KEGG   PATHWAY: dcr04141
Entry
dcr04141                    Pathway                                
Name
Protein processing in endoplasmic reticulum - Daucus carota (carrot)
Description
The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
dcr04141  Protein processing in endoplasmic reticulum
dcr04141

Other DBs
GO: 0030433 0034976
Organism
Daucus carota (carrot) [GN:dcr]
Gene
108207023  uncharacterized protein LOC108207023 [KO:K10956]
108215215  preprotein translocase subunit SCY1, chloroplastic [KO:K10956]
108199703  uncharacterized protein LOC108199703 [KO:K10956]
108199718  uncharacterized protein LOC108199718 [KO:K10956]
108216690  protein transport protein Sec61 subunit beta [KO:K09481]
108194506  protein transport protein Sec61 subunit beta [KO:K09481]
108211631  protein transport protein Sec61 subunit gamma-1-like [KO:K07342]
108217588  protein transport protein Sec61 subunit gamma-1 [KO:K07342]
108200270  translocation protein SEC62 isoform X1 [KO:K12275]
108214891  dnaJ protein ERDJ2A [KO:K09540]
108227899  dnaJ protein ERDJ2A [KO:K09540]
108209978  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1B [KO:K12666]
108218529  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1A [KO:K12666]
108204787  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 [KO:K12667]
108206652  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 [KO:K12668]
108209694  dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit-like [KO:K12670]
108222736  dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit [KO:K12670]
108214790  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B [KO:K07151] [EC:2.4.99.18]
108218980  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B [KO:K07151] [EC:2.4.99.18]
108199704  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A isoform X1 [KO:K07151] [EC:2.4.99.18]
108195922  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A [KO:K07151] [EC:2.4.99.18]
108219724  uncharacterized protein LOC108219724 [KO:K26501]
108192514  uncharacterized protein LOC108192514 [KO:K26502]
108197442  uncharacterized protein LOC108197442 [KO:K26502]
108201839  mannosyl-oligosaccharide glucosidase GCS1 isoform X1 [KO:K01228] [EC:3.2.1.106]
108198605  alpha-glucosidase 2 [KO:K01228] [EC:3.2.1.106]
108213531  heat shock 70 kDa protein 17 [KO:K09486]
108218724  heat shock 70 kDa protein 17 [KO:K09486]
108209191  luminal-binding protein [KO:K09490] [EC:3.6.4.10]
108212066  luminal-binding protein 5 [KO:K09490] [EC:3.6.4.10]
108211261  luminal-binding protein 5 [KO:K09490] [EC:3.6.4.10]
108213296  luminal-binding protein 5 [KO:K09490] [EC:3.6.4.10]
108227689  luminal-binding protein 5 [KO:K09490] [EC:3.6.4.10]
108208375  dnaJ protein ERDJ3B [KO:K09517]
108205409  dnaJ protein ERDJ3B [KO:K09517]
108213561  dnaJ protein P58IPK homolog [KO:K09523]
108193042  dnaJ protein P58IPK homolog [KO:K09523]
108218704  endoplasmin homolog [KO:K09487]
108227769  heat shock protein 90-6, mitochondrial isoform X1 [KO:K09487]
108227534  endoplasmin homolog isoform X2 [KO:K09487]
108202568  heat shock protein 90-5, chloroplastic [KO:K09487]
108227518  probable glucan 1,3-alpha-glucosidase [KO:K05546] [EC:3.2.1.207]
108196178  glucosidase 2 subunit beta [KO:K08288]
108223090  calnexin homolog 1 isoform X1 [KO:K08054]
108196469  calnexin homolog [KO:K08054]
108204902  calreticulin-3 [KO:K08057]
108196701  calreticulin [KO:K08057]
108200195  calreticulin-3 [KO:K08057]
108224247  mannosyl-oligosaccharide 1,2-alpha-mannosidase MNS1 isoform X1 [KO:K01230] [EC:3.2.1.113]
108223249  mannosyl-oligosaccharide 1,2-alpha-mannosidase MNS1 [KO:K01230] [EC:3.2.1.113]
108209987  mannosyl-oligosaccharide 1,2-alpha-mannosidase MNS3 [KO:K23741] [EC:3.2.1.209]
108209697  SEC12-like protein 1 [KO:K14003]
108192299  SEC12-like protein 2 [KO:K14003]
108201920  SEC12-like protein 2 [KO:K14003]
108210238  GTP-binding protein SAR1A [KO:K07953] [EC:3.6.5.-]
108219752  GTP-binding protein SAR1A [KO:K07953] [EC:3.6.5.-]
108204631  GTP-binding protein SAR1A [KO:K07953] [EC:3.6.5.-]
108200375  GTP-binding protein SAR1A [KO:K07953] [EC:3.6.5.-]
108210406  protein transport protein SEC13 homolog A [KO:K14004]
108205643  protein transport protein SEC13 homolog A [KO:K14004]
108202464  protein transport protein SEC31 homolog B [KO:K14005]
108192999  protein transport protein SEC31 homolog B [KO:K14005]
108199551  protein transport protein SEC23 E-like [KO:K14006]
108200372  protein transport protein SEC23 G [KO:K14006]
108196054  protein transport protein SEC23 F [KO:K14006]
108223301  protein transport protein SEC24 A [KO:K14007]
108202325  protein transport protein SEC24 B [KO:K14007]
108203490  protein transport protein SEC24 A [KO:K14007]
108204390  protein transport protein SEC24 B isoform X1 [KO:K14007]
108208913  UDP-glucose:glycoprotein glucosyltransferase [KO:K11718] [EC:2.4.1.-]
108196936  alpha-mannosidase I MNS5 isoform X1 [KO:K10084]
108193261  alpha-mannosidase I MNS4 isoform X2 [KO:K10085]
108213221  protein disulfide-isomerase [KO:K09580] [EC:5.3.4.1]
108210117  protein disulfide isomerase-like 1-6 [KO:K09580] [EC:5.3.4.1]
108218504  protein disulfide-isomerase [KO:K09580] [EC:5.3.4.1]
108223692  protein disulfide isomerase-like 1-4 [KO:K09580] [EC:5.3.4.1]
108227913  protein disulfide-isomerase [KO:K09580] [EC:5.3.4.1]
108203209  protein disulfide-isomerase 5-2 [KO:K09580] [EC:5.3.4.1]
108210093  probable protein disulfide-isomerase A6 [KO:K09584] [EC:5.3.4.1]
108220273  protein disulfide isomerase-like 2-3 [KO:K09584] [EC:5.3.4.1]
108193913  protein disulfide-isomerase like 2-1 [KO:K09584] [EC:5.3.4.1]
108192936  protein disulfide isomerase-like 2-3 [KO:K09584] [EC:5.3.4.1]
108200332  probable protein disulfide-isomerase A6 [KO:K09584] [EC:5.3.4.1]
108224740  endoplasmic reticulum oxidoreductin-1 [KO:K10950] [EC:1.8.4.-]
108222073  endoplasmic reticulum oxidoreductin-1 [KO:K10950] [EC:1.8.4.-]
108197025  endoplasmic reticulum oxidoreductin-2 [KO:K10950] [EC:1.8.4.-]
108215453  protein OS-9 homolog [KO:K10088]
108224602  translocon-associated protein subunit alpha [KO:K13249]
108205463  translocon-associated protein subunit alpha [KO:K13249]
108224419  uncharacterized protein LOC108224419 [KO:K13250]
108211775  uncharacterized protein LOC108211775 [KO:K14009]
108211275  uncharacterized protein LOC108211275 [KO:K14009]
108224561  uncharacterized protein LOC108224561 [KO:K14009]
108220886  uncharacterized protein LOC108220886 [KO:K14009]
108205974  uncharacterized protein LOC108205974 [KO:K14009]
108213051  derlin-1 [KO:K13989]
108205924  derlin-2.2 [KO:K13989]
108204183  derlin-2.2 [KO:K13989]
108193989  derlin-1-like [KO:K13989]
108193148  uncharacterized protein LOC108193148 [KO:K24348]
108199796  plant UBX domain-containing protein 11 [KO:K24348]
108205873  plant UBX domain-containing protein 2 [KO:K14011]
108224274  plant UBX domain-containing protein 4 [KO:K14012]
108202706  plant UBX domain-containing protein 4 [KO:K14012]
108218524  cell division control protein 48 homolog E [KO:K13525]
108227584  cell division control protein 48 homolog E [KO:K13525]
108223037  cell division cycle protein 48 homolog [KO:K13525]
108221030  cell division control protein 48 homolog E [KO:K13525]
108215155  NPL4-like protein 2 [KO:K14015]
108209448  uncharacterized protein LOC108209448 [KO:K14016]
108200213  uncharacterized protein LOC108200213 [KO:K14016]
108206650  heat shock cognate 70 kDa protein 2 [KO:K03283]
108209241  heat shock cognate 70 kDa protein [KO:K03283]
108208857  heat shock cognate 70 kDa protein 2 [KO:K03283]
108208858  heat shock cognate 70 kDa protein 2 [KO:K03283]
108209334  stromal 70 kDa heat shock-related protein, chloroplastic [KO:K03283]
108214401  heat shock cognate 70 kDa protein 2 [KO:K03283]
108216075  heat shock 70 kDa protein 18 [KO:K03283]
108216229  heat shock 70 kDa protein 18 [KO:K03283]
108216455  LOW QUALITY PROTEIN: heat shock cognate 70 kDa protein [KO:K03283]
108217465  heat shock cognate 70 kDa protein [KO:K03283]
108218466  heat shock cognate 70 kDa protein 2 [KO:K03283]
108217428  heat shock 70 kDa protein [KO:K03283]
108217429  heat shock cognate 70 kDa protein 2 [KO:K03283]
108218630  heat shock cognate 70 kDa protein 2 [KO:K03283]
108200059  heat shock cognate 70 kDa protein [KO:K03283]
108204337  stromal 70 kDa heat shock-related protein, chloroplastic [KO:K03283]
108197161  heat shock 70 kDa protein 18 isoform X1 [KO:K03283]
108222404  heat shock cognate 70 kDa protein [KO:K03283]
108196141  stromal 70 kDa heat shock-related protein, chloroplastic [KO:K03283]
108223701  heat shock cognate 70 kDa protein 2 [KO:K03283]
108198470  uncharacterized protein LOC108198470 [KO:K03283]
108198483  heat shock cognate 70 kDa protein [KO:K03283]
108199595  heat shock cognate 70 kDa protein [KO:K03283]
108195202  heat shock cognate 70 kDa protein [KO:K03283]
108205782  heat shock 70 kDa protein 18 [KO:K03283]
108200866  heat shock cognate 70 kDa protein [KO:K03283]
108222768  heat shock 70 kDa protein [KO:K03283]
108200880  heat shock cognate 70 kDa protein [KO:K03283]
108202013  heat shock cognate 70 kDa protein [KO:K03283]
108194298  heat shock cognate 70 kDa protein 2 [KO:K03283]
108227451  heat shock cognate 70 kDa protein 2 [KO:K03283]
108196569  heat shock cognate 70 kDa protein [KO:K03283]
108198786  heat shock cognate 70 kDa protein [KO:K03283]
108197763  heat shock cognate 70 kDa protein isoform X1 [KO:K03283]
108214765  dnaJ protein homolog [KO:K09503]
108222152  dnaJ protein homolog [KO:K09503]
108223241  dnaJ protein homolog [KO:K09503]
108202694  dnaJ protein homolog 2 [KO:K09503]
108215557  chaperone protein dnaJ 49 [KO:K09518]
108214875  chaperone protein dnaJ 49 [KO:K09518]
108203030  chaperone protein dnaJ 49 [KO:K09518]
108211101  heat shock protein 83 [KO:K04079]
108210519  heat shock protein 83 [KO:K04079]
108219006  heat shock protein 90-2 [KO:K04079]
108222698  heat shock protein 90-3 [KO:K04079]
108227515  heat shock protein 83 [KO:K04079]
108210532  hsp70 nucleotide exchange factor FES1 [KO:K09562]
108196822  uncharacterized protein LOC108196822 [KO:K09562]
108208354  17.3 kDa class II heat shock protein [KO:K13993]
108208113  17.3 kDa class II heat shock protein-like [KO:K13993]
108208479  17.3 kDa class II heat shock protein-like [KO:K13993]
108211448  small heat shock protein, chloroplastic [KO:K13993]
108211582  18.2 kDa class I heat shock protein [KO:K13993]
108214382  17.8 kDa class I heat shock protein [KO:K13993]
108211516  17.3 kDa class I heat shock protein [KO:K13993]
108213227  17.8 kDa class I heat shock protein [KO:K13993]
108213314  15.4 kDa class V heat shock protein [KO:K13993]
108215460  18.2 kDa class I heat shock protein [KO:K13993]
108224335  17.4 kDa class III heat shock protein [KO:K13993]
108225374  17.1 kDa class II heat shock protein [KO:K13993]
108222175  26.5 kDa heat shock protein, mitochondrial [KO:K13993]
108226767  17.9 kDa class II heat shock protein-like [KO:K13993]
108226827  17.1 kDa class II heat shock protein-like [KO:K13993]
108226843  17.1 kDa class II heat shock protein-like [KO:K13993]
108225799  17.3 kDa class II heat shock protein-like [KO:K13993]
108225801  17.8 kDa class I heat shock protein [KO:K13993]
108222609  17.1 kDa class II heat shock protein-like [KO:K13993]
108198674  small heat shock protein, chloroplastic [KO:K13993]
108198740  17.8 kDa class I heat shock protein [KO:K13993]
108202086  22.0 kDa heat shock protein [KO:K13993]
108198986  17.1 kDa class II heat shock protein-like [KO:K13993]
108193601  17.8 kDa class I heat shock protein [KO:K13993]
108193767  small heat shock protein, chloroplastic [KO:K13993]
108197184  small heat shock protein, chloroplastic [KO:K13993]
108192288  22.0 kDa heat shock protein [KO:K13993]
108224854  OVARIAN TUMOR DOMAIN-containing deubiquitinating enzyme 2 [KO:K13719] [EC:3.1.2.-]
108227669  uncharacterized protein LOC108227669 [KO:K14018]
108223792  ubiquitin receptor RAD23d [KO:K10839]
108227390  ubiquitin receptor RAD23d-like isoform X1 [KO:K10839]
108221999  ubiquitin receptor RAD23b [KO:K10839]
108199794  ubiquitin receptor RAD23d [KO:K10839]
108196725  ubiquitin receptor RAD23d isoform X1 [KO:K10839]
108193997  ubiquitin receptor RAD23b [KO:K10839]
108209494  ubiquitin domain-containing protein DSK2a isoform X1 [KO:K04523]
108219051  ubiquitin domain-containing protein DSK2a isoform X1 [KO:K04523]
108202983  peptide-N(4)-(N-acetyl-beta- glucosaminyl)asparagine amidase [KO:K01456] [EC:3.5.1.52]
108197367  ataxin-3 homolog [KO:K11863] [EC:3.4.22.-]
108214402  probable ubiquitin conjugation factor E4 [KO:K10597] [EC:2.3.2.27]
108200062  eukaryotic translation initiation factor 2 subunit alpha homolog [KO:K03237]
108200164  eukaryotic translation initiation factor 2 subunit alpha homolog [KO:K03237]
108196558  subtilisin-like protease SBT6.1 isoform X1 [KO:K08653] [EC:3.4.21.112]
108198862  membrane-bound transcription factor site-2 protease homolog [KO:K07765] [EC:3.4.24.85]
108223255  serine/threonine-protein kinase/endoribonuclease IRE1a isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
108204738  serine/threonine-protein kinase/endoribonuclease IRE1a [KO:K08852] [EC:2.7.11.1 3.1.26.-]
108202558  probable E3 ubiquitin ligase SUD1 [KO:K10661] [EC:2.3.2.27]
108225715  probable E3 ubiquitin ligase SUD1 isoform X1 [KO:K10661] [EC:2.3.2.27]
108197408  ubiquitin-conjugating enzyme E2 32 [KO:K10578] [EC:2.3.2.23]
108205637  ubiquitin-conjugating enzyme E2 34 [KO:K04554] [EC:2.3.2.23]
108219169  ubiquitin-conjugating enzyme E2 7-like [KO:K10575] [EC:2.3.2.23]
108219275  ubiquitin-conjugating enzyme E2 7 [KO:K10575] [EC:2.3.2.23]
108220753  ubiquitin-conjugating enzyme E2 7 isoform X1 [KO:K10575] [EC:2.3.2.23]
108220959  ubiquitin-conjugating enzyme E2 7 [KO:K10575] [EC:2.3.2.23]
108228036  ERAD-associated E3 ubiquitin-protein ligase HRD1B [KO:K10601] [EC:2.3.2.27]
108223586  uncharacterized protein LOC108223586 [KO:K10666] [EC:2.3.2.27]
108210822  E3 ubiquitin-protein ligase RMA1H1 [KO:K10666] [EC:2.3.2.27]
108224530  E3 ubiquitin-protein ligase RMA1H1 [KO:K10666] [EC:2.3.2.27]
108224783  uncharacterized protein LOC108224783 [KO:K10666] [EC:2.3.2.27]
108202897  ERAD-associated E3 ubiquitin-protein ligase component HRD3A [KO:K14026]
108223229  E3 ubiquitin protein ligase RIN2 isoform X1 [KO:K10636] [EC:2.3.2.36]
108210879  E3 ubiquitin-protein ligase CHIP [KO:K09561] [EC:2.3.2.27]
108205095  E3 ubiquitin-protein ligase CHIP [KO:K09561] [EC:2.3.2.27]
108209972  ubiquitin-conjugating enzyme E2-17 kDa [KO:K06689] [EC:2.3.2.23]
108209678  ubiquitin-conjugating enzyme E2-17 kDa [KO:K06689] [EC:2.3.2.23]
108209709  ubiquitin-conjugating enzyme E2-17 kDa [KO:K06689] [EC:2.3.2.23]
108215132  ubiquitin-conjugating enzyme E2 28 [KO:K06689] [EC:2.3.2.23]
108215162  ubiquitin-conjugating enzyme E2 10 [KO:K06689] [EC:2.3.2.23]
108214274  SUMO-conjugating enzyme UBC9 [KO:K06689] [EC:2.3.2.23]
108215994  LOW QUALITY PROTEIN: ubiquitin-conjugating enzyme E2 28 [KO:K06689] [EC:2.3.2.23]
108219743  ubiquitin-conjugating enzyme E2 28 [KO:K06689] [EC:2.3.2.23]
108196635  ubiquitin-conjugating enzyme E2-17 kDa [KO:K06689] [EC:2.3.2.23]
108199744  ubiquitin-conjugating enzyme E2-17 kDa [KO:K06689] [EC:2.3.2.23]
108211059  RING-box protein 1a-like [KO:K03868] [EC:2.3.2.32]
108219676  RING-box protein 1a [KO:K03868] [EC:2.3.2.32]
108224330  RING-box protein 1a [KO:K03868] [EC:2.3.2.32]
108193846  uncharacterized protein LOC108193846 [KO:K03868] [EC:2.3.2.32]
108202763  cullin-1 [KO:K03347]
108196163  cullin-1 [KO:K03347]
108199610  cullin-1 [KO:K03347]
108209966  SKP1-like protein 13 [KO:K03094]
108226880  SKP1-like protein 1B [KO:K03094]
108225043  SKP1-like protein 1B [KO:K03094]
108224888  CBL-interacting protein kinase 1-like [KO:K03094]
108205111  SKP1-like protein 20 [KO:K03094]
108192992  SKP1-like protein 1A [KO:K03094]
Compound
C00076  Calcium cation
G00009   
G00010   
G00011   
G00012   
G10694   
Reference
PMID:19491040
  Authors
Naidoo N
  Title
ER and aging-Protein folding and the ER stress response.
  Journal
Ageing Res Rev 8:150-9 (2009)
DOI:10.1016/j.arr.2009.03.001
Reference
PMID:18023214
  Authors
Malhotra JD, Kaufman RJ
  Title
The endoplasmic reticulum and the unfolded protein response.
  Journal
Semin Cell Dev Biol 18:716-31 (2007)
DOI:10.1016/j.semcdb.2007.09.003
Reference
PMID:20347046
  Authors
Maattanen P, Gehring K, Bergeron JJ, Thomas DY
  Title
Protein quality control in the ER: the recognition of misfolded proteins.
  Journal
Semin Cell Dev Biol 21:500-11 (2010)
DOI:10.1016/j.semcdb.2010.03.006
Reference
PMID:20219571
  Authors
Stolz A, Wolf DH
  Title
Endoplasmic reticulum associated protein degradation: a chaperone assisted journey to hell.
  Journal
Biochim Biophys Acta 1803:694-705 (2010)
DOI:10.1016/j.bbamcr.2010.02.005
Reference
PMID:20112977
  Authors
Dejgaard K, Theberge JF, Heath-Engel H, Chevet E, Tremblay ML, Thomas DY
  Title
Organization of the Sec61 translocon, studied by high resolution native electrophoresis.
  Journal
J Proteome Res 9:1763-71 (2010)
DOI:10.1021/pr900900x
Related
pathway
dcr00510  N-Glycan biosynthesis
dcr03050  Proteasome
dcr03060  Protein export
KO pathway
ko04141   
LinkDB

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