KEGG   PATHWAY: caty04217
Entry
caty04217                   Pathway                                
Name
Necroptosis - Cercocebus atys (sooty mangabey)
Description
Necroptosis is a programmed form of necrosis. It can be initiated by different stimuli, such as tumor necrosis factor (TNF), TNF-related apoptosis-inducing ligand (TRAIL), Fas ligand (FasL), interferon (IFN), LPS, viral DNA or RNA, DNA-damage agent and requires the kinase activity of receptor-interacting protein 1 (RIPK1) and RIPK3. Its execution involves ROS generation, calcium overload, the opening of the mitochondrial permeability transition pore, mitochondrial fission, inflammatory response and chromatinolysis. Necroptosis participates in many pathogenesis of diseases, including neurological diseases, retinal disorders, acute kidney injury, inflammatory diseases and microbial infections.
Class
Cellular Processes; Cell growth and death
Pathway map
caty04217  Necroptosis
caty04217

Organism
Cercocebus atys (sooty mangabey) [GN:caty]
Gene
105573465  TNF; tumor necrosis factor [KO:K03156]
105583011  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
105587262  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
105580591  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
105577052  TRAF5; TNF receptor-associated factor 5 isoform X1 [KO:K09849]
105596428  RIPK1; receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861] [EC:2.7.11.1]
105591400  BIRC3; baculoviral IAP repeat-containing protein 3 isoform X1 [KO:K16060]
105591401  BIRC2; baculoviral IAP repeat-containing protein 2 isoform X1 [KO:K16060]
105586304  XIAP; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
105591186  BIRC8; LOW QUALITY PROTEIN: baculoviral IAP repeat-containing protein 8 [KO:K04725] [EC:2.3.2.27]
105582208  RBCK1; ranBP-type and C3HC4-type zinc finger-containing protein 1 isoform X1 [KO:K10630] [EC:2.3.2.31]
105600245  RNF31; E3 ubiquitin-protein ligase RNF31 isoform X1 [KO:K11974] [EC:2.3.2.31]
105581236  sharpin [KO:K20894]
105585402  SPATA2; spermatogenesis-associated protein 2 [KO:K17595]
105587567  LOW QUALITY PROTEIN: uncharacterized protein LOC105587567 [KO:K17595]
105572040  SPATA2L; spermatogenesis-associated protein 2-like protein [KO:K17595]
105588862  CYLD; ubiquitin carboxyl-terminal hydrolase CYLD isoform X1 [KO:K08601] [EC:3.4.19.12]
105577297  FADD; FAS-associated death domain protein [KO:K02373]
105580035  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
105580032  CFLAR; CASP8 and FADD-like apoptosis regulator isoform X1 [KO:K04724]
105600226  RIPK3; receptor-interacting serine/threonine-protein kinase 3 [KO:K08847] [EC:2.7.11.1]
105581150  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
105571464  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
105596908  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
105589879  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
105597344  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
105594248  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
105587427  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
105574783  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
105598386  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
105597876  PPID; peptidyl-prolyl cis-trans isomerase D [KO:K05864] [EC:5.2.1.8]
105599763  VDAC1; LOW QUALITY PROTEIN: voltage-dependent anion-selective channel protein 1 [KO:K05862]
105597362  VDAC2; voltage-dependent anion-selective channel protein 2 isoform X1 [KO:K15040]
105595755  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
105593705  LOW QUALITY PROTEIN: glutamate dehydrogenase 1, mitochondrial-like [KO:K00261] [EC:1.4.1.3]
105591424  glutamate dehydrogenase 1, mitochondrial isoform X1 [KO:K00261] [EC:1.4.1.3]
105586524  glutamine synthetase [KO:K01915] [EC:6.3.1.2]
105580432  GLUL; glutamine synthetase [KO:K01915] [EC:6.3.1.2]
105577478  PYGM; glycogen phosphorylase, muscle form [KO:K00688] [EC:2.4.1.1]
105586607  PYGL; glycogen phosphorylase, liver form isoform X1 [KO:K00688] [EC:2.4.1.1]
105581955  PYGB; glycogen phosphorylase, brain form [KO:K00688] [EC:2.4.1.1]
105590417  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
105591436  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
105576775  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
105577573  FTH1; ferritin heavy chain [KO:K00522] [EC:1.16.3.1]
105595266  FTL; ferritin light chain [KO:K13625]
105582088  LOW QUALITY PROTEIN: ferritin light chain-like [KO:K13625]
105579889  PLA2G4A; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
105595443  PLA2G4C; cytosolic phospholipase A2 gamma [KO:K16342] [EC:3.1.1.4]
105574211  PLA2G4B; cytosolic phospholipase A2 beta isoform X1 [KO:K16342] [EC:3.1.1.4]
105574213  PLA2G4E; cytosolic phospholipase A2 epsilon isoform X1 [KO:K16342] [EC:3.1.1.4]
105574214  PLA2G4F; cytosolic phospholipase A2 zeta isoform X1 [KO:K16342] [EC:3.1.1.4]
105574265  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
105583615  ALOX15; arachidonate 15-lipoxygenase [KO:K00460] [EC:1.13.11.33]
105577619  CAPN1; LOW QUALITY PROTEIN: calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
105576962  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
105575054  SMPD1; sphingomyelin phosphodiesterase [KO:K12350] [EC:3.1.4.12]
105574056  MLKL; mixed lineage kinase domain-like protein isoform X1 [KO:K08849] [EC:2.7.11.1]
105600720  PGAM5; serine/threonine-protein phosphatase PGAM5, mitochondrial isoform X1 [KO:K15637] [EC:3.1.3.16]
105591360  DNM1L; dynamin-1-like protein isoform X1 [KO:K17065] [EC:3.6.5.5]
105599484  NLRP3; NACHT, LRR and PYD domains-containing protein 3 isoform X1 [KO:K12800]
105599574  PYCARD; apoptosis-associated speck-like protein containing a CARD [KO:K12799]
105588753  caspase-1-like [KO:K01370] [EC:3.4.22.36]
105588757  caspase-1-like isoform X1 [KO:K01370] [EC:3.4.22.36]
105591123  IL1B; interleukin-1 beta [KO:K04519]
105593289  CHMP2A; charged multivesicular body protein 2a isoform X1 [KO:K12191]
105583589  CHMP2B; charged multivesicular body protein 2b [KO:K12192]
105587673  CHMP3; charged multivesicular body protein 3 isoform X1 [KO:K12193]
105600242  CHMP4A; LOW QUALITY PROTEIN: charged multivesicular body protein 4a [KO:K12194]
105582285  CHMP4B; charged multivesicular body protein 4b [KO:K12194]
105572912  CHMP4C; charged multivesicular body protein 4c [KO:K24782]
105588625  CHMP6; charged multivesicular body protein 6 [KO:K12195]
105581326  VPS4A; vacuolar protein sorting-associated protein 4A [KO:K12196]
105590008  VPS4B; vacuolar protein sorting-associated protein 4B [KO:K12196]
105579340  CHMP1B; charged multivesicular body protein 1b [KO:K12197]
105580094  CHMP1A; charged multivesicular body protein 1a [KO:K12197]
105590078  CHMP5; charged multivesicular body protein 5 [KO:K12198]
105579210  CHMP7; charged multivesicular body protein 7 isoform X1 [KO:K15053]
105588226  TRPM7; transient receptor potential cation channel subfamily M member 7 isoform X1 [KO:K04982] [EC:2.7.11.1]
105591122  IL1A; interleukin-1 alpha isoform X1 [KO:K04383]
105584074  IL33; interleukin-33 isoform X1 [KO:K12967]
105587913  HMGB1; high mobility group protein B1 [KO:K10802]
105587074  high mobility group protein B1-like [KO:K10802]
105586081  TNFSF10; tumor necrosis factor ligand superfamily member 10 [KO:K04721]
105579211  TNFRSF10A; tumor necrosis factor receptor superfamily member 10A [KO:K04722]
105579216  TNFRSF10B; tumor necrosis factor receptor superfamily member 10B isoform X1 [KO:K04722]
105597557  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
105587157  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
105591326  interferon alpha-1/13 [KO:K05414]
105591327  IFNA8; interferon alpha-8 [KO:K05414]
105591328  IFNA2; interferon alpha-2 [KO:K05414]
105591330  interferon alpha-1/13-like [KO:K05414]
105591332  interferon alpha-6 [KO:K05414]
105591336  LOW QUALITY PROTEIN: interferon alpha-6-like [KO:K05414]
105591337  LOW QUALITY PROTEIN: interferon alpha-21-like [KO:K05414]
105591338  interferon alpha-14 isoform X1 [KO:K05414]
105584002  IFNB1; interferon beta [KO:K05415]
105600509  IFNG; interferon gamma [KO:K04687]
105575378  IFNAR1; interferon alpha/beta receptor 1 isoform X1 [KO:K05130]
105575579  IFNAR2; interferon alpha/beta receptor 2 [KO:K05131]
105600393  IFNGR1; interferon gamma receptor 1 isoform X1 [KO:K05132]
105575379  IFNGR2; interferon gamma receptor 2 [KO:K05133]
105595926  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
105584100  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
105601679  JAK3; tyrosine-protein kinase JAK3 isoform X1 [KO:K11218] [EC:2.7.10.2]
105571283  TYK2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
105579958  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
105587295  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
105579724  STAT3; signal transducer and activator of transcription 3 [KO:K04692]
105580191  STAT4; signal transducer and activator of transcription 4 [KO:K11222]
105579667  STAT5A; signal transducer and activator of transcription 5A [KO:K11223]
105579668  STAT5B; signal transducer and activator of transcription 5B isoform X1 [KO:K11224]
105587270  STAT6; signal transducer and activator of transcription 6 isoform X1 [KO:K11225]
105600246  IRF9; interferon regulatory factor 9 [KO:K04693]
105597175  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase isoform X1 [KO:K16195] [EC:2.7.11.1]
105600415  TLR4; toll-like receptor 4 isoform X1 [KO:K10160]
105590667  TICAM2; TIR domain-containing adapter molecule 2 [KO:K05409]
105591822  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
105594261  TLR3; toll-like receptor 3 isoform X1 [KO:K05401]
105585333  ZBP1; Z-DNA-binding protein 1 isoform X1 [KO:K12965]
105589251  USP21; ubiquitin carboxyl-terminal hydrolase 21 isoform X1 [KO:K21634] [EC:3.4.19.12]
105590410  SQSTM1; sequestosome-1 isoform X1 [KO:K14381]
105596717  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
105591024  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
105600386  TNFAIP3; tumor necrosis factor alpha-induced protein 3 [KO:K11859] [EC:3.4.19.12]
105576925  PARP1; poly [ADP-ribose] polymerase 1 [KO:K24070] [EC:2.4.2.30]
105591256  BID; BH3-interacting domain death agonist isoform X1 [KO:K04726]
105595265  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
105586270  AIFM1; apoptosis-inducing factor 1, mitochondrial isoform X1 [KO:K04727] [EC:1.-.-.-]
105585119  histone H2A.J [KO:K11251]
105592902  histone H2A type 2-A [KO:K11251]
105593168  histone H2A type 1 [KO:K11251]
105593171  histone H2A type 1 [KO:K11251]
105593175  histone H2A type 1-H-like [KO:K11251]
105593178  histone H2A type 1 [KO:K11251]
105593180  histone H2A type 1-J [KO:K11251]
105593193  histone H2A type 1-H [KO:K11251]
105593196  histone H2A type 1 [KO:K11251]
105572092  histone H2A.Z-like [KO:K11251]
105572636  histone H2A type 1-A [KO:K11251]
105572649  histone H2A type 1 [KO:K11251]
105572659  histone H2A type 1-C [KO:K11251]
105572669  histone H2A type 1 [KO:K11251]
105572674  histone H2A type 1-D [KO:K11251]
105573760  histone H2A-Bbd type 2/3 [KO:K11251]
105596899  histone H2A.V isoform X1 [KO:K11251]
105597270  core histone macro-H2A.2 [KO:K11251]
105582501  histone H2AX [KO:K11251]
105590173  histone H2A type 2-C [KO:K11251]
105590174  histone H2A type 2-B [KO:K11251]
105597695  histone H2A type 3 [KO:K11251]
105599793  core histone macro-H2A.1 isoform X1 [KO:K11251]
105600948  peptidyl-prolyl cis-trans isomerase A [KO:K03767] [EC:5.2.1.8]
105596944  PPIA; peptidyl-prolyl cis-trans isomerase A [KO:K03767] [EC:5.2.1.8]
105590726  peptidyl-prolyl cis-trans isomerase A-like [KO:K03767] [EC:5.2.1.8]
105590006  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
Compound
C00002  ATP
C00027  Hydrogen peroxide
C00076  Calcium cation
C00195  N-Acylsphingosine
C00219  Arachidonate
C00305  Magnesium cation
C00319  Sphingosine
C00550  Sphingomyelin
C14592  N-Methyl-N'-nitro-N-nitrosoguanidine
C16844  Hydroxyl radical
Reference
PMID:20823910
  Authors
Vandenabeele P, Galluzzi L, Vanden Berghe T, Kroemer G
  Title
Molecular mechanisms of necroptosis: an ordered cellular explosion.
  Journal
Nat Rev Mol Cell Biol 11:700-14 (2010)
DOI:10.1038/nrm2970
Reference
PMID:26008591
  Authors
Brenner D, Blaser H, Mak TW
  Title
Regulation of tumour necrosis factor signalling: live or let die.
  Journal
Nat Rev Immunol 15:362-74 (2015)
DOI:10.1038/nri3834
Reference
PMID:26775689
  Authors
Conrad M, Angeli JP, Vandenabeele P, Stockwell BR
  Title
Regulated necrosis: disease relevance and therapeutic opportunities.
  Journal
Nat Rev Drug Discov 15:348-66 (2016)
DOI:10.1038/nrd.2015.6
Reference
PMID:24129419
  Authors
Ofengeim D, Yuan J
  Title
Regulation of RIP1 kinase signalling at the crossroads of inflammation and cell death.
  Journal
Nat Rev Mol Cell Biol 14:727-36 (2013)
DOI:10.1038/nrm3683
Reference
PMID:27158445
  Authors
Murphy JM, Vince JE
  Title
Post-translational control of RIPK3 and MLKL mediated necroptotic cell death.
  Journal
F1000Res 4:F1000 Faculty Rev-1297 (2015)
DOI:10.12688/f1000research.7046.1
Reference
PMID:24452471
  Authors
Vanden Berghe T, Linkermann A, Jouan-Lanhouet S, Walczak H, Vandenabeele P
  Title
Regulated necrosis: the expanding network of non-apoptotic cell death pathways.
  Journal
Nat Rev Mol Cell Biol 15:135-47 (2014)
DOI:10.1038/nrm3737
Reference
PMID:27368376
  Authors
Dondelinger Y, Hulpiau P, Saeys Y, Bertrand MJ, Vandenabeele P
  Title
An evolutionary perspective on the necroptotic pathway.
  Journal
Trends Cell Biol 26:721-32 (2016)
DOI:10.1016/j.tcb.2016.06.004
Reference
PMID:27746097
  Authors
Thapa RJ, Ingram JP, Ragan KB, Nogusa S, Boyd DF, Benitez AA, Sridharan H, Kosoff R, Shubina M, Landsteiner VJ, Andrake M, Vogel P, Sigal LJ, tenOever BR, Thomas PG, Upton JW, Balachandran S
  Title
DAI Senses Influenza A Virus Genomic RNA and Activates RIPK3-Dependent Cell Death.
  Journal
Cell Host Microbe 20:674-681 (2016)
DOI:10.1016/j.chom.2016.09.014
Reference
PMID:27984721
  Authors
Yuan J, Najafov A, Py BF
  Title
Roles of Caspases in Necrotic Cell Death.
  Journal
Cell 167:1693-1704 (2016)
DOI:10.1016/j.cell.2016.11.047
Reference
PMID:28138137
  Authors
Jorgensen I, Rayamajhi M, Miao EA
  Title
Programmed cell death as a defence against infection.
  Journal
Nat Rev Immunol 17:151-164 (2017)
DOI:10.1038/nri.2016.147
Reference
PMID:20354226
  Authors
Vandenabeele P, Declercq W, Van Herreweghe F, Vanden Berghe T
  Title
The role of the kinases RIP1 and RIP3 in TNF-induced necrosis.
  Journal
Sci Signal 3:re4 (2010)
DOI:10.1126/scisignal.3115re4
Reference
PMID:22075985
  Authors
Vanlangenakker N, Vanden Berghe T, Vandenabeele P
  Title
Many stimuli pull the necrotic trigger, an overview.
  Journal
Cell Death Differ 19:75-86 (2012)
DOI:10.1038/cdd.2011.164
Reference
PMID:23913919
  Authors
Moriwaki K, Chan FK
  Title
RIP3: a molecular switch for necrosis and inflammation.
  Journal
Genes Dev 27:1640-9 (2013)
DOI:10.1101/gad.223321.113
Reference
PMID:25146926
  Authors
Humphries F, Yang S, Wang B, Moynagh PN
  Title
RIP kinases: key decision makers in cell death and innate immunity.
  Journal
Cell Death Differ 22:225-36 (2015)
DOI:10.1038/cdd.2014.126
Reference
PMID:28126382
  Authors
Wegner KW, Saleh D, Degterev A
  Title
Complex Pathologic Roles of RIPK1 and RIPK3: Moving Beyond Necroptosis.
  Journal
Trends Pharmacol Sci 38:202-225 (2017)
DOI:10.1016/j.tips.2016.12.005
Reference
PMID:27545878
  Authors
Kupka S, De Miguel D, Draber P, Martino L, Surinova S, Rittinger K, Walczak H
  Title
SPATA2-Mediated Binding of CYLD to HOIP Enables CYLD Recruitment to Signaling Complexes.
  Journal
Cell Rep 16:2271-80 (2016)
DOI:10.1016/j.celrep.2016.07.086
Reference
PMID:27219062
  Authors
Goodall ML, Fitzwalter BE, Zahedi S, Wu M, Rodriguez D, Mulcahy-Levy JM, Green DR, Morgan M, Cramer SD, Thorburn A
  Title
The Autophagy Machinery Controls Cell Death Switching between Apoptosis and Necroptosis.
  Journal
Dev Cell 37:337-49 (2016)
DOI:10.1016/j.devcel.2016.04.018
Reference
PMID:19910467
  Authors
Xu G, Tan X, Wang H, Sun W, Shi Y, Burlingame S, Gu X, Cao G, Zhang T, Qin J, Yang J
  Title
Ubiquitin-specific peptidase 21 inhibits tumor necrosis factor alpha-induced nuclear factor kappaB activation via binding to and deubiquitinating receptor-interacting protein 1.
  Journal
J Biol Chem 285:969-78 (2010)
DOI:10.1074/jbc.M109.042689
Reference
PMID:26971869
  Authors
Jacobsen AV, Silke J
  Title
The importance of being chaperoned: HSP90 and necroptosis.
  Journal
Cell Chem Biol 23:205-7 (2016)
DOI:10.1016/j.chembiol.2016.02.003
Reference
PMID:25988900
  Authors
Gurung P, Man SM, Kanneganti TD
  Title
A20 is a regulator of necroptosis.
  Journal
Nat Immunol 16:596-7 (2015)
DOI:10.1038/ni.3174
Reference
PMID:28025046
  Authors
Feng N, Anderson ME
  Title
CaMKII is a nodal signal for multiple programmed cell death pathways in heart.
  Journal
J Mol Cell Cardiol 103:102-109 (2017)
DOI:10.1016/j.yjmcc.2016.12.007
Reference
PMID:19696789
  Authors
Zhivotovsky B, Galluzzi L, Kepp O, Kroemer G
  Title
Adenine nucleotide translocase: a component of the phylogenetically conserved cell death machinery.
  Journal
Cell Death Differ 16:1419-25 (2009)
DOI:10.1038/cdd.2009.118
Reference
PMID:23898178
  Authors
Thapa RJ, Nogusa S, Chen P, Maki JL, Lerro A, Andrake M, Rall GF, Degterev A, Balachandran S
  Title
Interferon-induced RIP1/RIP3-mediated necrosis requires PKR and is licensed by FADD and caspases.
  Journal
Proc Natl Acad Sci U S A 110:E3109-18 (2013)
DOI:10.1073/pnas.1301218110
Reference
PMID:21576359
  Authors
Thapa RJ, Basagoudanavar SH, Nogusa S, Irrinki K, Mallilankaraman K, Slifker MJ, Beg AA, Madesh M, Balachandran S
  Title
NF-kappaB protects cells from gamma interferon-induced RIP1-dependent necroptosis.
  Journal
Mol Cell Biol 31:2934-46 (2011)
DOI:10.1128/MCB.05445-11
Reference
PMID:24565922
  Authors
Sridharan H, Upton JW
  Title
Programmed necrosis in microbial pathogenesis.
  Journal
Trends Microbiol 22:199-207 (2014)
DOI:10.1016/j.tim.2014.01.005
Reference
PMID:21738214
  Authors
Cabon L, Galan-Malo P, Bouharrour A, Delavallee L, Brunelle-Navas MN, Lorenzo HK, Gross A, Susin SA
  Title
BID regulates AIF-mediated caspase-independent necroptosis by promoting BAX activation.
  Journal
Cell Death Differ 19:245-56 (2012)
DOI:10.1038/cdd.2011.91
Reference
PMID:20697198
  Authors
Baritaud M, Boujrad H, Lorenzo HK, Krantic S, Susin SA
  Title
Histone H2AX: The missing link in AIF-mediated caspase-independent programmed necrosis.
  Journal
Cell Cycle 9:3166-73 (2010)
DOI:10.4161/cc.9.16.12887
Reference
PMID:28279333
  Authors
Upton JW, Kaiser WJ
  Title
DAI Another Way: Necroptotic Control of Viral Infection.
  Journal
Cell Host Microbe 21:290-293 (2017)
DOI:10.1016/j.chom.2017.01.016
Reference
PMID:26086143
  Authors
Silke J, Rickard JA, Gerlic M
  Title
The diverse role of RIP kinases in necroptosis and inflammation.
  Journal
Nat Immunol 16:689-97 (2015)
DOI:10.1038/ni.3206
Reference
PMID:28388403
  Authors
Guo H, Kaiser WJ
  Title
ESCRTing Necroptosis.
  Journal
Cell 169:186-187 (2017)
DOI:10.1016/j.cell.2017.03.030
Reference
PMID:28388412
  Authors
Gong YN, Guy C, Olauson H, Becker JU, Yang M, Fitzgerald P, Linkermann A, Green DR
  Title
ESCRT-III Acts Downstream of MLKL to Regulate Necroptotic Cell Death and Its Consequences.
  Journal
Cell 169:286-300.e16 (2017)
DOI:10.1016/j.cell.2017.03.020
Reference
PMID:27999433
  Authors
Petrie EJ, Hildebrand JM, Murphy JM
  Title
Insane in the membrane: a structural perspective of MLKL function in necroptosis.
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Immunol Cell Biol 95:152-159 (2017)
DOI:10.1038/icb.2016.125
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PMID:24316671
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Cai Z, Jitkaew S, Zhao J, Chiang HC, Choksi S, Liu J, Ward Y, Wu LG, Liu ZG
  Title
Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis.
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Nat Cell Biol 16:55-65 (2014)
DOI:10.1038/ncb2883
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PMID:25693118
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Lawlor KE, Khan N, Mildenhall A, Gerlic M, Croker BA, D'Cruz AA, Hall C, Kaur Spall S, Anderton H, Masters SL, Rashidi M, Wicks IP, Alexander WS, Mitsuuchi Y, Benetatos CA, Condon SM, Wong WW, Silke J, Vaux DL, Vince JE
  Title
RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL.
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Nat Commun 6:6282 (2015)
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PMID:27974745
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Shlomovitz I, Zargrian S, Gerlic M
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Mechanisms of RIPK3-induced inflammation.
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Immunol Cell Biol 95:166-172 (2017)
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Related
pathway
caty00250  Alanine, aspartate and glutamate metabolism
caty04210  Apoptosis
caty04668  TNF signaling pathway
caty04922  Glucagon signaling pathway
KO pathway
ko04217   
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