KEGG   PATHWAY: caty04210
Entry
caty04210                   Pathway                                
Name
Apoptosis - Cercocebus atys (sooty mangabey)
Description
Apoptosis is a genetically programmed process for the elimination of damaged or redundant cells by activation of caspases (aspartate-specific cysteine proteases). The onset of apoptosis is controlled by numerous interrelating processes. The 'extrinsic' pathway involves stimulation of members of the tumor necrosis factor (TNF) receptor subfamily, such as TNFRI, CD95/Fas or TRAILR (death receptors), located at the cell surface, by their specific ligands, such as TNF-alpha, FasL or TRAIL, respectively. The 'intrinsic' pathway is activated mainly by non-receptor stimuli, such as DNA damage, ER stress, metabolic stress, UV radiation or growth-factor deprivation. The central event in the 'intrinsic' pathway is the mitochondrial outer membrane permeabilization (MOMP), which leads to the release of cytochrome c. These two pathways converge at the level of effector caspases, such as caspase-3 and caspase-7. The third major pathway is initiated by the constituents of cytotoxic granules (e.g. Perforin and Granzyme B) that are released by CTLs (cytotoxic T-cells) and NK (natural killer) cells. Granzyme B, similarly to the caspases, cleaves its substrates after aspartic acid residues, suggesting that this protease has the ability to activate members of the caspase family directly. It is the balance between the pro-apoptotic and anti-apoptotic signals that eventually determines whether cells will undergo apoptosis, survive or proliferate. TNF family of ligands activates anti-apoptotic or cell-survival signals as well as apoptotic signals. NGF and Interleukin-3 promotes the survival, proliferation and differentiation of neurons or hematopoietic cells, respectively. Withdrawal of these growth factors leads to cell death, as described above.
Class
Cellular Processes; Cell growth and death
Pathway map
caty04210  Apoptosis
caty04210

Other DBs
GO: 0006915
Organism
Cercocebus atys (sooty mangabey) [GN:caty]
Gene
105586081  TNFSF10; tumor necrosis factor ligand superfamily member 10 [KO:K04721]
105579211  TNFRSF10A; tumor necrosis factor receptor superfamily member 10A [KO:K04722]
105579216  TNFRSF10B; tumor necrosis factor receptor superfamily member 10B isoform X1 [KO:K04722]
105597557  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
105587157  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
105577297  FADD; FAS-associated death domain protein [KO:K02373]
105573465  TNF; tumor necrosis factor [KO:K03156]
105583011  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
105587262  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
105580032  CFLAR; CASP8 and FADD-like apoptosis regulator isoform X1 [KO:K04724]
105580035  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
105580202  CASP10; caspase-10 [KO:K04400] [EC:3.4.22.63]
105571423  CASP6; caspase-6 isoform X1 [KO:K04396] [EC:3.4.22.59]
105593734  LOW QUALITY PROTEIN: caspase-3-like [KO:K02187] [EC:3.4.22.56]
105597738  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
105577913  CASP7; caspase-7 isoform X1 [KO:K04397] [EC:3.4.22.60]
105591256  BID; BH3-interacting domain death agonist isoform X1 [KO:K04726]
105595265  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
105593255  BAK1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
105590982  DIABLO; diablo homolog, mitochondrial isoform X1 [KO:K10522]
105583319  uncharacterized protein C17orf47 homolog [KO:K16943]
105583320  SEPT4; septin-4 isoform X1 [KO:K16943]
105596870  HTRA2; serine protease HTRA2, mitochondrial isoform X1 [KO:K08669] [EC:3.4.21.108]
105597193  uncharacterized protein LOC105597193 [KO:K08738]
105571593  cytochrome c-like [KO:K08738]
105588083  cytochrome c [KO:K08738]
105595720  cytochrome c-like [KO:K08738]
105589984  cytochrome c-like [KO:K08738]
105590205  cytochrome c-like [KO:K08738]
105573341  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
105599419  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
105597281  PRF1; perforin-1 isoform X1 [KO:K07818]
105600215  GZMB; granzyme B [KO:K01353] [EC:3.4.21.79]
105587029  tubulin alpha-4A chain isoform X1 [KO:K07374]
105571676  tubulin alpha-3 chain isoform X1 [KO:K07374]
105580387  LOW QUALITY PROTEIN: tubulin alpha-1C chain-like [KO:K07374]
105580388  tubulin alpha-1B chain [KO:K07374]
105574111  TUBA3E; LOW QUALITY PROTEIN: tubulin alpha-3E chain [KO:K07374]
105597442  TUBAL3; tubulin alpha chain-like 3 [KO:K07374]
105591250  TUBA8; tubulin alpha-8 chain isoform X1 [KO:K07374]
105590194  MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 isoform X1 [KO:K02539]
105577106  LOW QUALITY PROTEIN: actin, alpha skeletal muscle-like [KO:K05692]
105588610  ACTG1; actin, cytoplasmic 2 [KO:K05692]
105574978  LOW QUALITY PROTEIN: actin-like [KO:K05692]
105598339  ACTB; actin, cytoplasmic 1 [KO:K05692]
105576219  SPTAN1; spectrin alpha chain, non-erythrocytic 1 isoform X1 [KO:K06114]
105594502  LMNA; lamin [KO:K12641]
105591753  LMNB2; lamin-B2 isoform X1 [KO:K07611]
105599697  LMNB1; lamin-B1 [KO:K07611]
105576925  PARP1; poly [ADP-ribose] polymerase 1 [KO:K24070] [EC:2.4.2.30]
105594070  PARP2; poly [ADP-ribose] polymerase 2 [KO:K10798] [EC:2.4.2.30]
105597073  PARP4; poly [ADP-ribose] polymerase 4 [KO:K10798] [EC:2.4.2.30]
105574275  PARP3; poly [ADP-ribose] polymerase 3 isoform X1 [KO:K10798] [EC:2.4.2.30]
105580881  DFFA; DNA fragmentation factor subunit alpha [KO:K02310]
105594479  DFFB; DNA fragmentation factor subunit beta isoform X1 [KO:K02311] [EC:3.-.-.-]
105576212  ENDOG; endonuclease G, mitochondrial [KO:K01173]
105586270  AIFM1; apoptosis-inducing factor 1, mitochondrial isoform X1 [KO:K04727] [EC:1.-.-.-]
105590750  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
105580591  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
105585726  ITPR1; LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
105601409  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
105593244  ITPR3; LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
105577619  CAPN1; LOW QUALITY PROTEIN: calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
105576962  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
105588760  caspase-12 [KO:K04741] [EC:3.4.22.-]
105598836  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
105582856  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
105572871  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
105587252  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
105579388  CTSB; cathepsin B [KO:K01363] [EC:3.4.22.1]
105592961  CTSC; dipeptidyl peptidase 1 isoform X1 [KO:K01275] [EC:3.4.14.1]
105577246  CTSD; cathepsin D [KO:K01379] [EC:3.4.23.5]
105577616  CTSF; LOW QUALITY PROTEIN: cathepsin F [KO:K01373] [EC:3.4.22.41]
105571724  CTSH; pro-cathepsin H [KO:K01366] [EC:3.4.22.16]
105590201  CTSK; cathepsin K [KO:K01371] [EC:3.4.22.38]
105574805  LOW QUALITY PROTEIN: putative cathepsin L-like protein 6 [KO:K01365] [EC:3.4.22.15]
105584265  CTSL; cathepsin L1 [KO:K01365] [EC:3.4.22.15]
105584266  LOW QUALITY PROTEIN: putative inactive cathepsin L-like protein CTSL3P [KO:K01365] [EC:3.4.22.15]
105597892  CTSO; cathepsin O [KO:K01374] [EC:3.4.22.42]
105590202  CTSS; cathepsin S isoform X1 [KO:K01368] [EC:3.4.22.27]
105579323  CTSV; cathepsin L2 [KO:K01375] [EC:3.4.22.43]
105577420  CTSW; cathepsin W isoform X1 [KO:K08569] [EC:3.4.22.-]
105585314  CTSZ; cathepsin Z [KO:K08568] [EC:3.4.18.1]
105591400  BIRC3; baculoviral IAP repeat-containing protein 3 isoform X1 [KO:K16060]
105591401  BIRC2; baculoviral IAP repeat-containing protein 2 isoform X1 [KO:K16060]
105586304  XIAP; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
105591186  BIRC8; LOW QUALITY PROTEIN: baculoviral IAP repeat-containing protein 8 [KO:K04725] [EC:2.3.2.27]
105577651  BIRC5; baculoviral IAP repeat-containing protein 5 isoform X1 [KO:K08731]
105591145  BCL2L11; bcl-2-like protein 11 isoform X1 [KO:K16341]
105582236  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
105590006  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
105593386  DAXX; death domain-associated protein 6 isoform X1 [KO:K02308]
105596428  RIPK1; receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861] [EC:2.7.11.1]
105600049  DAB2IP; disabled homolog 2-interacting protein isoform X1 [KO:K19901]
105600400  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
105590417  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
105591436  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
105576775  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
105577493  BAD; bcl2-associated agonist of cell death [KO:K02158]
105595973  JUN; transcription factor AP-1 [KO:K04448]
105590868  FOS; proto-oncogene c-Fos [KO:K04379]
105582225  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
105592737  HRK; activator of apoptosis harakiri [KO:K02512]
105585587  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
105581830  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
105595759  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
105573773  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
105589068  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
105571369  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
105577432  RELA; transcription factor p65 isoform X1 [KO:K04735]
105576773  PTPN13; tyrosine-protein phosphatase non-receptor type 13 isoform X1 [KO:K02374]
105595891  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
105584287  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
105591754  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
105600240  TRAF1; TNF receptor-associated factor 1 isoform X1 [KO:K03172]
105571616  BCL2A1; bcl-2-related protein A1 [KO:K02162]
105588729  ATM; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
105577217  PIDD1; p53-induced death domain-containing protein 1 isoform X1 [KO:K10130]
105582640  TP53AIP1; p53-regulated apoptosis-inducing protein 1 isoform X1 [KO:K13773]
105595200  BBC3; bcl-2-binding component 3 isoform X1 [KO:K10132]
105584645  CASP2; caspase-2 isoform X1 [KO:K02186] [EC:3.4.22.55]
105596338  NGF; beta-nerve growth factor isoform X1 [KO:K02582]
105594539  NTRK1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
105599729  IL3; interleukin-3 [KO:K04736]
105574782  IL3RA; LOW QUALITY PROTEIN: interleukin-3 receptor subunit alpha [KO:K04737]
105575809  CSF2RB; cytokine receptor common subunit beta isoform X1 [KO:K04738]
105586383  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
105580892  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
105597716  PIK3CA; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
105571321  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
105594576  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
105599262  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
105573290  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
105596769  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105597977  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105574942  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105577198  HRAS; GTPase HRas isoform X1 [KO:K02833]
105585038  KRAS; GTPase KRas isoform X1 [KO:K07827]
105596344  NRAS; GTPase NRas isoform X1 [KO:K07828]
105585803  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
105601165  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
105591800  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
105598233  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
105598850  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00319  Sphingosine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:26615431
  Authors
Savitskaya MA, Onishchenko GE
  Title
Mechanisms of Apoptosis.
  Journal
Biochemistry (Mosc) 80:1393-417 (2015)
DOI:10.1134/S0006297915110012
Reference
PMID:23803157
  Authors
Schleich K, Lavrik IN
  Title
Mathematical modeling of apoptosis.
  Journal
Cell Commun Signal 11:44 (2013)
DOI:10.1186/1478-811X-11-44
Reference
PMID:15654015
  Authors
Lavrik I, Golks A, Krammer PH
  Title
Death receptor signaling.
  Journal
J Cell Sci 118:265-7 (2005)
DOI:10.1242/jcs.01610
Reference
PMID:15725726
  Authors
Jin Z, El-Deiry WS
  Title
Overview of cell death signaling pathways.
  Journal
Cancer Biol Ther 4:139-63 (2005)
DOI:10.4161/cbt.4.2.1508
Reference
PMID:15322527
  Authors
Benn SC, Woolf CJ
  Title
Adult neuron survival strategies--slamming on the brakes.
  Journal
Nat Rev Neurosci 5:686-700 (2004)
DOI:10.1038/nrn1477
Reference
PMID:12838338
  Authors
Orrenius S, Zhivotovsky B, Nicotera P
  Title
Regulation of cell death: the calcium-apoptosis link.
  Journal
Nat Rev Mol Cell Biol 4:552-65 (2003)
DOI:10.1038/nrm1150
Reference
PMID:19148180
  Authors
Clarke P, Tyler KL
  Title
Apoptosis in animal models of virus-induced disease.
  Journal
Nat Rev Microbiol 7:144-55 (2009)
DOI:10.1038/nrmicro2071
Reference
PMID:22429822
  Authors
Wen X, Lin ZQ, Liu B, Wei YQ
  Title
Caspase-mediated programmed cell death pathways as potential therapeutic targets in cancer.
  Journal
Cell Prolif 45:217-24 (2012)
DOI:10.1111/j.1365-2184.2012.00814.x
Reference
PMID:25526085
  Authors
Shalini S, Dorstyn L, Dawar S, Kumar S
  Title
Old, new and emerging functions of caspases.
  Journal
Cell Death Differ 22:526-39 (2015)
DOI:10.1038/cdd.2014.216
Reference
PMID:15601572
  Authors
Philchenkov A
  Title
Caspases: potential targets for regulating cell death.
  Journal
J Cell Mol Med 8:432-44 (2004)
DOI:10.1111/j.1582-4934.2004.tb00468.x
Reference
PMID:9894605
  Authors
Stroh C, Schulze-Osthoff K
  Title
Death by a thousand cuts: an ever increasing list of caspase substrates.
  Journal
Cell Death Differ 5:997-1000 (1998)
DOI:10.1038/sj.cdd.4400451
Reference
PMID:23070002
  Authors
Safa AR
  Title
c-FLIP, a master anti-apoptotic regulator.
  Journal
Exp Oncol 34:176-84 (2012)
Reference
PMID:18304445
  Authors
Jeong SY, Seol DW
  Title
The role of mitochondria in apoptosis.
  Journal
BMB Rep 41:11-22 (2008)
DOI:10.5483/bmbrep.2008.41.1.011
Reference
PMID:20533903
  Authors
Parsons MJ, Green DR
  Title
Mitochondria in cell death.
  Journal
Essays Biochem 47:99-114 (2010)
DOI:10.1042/bse0470099
Reference
PMID:15719025
  Authors
Strasser A
  Title
The role of BH3-only proteins in the immune system.
  Journal
Nat Rev Immunol 5:189-200 (2005)
DOI:10.1038/nri1568
Reference
PMID:24278747
  Authors
Schonthal AH
  Title
Endoplasmic reticulum stress: its role in disease and novel prospects for therapy.
  Journal
Scientifica (Cairo) 2012:857516 (2012)
DOI:10.6064/2012/857516
Reference
PMID:21145844
  Authors
Malhi H, Kaufman RJ
  Title
Endoplasmic reticulum stress in liver disease.
  Journal
J Hepatol 54:795-809 (2011)
DOI:10.1016/j.jhep.2010.11.005
Reference
PMID:18023214
  Authors
Malhotra JD, Kaufman RJ
  Title
The endoplasmic reticulum and the unfolded protein response.
  Journal
Semin Cell Dev Biol 18:716-31 (2007)
DOI:10.1016/j.semcdb.2007.09.003
Reference
PMID:16397578
  Authors
Wu J, Kaufman RJ
  Title
From acute ER stress to physiological roles of the Unfolded Protein Response.
  Journal
Cell Death Differ 13:374-84 (2006)
DOI:10.1038/sj.cdd.4401840
Reference
PMID:21914490
  Authors
Repnik U, Stoka V, Turk V, Turk B
  Title
Lysosomes and lysosomal cathepsins in cell death.
  Journal
Biochim Biophys Acta 1824:22-33 (2012)
DOI:10.1016/j.bbapap.2011.08.016
Reference
PMID:22465226
  Authors
Cesen MH, Pegan K, Spes A, Turk B
  Title
Lysosomal pathways to cell death and their therapeutic applications.
  Journal
Exp Cell Res 318:1245-51 (2012)
DOI:10.1016/j.yexcr.2012.03.005
Reference
PMID:26231733
  Authors
Dashzeveg N, Yoshida K
  Title
Cell death decision by p53 via control of the mitochondrial membrane.
  Journal
Cancer Lett 367:108-12 (2015)
DOI:10.1016/j.canlet.2015.07.019
Reference
PMID:22075987
  Authors
Bouchier-Hayes L, Green DR
  Title
Caspase-2: the orphan caspase.
  Journal
Cell Death Differ 19:51-7 (2012)
DOI:10.1038/cdd.2011.157
Reference
PMID:18238895
  Authors
Baptiste-Okoh N, Barsotti AM, Prives C
  Title
A role for caspase 2 and PIDD in the process of p53-mediated apoptosis.
  Journal
Proc Natl Acad Sci U S A 105:1937-42 (2008)
DOI:10.1073/pnas.0711800105
Reference
PMID:12949498
  Authors
Aggarwal BB
  Title
Signalling pathways of the TNF superfamily: a double-edged sword.
  Journal
Nat Rev Immunol 3:745-56 (2003)
DOI:10.1038/nri1184
Reference
PMID:14737178
  Authors
Steelman LS, Pohnert SC, Shelton JG, Franklin RA, Bertrand FE, McCubrey JA.
  Title
JAK/STAT, Raf/MEK/ERK, PI3K/Akt and BCR-ABL in cell cycle progression and leukemogenesis.
  Journal
Leukemia 18:189-218 (2004)
DOI:10.1038/sj.leu.2403241
Reference
PMID:9916983
  Authors
Dragovich T, Rudin CM, Thompson CB
  Title
Signal transduction pathways that regulate cell survival and cell death.
  Journal
Oncogene 17:3207-13 (1998)
DOI:10.1038/sj.onc.1202587
Reference
PMID:11520933
  Authors
Sofroniew MV, Howe CL, Mobley WC
  Title
Nerve growth factor signaling, neuroprotection, and neural repair.
  Journal
Annu Rev Neurosci 24:1217-81 (2001)
DOI:10.1146/annurev.neuro.24.1.1217
Reference
PMID:24769728
  Authors
Kristiansen M, Ham J
  Title
Programmed cell death during neuronal development: the sympathetic neuron model.
  Journal
Cell Death Differ 21:1025-35 (2014)
DOI:10.1038/cdd.2014.47
Reference
PMID:18208375
  Authors
Logue SE, Martin SJ
  Title
Caspase activation cascades in apoptosis.
  Journal
Biochem Soc Trans 36:1-9 (2008)
DOI:10.1042/BST0360001
Reference
PMID:19770840
  Authors
Boivin WA, Cooper DM, Hiebert PR, Granville DJ
  Title
Intracellular versus extracellular granzyme B in immunity and disease: challenging the dogma.
  Journal
Lab Invest 89:1195-220 (2009)
DOI:10.1038/labinvest.2009.91
Reference
PMID:20075940
  Authors
Cullen SP, Brunet M, Martin SJ
  Title
Granzymes in cancer and immunity.
  Journal
Cell Death Differ 17:616-23 (2010)
DOI:10.1038/cdd.2009.206
Related
pathway
caty04010  MAPK signaling pathway
caty04020  Calcium signaling pathway
caty04064  NF-kappa B signaling pathway
caty04115  p53 signaling pathway
caty04141  Protein processing in endoplasmic reticulum
caty04151  PI3K-Akt signaling pathway
caty04650  Natural killer cell mediated cytotoxicity
caty04668  TNF signaling pathway
KO pathway
ko04210   
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