KEGG   PATHWAY: biu05415
Entry
biu05415                    Pathway                                
Name
Diabetic cardiomyopathy - Bos indicus (zebu cattle)
Description
Diabetic cardiomyopathy has been defined as left ventricular dysfunction that occurs among patients with diabetes mellitus independent of a recognized cause such as coronary artery disease or hypertension. The pathogenesis of diabetic cardiomyopathy broadly involves hyperglycemia, increased circulating fatty acids, and insulin resistance contributing to reactive oxygen species (ROS) generation, mitochondrial dysfunction, impaired calcium metabolism, Renin-Angiotensin System (RAS) activation, and altered substrate metabolism. These effects result in cardiac fibrosis, hypertrophy, cardiomyocyte death, contractile dysfunction, endothelial cell damage and eventually heart failure. In the process of cardiac fibrosis, cardiac fibroblasts are the final effector cell.
Class
Human Diseases; Cardiovascular disease
Pathway map
biu05415  Diabetic cardiomyopathy
biu05415

Organism
Bos indicus (zebu cattle) [GN:biu]
Gene
109556419  SLC2A1; solute carrier family 2, facilitated glucose transporter member 1 isoform X1 [KO:K07299]
109574066  SLC2A4; solute carrier family 2, facilitated glucose transporter member 4 [KO:K07191]
109561329  GFPT2; glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 [KO:K00820] [EC:2.6.1.16]
109566236  GFPT1; glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 isoform X1 [KO:K00820] [EC:2.6.1.16]
109553698  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
109560236  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
109557541  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
109562200  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515] [EC:2.7.11.17]
109572857  TNNI3; troponin I, cardiac muscle [KO:K12044]
109553606  RYR2; ryanodine receptor 2 [KO:K04962]
109563783  PLN; cardiac phospholamban [KO:K05852]
109574167  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
109578141  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
109571032  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
109559035  SP1; transcription factor Sp1 isoform X1 [KO:K04684]
109553744  AGT; angiotensinogen [KO:K09821]
109570766  REN; renin [KO:K01380] [EC:3.4.23.15]
109575276  mast cell protease 2 [KO:K01329] [EC:3.4.21.39]
109575291  mast cell protease 2-like [KO:K01329] [EC:3.4.21.39]
109578560  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
109577209  AGER; advanced glycosylation end product-specific receptor isoform X1 [KO:K19722]
109578828  NCF1; neutrophil cytosol factor 1 [KO:K08011]
109572735  cytochrome b-245 light chain [KO:K08009]
109570384  NCF2; neutrophil cytosol factor 2 isoform X1 [KO:K08010]
109559523  NCF4; neutrophil cytosol factor 4 isoform X1 [KO:K08012]
109578192  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
109559531  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
109559421  AGTR1; type-1 angiotensin II receptor [KO:K04166]
109560296  NFKB1; LOW QUALITY PROTEIN: nuclear factor NF-kappa-B p105 subunit [KO:K02580]
109554392  RELA; transcription factor p65 [KO:K04735]
109577010  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
109577419  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
109561331  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
109560650  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
109553773  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
109572595  MMP2; 72 kDa type IV collagenase [KO:K01398] [EC:3.4.24.24]
109567506  MMP9; matrix metalloproteinase-9 [KO:K01403] [EC:3.4.24.35]
109573749  COL1A1; collagen alpha-1(I) chain [KO:K06236]
109558214  COL1A2; collagen alpha-2(I) chain [KO:K06236]
109565673  COL3A1; collagen alpha-1(III) chain [KO:K19720]
109572866  TGFB1; transforming growth factor beta-1 [KO:K13375]
109570509  TGFB2; transforming growth factor beta-2 isoform X1 [KO:K13376]
109565371  TGFB3; transforming growth factor beta-3 [KO:K13377]
109557879  LOW QUALITY PROTEIN: platelet glycoprotein 4-like [KO:K06259]
109557335  platelet glycoprotein 4-like [KO:K06259]
109559910  PPARA; peroxisome proliferator-activated receptor alpha [KO:K07294]
109573763  PDK2; pyruvate dehydrogenase kinase, isozyme 2 isoform X1 [KO:K00898] [EC:2.7.11.2]
109555405  PDK3; LOW QUALITY PROTEIN: pyruvate dehydrogenase kinase, isozyme 3 isoform X1 [KO:K00898] [EC:2.7.11.2]
109558225  PDK4; LOW QUALITY PROTEIN: pyruvate dehydrogenase kinase, isozyme 4 [KO:K00898] [EC:2.7.11.2]
109573366  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
109576388  PRKCD; protein kinase C delta type isoform X1 [KO:K06068] [EC:2.7.11.13]
109566535  PTPA; serine/threonine-protein phosphatase 2A activator [KO:K17605]
109554414  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
109571193  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
109566263  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
109554428  CTSD; cathepsin D [KO:K01379] [EC:3.4.23.5]
109570580  PRKCZ; protein kinase C zeta type [KO:K18952] [EC:2.7.11.13]
109556280  CPT2; carnitine O-palmitoyltransferase 2, mitochondrial isoform X1 [KO:K08766] [EC:2.3.1.21]
109554336  INS; insulin isoform X1 [KO:K04526]
109571355  IRS1; insulin receptor substrate 1 [KO:K16172]
109559805  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
109570415  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
109557823  PIK3CA; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
109574805  PIK3R1; LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
109561418  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
109556345  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
109552991  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
109572496  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
109570286  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
109570401  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
109571966  glycogen [starch] synthase, muscle [KO:K00693] [EC:2.4.1.11]
109572216  GYS1; glycogen [starch] synthase, muscle [KO:K00693] [EC:2.4.1.11]
109559597  GYS2; glycogen [starch] synthase, liver [KO:K00693] [EC:2.4.1.11]
109566880  TBC1D4; TBC1 domain family member 4 isoform X1 [KO:K17902]
109564112  MPC1; mitochondrial pyruvate carrier 1 [KO:K22138]
109577561  MPC2; mitochondrial pyruvate carrier 2 [KO:K22139]
109555177  PDHA1; pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial [KO:K00161] [EC:1.2.4.1]
109560127  PDHA2; pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial [KO:K00161] [EC:1.2.4.1]
109576340  PDHB; pyruvate dehydrogenase E1 component subunit beta, mitochondrial [KO:K00162] [EC:1.2.4.1]
2885975  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
2885976  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
2885978  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
2885973  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
2885969  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
2885979  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
2885971  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
109554559  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
109577897  NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
109577904  NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial-like [KO:K03943] [EC:7.1.1.2]
109560673  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
109556362  NDUFA1; LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
109562108  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
109559332  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
109557257  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
109563031  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like [KO:K03949]
109557580  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
109559877  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
109561663  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
109566422  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
109559737  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
109561707  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
109558990  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
109561373  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
109575488  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
109557699  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
109569478  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 isoform X1 [KO:K03959]
109578522  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
109557803  NDUFB5; LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
109562816  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
109561494  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
109579157  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
109568198  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 isoform X1 [KO:K03965]
109578665  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
109569901  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial isoform X1 [KO:K03934] [EC:7.1.1.2]
109578296  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial isoform X1 [KO:K03935] [EC:7.1.1.2]
109569054  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
109574960  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial isoform X1 [KO:K03937]
109556470  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
109564592  NDUFS6; LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
109561987  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial [KO:K03940] [EC:7.1.1.2]
109554324  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [KO:K03941] [EC:7.1.1.2]
109571065  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
109554455  NDUFC2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
109574556  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
109578214  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial [KO:K00236]
109556917  SDHD; LOW QUALITY PROTEIN: succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial [KO:K00237]
109571597  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
2885974  CYTB; cytochrome b [KO:K00412]
109568168  cytochrome c1, heme protein, mitochondrial [KO:K00413]
109576285  cytochrome b-c1 complex subunit 1, mitochondrial [KO:K00414]
109578614  cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
109556339  cytochrome b-c1 complex subunit 6, mitochondrial isoform X1 [KO:K00416]
109568482  cytochrome b-c1 complex subunit 7 isoform X1 [KO:K00417]
109562006  cytochrome b-c1 complex subunit 8 [KO:K00418]
109571410  cytochrome b-c1 complex subunit 9 isoform X1 [KO:K00419]
109561994  cytochrome b-c1 complex subunit 10 [KO:K00420]
2885977  COX3; cytochrome c oxidase subunit III [KO:K02262]
2885981  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
2885980  COX2; cytochrome c oxidase subunit II [KO:K02261]
109572206  cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
109567344  cytochrome c oxidase subunit 4 isoform 2, mitochondrial isoform X1 [KO:K02263]
109575575  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
109565794  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
109578798  cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
109571230  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
109572149  cytochrome c oxidase subunit 6B2 [KO:K02267]
109576415  cytochrome c oxidase subunit 6B1-like [KO:K02267]
109559616  cytochrome c oxidase subunit 6B1 [KO:K02267]
109572405  uncharacterized protein LOC109572405 [KO:K02267]
109568427  cytochrome c oxidase subunit 6C [KO:K02268]
109566018  cytochrome c oxidase subunit 7A-related protein, mitochondrial [KO:K02270]
109563709  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
109572397  cytochrome c oxidase subunit 7A1, mitochondrial [KO:K02270]
109560438  cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
109561950  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
109565214  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
109562311  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
109562312  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
109573429  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
109554587  cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
109577844  ATP5A1; ATP synthase subunit alpha, mitochondrial [KO:K02132]
109559350  ATP5B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
109567885  ATP5C1; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
109561980  ATP5D; ATP synthase subunit delta, mitochondrial [KO:K02134]
109557063  ATP synthase subunit epsilon, mitochondrial-like [KO:K02135]
109575930  ATP synthase subunit epsilon, mitochondrial [KO:K02135]
109567286  ATP5E; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
2885970  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
109555938  ATP5F1; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
109557834  LOW QUALITY PROTEIN: ATP synthase F(0) complex subunit C2, mitochondrial-like [KO:K02128]
109559025  ATP5G2; ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
109573703  ATP5G1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
109566261  ATP5G3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
109574351  ATP5H; ATP synthase subunit d, mitochondrial [KO:K02138]
109557402  ATP5O; ATP synthase subunit O, mitochondrial [KO:K02137]
109559046  ATP5J; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
2885972  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
109562011  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
109553821  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
109553397  VDAC3; voltage-dependent anion-selective channel protein 3 [KO:K15041]
109561148  ADP/ATP translocase 1-like [KO:K05863]
109571027  SLC25A31; ADP/ATP translocase 4 isoform X1 [KO:K05863]
109553455  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
109553895  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
109572998  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
109557793  NOS3; nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
109559721  glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
109558933  GAPDH; glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
109570525  PARP1; poly [ADP-ribose] polymerase 1 isoform X1 [KO:K24070] [EC:2.4.2.30]
109555318  G6PD; glucose-6-phosphate 1-dehydrogenase isoform X1 [KO:K00036] [EC:1.1.1.49 1.1.1.363]
109553532  GSR; glutathione reductase, mitochondrial [KO:K00383] [EC:1.8.1.7]
109563078  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
109576148  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
109564704  SMAD3; mothers against decapentaplegic homolog 3 [KO:K23605]
109554384  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
109567852  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
109567854  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
109564927  PLCB2; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
109573322  angiotensin-converting enzyme-like [KO:K01283] [EC:3.4.15.1]
109574310  LOW QUALITY PROTEIN: angiotensin-converting enzyme-like [KO:K01283] [EC:3.4.15.1]
Compound
C00001  H2O
C00002  ATP
C00005  NADPH
C00006  NADP+
C00022  Pyruvate
C00024  Acetyl-CoA
C00027  Hydrogen peroxide
C00031  D-Glucose
C00043  UDP-N-acetyl-alpha-D-glucosamine
C00051  Glutathione
C00076  Calcium cation
C00085  D-Fructose 6-phosphate
C00092  D-Glucose 6-phosphate
C00095  D-Fructose
C00118  D-Glyceraldehyde 3-phosphate
C00127  Glutathione disulfide
C00162  Fatty acid
C00165  Diacylglycerol
C00195  N-Acylsphingosine
C00236  3-Phospho-D-glyceroyl phosphate
C00318  L-Carnitine
C00352  D-Glucosamine 6-phosphate
C00369  Starch
C00533  Nitric oxide
C00546  Methylglyoxal
C00704  Superoxide
C00794  D-Sorbitol
C00873  Angiotensin I
C02135  Angiotensin II
C02843  Long-chain acyl-CoA
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06156  alpha-D-Glucosamine 1-phosphate
C16844  Hydroxyl radical
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
C22310  Fructose 3-phosphate
C22311  3-Deoxyglucosone
Reference
PMID:30443826
  Authors
Riehle C, Bauersachs J
  Title
Of mice and men: models and mechanisms of diabetic cardiomyopathy.
  Journal
Basic Res Cardiol 114:2 (2018)
DOI:10.1007/s00395-018-0711-0
Reference
PMID:24462787
  Authors
Huynh K, Bernardo BC, McMullen JR, Ritchie RH
  Title
Diabetic cardiomyopathy: mechanisms and new treatment strategies targeting antioxidant signaling pathways.
  Journal
Pharmacol Ther 142:375-415 (2014)
DOI:10.1016/j.pharmthera.2014.01.003
Reference
PMID:28231848
  Authors
Lorenzo-Almoros A, Tunon J, Orejas M, Cortes M, Egido J, Lorenzo O
  Title
Diagnostic approaches for diabetic cardiomyopathy.
  Journal
Cardiovasc Diabetol 16:28 (2017)
DOI:10.1186/s12933-017-0506-x
Reference
PMID:32080423
  Authors
Tan Y, Zhang Z, Zheng C, Wintergerst KA, Keller BB, Cai L
  Title
Mechanisms of diabetic cardiomyopathy and potential therapeutic strategies: preclinical and clinical evidence.
  Journal
Nat Rev Cardiol 17:585-607 (2020)
DOI:10.1038/s41569-020-0339-2
Reference
PMID:31212580
  Authors
Zamora M, Villena JA
  Title
Contribution of Impaired Insulin Signaling to the Pathogenesis of Diabetic Cardiomyopathy.
  Journal
Int J Mol Sci 20:E2833 (2019)
DOI:10.3390/ijms20112833
Reference
PMID:29605388
  Authors
Palomer X, Pizarro-Delgado J, Vazquez-Carrera M
  Title
Emerging Actors in Diabetic Cardiomyopathy: Heartbreaker Biomarkers or Therapeutic Targets?
  Journal
Trends Pharmacol Sci 39:452-467 (2018)
DOI:10.1016/j.tips.2018.02.010
Reference
PMID:28439258
  Authors
Mishra PK, Ying W, Nandi SS, Bandyopadhyay GK, Patel KK, Mahata SK
  Title
Diabetic Cardiomyopathy: An Immunometabolic Perspective.
  Journal
Front Endocrinol (Lausanne) 8:72 (2017)
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Related
pathway
biu00010  Glycolysis / Gluconeogenesis
biu00020  Citrate cycle (TCA cycle)
biu00190  Oxidative phosphorylation
biu00520  Amino sugar and nucleotide sugar metabolism
biu03320  PPAR signaling pathway
biu04071  Sphingolipid signaling pathway
biu04150  mTOR signaling pathway
biu04210  Apoptosis
biu04260  Cardiac muscle contraction
biu04350  TGF-beta signaling pathway
biu04614  Renin-angiotensin system
biu04910  Insulin signaling pathway
biu04930  Type II diabetes mellitus
biu04931  Insulin resistance
biu04933  AGE-RAGE signaling pathway in diabetic complications
biu04940  Type I diabetes mellitus
KO pathway
ko05415   
LinkDB

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