KEGG   PATHWAY: cmao04621
Entry
cmao04621                   Pathway                                
Name
NOD-like receptor signaling pathway - Colossoma macropomum (tambaqui)
Description
Specific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains more than 20 members in mammals and plays a pivotal role in the recognition of intracellular ligands. NOD1 and NOD2, two prototypic NLRs, sense the cytosolic presence of the bacterial peptidoglycan fragments that escaped from endosomal compartments, driving the activation of NF-{kappa}B and MAPK, cytokine production and apoptosis. On the other hand, a different set of NLRs induces caspase-1 activation through the assembly of multiprotein complexes called inflammasomes. The activated of caspase-1 regulates maturation of the pro-inflammatory cytokines IL-1B, IL-18 and drives pyroptosis.
Class
Organismal Systems; Immune system
Pathway map
cmao04621  NOD-like receptor signaling pathway
cmao04621

Organism
Colossoma macropomum (tambaqui) [GN:cmao]
Gene
118798646  nod1; nucleotide-binding oligomerization domain-containing protein 1 [KO:K08727]
118826197  receptor-interacting serine/threonine-protein kinase 2-like [KO:K08846] [EC:2.7.11.1]
118822022  ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
118810516  inhibitor of nuclear factor kappa-B kinase subunit alpha-like isoform X1 [KO:K04467] [EC:2.7.11.10]
118810719  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
118813511  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
118815986  nfkbiaa; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a [KO:K04734]
118823828  nfkbiab; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b [KO:K04734]
118821638  nfkb1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
118816672  rela; transcription factor p65 [KO:K04735]
118824594  interleukin-1 beta-like [KO:K04519]
118824620  il1b; interleukin-1 beta [KO:K04519]
118806159  il6; interleukin-6 [KO:K05405]
118805034  tnfa; tumor necrosis factor a (TNF superfamily, member 2) [KO:K03156]
118817038  interleukin-8-like isoform X1 [KO:K10030]
118817039  growth-regulated alpha protein-like [KO:K10030]
118817041  interleukin-8-like [KO:K10030]
118826216  alveolar macrophage chemotactic factor-like [KO:K10030]
118826505  interleukin-8-like [KO:K10030]
118806375  monocyte chemotactic protein 1B-like [KO:K14624]
118817664  nod2; nucleotide-binding oligomerization domain-containing protein 2 [KO:K10165]
118815329  map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
118807882  tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
118815291  tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
118813953  tab3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 [KO:K12793]
118820974  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
118827508  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
118810413  mapk8a; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
118820022  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
118820354  mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
118809785  mapk8b; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
118822615  zgc:171775; STKc_p38 domain-containing protein [KO:K04441] [EC:2.7.11.24]
118799753  mapk14b; mitogen-activated protein kinase 14B isoform X1 [KO:K04441] [EC:2.7.11.24]
118818088  mapk12a; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
118812248  mapk12b; mitogen-activated protein kinase 12b isoform X1 [KO:K04441] [EC:2.7.11.24]
118812249  mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
118813192  mapk14a; mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
118813814  mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
118814879  june; junE proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
118815433  jun; transcription factor AP-1 [KO:K04448]
118798524  atg16l1; autophagy-related protein 16-1 isoform X1 [KO:K17890]
118796986  atg5; autophagy protein 5 isoform X1 [KO:K08339]
118814353  atg12; ubiquitin-like protein ATG12 [KO:K08336]
118806558  gabarapl2; gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
118824886  zgc:92606; gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
118826752  gabarapb; GABA(A) receptor-associated protein b [KO:K08341]
118814956  gamma-aminobutyric acid receptor-associated protein [KO:K08341]
118806541  map1lc3b; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
118806824  map1lc3cl; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
118799875  map1lc3a; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
118819018  map1lc3c; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
118797911  sugt1; protein SGT1 homolog [KO:K12795]
118825706  sharpin; ranBP-type and C3HC4-type zinc finger-containing protein 1 [KO:K20894]
118799731  rbck1; ranBP-type and C3HC4-type zinc finger-containing protein 1 isoform X1 [KO:K10630] [EC:2.3.2.31]
118802062  shrprbck1r; ranBP-type and C3HC4-type zinc finger-containing protein 1 [KO:K10630] [EC:2.3.2.31]
118797116  E3 ubiquitin-protein ligase RNF31 isoform X1 [KO:K11974] [EC:2.3.2.31]
118796819  si:dkey-181m9.8; uncharacterized protein si:dkey-181m9.8 isoform X1 [KO:K11974] [EC:2.3.2.31]
118806894  E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
118825657  trip6; thyroid receptor-interacting protein 6 [KO:K12792]
118825160  erbin; erbin isoform X1 [KO:K12796]
118820703  birc2; baculoviral IAP repeat-containing protein 2 isoform X1 [KO:K16060]
118814555  traf2b; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
118827146  traf2a; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
118819514  traf5; TNF receptor-associated factor 5 [KO:K09849]
118817529  traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
118827096  card9; caspase recruitment domain-containing protein 9 isoform X1 [KO:K12794]
118810129  tnfaip3; tumor necrosis factor alpha-induced protein 3 [KO:K11859] [EC:3.4.19.12]
118823830  traf3; TNF receptor-associated factor 3 [KO:K03174]
118812267  tbk1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
118799428  ikbke; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
118806335  tank; TRAF family member-associated NF-kappa-B activator [KO:K12650]
118809735  irf3; interferon regulatory factor 3 [KO:K05411]
118811522  irf7; interferon regulatory factor 7 isoform X1 [KO:K09447]
118803659  interferon alpha-17-like [KO:K05414]
118803660  interferon alpha-3-like [KO:K05414]
118803661  interferon alpha-7-like [KO:K05414]
118804958  interferon alpha-3-like [KO:K05414]
118804959  uncharacterized protein LOC118804959 [KO:K05414]
118804960  interferon a3-like [KO:K05414]
118804962  interferon a3-like [KO:K05414]
118800835  nlrx1; NLR family member X1 isoform X1 [KO:K12653]
118810410  antxr1d; LOW QUALITY PROTEIN: anthrax toxin receptor 1 [KO:K20909]
118824509  antxr1b; anthrax toxin receptor 1 isoform X1 [KO:K20909]
118824603  antxr2b; ANTXR cell adhesion molecule 2b [KO:K20909]
118813269  antxr1a; anthrax toxin receptor 1 [KO:K20909]
118826949  antxr2a; ANTXR cell adhesion molecule 2a [KO:K20909]
118809787  antxr1c; anthrax toxin receptor 1 [KO:K20909]
118798716  caspase-1-like [KO:K01370] [EC:3.4.22.36]
118799123  caspase-4-like [KO:K01370] [EC:3.4.22.36]
118798671  bcl2a; apoptosis regulator Bcl-2a [KO:K02161]
118826264  bcl2b; apoptosis regulator Bcl-2 [KO:K02161]
118822077  bcl2l1; bcl-2-like protein 1 [KO:K04570]
118803181  ctsba; cathepsin B [KO:K01363] [EC:3.4.22.1]
118815880  ctsbb; cathepsin Bb [KO:K01363] [EC:3.4.22.1]
118802001  panx1a; pannexin-1a isoform X1 [KO:K03443]
118815039  panx1b; pannexin-1b [KO:K03443]
118802306  p2rx7; P2X purinoceptor 7 [KO:K05220]
118807595  trpm2; transient receptor potential cation channel subfamily M member 2 [KO:K04977] [EC:3.6.1.13]
118804019  trpm7; transient receptor potential cation channel subfamily M member 7 isoform X1 [KO:K04982] [EC:2.7.11.1]
118815114  casr; extracellular calcium-sensing receptor [KO:K04612]
118823951  G-protein coupled receptor family C group 6 member A-like [KO:K04622]
118801771  G-protein coupled receptor family C group 6 member A-like [KO:K04622]
118801772  G-protein coupled receptor family C group 6 member A-like [KO:K04622]
118801855  G-protein coupled receptor family C group 6 member A-like [KO:K04622]
118801856  G-protein coupled receptor family C group 6 member A-like [KO:K04622]
118801857  G-protein coupled receptor family C group 6 member A-like [KO:K04622]
118801858  G-protein coupled receptor family C group 6 member A-like [KO:K04622]
118801859  G-protein coupled receptor family C group 6 member A-like [KO:K04622]
118801860  G-protein coupled receptor family C group 6 member A-like [KO:K04622]
118801861  G-protein coupled receptor family C group 6 member A-like [KO:K04622]
118801863  LOW QUALITY PROTEIN: G-protein coupled receptor family C group 6 member A-like [KO:K04622]
118801866  G-protein coupled receptor family C group 6 member A-like [KO:K04622]
118797162  gprc6a; G-protein coupled receptor family C group 6 member A [KO:K04622]
118823433  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
118823435  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
118823890  plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
118825744  plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
118815567  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
118815569  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4-like [KO:K05858] [EC:3.1.4.11]
118799312  itpr1b; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
118808278  itpr1a; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
118818001  itpr2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
118813746  itpr3; LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
118820044  vdac1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
118810340  vdac2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
118809001  voltage-dependent anion-selective channel protein 2-like [KO:K15040]
118824602  zgc:56235; voltage-dependent anion-selective channel protein 2 [KO:K15041]
118813513  vdac3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
118810162  mcu; calcium uniporter protein, mitochondrial [KO:K20858]
118814754  dhx33; ATP-dependent RNA helicase DHX33 [KO:K17820] [EC:5.6.2.6]
118818779  mfn1b; mitofusin-1b isoform X1 [KO:K21356] [EC:3.6.5.-]
118797087  mfn1a; mitofusin-1 [KO:K21356] [EC:3.6.5.-]
118813604  mfn2; LOW QUALITY PROTEIN: mitofusin-2 [KO:K06030] [EC:3.6.5.-]
118825895  ripk1l; receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
118816549  ripk3; LOW QUALITY PROTEIN: receptor-interacting serine/threonine-protein kinase 3 [KO:K08847] [EC:2.7.11.1]
118806770  dnm1l; dynamin-1-like protein isoform X1 [KO:K17065] [EC:3.6.5.5]
118813277  si:dkey-32e23.4; dynamin-1-like protein isoform X1 [KO:K17065] [EC:3.6.5.5]
118799353  nampt2; nicotinamide phosphoribosyltransferase 2 [KO:K03462] [EC:2.4.2.12]
118812667  nampt1; nicotinamide phosphoribosyltransferase [KO:K03462] [EC:2.4.2.12]
118802696  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
118818357  cytochrome b-245 light chain [KO:K08009]
118816762  txnipb; thioredoxin interacting protein b [KO:K20910]
118805249  txnipa; thioredoxin interacting protein a [KO:K20910]
118810518  thioredoxin-like [KO:K03671]
118825553  txn; thioredoxin [KO:K03671]
118805308  txn2; thioredoxin, mitochondrial [KO:K03671]
118819217  nek7; serine/threonine-protein kinase Nek7 isoform X1 [KO:K20876] [EC:2.7.11.34]
118820251  brcc3; lys-63-specific deubiquitinase BRCC36 [KO:K11864] [EC:3.4.19.-]
118815595  hsp90aa1.2; heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2 [KO:K04079]
118815596  hsp90aa1.1; heat shock protein HSP 90-alpha 1 [KO:K04079]
118815825  hsp90ab1; heat shock protein HSP 90-beta [KO:K04079]
118801362  pstpip1a; proline-serine-threonine phosphatase-interacting protein 1a [KO:K12804]
118819142  pstpip1b; proline-serine-threonine phosphatase-interacting protein 1b isoform X1 [KO:K12804]
118805906  casp10; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
118807777  casp8; caspase-8 [KO:K04398] [EC:3.4.22.61]
118797027  casp22; caspase-22 [KO:K04398] [EC:3.4.22.61]
118819390  fadd; protein FADD [KO:K02373]
118799424  prkcdb; protein kinase C, delta b isoform X1 [KO:K06068] [EC:2.7.11.13]
118808294  prkcda; protein kinase C, delta a [KO:K06068] [EC:2.7.11.13]
118817561  tp53bp1; TP53-binding protein 1 isoform X1 [KO:K20915]
118822446  rhoac; rho-related GTP-binding protein RhoA-C [KO:K04513]
118799410  transforming protein RhoA-like [KO:K04513]
118813650  rhoab; rho-related GTP-binding protein RhoA-B [KO:K04513]
118813692  rhocb; rho-related GTP-binding protein RhoA-D [KO:K04513]
118808426  rhoca; ras homolog family member Ca [KO:K04513]
118813978  rhoaa; rho-related GTP-binding protein RhoA-A [KO:K04513]
118802951  pkn1a; serine/threonine-protein kinase N1 isoform X1 [KO:K06071] [EC:2.7.11.13]
118805311  pkn1b; serine/threonine-protein kinase N1b isoform X1 [KO:K06071] [EC:2.7.11.13]
118808060  zgc:153916; serine/threonine-protein kinase N2 isoform X1 [KO:K23691] [EC:2.7.11.13]
118804743  pkn2; serine/threonine-protein kinase N2 [KO:K23691] [EC:2.7.11.13]
118801390  ywhae1; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 1 isoform X1 [KO:K06630]
118814797  ywhae2; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 2 isoform X1 [KO:K06630]
118802002  guanylate-binding protein 1-like [KO:K20899]
118802003  gbp2; guanylate-binding protein 1 [KO:K20899]
118802004  guanylate-binding protein 1-like isoform X1 [KO:K20899]
118813990  guanylate-binding protein 1-like [KO:K20899]
118814008  guanylate-binding protein 1-like [KO:K20899]
118825625  tyrosine-protein kinase JAK1-like [KO:K11217] [EC:2.7.10.2]
118807976  jak1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
118805812  tyk2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
118801704  stat1a; signal transducer and activator of transcription 1a [KO:K11220]
118809414  signal transducer and activator of transcription 1-alpha/beta-like [KO:K11220]
118821121  stat1b; signal transducer and activator of transcription 1b [KO:K11220]
118808245  stat2; LOW QUALITY PROTEIN: signal transducer and activator of transcription 2 [KO:K11221]
118809116  irf9; interferon regulatory factor 9 [KO:K04693]
118810322  toll-like receptor 4 [KO:K10160]
118810323  toll-like receptor 4 [KO:K10160]
118810324  toll-like receptor 4 [KO:K10160]
118819127  ticam1; TIR domain-containing adapter molecule 1 [KO:K05842]
118798879  myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
118811803  irak4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
118801446  sting1; stimulator of interferon genes protein [KO:K12654]
Compound
C00002  ATP
C00076  Calcium cation
C00155  L-Homocysteine
C00238  Potassium cation
C00533  Nitric oxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:23124073
  Authors
Vandenabeele P, Bertrand MJ
  Title
The role of the IAP E3 ubiquitin ligases in regulating pattern-recognition receptor signalling.
  Journal
Nat Rev Immunol 12:833-44 (2012)
DOI:10.1038/nri3325
Reference
PMID:16493424
  Authors
Strober W, Murray PJ, Kitani A, Watanabe T
  Title
Signalling pathways and molecular interactions of NOD1 and NOD2.
  Journal
Nat Rev Immunol 6:9-20 (2006)
DOI:10.1038/nri1747
Reference
PMID:24718315
  Authors
Estornes Y, Bertrand MJ
  Title
IAPs, regulators of innate immunity and inflammation.
  Journal
Semin Cell Dev Biol 39:106-14 (2015)
DOI:10.1016/j.semcdb.2014.03.035
Reference
PMID:24707857
  Authors
Jakopin Z
  Title
Nucleotide-binding oligomerization domain (NOD) inhibitors: a rational approach toward inhibition of NOD signaling pathway.
  Journal
J Med Chem 57:6897-918 (2014)
DOI:10.1021/jm401841p
Reference
PMID:25526305
  Authors
Caruso R, Warner N, Inohara N, Nunez G
  Title
NOD1 and NOD2: signaling, host defense, and inflammatory disease.
  Journal
Immunity 41:898-908 (2014)
DOI:10.1016/j.immuni.2014.12.010
Reference
PMID:19767725
  Authors
Murray PJ
  Title
Beyond peptidoglycan for Nod2.
  Journal
Nat Immunol 10:1053-4 (2009)
DOI:10.1038/ni1009-1053
Reference
PMID:20643110
  Authors
Lecat A, Piette J, Legrand-Poels S
  Title
The protein Nod2: an innate receptor more complex than previously assumed.
  Journal
Biochem Pharmacol 80:2021-31 (2010)
DOI:10.1016/j.bcp.2010.07.016
Reference
PMID:26655628
  Authors
Man SM, Kanneganti TD
  Title
Converging roles of caspases in inflammasome activation, cell death and innate immunity.
  Journal
Nat Rev Immunol 16:7-21 (2016)
DOI:10.1038/nri.2015.7
Reference
PMID:27291964
  Authors
Broz P, Dixit VM
  Title
Inflammasomes: mechanism of assembly, regulation and signalling.
  Journal
Nat Rev Immunol 16:407-20 (2016)
DOI:10.1038/nri.2016.58
Reference
PMID:25879280
  Authors
Man SM, Kanneganti TD
  Title
Regulation of inflammasome activation.
  Journal
Immunol Rev 265:6-21 (2015)
DOI:10.1111/imr.12296
Reference
PMID:26549800
  Authors
Jo EK, Kim JK, Shin DM, Sasakawa C
  Title
Molecular mechanisms regulating NLRP3 inflammasome activation.
  Journal
Cell Mol Immunol 13:148-59 (2016)
DOI:10.1038/cmi.2015.95
Reference
PMID:23846113
  Authors
Broz P, Monack DM
  Title
Newly described pattern recognition receptors team up against intracellular pathogens.
  Journal
Nat Rev Immunol 13:551-65 (2013)
DOI:10.1038/nri3479
Reference
PMID:22430786
  Authors
Rathinam VA, Vanaja SK, Fitzgerald KA
  Title
Regulation of inflammasome signaling.
  Journal
Nat Immunol 13:333-42 (2012)
DOI:10.1038/ni.2237
Reference
PMID:24840700
  Authors
Sutterwala FS, Haasken S, Cassel SL
  Title
Mechanism of NLRP3 inflammasome activation.
  Journal
Ann N Y Acad Sci 1319:82-95 (2014)
DOI:10.1111/nyas.12458
Reference
PMID:23702978
  Authors
Latz E, Xiao TS, Stutz A
  Title
Activation and regulation of the inflammasomes.
  Journal
Nat Rev Immunol 13:397-411 (2013)
DOI:10.1038/nri3452
Reference
PMID:25145756
  Authors
Blander JM
  Title
A long-awaited merger of the pathways mediating host defence and programmed cell death.
  Journal
Nat Rev Immunol 14:601-18 (2014)
DOI:10.1038/nri3720
Reference
PMID:23215645
  Authors
von Moltke J, Ayres JS, Kofoed EM, Chavarria-Smith J, Vance RE
  Title
Recognition of bacteria by inflammasomes.
  Journal
Annu Rev Immunol 31:73-106 (2013)
DOI:10.1146/annurev-immunol-032712-095944
Reference
PMID:25330206
  Authors
Abais JM, Xia M, Zhang Y, Boini KM, Li PL
  Title
Redox regulation of NLRP3 inflammasomes: ROS as trigger or effector?
  Journal
Antioxid Redox Signal 22:1111-29 (2015)
DOI:10.1089/ars.2014.5994
Reference
PMID:25879288
  Authors
Storek KM, Monack DM
  Title
Bacterial recognition pathways that lead to inflammasome activation.
  Journal
Immunol Rev 265:112-29 (2015)
DOI:10.1111/imr.12289
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PMID:27012466
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Hu H, Sun SC
  Title
Ubiquitin signaling in immune responses.
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Cell Res 26:457-83 (2016)
DOI:10.1038/cr.2016.40
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PMID:26121197
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Guo H, Callaway JB, Ting JP
  Title
Inflammasomes: mechanism of action, role in disease, and therapeutics.
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Nat Med 21:677-87 (2015)
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PMID:26482951
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Man SM, Kanneganti TD
  Title
Gasdermin D: the long-awaited executioner of pyroptosis.
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Cell Res 25:1183-4 (2015)
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PMID:22819539
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Rathinam VA, Vanaja SK, Waggoner L, Sokolovska A, Becker C, Stuart LM, Leong JM, Fitzgerald KA
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TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gram-negative bacteria.
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Cell 150:606-19 (2012)
DOI:10.1016/j.cell.2012.07.007
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PMID:21575908
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Kerur N, Veettil MV, Sharma-Walia N, Bottero V, Sadagopan S, Otageri P, Chandran B
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IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection.
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Cell Host Microbe 9:363-75 (2011)
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PMID:29148036
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Heilig R, Broz P
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Function and mechanism of the pyrin inflammasome.
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Eur J Immunol 48:230-238 (2018)
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PMID:25816776
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Chakrabarti A, Banerjee S, Franchi L, Loo YM, Gale M Jr, Nunez G, Silverman RH
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RNase L activates the NLRP3 inflammasome during viral infections.
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Cell Host Microbe 17:466-77 (2015)
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