KEGG   PATHWAY: cide04217
Entry
cide04217                   Pathway                                
Name
Necroptosis - Ctenopharyngodon idella (grass carp)
Description
Necroptosis is a programmed form of necrosis. It can be initiated by different stimuli, such as tumor necrosis factor (TNF), TNF-related apoptosis-inducing ligand (TRAIL), Fas ligand (FasL), interferon (IFN), LPS, viral DNA or RNA, DNA-damage agent and requires the kinase activity of receptor-interacting protein 1 (RIPK1) and RIPK3. Its execution involves ROS generation, calcium overload, the opening of the mitochondrial permeability transition pore, mitochondrial fission, inflammatory response and chromatinolysis. Necroptosis participates in many pathogenesis of diseases, including neurological diseases, retinal disorders, acute kidney injury, inflammatory diseases and microbial infections.
Class
Cellular Processes; Cell growth and death
Pathway map
cide04217  Necroptosis
cide04217

Organism
Ctenopharyngodon idella (grass carp) [GN:cide]
Gene
127500528  tumor necrosis factor a (TNF superfamily, member 2) [KO:K03156]
127496665  tumor necrosis factor receptor superfamily member 1A [KO:K03158]
127515345  tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
127512151  TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
127512173  TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
127513416  TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
127520774  TNF receptor-associated factor 5 [KO:K09849]
127502910  receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
127503263  baculoviral IAP repeat-containing protein 2 isoform X1 [KO:K16060]
127525703  E3 ubiquitin-protein ligase XIAP isoform X1 [KO:K04725] [EC:2.3.2.27]
127516420  ranBP-type and C3HC4-type zinc finger-containing protein 1 [KO:K10630] [EC:2.3.2.31]
127519763  ranBP-type and C3HC4-type zinc finger-containing protein 1 [KO:K10630] [EC:2.3.2.31]
127498416  E3 ubiquitin-protein ligase RNF31 [KO:K11974] [EC:2.3.2.31]
127499732  si:dkey-181m9.8; uncharacterized protein si:dkey-181m9.8 [KO:K11974] [EC:2.3.2.31]
127503207  ranBP-type and C3HC4-type zinc finger-containing protein 1 [KO:K20894]
127499373  spermatogenesis associated 2-like [KO:K17595]
127515711  si:ch211-189a15.5; uncharacterized protein si:ch211-189a15.5 [KO:K17595]
127505168  spermatogenesis-associated protein 2 isoform X1 [KO:K17595]
127515227  ubiquitin carboxyl-terminal hydrolase CYLD isoform X1 [KO:K08601] [EC:3.4.19.12]
127516493  si:cabz01101003.1; ubiquitin carboxyl-terminal hydrolase CYLD [KO:K08601] [EC:3.4.19.12]
127514169  ubiquitin carboxyl-terminal hydrolase CYLD isoform X1 [KO:K08601] [EC:3.4.19.12]
127516809  protein FADD [KO:K02373]
127514801  caspase 8, apoptosis-related cysteine peptidase, like 1 [KO:K04398] [EC:3.4.22.61]
127519169  caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
127513314  caspase-22 isoform X1 [KO:K04398] [EC:3.4.22.61]
127514005  caspase-8 [KO:K04398] [EC:3.4.22.61]
127522206  CASP8 and FADD-like apoptosis regulator a [KO:K04724]
127519170  CASP8 and FADD-like apoptosis regulator isoform X1 [KO:K04724]
127516504  receptor-interacting serine/threonine-protein kinase 3-like [KO:K08847] [EC:2.7.11.1]
127516575  receptor-interacting serine/threonine-protein kinase 3-like [KO:K08847] [EC:2.7.11.1]
127522405  cytochrome b-245 heavy chain isoform X1 [KO:K21421] [EC:1.-.-.-]
127521735  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
127515592  calcium/calmodulin-dependent protein kinase type II delta 1 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
127509896  calcium/calmodulin-dependent protein kinase type II delta 2 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
127524192  calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma 1 isoform X1 [KO:K04515] [EC:2.7.11.17]
127524622  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
127503963  calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
127513679  calcium/calmodulin-dependent protein kinase (CaM kinase) II beta 1 isoform X1 [KO:K04515] [EC:2.7.11.17]
127510559  ADP/ATP translocase 1 [KO:K05863]
127519433  ADP/ATP translocase 3 [KO:K05863]
127525677  ADP/ATP translocase 2 [KO:K05863]
127513667  si:dkey-251i10.1; ADP/ATP translocase 2 [KO:K05863]
127525672  peptidyl-prolyl cis-trans isomerase D [KO:K05864] [EC:5.2.1.8]
127504160  voltage-dependent anion-selective channel protein 1 [KO:K05862]
127523219  voltage-dependent anion-selective channel protein 2 [KO:K15040]
127517701  voltage-dependent anion-selective channel protein 3 [KO:K15041]
127521015  zgc:56235; voltage-dependent anion-selective channel protein 2-like [KO:K15041]
127523559  glutamate dehydrogenase 1b [KO:K00261] [EC:1.4.1.3]
127523582  glutamate dehydrogenase, mitochondrial [KO:K00261] [EC:1.4.1.3]
127524548  glutamate dehydrogenase 1a [KO:K00261] [EC:1.4.1.3]
127514534  glutamine synthetase [KO:K01915] [EC:6.3.1.2]
127499809  glutamate-ammonia ligase (glutamine synthase) a [KO:K01915] [EC:6.3.1.2]
127504324  glutamine synthetase-like [KO:K01915] [EC:6.3.1.2]
127516259  phosphorylase, glycogen, muscle b [KO:K00688] [EC:2.4.1.1]
127504089  glycogen phosphorylase, muscle form [KO:K00688] [EC:2.4.1.1]
127525058  glycogen phosphorylase, liver form [KO:K00688] [EC:2.4.1.1]
127498152  glycogen phosphorylase, brain form [KO:K00688] [EC:2.4.1.1]
127523601  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
127503188  mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
127524755  mitogen-activated protein kinase 10-like isoform X1 [KO:K04440] [EC:2.7.11.24]
127524923  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
127503882  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
127506217  zgc:56095; ferritin, lower subunit-like [KO:K00522] [EC:1.16.3.1]
127506540  ferritin, heavy polypeptide 1b [KO:K00522] [EC:1.16.3.1]
127515937  ferritin, heavy polypeptide 1a [KO:K00522] [EC:1.16.3.1]
127509220  LOW QUALITY PROTEIN: ferritin, heavy polypeptide-like 27 [KO:K00522] [EC:1.16.3.1]
127509222  ferritin, middle subunit-like [KO:K00522] [EC:1.16.3.1]
127509223  ferritin, middle subunit-like [KO:K00522] [EC:1.16.3.1]
127502123  cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
127495782  cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
127512115  cytosolic phospholipase A2 gamma-like isoform X1 [KO:K16342] [EC:3.1.1.4]
127512273  cytosolic phospholipase A2 gamma-like isoform X1 [KO:K16342] [EC:3.1.1.4]
127512906  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
127512908  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
127513086  cytosolic phospholipase A2 gamma-like isoform X1 [KO:K16342] [EC:3.1.1.4]
127513088  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
127513089  cytosolic phospholipase A2 gamma-like isoform X1 [KO:K16342] [EC:3.1.1.4]
127513090  cytosolic phospholipase A2 gamma-like isoform X1 [KO:K16342] [EC:3.1.1.4]
127513122  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
127513529  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
127498743  cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
127498856  cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
127498857  cytosolic phospholipase A2 delta isoform X1 [KO:K16342] [EC:3.1.1.4]
127515870  calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
127503143  si:dkeyp-50d11.2; calpain-1 catalytic subunit isoform X1 [KO:K01367] [EC:3.4.22.52]
127524775  calpain 1, (mu/I) large subunit a isoform X1 [KO:K01367] [EC:3.4.22.52]
127520138  calpain-1 catalytic subunit b [KO:K01367] [EC:3.4.22.52]
127498406  calpain-1 catalytic subunit-like [KO:K01367] [EC:3.4.22.52]
127498407  calpain-8-like [KO:K01367] [EC:3.4.22.52]
127521576  calpain-8 [KO:K03853] [EC:3.4.22.53]
127521577  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
127524777  calpain 2, (m/II) large subunit a [KO:K03853] [EC:3.4.22.53]
127520139  calpain 2, (m/II) large subunit b isoform X1 [KO:K03853] [EC:3.4.22.53]
127520684  calpain 2, (m/II) large subunit, like [KO:K03853] [EC:3.4.22.53]
127520262  sphingomyelin phosphodiesterase [KO:K12350] [EC:3.1.4.12]
127507187  mixed lineage kinase domain-like protein [KO:K08849] [EC:2.7.11.1]
127512065  serine/threonine-protein phosphatase PGAM5, mitochondrial isoform X1 [KO:K15637] [EC:3.1.3.16]
127506622  dynamin-1-like protein isoform X1 [KO:K17065] [EC:3.6.5.5]
127517085  si:dkey-32e23.4; dynamin-1-like protein isoform X1 [KO:K17065] [EC:3.6.5.5]
127496876  apoptosis-associated speck-like protein containing a CARD isoform X1 [KO:K12799]
127508390  caspase b-like [KO:K01370] [EC:3.4.22.36]
127511353  caspase b-like [KO:K01370] [EC:3.4.22.36]
127496856  caspase a [KO:K01370] [EC:3.4.22.36]
127520202  interleukin-1 beta isoform X1 [KO:K04519]
127523312  charged multivesicular body protein 2a [KO:K12191]
127512409  charged multivesicular body protein 2b isoform X1 [KO:K12192]
127518926  charged multivesicular body protein 2Ba isoform X1 [KO:K12192]
127498853  charged multivesicular body protein 3 isoform X1 [KO:K12193]
127517622  charged multivesicular body protein 4c [KO:K12194]
127513868  charged multivesicular body protein 4b [KO:K12194]
127506347  charged multivesicular body protein 4c [KO:K24782]
127508205  charged multivesicular body protein 6 [KO:K12195]
127524209  charged multivesicular body protein 6 [KO:K12195]
127507096  vacuolar protein sorting-associated protein 4A [KO:K12196]
127497259  vacuolar protein sorting-associated protein 4B isoform X1 [KO:K12196]
127520838  vacuolar protein sorting-associated protein 4B-like [KO:K12196]
127506988  charged multivesicular body protein 1a [KO:K12197]
127513175  charged multivesicular body protein 1b [KO:K12197]
127516518  charged multivesicular body protein 5 [KO:K12198]
127496912  charged multivesicular body protein 5 isoform X1 [KO:K12198]
127517790  charged multivesicular body protein 7 isoform X1 [KO:K15053]
127499641  transient receptor potential cation channel subfamily M member 7 [KO:K04982] [EC:2.7.11.1]
127495794  high mobility group protein B1b [KO:K10802]
127521040  high mobility group protein B1a [KO:K10802]
127506009  tumor necrosis factor ligand superfamily member 10 [KO:K04721]
127512245  hematopoietic death receptor isoform X1 [KO:K04722]
127502691  tumor necrosis factor ligand superfamily member 6 [KO:K04389]
127499172  tumor necrosis factor receptor superfamily member 6 [KO:K04390]
127507370  LOW QUALITY PROTEIN: interferon phi 1 [KO:K05414]
127509065  interferon phi 3 [KO:K05414]
127519395  cytokine receptor family member b2 [KO:K05131]
127524637  LOW QUALITY PROTEIN: interferon gamma receptor 1-like [KO:K05132]
127515616  interferon gamma receptor 1 [KO:K05132]
127523162  tyrosine-protein kinase JAK1-like [KO:K11217] [EC:2.7.10.2]
127513981  tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
127504202  tyrosine-protein kinase JAK2a [KO:K04447] [EC:2.7.10.2]
127512874  tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
127517633  tyrosine-protein kinase JAK2 isoform X1 [KO:K11218] [EC:2.7.10.2]
127509201  non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
127519048  signal transducer and activator of transcription 1b isoform X1 [KO:K11220]
127519050  signal transducer and activator of transcription 1-like [KO:K11220]
127519975  signal transducer and activator of transcription 1a isoform X1 [KO:K11220]
127513816  signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
127510137  signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
127519047  signal transducer and activator of transcription 4 isoform X1 [KO:K11222]
127523584  signal transducer and activator of transcription 5B isoform X1 [KO:K11224]
127510139  signal transducer and activator of transcription 5A isoform X1 [KO:K11224]
127504671  signal transducer and activator of transcription 6 [KO:K11225]
127523236  interferon regulatory factor 9 [KO:K04693]
127524372  interferon-induced, double-stranded RNA-activated protein kinase isoform X1 [KO:K16195] [EC:2.7.11.1]
127525007  toll-like receptor 4 isoform X1 [KO:K10160]
127525009  toll-like receptor 4b, duplicate b [KO:K10160]
127525012  toll-like receptor 4 [KO:K10160]
127521475  TIR domain-containing adapter molecule 1 [KO:K05842]
127512541  toll-like receptor 3 isoform X1 [KO:K05401]
127505013  ubiquitin carboxyl-terminal hydrolase 21 [KO:K21634] [EC:3.4.19.12]
127494206  sequestosome-1 isoform X1 [KO:K14381]
127501922  heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2 isoform X1 [KO:K04079]
127501923  heat shock protein HSP 90-alpha 1 [KO:K04079]
127502106  heat shock protein HSP 90-beta [KO:K04079]
127524917  tumor necrosis factor alpha-induced protein 3 [KO:K11859] [EC:3.4.19.12]
127502321  poly [ADP-ribose] polymerase 1 [KO:K24070] [EC:2.4.2.30]
127500151  BH3 interacting domain death agonist [KO:K04726]
127509026  BCL2 associated X, apoptosis regulator a [KO:K02159]
127516808  zgc:153993; apoptosis regulator BAX isoform X1 [KO:K02159]
127512388  apoptosis-inducing factor 1, mitochondrial isoform X1 [KO:K04727] [EC:1.-.-.-]
127521604  histone H2A [KO:K11251]
127506824  histone H2A [KO:K11251]
127506825  histone H2A-like [KO:K11251]
127506826  histone H2A [KO:K11251]
127506827  histone H2A-like [KO:K11251]
127506828  histone H2A-like [KO:K11251]
127506829  histone H2A-like [KO:K11251]
127506830  histone H2A-like [KO:K11251]
127506860  histone H2A [KO:K11251]
127506861  histone H2A [KO:K11251]
127506862  histone H2A [KO:K11251]
127506863  histone H2A [KO:K11251]
127506864  histone H2A [KO:K11251]
127506865  histone H2A [KO:K11251]
127506866  histone H2A [KO:K11251]
127506867  histone H2A [KO:K11251]
127506868  histone H2A [KO:K11251]
127506869  histone H2A [KO:K11251]
127506870  histone H2A [KO:K11251]
127506871  histone H2A [KO:K11251]
127506872  histone H2A [KO:K11251]
127506873  histone H2A-like [KO:K11251]
127506874  histone H2A-like [KO:K11251]
127506875  histone H2A-like [KO:K11251]
127506876  histone H2A [KO:K11251]
127506877  histone H2A [KO:K11251]
127506878  histone H2A-like [KO:K11251]
127506879  histone H2A [KO:K11251]
127515309  histone H2A-like [KO:K11251]
127515314  histone H2A-like isoform X1 [KO:K11251]
127515316  histone H2A-like [KO:K11251]
127515317  histone H2A-like [KO:K11251]
127515319  histone H2A-like [KO:K11251]
127515320  histone H2A-like [KO:K11251]
127515321  histone H2A-like [KO:K11251]
127515322  histone H2A-like [KO:K11251]
127515631  histone H2A-beta, sperm-like [KO:K11251]
127515776  histone H2A [KO:K11251]
127515777  histone H2A [KO:K11251]
127515778  histone H2A [KO:K11251]
127515779  histone H2A [KO:K11251]
127515876  histone H2A-like [KO:K11251]
127516310  histone H2A-like [KO:K11251]
127516312  histone H2A-like [KO:K11251]
127516313  histone H2A-like [KO:K11251]
127516568  LOW QUALITY PROTEIN: histone H2A.Z-like [KO:K11251]
127509059  histone H2A, sperm [KO:K11251]
127524439  core histone macro-H2A.2 [KO:K11251]
127504059  core histone macro-H2A.1 isoform X1 [KO:K11251]
127512483  histone H2A.V [KO:K11251]
127520205  histone H2A.V [KO:K11251]
127520299  histone H2AX-like [KO:K11251]
127520062  peptidylprolyl isomerase Ab (cyclophilin A) [KO:K03767] [EC:5.2.1.8]
127517625  peptidyl-prolyl cis-trans isomerase A [KO:K03767] [EC:5.2.1.8]
127498514  apoptosis regulator Bcl-2 [KO:K02161]
127505882  apoptosis regulator Bcl-2a isoform X1 [KO:K02161]
Compound
C00002  ATP
C00027  Hydrogen peroxide
C00076  Calcium cation
C00195  N-Acylsphingosine
C00219  Arachidonate
C00305  Magnesium cation
C00319  Sphingosine
C00550  Sphingomyelin
C14592  N-Methyl-N'-nitro-N-nitrosoguanidine
C16844  Hydroxyl radical
Reference
PMID:20823910
  Authors
Vandenabeele P, Galluzzi L, Vanden Berghe T, Kroemer G
  Title
Molecular mechanisms of necroptosis: an ordered cellular explosion.
  Journal
Nat Rev Mol Cell Biol 11:700-14 (2010)
DOI:10.1038/nrm2970
Reference
PMID:26008591
  Authors
Brenner D, Blaser H, Mak TW
  Title
Regulation of tumour necrosis factor signalling: live or let die.
  Journal
Nat Rev Immunol 15:362-74 (2015)
DOI:10.1038/nri3834
Reference
PMID:26775689
  Authors
Conrad M, Angeli JP, Vandenabeele P, Stockwell BR
  Title
Regulated necrosis: disease relevance and therapeutic opportunities.
  Journal
Nat Rev Drug Discov 15:348-66 (2016)
DOI:10.1038/nrd.2015.6
Reference
PMID:24129419
  Authors
Ofengeim D, Yuan J
  Title
Regulation of RIP1 kinase signalling at the crossroads of inflammation and cell death.
  Journal
Nat Rev Mol Cell Biol 14:727-36 (2013)
DOI:10.1038/nrm3683
Reference
PMID:27158445
  Authors
Murphy JM, Vince JE
  Title
Post-translational control of RIPK3 and MLKL mediated necroptotic cell death.
  Journal
F1000Res 4:F1000 Faculty Rev-1297 (2015)
DOI:10.12688/f1000research.7046.1
Reference
PMID:24452471
  Authors
Vanden Berghe T, Linkermann A, Jouan-Lanhouet S, Walczak H, Vandenabeele P
  Title
Regulated necrosis: the expanding network of non-apoptotic cell death pathways.
  Journal
Nat Rev Mol Cell Biol 15:135-47 (2014)
DOI:10.1038/nrm3737
Reference
PMID:27368376
  Authors
Dondelinger Y, Hulpiau P, Saeys Y, Bertrand MJ, Vandenabeele P
  Title
An evolutionary perspective on the necroptotic pathway.
  Journal
Trends Cell Biol 26:721-32 (2016)
DOI:10.1016/j.tcb.2016.06.004
Reference
PMID:27746097
  Authors
Thapa RJ, Ingram JP, Ragan KB, Nogusa S, Boyd DF, Benitez AA, Sridharan H, Kosoff R, Shubina M, Landsteiner VJ, Andrake M, Vogel P, Sigal LJ, tenOever BR, Thomas PG, Upton JW, Balachandran S
  Title
DAI Senses Influenza A Virus Genomic RNA and Activates RIPK3-Dependent Cell Death.
  Journal
Cell Host Microbe 20:674-681 (2016)
DOI:10.1016/j.chom.2016.09.014
Reference
PMID:27984721
  Authors
Yuan J, Najafov A, Py BF
  Title
Roles of Caspases in Necrotic Cell Death.
  Journal
Cell 167:1693-1704 (2016)
DOI:10.1016/j.cell.2016.11.047
Reference
PMID:28138137
  Authors
Jorgensen I, Rayamajhi M, Miao EA
  Title
Programmed cell death as a defence against infection.
  Journal
Nat Rev Immunol 17:151-164 (2017)
DOI:10.1038/nri.2016.147
Reference
PMID:20354226
  Authors
Vandenabeele P, Declercq W, Van Herreweghe F, Vanden Berghe T
  Title
The role of the kinases RIP1 and RIP3 in TNF-induced necrosis.
  Journal
Sci Signal 3:re4 (2010)
DOI:10.1126/scisignal.3115re4
Reference
PMID:22075985
  Authors
Vanlangenakker N, Vanden Berghe T, Vandenabeele P
  Title
Many stimuli pull the necrotic trigger, an overview.
  Journal
Cell Death Differ 19:75-86 (2012)
DOI:10.1038/cdd.2011.164
Reference
PMID:23913919
  Authors
Moriwaki K, Chan FK
  Title
RIP3: a molecular switch for necrosis and inflammation.
  Journal
Genes Dev 27:1640-9 (2013)
DOI:10.1101/gad.223321.113
Reference
PMID:25146926
  Authors
Humphries F, Yang S, Wang B, Moynagh PN
  Title
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Cell Death Differ 22:225-36 (2015)
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Wegner KW, Saleh D, Degterev A
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Complex Pathologic Roles of RIPK1 and RIPK3: Moving Beyond Necroptosis.
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Trends Pharmacol Sci 38:202-225 (2017)
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SPATA2-Mediated Binding of CYLD to HOIP Enables CYLD Recruitment to Signaling Complexes.
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Cell Rep 16:2271-80 (2016)
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The Autophagy Machinery Controls Cell Death Switching between Apoptosis and Necroptosis.
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Dev Cell 37:337-49 (2016)
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J Biol Chem 285:969-78 (2010)
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Cell Chem Biol 23:205-7 (2016)
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Nat Immunol 16:596-7 (2015)
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J Mol Cell Cardiol 103:102-109 (2017)
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Cell Death Differ 16:1419-25 (2009)
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Proc Natl Acad Sci U S A 110:E3109-18 (2013)
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NF-kappaB protects cells from gamma interferon-induced RIP1-dependent necroptosis.
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Mol Cell Biol 31:2934-46 (2011)
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Programmed necrosis in microbial pathogenesis.
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Trends Microbiol 22:199-207 (2014)
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Cell Death Differ 19:245-56 (2012)
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Cell Cycle 9:3166-73 (2010)
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Cell Host Microbe 21:290-293 (2017)
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The diverse role of RIP kinases in necroptosis and inflammation.
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Nat Immunol 16:689-97 (2015)
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Cell 169:186-187 (2017)
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ESCRT-III Acts Downstream of MLKL to Regulate Necroptotic Cell Death and Its Consequences.
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Cell 169:286-300.e16 (2017)
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Immunol Cell Biol 95:152-159 (2017)
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Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis.
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Nat Cell Biol 16:55-65 (2014)
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Lawlor KE, Khan N, Mildenhall A, Gerlic M, Croker BA, D'Cruz AA, Hall C, Kaur Spall S, Anderton H, Masters SL, Rashidi M, Wicks IP, Alexander WS, Mitsuuchi Y, Benetatos CA, Condon SM, Wong WW, Silke J, Vaux DL, Vince JE
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RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL.
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Nat Commun 6:6282 (2015)
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Mechanisms of RIPK3-induced inflammation.
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Immunol Cell Biol 95:166-172 (2017)
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pathway
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cide04210  Apoptosis
KO pathway
ko04217   
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