KEGG   PATHWAY: cimi05202
Entry
cimi05202                   Pathway                                
Name
Transcriptional misregulation in cancer - Cebus imitator (Panamanian white-faced capuchin)
Description
In tumor cells, genes encoding transcription factors (TFs) are often amplified, deleted, rearranged via chromosomal translocation and inversion, or subjected to point mutations that result in a gain- or loss-of- function. In hematopoietic cancers and solid tumors, the translocations and inversions increase or deregulate transcription of the oncogene. Recurrent chromosome translocations generate novel fusion oncoproteins, which are common in myeloid cancers and soft-tissue sarcomas. The fusion proteins have aberrant transcriptional function compared to their wild-type counterparts. These fusion transcription factors alter expression of target genes, and thereby result in a variety of altered cellular properties that contribute to the tumourigenic process.
Class
Human Diseases; Cancer: overview
Pathway map
cimi05202  Transcriptional misregulation in cancer
cimi05202

Organism
Cebus imitator (Panamanian white-faced capuchin) [GN:cimi]
Gene
108302545  RUNX1; runt-related transcription factor 1 isoform X1 [KO:K08367]
108306404  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
108312045  MPO; myeloperoxidase [KO:K10789] [EC:1.11.2.2]
108307021  CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427]
108307022  IL3; interleukin-3 [KO:K04736]
108310889  RUNX1T1; LOW QUALITY PROTEIN: protein CBFA2T1 [KO:K10053]
108303947  HDAC1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
108306044  HDAC2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
108317469  SIN3A; paired amphipathic helix protein Sin3a [KO:K11644]
108281319  NCOR1; nuclear receptor corepressor 1 [KO:K04650]
108286404  CEBPA; CCAAT/enhancer-binding protein alpha [KO:K09055]
108310692  PER2; period circadian protein homolog 2 [KO:K02633]
108304844  SPI1; transcription factor PU.1 isoform X1 [KO:K09438]
108310098  CD14; monocyte differentiation antigen CD14 [KO:K04391]
108293916  ITGAM; integrin alpha-M isoform X1 [KO:K06461]
108297700  LOW QUALITY PROTEIN: high affinity immunoglobulin gamma Fc receptor IB [KO:K06498]
108316383  FCGR1A; high affinity immunoglobulin gamma Fc receptor I [KO:K06498]
108289851  junction plakoglobin [KO:K10056]
108317496  PML; protein PML isoform X1 [KO:K10054] [EC:2.3.2.-]
108281518  RARA; retinoic acid receptor alpha isoform X1 [KO:K08527]
108310820  CCNA1; cyclin-A1 [KO:K06627]
108281889  CCNA2; cyclin-A2 [KO:K06627]
108315273  CEBPE; CCAAT/enhancer-binding protein epsilon [KO:K10051]
108289681  BCL2A1; LOW QUALITY PROTEIN: bcl-2-related protein A1 [KO:K02162]
108300527  ZBTB16; zinc finger and BTB domain-containing protein 16 [KO:K10055]
108283896  MYC; myc proto-oncogene protein [KO:K04377]
108292184  DUSP6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
108293140  TCF3; transcription factor E2-alpha isoform X2 [KO:K09063]
108308288  PBX1; pre-B-cell leukemia transcription factor 1 isoform X1 [KO:K09355]
108292788  WNT16; protein Wnt-16 [KO:K01558]
108287706  ETV6; transcription factor ETV6 isoform X1 [KO:K03211]
108299998  ETV7; transcription factor ETV7 isoform X2 [KO:K03211]
108291083  uncharacterized protein LOC108291083 [KO:K10785]
108291134  uncharacterized protein LOC108291134 [KO:K10785]
108291137  uncharacterized protein LOC108291137 [KO:K10785]
108298913  theta defensin subunit A-like [KO:K05230]
108298912  theta defensin subunit A-like [KO:K05230]
108293116  neutrophil defensin 4-like [KO:K05230]
108293123  demidefensin-3-like [KO:K05230]
108293124  neutrophil defensin 1-like [KO:K05230]
108293125  defensin-5-like [KO:K05230]
108293190  ELANE; neutrophil elastase [KO:K01327] [EC:3.4.21.37]
108295519  granzyme B-like [KO:K01353] [EC:3.4.21.79]
108300601  KMT2A; histone-lysine N-methyltransferase 2A isoform X1 [KO:K09186] [EC:2.1.1.354]
108315645  AFF1; AF4/FMR2 family member 1 [KO:K15184]
108318197  CDK9; cyclin-dependent kinase 9 isoform X1 [KO:K02211] [EC:2.7.11.22 2.7.11.23]
108309649  CCNT2; cyclin-T2 isoform X1 [KO:K15188]
108316025  CCNT1; cyclin-T1 [KO:K15188]
108284003  MLLT3; protein AF-9 isoform X1 [KO:K15187]
108304231  MLLT1; protein ENL isoform X1 [KO:K15187]
108288448  DOT1L; histone-lysine N-methyltransferase, H3 lysine-79 specific [KO:K11427] [EC:2.1.1.360]
108305776  LMO2; rhombotin-2 isoform X1 [KO:K15612]
108318231  PBX3; pre-B-cell leukemia transcription factor 3 isoform X1 [KO:K15610]
108286968  RUNX2; runt-related transcription factor 2 isoform X1 [KO:K09278]
108308725  SMAD1; mothers against decapentaplegic homolog 1 [KO:K04676]
108303461  KLF3; Krueppel-like factor 3 isoform X1 [KO:K15605]
108289016  MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
108303270  HOXA9; homeobox protein Hox-A9 [KO:K21950]
108303269  HOXA10; homeobox protein Hox-A10 [KO:K17443]
108292237  JMJD1C; probable JmjC domain-containing histone demethylation protein 2C [KO:K11449] [EC:1.14.11.-]
108294104  HMGA2; high mobility group protein HMGI-C isoform X2 [KO:K09283]
108285076  KDM6A; lysine-specific demethylase 6A [KO:K11447] [EC:1.14.11.68]
108317163  SUPT3H; transcription initiation protein SPT3 homolog isoform X1 [KO:K11313]
108282742  PROM1; prominin-1 isoform X1 [KO:K06532]
108310422  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
108312252  BMP2K; BMP-2-inducible protein kinase isoform X1 [KO:K08854] [EC:2.7.11.1]
108294997  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
108304025  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
108309924  CDK14; cyclin-dependent kinase 14 isoform X1 [KO:K08821] [EC:2.7.11.22]
108299691  MEIS1; homeobox protein Meis1 isoform X1 [KO:K15613]
108303272  HOXA11; homeobox protein Hox-A11 [KO:K21951]
108308199  SIX1; homeobox protein SIX1 [KO:K15614]
108308200  SIX4; homeobox protein SIX4 [KO:K15615]
108315280  EYA1; eyes absent homolog 1 isoform X1 [KO:K15616] [EC:3.1.3.48]
108318024  CDKN2C; cyclin-dependent kinase 4 inhibitor C [KO:K06622]
108282550  HPGD; 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform X1 [KO:K00069] [EC:1.1.1.141]
108281822  GRIA3; glutamate receptor 3 isoform X1 [KO:K05199]
108308258  FUT8; alpha-(1,6)-fucosyltransferase isoform X1 [KO:K00717] [EC:2.4.1.68]
108317347  TLX3; T-cell leukemia homeobox protein 3 [KO:K15607]
108306342  TLX1; T-cell leukemia homeobox protein 1 [KO:K09340]
108312337  B-cell lymphoma/leukemia 11B-like [KO:K22046]
108306320  LDB1; LIM domain-binding protein 1 isoform X1 [KO:K15617]
108281967  LYL1; protein lyl-1 isoform X1 [KO:K15604]
108282304  HHEX; hematopoietically-expressed homeobox protein HHEX [KO:K08024]
108317106  PTCRA; pre T-cell antigen receptor alpha [KO:K06056]
108315607  REL; proto-oncogene c-Rel [KO:K09254]
108316314  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
108315419  BIRC2; baculoviral IAP repeat-containing protein 2 isoform X1 [KO:K16060]
108307639  BIRC3; baculoviral IAP repeat-containing protein 3 isoform X1 [KO:K16060]
108285843  TRAF1; TNF receptor-associated factor 1 [KO:K03172]
108293471  BCL2L1; bcl-2-like protein 1 [KO:K04570]
108288944  CD86; T-lymphocyte activation antigen CD86 isoform X1 [KO:K05413]
108313050  CD40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160]
108318511  BCL6; B-cell lymphoma 6 protein [KO:K15618]
108313473  MAF; transcription factor Maf isoform X1 [KO:K09035]
108284857  ITGB7; integrin beta-7 isoform X1 [KO:K06590]
108311573  NSD2; histone-lysine N-methyltransferase NSD2 isoform X1 [KO:K11424] [EC:2.1.1.357]
108298782  histone H3.1-like [KO:K11253]
108309432  histone H3.3A [KO:K11253]
108311240  histone H3.3A-like [KO:K11253]
119469499  histone H3.1 [KO:K11253]
108282019  histone H3.3A-like [KO:K11253]
108301525  histone H3.Y-like [KO:K11253]
108301526  histone H3.Y-like [KO:K11253]
108297243  histone H3-like centromeric protein CSE4 [KO:K11253]
108291677  LOW QUALITY PROTEIN: histone H3-like 3 [KO:K11253]
108302741  histone H3.3A [KO:K11253]
119473709  histone H3.3A-like [KO:K11253]
119473829  histone H3-like [KO:K11253]
108314971  histone H3.3C-like [KO:K11253]
108315074  histone H3.3A-like [KO:K11253]
108285395  histone H3.3A-like [KO:K11253]
108306905  histone H3.3A-like [KO:K11253]
108286890  histone H3.3A-like [KO:K11253]
108287010  histone H3.1 [KO:K11253]
108287021  histone H3.1-like [KO:K11253]
108317468  histone H3.3A-like [KO:K11253]
108306906  histone H3.3A-like [KO:K11253]
108314278  PAX5; paired box protein Pax-5 isoform X1 [KO:K09383]
108318629  PAX8; paired box protein Pax-8 isoform X1 [KO:K09293]
108284639  PPARG; peroxisome proliferator-activated receptor gamma isoform X1 [KO:K08530]
108304340  retinoic acid receptor RXR-alpha-like [KO:K08524]
108292290  RXRA; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
108300058  RXRB; retinoic acid receptor RXR-beta isoform X1 [KO:K08525]
108308292  RXRG; retinoic acid receptor RXR-gamma [KO:K08526]
108290255  PRCC; proline-rich protein PRCC [KO:K13105]
108298369  TFE3; transcription factor E3 isoform X1 [KO:K09105]
108299987  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
108311235  TMPRSS2; transmembrane protease serine 2 isoform X1 [KO:K09633] [EC:3.4.21.122]
108302580  ERG; transcriptional regulator ERG isoform X1 [KO:K09435]
108318551  PLAU; urokinase-type plasminogen activator [KO:K01348] [EC:3.4.21.73]
108316182  PLAT; tissue-type plasminogen activator [KO:K01343] [EC:3.4.21.68]
108315431  MMP3; stromelysin-1 [KO:K01394] [EC:3.4.24.17]
108313047  MMP9; matrix metalloproteinase-9 [KO:K01403] [EC:3.4.24.35]
108309209  ZEB1; zinc finger E-box-binding homeobox 1 isoform X1 [KO:K09299]
108317430  IL1R2; LOW QUALITY PROTEIN: interleukin-1 receptor type 2 [KO:K04387]
108306158  SPINT1; kunitz-type protease inhibitor 1 [KO:K15619]
108290524  ETV1; ETS translocation variant 1 [KO:K09431]
108294302  ETV4; ETS translocation variant 4 isoform X1 [KO:K15592]
108311108  ETV5; ETS translocation variant 5 isoform X2 [KO:K15593]
108302063  SLC45A3; solute carrier family 45 member 3 [KO:K15379]
108302062  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
108295567  DDX5; probable ATP-dependent RNA helicase DDX5 [KO:K12823] [EC:5.6.2.7]
108302488  MYCN; N-myc proto-oncogene protein [KO:K09109]
108308255  MAX; protein max isoform X1 [KO:K04453]
108300229  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
108284810  PTK2; focal adhesion kinase 1 isoform X11 [KO:K05725] [EC:2.7.10.2]
108306559  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
108291478  BMI1; polycomb complex protein BMI-1 [KO:K11459]
108284876  SP1; transcription factor Sp1 [KO:K04684]
108287007  ZBTB17; zinc finger and BTB domain-containing protein 17 isoform X2 [KO:K10500]
108290257  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
108312274  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
108310275  MEN1; menin isoform X1 [KO:K14970]
108294231  LOW QUALITY PROTEIN: RNA-binding protein EWS-like [KO:K13209]
108294819  LOW QUALITY PROTEIN: RNA-binding protein EWS-like [KO:K13209]
108283249  EWSR1; RNA-binding protein EWS isoform X1 [KO:K13209]
108300642  FLI1; Friend leukemia integration 1 transcription factor [KO:K09436]
108294842  IGF1; insulin-like growth factor I isoform X2 [KO:K05459]
108301757  ID2; DNA-binding protein inhibitor ID-2 isoform X2 [KO:K17693]
108299396  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
108301430  IGFBP3; insulin-like growth factor-binding protein 3 [KO:K10138]
108309018  FEV; protein FEV [KO:K09437]
108316093  ATF1; cyclic AMP-dependent transcription factor ATF-1 isoform X1 [KO:K09053]
108289673  ARNT2; aryl hydrocarbon receptor nuclear translocator 2 isoform X1 [KO:K15589]
108316892  ATM; serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
108314073  MITF; microphthalmia-associated transcription factor isoform X1 [KO:K09455]
108293074  WT1; Wilms tumor protein isoform X1 [KO:K09234]
108289011  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
108289466  IL2RB; interleukin-2 receptor subunit beta isoform X2 [KO:K05069]
108290899  BAIAP3; BAI1-associated protein 3 [KO:K15621]
108288157  TSPAN7; tetraspanin-7 [KO:K06571]
108284121  MLF1; myeloid leukemia factor 1 isoform X1 [KO:K15622]
108303871  NR4A3; nuclear receptor subfamily 4 group A member 3 [KO:K08559]
108308384  TAF15; TATA-binding protein-associated factor 2N [KO:K14651]
108293912  FUS; RNA-binding protein FUS isoform X1 [KO:K13098]
108309731  DDIT3; LOW QUALITY PROTEIN: DNA damage-inducible transcript 3 protein [KO:K04452]
108305331  CEBPB; CCAAT/enhancer-binding protein beta [KO:K10048]
108303199  IL6; interleukin-6 isoform X1 [KO:K05405]
108286482  NFKBIZ; NF-kappa-B inhibitor zeta [KO:K14242]
108289254  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
108310400  RELA; transcription factor p65 isoform X2 [KO:K04735]
108292201  CXCL8; interleukin-8 [KO:K10030]
108309124  PAX3; paired box protein Pax-3 isoform X1 [KO:K09381]
108287402  PAX7; paired box protein Pax-7 isoform X1 [KO:K09381]
108313887  FOXO1; forkhead box protein O1 [KO:K07201]
108310455  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
108282370  SS18; protein SSXT isoform X1 [KO:K15623]
108285945  SS18L1; calcium-responsive transactivator isoform X1 [KO:K15623]
108296644  NUPR1; nuclear protein 1 [KO:K15626]
108301637  ASPSCR1; tether containing UBX domain for GLUT4 isoform X1 [KO:K15627]
108308984  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
108288511  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
108304315  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
108307085  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
108287107  apoptosis regulator BAX-like [KO:K02159]
108283911  BAX; apoptosis regulator BAX [KO:K02159]
108300037  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
108304850  DDB2; DNA damage-binding protein 2 isoform X1 [KO:K10140]
108303724  POLK; DNA polymerase kappa isoform X1 [KO:K03511] [EC:2.7.7.7]
Reference
PMID:11607818
  Authors
Alcalay M, Orleth A, Sebastiani C, Meani N, Chiaradonna F, Casciari C, Sciurpi MT, Gelmetti V, Riganelli D, Minucci S, Fagioli M, Pelicci PG
  Title
Common themes in the pathogenesis of acute myeloid leukemia.
  Journal
Oncogene 20:5680-94 (2001)
DOI:10.1038/sj.onc.1204642
Reference
PMID:12032780
  Authors
Scandura JM, Boccuni P, Cammenga J, Nimer SD
  Title
Transcription factor fusions in acute leukemia: variations on a theme.
  Journal
Oncogene 21:3422-44 (2002)
DOI:10.1038/sj.onc.1205315
Reference
PMID:12529654
  Authors
Roumier C, Fenaux P, Lafage M, Imbert M, Eclache V, Preudhomme C
  Title
New mechanisms of AML1 gene alteration in hematological malignancies.
  Journal
Leukemia 17:9-16 (2003)
DOI:10.1038/sj.leu.2402766
Reference
PMID:10717473
  Authors
Lutterbach B, Hiebert SW
  Title
Role of the transcription factor AML-1 in acute leukemia and hematopoietic differentiation.
  Journal
Gene 245:223-35 (2000)
DOI:10.1016/S0378-1119(00)00014-7
Reference
PMID:19075268
  Authors
Koschmieder S, Halmos B, Levantini E, Tenen DG
  Title
Dysregulation of the C/EBPalpha differentiation pathway in human cancer.
  Journal
J Clin Oncol 27:619-28 (2009)
DOI:10.1200/JCO.2008.17.9812
Reference
PMID:11340171
  Authors
Johansen LM, Iwama A, Lodie TA, Sasaki K, Felsher DW, Golub TR, Tenen DG
  Title
c-Myc is a critical target for c/EBPalpha in granulopoiesis.
  Journal
Mol Cell Biol 21:3789-806 (2001)
DOI:10.1128/MCB.21.11.3789-3806.2001
Reference
PMID:15985538
  Authors
Gery S, Gombart AF, Yi WS, Koeffler C, Hofmann WK, Koeffler HP
  Title
Transcription profiling of C/EBP targets identifies Per2 as a gene implicated in myeloid leukemia.
  Journal
Blood 106:2827-36 (2005)
DOI:10.1182/blood-2005-01-0358
Reference
PMID:12393465
  Authors
Vangala RK, Heiss-Neumann MS, Rangatia JS, Singh SM, Schoch C, Tenen DG, Hiddemann W, Behre G
  Title
The myeloid master regulator transcription factor PU.1 is inactivated by AML1-ETO in t(8;21) myeloid leukemia.
  Journal
Blood 101:270-7 (2003)
DOI:10.1182/blood-2002-04-1288
Reference
PMID:12130514
  Authors
Mueller BU, Pabst T, Osato M, Asou N, Johansen LM, Minden MD, Behre G, Hiddemann W, Ito Y, Tenen DG
  Title
Heterozygous PU.1 mutations are associated with acute myeloid leukemia.
  Journal
Blood 100:998-1007 (2002)
DOI:10.1182/blood.V100.3.998
Reference
PMID:15160934
  Authors
Jing Y
  Title
The PML-RARalpha fusion protein and targeted therapy for acute promyelocytic leukemia.
  Journal
Leuk Lymphoma 45:639-48 (2004)
DOI:10.1080/10428190310001609933
Reference
PMID:15024077
  Authors
Muller-Tidow C, Steffen B, Cauvet T, Tickenbrock L, Ji P, Diederichs S, Sargin B, Kohler G, Stelljes M, Puccetti E, Ruthardt M, deVos S, Hiebert SW, Koeffler HP, Berdel WE, Serve H
  Title
Translocation products in acute myeloid leukemia activate the Wnt signaling pathway in hematopoietic cells.
  Journal
Mol Cell Biol 24:2890-904 (2004)
DOI:10.1128/MCB.24.7.2890-2904.2004
Reference
PMID:19855079
  Authors
Rice KL, Hormaeche I, Doulatov S, Flatow JM, Grimwade D, Mills KI, Leiva M, Ablain J, Ambardekar C, McConnell MJ, Dick JE, Licht JD
  Title
Comprehensive genomic screens identify a role for PLZF-RARalpha as a positive regulator of cell proliferation via direct regulation of c-MYC.
  Journal
Blood 114:5499-511 (2009)
DOI:10.1182/blood-2009-03-206524
Reference
PMID:10500199
  Authors
McWhirter JR, Neuteboom ST, Wancewicz EV, Monia BP, Downing JR, Murre C
  Title
Oncogenic homeodomain transcription factor E2A-Pbx1 activates a novel WNT gene in pre-B acute lymphoblastoid leukemia.
  Journal
Proc Natl Acad Sci U S A 96:11464-9 (1999)
DOI:10.1073/pnas.96.20.11464
Reference
PMID:15156184
  Authors
Zelent A, Greaves M, Enver T
  Title
Role of the TEL-AML1 fusion gene in the molecular pathogenesis of childhood acute lymphoblastic leukaemia.
  Journal
Oncogene 23:4275-83 (2004)
DOI:10.1038/sj.onc.1207672
Reference
PMID:14630078
  Authors
Sawinska M, Ladon D
  Title
Mechanism, detection and clinical significance of the reciprocal translocation t(12;21)(p12;q22) in the children suffering from acute lymphoblastic leukaemia.
  Journal
Leuk Res 28:35-42 (2004)
DOI:10.1016/S0145-2126(03)00160-7
Reference
PMID:19141473
  Authors
Guenther MG, Lawton LN, Rozovskaia T, Frampton GM, Levine SS, Volkert TL, Croce CM, Nakamura T, Canaani E, Young RA
  Title
Aberrant chromatin at genes encoding stem cell regulators in human mixed-lineage leukemia.
  Journal
Genes Dev 22:3403-8 (2008)
DOI:10.1101/gad.1741408
Reference
PMID:16169901
  Authors
Xia ZB, Popovic R, Chen J, Theisler C, Stuart T, Santillan DA, Erfurth F, Diaz MO, Zeleznik-Le NJ
  Title
The MLL fusion gene, MLL-AF4, regulates cyclin-dependent kinase inhibitor CDKN1B (p27kip1) expression.
  Journal
Proc Natl Acad Sci U S A 102:14028-33 (2005)
DOI:10.1073/pnas.0506464102
Reference
PMID:21518926
  Authors
Wang QF, Wu G, Mi S, He F, Wu J, Dong J, Luo RT, Mattison R, Kaberlein JJ, Prabhakar S, Ji H, Thirman MJ
  Title
MLL fusion proteins preferentially regulate a subset of wild-type MLL target genes in the leukemic genome.
  Journal
Blood 117:6895-905 (2011)
DOI:10.1182/blood-2010-12-324699
Reference
PMID:14701735
  Authors
Zeisig BB, Milne T, Garcia-Cuellar MP, Schreiner S, Martin ME, Fuchs U, Borkhardt A, Chanda SK, Walker J, Soden R, Hess JL, Slany RK
  Title
Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization.
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Mol Cell Biol 24:617-28 (2004)
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PMID:19133982
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Riz I, Hawley TS, Johnston H, Hawley RG
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Br J Haematol 145:140-3 (2009)
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Gains of 2p involving the REL locus correlate with nuclear c-Rel protein accumulation in neoplastic cells of classical Hodgkin lymphoma.
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Blood 101:3681-6 (2003)
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Blood 97:2798-807 (2001)
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Best Pract Res Clin Haematol 16:1-13 (2003)
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Overexpression of c-maf is a frequent oncogenic event in multiple myeloma that promotes proliferation and pathological interactions with bone marrow stroma.
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Cancer Cell 5:191-9 (2004)
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The MMSET histone methyl transferase switches global histone methylation and alters gene expression in t(4;14) multiple myeloma cells.
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Blood 117:211-20 (2011)
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Haematologica 94:78-86 (2009)
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Leuk Lymphoma 36:435-45 (2000)
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Oncogenic gene fusions in epithelial carcinomas.
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Curr Opin Genet Dev 19:82-91 (2009)
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Translocations in epithelial cancers.
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Biochim Biophys Acta 1796:201-15 (2009)
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The paired box-8/peroxisome proliferator-activated receptor-gamma oncogene in thyroid tumorigenesis.
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Endocrinology 148:932-5 (2007)
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The renal cell carcinoma-associated oncogenic fusion protein PRCCTFE3 provokes p21 WAF1/CIP1-mediated cell cycle delay.
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Exp Cell Res 315:2399-409 (2009)
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Nat Rev Cancer 8:497-511 (2008)
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An integrated network of androgen receptor, polycomb, and TMPRSS2-ERG gene fusions in prostate cancer progression.
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Cancer Cell 17:443-54 (2010)
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TMPRSS2/ERG promotes epithelial to mesenchymal transition through the ZEB1/ZEB2 axis in a prostate cancer model.
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PLoS One 6:e21650 (2011)
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ETV1 is a novel androgen receptor-regulated gene that mediates prostate cancer cell invasion.
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Mol Endocrinol 21:1835-46 (2007)
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Characterization of TMPRSS2:ETV5 and SLC45A3:ETV5 gene fusions in prostate cancer.
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Cancer Res 68:73-80 (2008)
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The MYCN oncogene and differentiation in neuroblastoma.
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Semin Cancer Biol 21:256-66 (2011)
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PMID:20153925
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MYCN oncoprotein targets and their therapeutic potential.
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The p53 regulatory gene MDM2 is a direct transcriptional target of MYCN in neuroblastoma.
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Proc Natl Acad Sci U S A 102:731-6 (2005)
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Bmi1 is a MYCN target gene that regulates tumorigenesis through repression of KIF1Bbeta and TSLC1 in neuroblastoma.
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p53 is a direct transcriptional target of MYCN in neuroblastoma.
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Cancer Res 70:1377-88 (2010)
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N-MYC regulates focal adhesion kinase expression in human neuroblastoma.
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J Biol Chem 282:12503-16 (2007)
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Cancer Res 71:404-12 (2011)
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Mechanisms of disease: multiple endocrine neoplasia type 1-relation to chromatin modifications and transcription regulation.
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Nat Clin Pract Endocrinol Metab 2:562-70 (2006)
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Curr Mol Med 8:805-15 (2008)
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Unusual clinical and pathological presentation of a neuroendocrine tumor in a patient with multiple endocrine neoplasia type 1.
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Upregulation of Id2, an oncogenic helix-loop-helix protein, is mediated by the chimeric EWS/ets protein in Ewing sarcoma.
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Oncogene 22:1-9 (2003)
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Ewing Sarcoma, an enigmatic malignancy of likely progenitor cell origin, driven by transcription factor oncogenic fusions.
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Cancer Res 69:7140-50 (2009)
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Oncogene 22:41-9 (2003)
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Semin Cancer Biol 15:197-205 (2005)
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J Pathol 217:83-93 (2009)
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Fusion of the EWS-related gene TAF2N to TEC in extraskeletal myxoid chondrosarcoma.
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Int J Cancer 115:556-60 (2005)
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Oncogene 28:270-8 (2009)
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PAX3-FOXO1 fusion gene in rhabdomyosarcoma.
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Cancer Lett 270:10-8 (2008)
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Identification of target genes regulated by PAX3 and PAX3-FKHR in embryogenesis and alveolar rhabdomyosarcoma.
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Genomics 79:278-84 (2002)
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Ishida M, Miyamoto M, Naitoh S, Tatsuda D, Hasegawa T, Nemoto T, Yokozeki H, Nishioka K, Matsukage A, Ohki M, Ohta T
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The SYT-SSX fusion protein down-regulates the cell proliferation regulator COM1 in t(x;18) synovial sarcoma.
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Mol Cell Biol 27:1348-55 (2007)
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PMID:19472090
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Expression of MET in alveolar soft part sarcoma.
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Med Oncol 27:459-65 (2010)
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Mutations in the p53 Tumor Suppressor Gene: Important Milestones at the Various Steps of Tumorigenesis.
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Genes Cancer 2:466-74 (2011)
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Recent advances in p53 research and cancer treatment.
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J Biomed Biotechnol 2011:978312 (2011)
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Related
pathway
cimi04115  p53 signaling pathway
cimi05211  Renal cell carcinoma
cimi05215  Prostate cancer
cimi05216  Thyroid cancer
cimi05221  Acute myeloid leukemia
KO pathway
ko05202   
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