2015)
DOI:10.1038/ncomms7282
Reference
PMID:27974745
  Authors
Shlomovitz I, Zargrian S, Gerlic M
  Title
Mechanisms of RIPK3-induced inflammation.
  Journal
Immunol Cell Biol 95:166-172 (2017)
DOI:10.1038/icb.2016.124
Related
pathway
biu00250  Alanine, aspartate and glutamate metabolism
biu04210  Apoptosis
biu04668  TNF signaling pathway
biu04922  Glucagon signaling pathway
KO pathway
ko04217   
LinkDB

DBGET integrated database retrieval system