KEGG   PATHWAY: elk05202
Entry
elk05202                    Pathway                                
Name
Transcriptional misregulation in cancer - Enhydra lutris kenyoni (northern sea otter)
Description
In tumor cells, genes encoding transcription factors (TFs) are often amplified, deleted, rearranged via chromosomal translocation and inversion, or subjected to point mutations that result in a gain- or loss-of- function. In hematopoietic cancers and solid tumors, the translocations and inversions increase or deregulate transcription of the oncogene. Recurrent chromosome translocations generate novel fusion oncoproteins, which are common in myeloid cancers and soft-tissue sarcomas. The fusion proteins have aberrant transcriptional function compared to their wild-type counterparts. These fusion transcription factors alter expression of target genes, and thereby result in a variety of altered cellular properties that contribute to the tumourigenic process.
Class
Human Diseases; Cancer: overview
Pathway map
elk05202  Transcriptional misregulation in cancer
elk05202

Organism
Enhydra lutris kenyoni (northern sea otter) [GN:elk]
Gene
111155817  runt-related transcription factor 1 isoform X1 [KO:K08367]
111140850  LOW QUALITY PROTEIN: macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
111151617  myeloperoxidase isoform X1 [KO:K10789] [EC:1.11.2.2]
111141239  granulocyte-macrophage colony-stimulating factor [KO:K05427]
111140799  interleukin-3-like [KO:K04736]
111146561  protein CBFA2T1 isoform X1 [KO:K10053]
111142974  histone deacetylase 1 isoform X1 [KO:K06067] [EC:3.5.1.98]
111158262  histone deacetylase 2 isoform X1 [KO:K06067] [EC:3.5.1.98]
111153299  paired amphipathic helix protein Sin3a [KO:K11644]
111139473  nuclear receptor corepressor 1 isoform X1 [KO:K04650]
111161485  CCAAT/enhancer-binding protein alpha [KO:K09055]
111145278  LOW QUALITY PROTEIN: period circadian protein homolog 2 [KO:K02633]
111149957  transcription factor PU.1 isoform X1 [KO:K09438]
111140988  monocyte differentiation antigen CD14 [KO:K04391]
111162313  integrin alpha-M [KO:K06461]
111162063  high affinity immunoglobulin gamma Fc receptor I-like [KO:K06498]
111151683  junction plakoglobin [KO:K10056]
111153323  protein PML isoform X1 [KO:K10054] [EC:2.3.2.-]
111151320  retinoic acid receptor alpha isoform X1 [KO:K08527]
111154269  cyclin-A2 [KO:K06627]
111158563  cyclin-A1 [KO:K06627]
111139644  LOW QUALITY PROTEIN: CCAAT/enhancer-binding protein epsilon [KO:K10051]
111152662  bcl-2-related protein A1-like [KO:K02162]
111153896  zinc finger and BTB domain-containing protein 16 [KO:K10055]
111146783  myc proto-oncogene protein [KO:K04377]
111142278  dual specificity protein phosphatase 6 isoform X1 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
111161705  transcription factor E2-alpha isoform X1 [KO:K09063]
111151184  pre-B-cell leukemia transcription factor 1 isoform X1 [KO:K09355]
111152110  protein Wnt-16 [KO:K01558]
111141997  transcription factor ETV6 isoform X1 [KO:K03211]
111152463  transcription factor ETV7 [KO:K03211]
111161254  granzyme B-like isoform X1 [KO:K01353] [EC:3.4.21.79]
111139675  LOW QUALITY PROTEIN: mast cell protease 1A-like [KO:K01353] [EC:3.4.21.79]
111153928  histone-lysine N-methyltransferase 2A isoform X1 [KO:K09186] [EC:2.1.1.354]
111153808  AF4/FMR2 family member 1 isoform X1 [KO:K15184]
111145825  cyclin-dependent kinase 9 [KO:K02211] [EC:2.7.11.22 2.7.11.23]
111157918  cyclin-T1 isoform X1 [KO:K15188]
111155538  cyclin-T2 isoform X1 [KO:K15188]
111161748  protein ENL isoform X1 [KO:K15187]
111156605  protein AF-9 [KO:K15187]
111161720  histone-lysine N-methyltransferase, H3 lysine-79 specific-like [KO:K11427] [EC:2.1.1.360]
111161651  histone-lysine N-methyltransferase, H3 lysine-79 specific-like [KO:K11427] [EC:2.1.1.360]
111149680  rhombotin-2 [KO:K15612]
111145820  pre-B-cell leukemia transcription factor 3 isoform X1 [KO:K15610]
111147562  LOW QUALITY PROTEIN: runt-related transcription factor 2 [KO:K09278]
111154171  mothers against decapentaplegic homolog 1 [KO:K04676]
111148992  Krueppel-like factor 3 [KO:K15605]
111148445  myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
111147274  homeobox protein Hox-A9 [KO:K21950]
111147280  homeobox protein Hox-A10 [KO:K17443]
111144666  probable JmjC domain-containing histone demethylation protein 2C isoform X1 [KO:K11449] [EC:1.14.11.-]
111142359  high mobility group protein HMGI-C [KO:K09283]
111139444  lysine-specific demethylase 6A-like isoform X1 [KO:K11447] [EC:1.14.11.68]
111150336  lysine-specific demethylase 6A isoform X1 [KO:K11447] [EC:1.14.11.68]
111147563  transcription initiation protein SPT3 homolog isoform X1 [KO:K11313]
111149017  prominin-1 isoform X1 [KO:K06532]
111158528  receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
111149022  BMP-2-inducible protein kinase isoform X1 [KO:K08854] [EC:2.7.11.1]
111152643  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
111142072  cyclin-dependent kinase inhibitor 1B [KO:K06624]
111142115  cyclin-dependent kinase inhibitor 1B [KO:K06624]
111147311  cyclin-dependent kinase 14 isoform X1 [KO:K08821] [EC:2.7.11.22]
111148024  homeobox protein Meis1 isoform X1 [KO:K15613]
111147429  homeobox protein Hox-A11 [KO:K21951]
111162238  homeobox protein SIX1 [KO:K15614]
111140624  homeobox protein SIX4 [KO:K15615]
111156802  eyes absent homolog 1 isoform X1 [KO:K15616] [EC:3.1.3.48]
111143151  cyclin-dependent kinase 4 inhibitor C [KO:K06622]
111153747  15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform X1 [KO:K00069] [EC:1.1.1.141]
111157250  glutamate receptor 3 [KO:K05199]
111159793  alpha-(1,6)-fucosyltransferase isoform X1 [KO:K00717] [EC:2.4.1.68]
111141192  T-cell leukemia homeobox protein 3 [KO:K15607]
111145368  T-cell leukemia homeobox protein 1 [KO:K09340]
111148678  B-cell lymphoma/leukemia 11B isoform X1 [KO:K22046]
111144769  LIM domain-binding protein 1 isoform X1 [KO:K15617]
111162405  protein lyl-1 [KO:K15604]
111145351  hematopoietically-expressed homeobox protein HHEX [KO:K08024]
111147728  pre T-cell antigen receptor alpha [KO:K06056]
111148050  proto-oncogene c-Rel isoform X1 [KO:K09254]
111159766  G1/S-specific cyclin-D2 [KO:K10151]
111153673  baculoviral IAP repeat-containing protein 3-like [KO:K16060]
111153695  baculoviral IAP repeat-containing protein 2 [KO:K16060]
111146115  TNF receptor-associated factor 1 [KO:K03172]
111141775  bcl-2-like protein 1 [KO:K04570]
111155017  T-lymphocyte activation antigen CD86 isoform X1 [KO:K05413]
111141553  tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160]
111151749  B-cell lymphoma 6 protein [KO:K15618]
111153073  transcription factor Maf [KO:K09035]
111157851  integrin beta-7 [KO:K06590]
111149264  histone-lysine N-methyltransferase NSD2 isoform X1 [KO:K11424] [EC:2.1.1.357]
111162609  uncharacterized protein LOC111162609 [KO:K11253]
111160296  histone H3.3 [KO:K11253]
111138603  histone H3.3-like [KO:K11253]
111139406  histone H3.1 [KO:K11253]
111150659  histone H3.3 isoform X1 [KO:K11253]
111162073  histone H3 [KO:K11253]
111138530  histone H3.1 [KO:K11253]
111138531  histone H3.1 [KO:K11253]
111138532  histone H3.1 [KO:K11253]
111138533  histone H3.1 [KO:K11253]
111145877  paired box protein Pax-5 isoform X1 [KO:K09383]
111158488  paired box protein Pax-8 isoform X1 [KO:K09293]
111144031  peroxisome proliferator-activated receptor gamma [KO:K08530]
111146039  retinoic acid receptor RXR-alpha [KO:K08524]
111152195  retinoic acid receptor RXR-beta isoform X1 [KO:K08525]
111151020  retinoic acid receptor RXR-gamma isoform X1 [KO:K08526]
111138928  proline-rich protein PRCC [KO:K13105]
111150460  transcription factor E3 [KO:K09105]
111147618  cyclin-dependent kinase inhibitor 1 [KO:K06625]
111155673  transmembrane protease serine 2 [KO:K09633] [EC:3.4.21.122]
111155700  transcriptional regulator ERG isoform X1 [KO:K09435]
111144976  urokinase-type plasminogen activator isoform X1 [KO:K01348] [EC:3.4.21.73]
111144489  tissue-type plasminogen activator [KO:K01343] [EC:3.4.21.68]
111153872  stromelysin-1 [KO:K01394] [EC:3.4.24.17]
111141396  matrix metalloproteinase-9 [KO:K01403] [EC:3.4.24.35]
111155546  zinc finger E-box-binding homeobox 1 isoform X1 [KO:K09299]
111155901  interleukin-1 receptor type 2 [KO:K04387]
111161450  kunitz-type protease inhibitor 1 isoform X1 [KO:K15619]
111147307  ETS translocation variant 1 isoform X1 [KO:K09431]
111158096  ETS translocation variant 4 isoform X1 [KO:K15592]
111148276  ETS translocation variant 5 [KO:K15593]
111151017  solute carrier family 45 member 3 [KO:K15379]
111151167  ETS domain-containing protein Elk-4 [KO:K04376]
111158109  probable ATP-dependent RNA helicase DDX5 [KO:K12823] [EC:5.6.2.7]
111154145  N-myc proto-oncogene protein [KO:K09109]
111161903  protein max isoform X1 [KO:K04453]
111142120  E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
111146744  focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
111161133  cellular tumor antigen p53 [KO:K04451]
111155498  polycomb complex protein BMI-1 isoform X1 [KO:K11459]
111157856  transcription factor Sp1 isoform X1 [KO:K04684]
111154581  zinc finger and BTB domain-containing protein 17 isoform X1 [KO:K10500]
111138872  high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
111151744  tumor necrosis factor receptor superfamily member 16 [KO:K02583]
111150075  menin isoform X1 [KO:K14970]
111160077  RNA-binding protein EWS isoform X1 [KO:K13209]
111153687  Friend leukemia integration 1 transcription factor [KO:K09436]
111142293  insulin-like growth factor I [KO:K05459]
111142036  insulin-like growth factor I isoform X1 [KO:K05459]
111154111  DNA-binding protein inhibitor ID-2 [KO:K17693]
111158999  TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
111157077  insulin-like growth factor-binding protein 3 isoform X1 [KO:K10138]
111139048  LOW QUALITY PROTEIN: protein FEV [KO:K09437]
111157964  cyclic AMP-dependent transcription factor ATF-1 isoform X1 [KO:K09053]
111152532  aryl hydrocarbon receptor nuclear translocator 2 isoform X1 [KO:K15589]
111153730  serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
111143979  microphthalmia-associated transcription factor isoform X1 [KO:K09455]
111149985  Wilms tumor protein isoform X1 [KO:K09234]
111145884  platelet-derived growth factor subunit A isoform X1 [KO:K04359]
111157559  interleukin-2 receptor subunit beta isoform X1 [KO:K05069]
111155971  BAI1-associated protein 3 isoform X1 [KO:K15621]
111150426  tetraspanin-7 [KO:K06571]
111150679  myeloid leukemia factor 1 isoform X1 [KO:K15622]
111146169  nuclear receptor subfamily 4 group A member 3 isoform X1 [KO:K08559]
111151305  TATA-binding protein-associated factor 2N [KO:K14651]
111162225  RNA-binding protein FUS isoform X1 [KO:K13098]
111160240  DNA damage-inducible transcript 3 protein [KO:K04452]
111141657  CCAAT/enhancer-binding protein beta [KO:K10048]
111147365  interleukin-6 isoform X1 [KO:K05405]
111150522  NF-kappa-B inhibitor zeta isoform X1 [KO:K14242]
111153611  nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
111149956  transcription factor p65 [KO:K04735]
111149115  interleukin-8 [KO:K10030]
111144177  paired box protein Pax-3 isoform X1 [KO:K09381]
111154807  paired box protein Pax-7 isoform X1 [KO:K09381]
111158571  LOW QUALITY PROTEIN: forkhead box protein O1 [KO:K07201]
111158583  vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
111141332  LOW QUALITY PROTEIN: calcium-responsive transactivator [KO:K15623]
111142549  protein SSXT isoform X1 [KO:K15623]
111150567  putative protein SSX6 [KO:K15624]
111162318  nuclear protein 1 [KO:K15626]
111160425  tether containing UBX domain for GLUT4 isoform X1 [KO:K15627]
111151956  hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
111143201  growth arrest and DNA damage-inducible protein GADD45 alpha isoform X1 [KO:K04402]
111161789  growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
111153625  growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
111160657  apoptosis regulator BAX isoform X1 [KO:K02159]
111152355  bcl-2 homologous antagonist/killer [KO:K14021]
111150113  DNA damage-binding protein 2 isoform X1 [KO:K10140]
111148313  DNA polymerase kappa [KO:K03511] [EC:2.7.7.7]
Reference
PMID:11607818
  Authors
Alcalay M, Orleth A, Sebastiani C, Meani N, Chiaradonna F, Casciari C, Sciurpi MT, Gelmetti V, Riganelli D, Minucci S, Fagioli M, Pelicci PG
  Title
Common themes in the pathogenesis of acute myeloid leukemia.
  Journal
Oncogene 20:5680-94 (2001)
DOI:10.1038/sj.onc.1204642
Reference
PMID:12032780
  Authors
Scandura JM, Boccuni P, Cammenga J, Nimer SD
  Title
Transcription factor fusions in acute leukemia: variations on a theme.
  Journal
Oncogene 21:3422-44 (2002)
DOI:10.1038/sj.onc.1205315
Reference
PMID:12529654
  Authors
Roumier C, Fenaux P, Lafage M, Imbert M, Eclache V, Preudhomme C
  Title
New mechanisms of AML1 gene alteration in hematological malignancies.
  Journal
Leukemia 17:9-16 (2003)
DOI:10.1038/sj.leu.2402766
Reference
PMID:10717473
  Authors
Lutterbach B, Hiebert SW
  Title
Role of the transcription factor AML-1 in acute leukemia and hematopoietic differentiation.
  Journal
Gene 245:223-35 (2000)
DOI:10.1016/S0378-1119(00)00014-7
Reference
PMID:19075268
  Authors
Koschmieder S, Halmos B, Levantini E, Tenen DG
  Title
Dysregulation of the C/EBPalpha differentiation pathway in human cancer.
  Journal
J Clin Oncol 27:619-28 (2009)
DOI:10.1200/JCO.2008.17.9812
Reference
PMID:11340171
  Authors
Johansen LM, Iwama A, Lodie TA, Sasaki K, Felsher DW, Golub TR, Tenen DG
  Title
c-Myc is a critical target for c/EBPalpha in granulopoiesis.
  Journal
Mol Cell Biol 21:3789-806 (2001)
DOI:10.1128/MCB.21.11.3789-3806.2001
Reference
PMID:15985538
  Authors
Gery S, Gombart AF, Yi WS, Koeffler C, Hofmann WK, Koeffler HP
  Title
Transcription profiling of C/EBP targets identifies Per2 as a gene implicated in myeloid leukemia.
  Journal
Blood 106:2827-36 (2005)
DOI:10.1182/blood-2005-01-0358
Reference
PMID:12393465
  Authors
Vangala RK, Heiss-Neumann MS, Rangatia JS, Singh SM, Schoch C, Tenen DG, Hiddemann W, Behre G
  Title
The myeloid master regulator transcription factor PU.1 is inactivated by AML1-ETO in t(8;21) myeloid leukemia.
  Journal
Blood 101:270-7 (2003)
DOI:10.1182/blood-2002-04-1288
Reference
PMID:12130514
  Authors
Mueller BU, Pabst T, Osato M, Asou N, Johansen LM, Minden MD, Behre G, Hiddemann W, Ito Y, Tenen DG
  Title
Heterozygous PU.1 mutations are associated with acute myeloid leukemia.
  Journal
Blood 100:998-1007 (2002)
DOI:10.1182/blood.V100.3.998
Reference
PMID:15160934
  Authors
Jing Y
  Title
The PML-RARalpha fusion protein and targeted therapy for acute promyelocytic leukemia.
  Journal
Leuk Lymphoma 45:639-48 (2004)
DOI:10.1080/10428190310001609933
Reference
PMID:15024077
  Authors
Muller-Tidow C, Steffen B, Cauvet T, Tickenbrock L, Ji P, Diederichs S, Sargin B, Kohler G, Stelljes M, Puccetti E, Ruthardt M, deVos S, Hiebert SW, Koeffler HP, Berdel WE, Serve H
  Title
Translocation products in acute myeloid leukemia activate the Wnt signaling pathway in hematopoietic cells.
  Journal
Mol Cell Biol 24:2890-904 (2004)
DOI:10.1128/MCB.24.7.2890-2904.2004
Reference
PMID:19855079
  Authors
Rice KL, Hormaeche I, Doulatov S, Flatow JM, Grimwade D, Mills KI, Leiva M, Ablain J, Ambardekar C, McConnell MJ, Dick JE, Licht JD
  Title
Comprehensive genomic screens identify a role for PLZF-RARalpha as a positive regulator of cell proliferation via direct regulation of c-MYC.
  Journal
Blood 114:5499-511 (2009)
DOI:10.1182/blood-2009-03-206524
Reference
PMID:10500199
  Authors
McWhirter JR, Neuteboom ST, Wancewicz EV, Monia BP, Downing JR, Murre C
  Title
Oncogenic homeodomain transcription factor E2A-Pbx1 activates a novel WNT gene in pre-B acute lymphoblastoid leukemia.
  Journal
Proc Natl Acad Sci U S A 96:11464-9 (1999)
DOI:10.1073/pnas.96.20.11464
Reference
PMID:15156184
  Authors
Zelent A, Greaves M, Enver T
  Title
Role of the TEL-AML1 fusion gene in the molecular pathogenesis of childhood acute lymphoblastic leukaemia.
  Journal
Oncogene 23:4275-83 (2004)
DOI:10.1038/sj.onc.1207672
Reference
PMID:14630078
  Authors
Sawinska M, Ladon D
  Title
Mechanism, detection and clinical significance of the reciprocal translocation t(12;21)(p12;q22) in the children suffering from acute lymphoblastic leukaemia.
  Journal
Leuk Res 28:35-42 (2004)
DOI:10.1016/S0145-2126(03)00160-7
Reference
PMID:19141473
  Authors
Guenther MG, Lawton LN, Rozovskaia T, Frampton GM, Levine SS, Volkert TL, Croce CM, Nakamura T, Canaani E, Young RA
  Title
Aberrant chromatin at genes encoding stem cell regulators in human mixed-lineage leukemia.
  Journal
Genes Dev 22:3403-8 (2008)
DOI:10.1101/gad.1741408
Reference
PMID:16169901
  Authors
Xia ZB, Popovic R, Chen J, Theisler C, Stuart T, Santillan DA, Erfurth F, Diaz MO, Zeleznik-Le NJ
  Title
The MLL fusion gene, MLL-AF4, regulates cyclin-dependent kinase inhibitor CDKN1B (p27kip1) expression.
  Journal
Proc Natl Acad Sci U S A 102:14028-33 (2005)
DOI:10.1073/pnas.0506464102
Reference
PMID:21518926
  Authors
Wang QF, Wu G, Mi S, He F, Wu J, Dong J, Luo RT, Mattison R, Kaberlein JJ, Prabhakar S, Ji H, Thirman MJ
  Title
MLL fusion proteins preferentially regulate a subset of wild-type MLL target genes in the leukemic genome.
  Journal
Blood 117:6895-905 (2011)
DOI:10.1182/blood-2010-12-324699
Reference
PMID:14701735
  Authors
Zeisig BB, Milne T, Garcia-Cuellar MP, Schreiner S, Martin ME, Fuchs U, Borkhardt A, Chanda SK, Walker J, Soden R, Hess JL, Slany RK
  Title
Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization.
  Journal
Mol Cell Biol 24:617-28 (2004)
DOI:10.1128/MCB.24.2.617-628.2004
Reference
PMID:19133982
  Authors
Riz I, Hawley TS, Johnston H, Hawley RG
  Title
Role of TLX1 in T-cell acute lymphoblastic leukaemia pathogenesis.
  Journal
Br J Haematol 145:140-3 (2009)
DOI:10.1111/j.1365-2141.2008.07556.x
Reference
PMID:12511414
  Authors
Barth TF, Martin-Subero JI, Joos S, Menz CK, Hasel C, Mechtersheimer G, Parwaresch RM, Lichter P, Siebert R, Mooller P
  Title
Gains of 2p involving the REL locus correlate with nuclear c-Rel protein accumulation in neoplastic cells of classical Hodgkin lymphoma.
  Journal
Blood 101:3681-6 (2003)
DOI:10.1182/blood-2002-08-2577
Reference
PMID:11313274
  Authors
Hinz M, Loser P, Mathas S, Krappmann D, Dorken B, Scheidereit C
  Title
Constitutive NF-kappaB maintains high expression of a characteristic gene network, including CD40, CD86, and a set of antiapoptotic genes in Hodgkin/Reed-Sternberg cells.
  Journal
Blood 97:2798-807 (2001)
DOI:10.1182/blood.V97.9.2798
Reference
PMID:12670461
  Authors
Zuzel M, Cawley JC.
  Title
The biology of hairy cells.
  Journal
Best Pract Res Clin Haematol 16:1-13 (2003)
DOI:10.1016/S1521-6926(02)00082-8
Reference
PMID:14998494
  Authors
Hurt EM, Wiestner A, Rosenwald A, Shaffer AL, Campo E, Grogan T, Bergsagel PL, Kuehl WM, Staudt LM
  Title
Overexpression of c-maf is a frequent oncogenic event in multiple myeloma that promotes proliferation and pathological interactions with bone marrow stroma.
  Journal
Cancer Cell 5:191-9 (2004)
DOI:10.1016/S1535-6108(04)00019-4
Reference
PMID:20974671
  Authors
Martinez-Garcia E, Popovic R, Min DJ, Sweet SM, Thomas PM, Zamdborg L, Heffner A, Will C, Lamy L, Staudt LM, Levens DL, Kelleher NL, Licht JD
  Title
The MMSET histone methyl transferase switches global histone methylation and alters gene expression in t(4;14) multiple myeloma cells.
  Journal
Blood 117:211-20 (2011)
DOI:10.1182/blood-2010-07-298349
Reference
PMID:19059936
  Authors
Brito JL, Walker B, Jenner M, Dickens NJ, Brown NJ, Ross FM, Avramidou A, Irving JA, Gonzalez D, Davies FE, Morgan GJ
  Title
MMSET deregulation affects cell cycle progression and adhesion regulons in t(4;14) myeloma plasma cells.
  Journal
Haematologica 94:78-86 (2009)
DOI:10.3324/haematol.13426
Reference
PMID:10350329
  Authors
Iida S, Rao PH, Ueda R, Chaganti RS, Dalla-Favera R
  Title
Chromosomal rearrangement of the PAX-5 locus in lymphoplasmacytic lymphoma with t(9;14)(p13;q32).
  Journal
Leuk Lymphoma 34:25-33 (1999)
DOI:10.3109/10428199909083377
Reference
PMID:10784387
  Authors
Ohno H, Ueda C, Akasaka T
  Title
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Curr Opin Genet Dev 19:82-91 (2009)
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Translocations in epithelial cancers.
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Biochim Biophys Acta 1796:201-15 (2009)
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The paired box-8/peroxisome proliferator-activated receptor-gamma oncogene in thyroid tumorigenesis.
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Endocrinology 148:932-5 (2007)
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MYCN oncoprotein targets and their therapeutic potential.
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Proc Natl Acad Sci U S A 102:731-6 (2005)
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p53 is a direct transcriptional target of MYCN in neuroblastoma.
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Upregulation of Id2, an oncogenic helix-loop-helix protein, is mediated by the chimeric EWS/ets protein in Ewing sarcoma.
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The SYT-SSX fusion protein down-regulates the cell proliferation regulator COM1 in t(x;18) synovial sarcoma.
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Mutations in the p53 Tumor Suppressor Gene: Important Milestones at the Various Steps of Tumorigenesis.
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Recent advances in p53 research and cancer treatment.
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Related
pathway
elk04115  p53 signaling pathway
elk05211  Renal cell carcinoma
elk05215  Prostate cancer
elk05216  Thyroid cancer
elk05221  Acute myeloid leukemia
KO pathway
ko05202   
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