KEGG   PATHWAY: hai05202
Entry
hai05202                    Pathway                                
Name
Transcriptional misregulation in cancer - Hipposideros armiger (great roundleaf bat)
Description
In tumor cells, genes encoding transcription factors (TFs) are often amplified, deleted, rearranged via chromosomal translocation and inversion, or subjected to point mutations that result in a gain- or loss-of- function. In hematopoietic cancers and solid tumors, the translocations and inversions increase or deregulate transcription of the oncogene. Recurrent chromosome translocations generate novel fusion oncoproteins, which are common in myeloid cancers and soft-tissue sarcomas. The fusion proteins have aberrant transcriptional function compared to their wild-type counterparts. These fusion transcription factors alter expression of target genes, and thereby result in a variety of altered cellular properties that contribute to the tumourigenic process.
Class
Human Diseases; Cancer: overview
Pathway map
hai05202  Transcriptional misregulation in cancer
hai05202

Organism
Hipposideros armiger (great roundleaf bat) [GN:hai]
Gene
109391240  RUNX1; runt-related transcription factor 1 isoform X1 [KO:K08367]
109374995  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
109379730  MPO; myeloperoxidase [KO:K10789] [EC:1.11.2.2]
109382590  CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427]
109382577  IL3; interleukin-3 [KO:K04736]
109372090  RUNX1T1; protein CBFA2T1 isoform X1 [KO:K10053]
109391669  HDAC1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
109384760  HDAC2; histone deacetylase 2 isoform X1 [KO:K06067] [EC:3.5.1.98]
109372345  SIN3A; paired amphipathic helix protein Sin3a [KO:K11644]
109382177  nuclear receptor corepressor 1 [KO:K04650]
109389201  CEBPA; CCAAT/enhancer-binding protein alpha [KO:K09055]
109375021  PER2; period circadian protein homolog 2 [KO:K02633]
109390241  SPI1; transcription factor PU.1 isoform X1 [KO:K09438]
109393398  CD14; monocyte differentiation antigen CD14 [KO:K04391]
109374167  integrin alpha-M-like isoform X1 [KO:K06461]
109378026  LOW QUALITY PROTEIN: high affinity immunoglobulin gamma Fc receptor I-like [KO:K06498]
109395757  JUP; junction plakoglobin [KO:K10056]
109396273  PML; protein PML isoform X1 [KO:K10054] [EC:2.3.2.-]
109380809  RARA; retinoic acid receptor alpha isoform X1 [KO:K08527]
109396675  CCNA2; cyclin-A2 [KO:K06627]
109388453  CCNA1; cyclin-A1 [KO:K06627]
109393628  CEBPE; CCAAT/enhancer-binding protein epsilon [KO:K10051]
109381387  bcl-2-related protein A1-like [KO:K02162]
109376325  ZBTB16; zinc finger and BTB domain-containing protein 16 [KO:K10055]
109383211  MYC; myc proto-oncogene protein [KO:K04377]
109392791  DUSP6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
109390608  TCF3; transcription factor E2-alpha isoform X1 [KO:K09063]
109392313  PBX1; pre-B-cell leukemia transcription factor 1 isoform X1 [KO:K09355]
109371280  WNT16; protein Wnt-16 [KO:K01558]
109383159  ETV6; transcription factor ETV6 isoform X1 [KO:K03211]
109395958  ETV7; transcription factor ETV7 [KO:K03211]
109378262  uncharacterized protein LOC109378262 [KO:K10785]
109386808  defensin-5-like isoform X1 [KO:K05230]
109378345  neutrophil defensin 4-like [KO:K05230]
109390590  ELANE; neutrophil elastase isoform X1 [KO:K01327] [EC:3.4.21.37]
109378533  LOW QUALITY PROTEIN: granzyme B-like [KO:K01353] [EC:3.4.21.79]
109378535  mast cell protease 3-like [KO:K01353] [EC:3.4.21.79]
109378555  LOW QUALITY PROTEIN: granzyme H-like [KO:K01353] [EC:3.4.21.79]
109378558  mast cell protease 3-like [KO:K01353] [EC:3.4.21.79]
109378669  duodenase-1-like [KO:K01353] [EC:3.4.21.79]
109378715  duodenase-1-like [KO:K01353] [EC:3.4.21.79]
109378716  mast cell protease 1A-like [KO:K01353] [EC:3.4.21.79]
109378494  granzyme B-like [KO:K01353] [EC:3.4.21.79]
109385301  KMT2A; histone-lysine N-methyltransferase 2A isoform X1 [KO:K09186] [EC:2.1.1.354]
109396335  AFF1; AF4/FMR2 family member 1 [KO:K15184]
109379833  CDK9; cyclin-dependent kinase 9 [KO:K02211] [EC:2.7.11.22 2.7.11.23]
109393248  CCNT1; cyclin-T1 [KO:K15188]
109374687  CCNT2; cyclin-T2 isoform X1 [KO:K15188]
109388611  MLLT1; protein ENL isoform X1 [KO:K15187]
109396419  MLLT3; protein AF-9 [KO:K15187]
109390613  DOT1L; histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X1 [KO:K11427] [EC:2.1.1.360]
109381095  LMO2; rhombotin-2 isoform X1 [KO:K15612]
109379597  PBX3; pre-B-cell leukemia transcription factor 3 isoform X1 [KO:K15610]
109382927  RUNX2; runt-related transcription factor 2 isoform X1 [KO:K09278]
109393116  SMAD1; mothers against decapentaplegic homolog 1 [KO:K04676]
109379474  KLF3; Krueppel-like factor 3 isoform X1 [KO:K15605]
109381982  MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
109381375  HOXA9; homeobox protein Hox-A9 isoform X1 [KO:K21950]
109381373  HOXA10; homeobox protein Hox-A10 [KO:K17443]
109380623  JMJD1C; probable JmjC domain-containing histone demethylation protein 2C isoform X1 [KO:K11449] [EC:1.14.11.-]
109381670  HMGA2; high mobility group protein HMGI-C [KO:K09283]
109386479  KDM6A; lysine-specific demethylase 6A isoform X1 [KO:K11447] [EC:1.14.11.68]
109382928  SUPT3H; transcription initiation protein SPT3 homolog isoform X1 [KO:K11313]
109372166  PROM1; prominin-1 isoform X1 [KO:K06532]
109395206  FLT3; receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
109395489  BMP2K; BMP-2-inducible protein kinase isoform X1 [KO:K08854] [EC:2.7.11.1]
109380372  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
109383166  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
109395311  CDK14; cyclin-dependent kinase 14 [KO:K08821] [EC:2.7.11.22]
109379171  MEIS1; homeobox protein Meis1 isoform X1 [KO:K15613]
109381374  HOXA11; homeobox protein Hox-A11 [KO:K21951]
109384457  SIX1; homeobox protein SIX1 [KO:K15614]
109384412  SIX4; homeobox protein SIX4 isoform X1 [KO:K15615]
109372618  eyes absent homolog 1 [KO:K15616] [EC:3.1.3.48]
109383290  eyes absent homolog 1-like [KO:K15616] [EC:3.1.3.48]
109390269  CDKN2C; cyclin-dependent kinase 4 inhibitor C isoform X1 [KO:K06622]
109379564  HPGD; 15-hydroxyprostaglandin dehydrogenase [NAD(+)] [KO:K00069] [EC:1.1.1.141]
109390887  GRIA3; glutamate receptor 3 isoform X1 [KO:K05199]
109382084  FUT8; alpha-(1,6)-fucosyltransferase [KO:K00717] [EC:2.4.1.68]
109379380  TLX3; T-cell leukemia homeobox protein 3 [KO:K15607]
109379596  TLX1; T-cell leukemia homeobox protein 1 isoform X1 [KO:K09340]
109380978  BCL11B; B-cell lymphoma/leukemia 11B isoform X1 [KO:K22046]
109379690  LDB1; LIM domain-binding protein 1 isoform X1 [KO:K15617]
109394287  LYL1; protein lyl-1 [KO:K15604]
109380909  HHEX; hematopoietically-expressed homeobox protein HHEX [KO:K08024]
109382866  PTCRA; LOW QUALITY PROTEIN: pre T-cell antigen receptor alpha [KO:K06056]
109379353  REL; proto-oncogene c-Rel [KO:K09254]
109392488  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
109375115  baculoviral IAP repeat-containing protein 2-like [KO:K16060]
109375125  BIRC3; baculoviral IAP repeat-containing protein 3 isoform X1 [KO:K16060]
109376360  LOW QUALITY PROTEIN: putative inhibitor of apoptosis [KO:K16060]
109385737  TRAF1; TNF receptor-associated factor 1 [KO:K03172]
109384429  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
109373362  bcl-2-like protein 1 isoform X1 [KO:K04570]
109386841  CD86; T-lymphocyte activation antigen CD86 isoform X1 [KO:K05413]
109379888  CD40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160]
109371168  BCL6; B-cell lymphoma 6 protein isoform X1 [KO:K15618]
109378306  MAF; transcription factor Maf [KO:K09035]
109391828  ITGB7; integrin beta-7 isoform X1 [KO:K06590]
109390921  NSD2; histone-lysine N-methyltransferase NSD2 isoform X1 [KO:K11424] [EC:2.1.1.357]
109395804  histone H3.3 [KO:K11253]
109381654  histone H3.3-like [KO:K11253]
109386514  histone H3.3-like [KO:K11253]
109378623  histone H3.3-like [KO:K11253]
109394755  LOW QUALITY PROTEIN: histone H3.3-like [KO:K11253]
109375739  histone H3.1-like [KO:K11253]
109375740  histone H3.1-like [KO:K11253]
109375742  histone H3.1 [KO:K11253]
109375743  histone H3.1 [KO:K11253]
109375744  histone H3.1 [KO:K11253]
109375761  histone H3.1 [KO:K11253]
109383738  histone H3.3 [KO:K11253]
109378027  histone H3 [KO:K11253]
109396451  histone H3.3-like [KO:K11253]
109375766  histone H3.1-like [KO:K11253]
109393733  PAX5; paired box protein Pax-5 isoform X1 [KO:K09383]
109392002  PAX8; paired box protein Pax-8 isoform X1 [KO:K09293]
109384577  PPARG; peroxisome proliferator-activated receptor gamma isoform X1 [KO:K08530]
109381229  RXRA; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
109392460  RXRB; retinoic acid receptor RXR-beta isoform X1 [KO:K08525]
109385199  retinoic acid receptor RXR-gamma-like isoform X1 [KO:K08526]
109392300  retinoic acid receptor RXR-gamma-like [KO:K08526]
109393447  PRCC; proline-rich protein PRCC [KO:K13105]
109374805  TFE3; transcription factor E3 isoform X1 [KO:K09105]
109395991  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
109372657  TMPRSS2; transmembrane protease serine 2 [KO:K09633] [EC:3.4.21.122]
109389856  ERG; transcriptional regulator ERG isoform X1 [KO:K09435]
109371644  PLAU; urokinase-type plasminogen activator [KO:K01348] [EC:3.4.21.73]
109386253  PLAT; tissue-type plasminogen activator [KO:K01343] [EC:3.4.21.68]
109379910  MMP9; matrix metalloproteinase-9 [KO:K01403] [EC:3.4.24.35]
109392909  ZEB1; zinc finger E-box-binding homeobox 1 isoform X1 [KO:K09299]
109395468  IL1R2; interleukin-1 receptor type 2 isoform X1 [KO:K04387]
109384036  SPINT1; kunitz-type protease inhibitor 1 isoform X1 [KO:K15619]
109371392  ETV1; ETS translocation variant 1 isoform X1 [KO:K09431]
109394982  ETV4; ETS translocation variant 4 isoform X1 [KO:K15592]
109371347  ETV5; ETS translocation variant 5 isoform X1 [KO:K15593]
109386509  SLC45A3; solute carrier family 45 member 3 [KO:K15379]
109386500  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
109380301  DDX5; probable ATP-dependent RNA helicase DDX5 [KO:K12823] [EC:5.6.2.7]
109390070  MYCN; N-myc proto-oncogene protein [KO:K09109]
109382105  MAX; protein max isoform X1 [KO:K04453]
109381699  MDM2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
109390857  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
109394672  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
109394756  BMI1; polycomb complex protein BMI-1 [KO:K11459]
109391846  SP1; transcription factor Sp1 [KO:K04684]
109389399  ZBTB17; zinc finger and BTB domain-containing protein 17 isoform X1 [KO:K10500]
109393379  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
109380655  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
109384103  MEN1; menin isoform X1 [KO:K14970]
109383058  EWSR1; RNA-binding protein EWS isoform X1 [KO:K13209]
109392083  FLI1; Friend leukemia integration 1 transcription factor isoform X1 [KO:K09436]
109387785  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
109372307  ID2; DNA-binding protein inhibitor ID-2 [KO:K17693]
109394441  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
109373013  IGFBP3; insulin-like growth factor-binding protein 3 [KO:K10138]
109380557  FEV; protein FEV [KO:K09437]
109393258  ATF1; cyclic AMP-dependent transcription factor ATF-1 isoform X1 [KO:K09053]
109371882  LOW QUALITY PROTEIN: cyclic AMP-dependent transcription factor ATF-1-like [KO:K09053]
109381464  ARNT2; aryl hydrocarbon receptor nuclear translocator 2 isoform X1 [KO:K15589]
109371552  ATM; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
109387441  MITF; microphthalmia-associated transcription factor isoform X1 [KO:K09455]
109381159  WT1; Wilms tumor protein isoform X1 [KO:K09234]
109380137  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
109394467  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
109385921  BAIAP3; BAI1-associated protein 3 isoform X1 [KO:K15621]
109386775  TSPAN7; tetraspanin-7 [KO:K06571]
109373373  MLF1; myeloid leukemia factor 1 isoform X1 [KO:K15622]
109386430  NR4A3; nuclear receptor subfamily 4 group A member 3 [KO:K08559]
109373180  TAF15; TATA-binding protein-associated factor 2N [KO:K14651]
109374204  FUS; RNA-binding protein FUS isoform X1 [KO:K13098]
109390744  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
109381855  CEBPB; CCAAT/enhancer-binding protein beta [KO:K10048]
109387871  IL6; interleukin-6 [KO:K05405]
109385786  NFKBIZ; NF-kappa-B inhibitor zeta isoform X1 [KO:K14242]
109372541  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
109384322  RELA; transcription factor p65 isoform X1 [KO:K04735]
109394819  CXCL8; interleukin-8 [KO:K10030]
109396187  PAX3; paired box protein Pax-3 isoform X1 [KO:K09381]
109389394  PAX7; paired box protein Pax-7 isoform X1 [KO:K09381]
109387667  FOXO1; forkhead box protein O1 [KO:K07201]
109395227  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
109390085  vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
109380075  SS18L1; calcium-responsive transactivator isoform X1 [KO:K15623]
109390106  SS18; protein SSXT isoform X1 [KO:K15623]
109374413  SSX7; LOW QUALITY PROTEIN: protein SSX7 [KO:K15624]
109385807  NUPR1; nuclear protein 1 [KO:K15626]
109393039  ASPSCR1; tether containing UBX domain for GLUT4 isoform X1 [KO:K15627]
109389346  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
109384926  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
109374090  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
109390584  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
109391068  BAX; apoptosis regulator BAX [KO:K02159]
109392454  BAK1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
109390202  DDB2; DNA damage-binding protein 2 [KO:K10140]
109381899  POLK; DNA polymerase kappa [KO:K03511] [EC:2.7.7.7]
Reference
PMID:11607818
  Authors
Alcalay M, Orleth A, Sebastiani C, Meani N, Chiaradonna F, Casciari C, Sciurpi MT, Gelmetti V, Riganelli D, Minucci S, Fagioli M, Pelicci PG
  Title
Common themes in the pathogenesis of acute myeloid leukemia.
  Journal
Oncogene 20:5680-94 (2001)
DOI:10.1038/sj.onc.1204642
Reference
PMID:12032780
  Authors
Scandura JM, Boccuni P, Cammenga J, Nimer SD
  Title
Transcription factor fusions in acute leukemia: variations on a theme.
  Journal
Oncogene 21:3422-44 (2002)
DOI:10.1038/sj.onc.1205315
Reference
PMID:12529654
  Authors
Roumier C, Fenaux P, Lafage M, Imbert M, Eclache V, Preudhomme C
  Title
New mechanisms of AML1 gene alteration in hematological malignancies.
  Journal
Leukemia 17:9-16 (2003)
DOI:10.1038/sj.leu.2402766
Reference
PMID:10717473
  Authors
Lutterbach B, Hiebert SW
  Title
Role of the transcription factor AML-1 in acute leukemia and hematopoietic differentiation.
  Journal
Gene 245:223-35 (2000)
DOI:10.1016/S0378-1119(00)00014-7
Reference
PMID:19075268
  Authors
Koschmieder S, Halmos B, Levantini E, Tenen DG
  Title
Dysregulation of the C/EBPalpha differentiation pathway in human cancer.
  Journal
J Clin Oncol 27:619-28 (2009)
DOI:10.1200/JCO.2008.17.9812
Reference
PMID:11340171
  Authors
Johansen LM, Iwama A, Lodie TA, Sasaki K, Felsher DW, Golub TR, Tenen DG
  Title
c-Myc is a critical target for c/EBPalpha in granulopoiesis.
  Journal
Mol Cell Biol 21:3789-806 (2001)
DOI:10.1128/MCB.21.11.3789-3806.2001
Reference
PMID:15985538
  Authors
Gery S, Gombart AF, Yi WS, Koeffler C, Hofmann WK, Koeffler HP
  Title
Transcription profiling of C/EBP targets identifies Per2 as a gene implicated in myeloid leukemia.
  Journal
Blood 106:2827-36 (2005)
DOI:10.1182/blood-2005-01-0358
Reference
PMID:12393465
  Authors
Vangala RK, Heiss-Neumann MS, Rangatia JS, Singh SM, Schoch C, Tenen DG, Hiddemann W, Behre G
  Title
The myeloid master regulator transcription factor PU.1 is inactivated by AML1-ETO in t(8;21) myeloid leukemia.
  Journal
Blood 101:270-7 (2003)
DOI:10.1182/blood-2002-04-1288
Reference
PMID:12130514
  Authors
Mueller BU, Pabst T, Osato M, Asou N, Johansen LM, Minden MD, Behre G, Hiddemann W, Ito Y, Tenen DG
  Title
Heterozygous PU.1 mutations are associated with acute myeloid leukemia.
  Journal
Blood 100:998-1007 (2002)
DOI:10.1182/blood.V100.3.998
Reference
PMID:15160934
  Authors
Jing Y
  Title
The PML-RARalpha fusion protein and targeted therapy for acute promyelocytic leukemia.
  Journal
Leuk Lymphoma 45:639-48 (2004)
DOI:10.1080/10428190310001609933
Reference
PMID:15024077
  Authors
Muller-Tidow C, Steffen B, Cauvet T, Tickenbrock L, Ji P, Diederichs S, Sargin B, Kohler G, Stelljes M, Puccetti E, Ruthardt M, deVos S, Hiebert SW, Koeffler HP, Berdel WE, Serve H
  Title
Translocation products in acute myeloid leukemia activate the Wnt signaling pathway in hematopoietic cells.
  Journal
Mol Cell Biol 24:2890-904 (2004)
DOI:10.1128/MCB.24.7.2890-2904.2004
Reference
PMID:19855079
  Authors
Rice KL, Hormaeche I, Doulatov S, Flatow JM, Grimwade D, Mills KI, Leiva M, Ablain J, Ambardekar C, McConnell MJ, Dick JE, Licht JD
  Title
Comprehensive genomic screens identify a role for PLZF-RARalpha as a positive regulator of cell proliferation via direct regulation of c-MYC.
  Journal
Blood 114:5499-511 (2009)
DOI:10.1182/blood-2009-03-206524
Reference
PMID:10500199
  Authors
McWhirter JR, Neuteboom ST, Wancewicz EV, Monia BP, Downing JR, Murre C
  Title
Oncogenic homeodomain transcription factor E2A-Pbx1 activates a novel WNT gene in pre-B acute lymphoblastoid leukemia.
  Journal
Proc Natl Acad Sci U S A 96:11464-9 (1999)
DOI:10.1073/pnas.96.20.11464
Reference
PMID:15156184
  Authors
Zelent A, Greaves M, Enver T
  Title
Role of the TEL-AML1 fusion gene in the molecular pathogenesis of childhood acute lymphoblastic leukaemia.
  Journal
Oncogene 23:4275-83 (2004)
DOI:10.1038/sj.onc.1207672
Reference
PMID:14630078
  Authors
Sawinska M, Ladon D
  Title
Mechanism, detection and clinical significance of the reciprocal translocation t(12;21)(p12;q22) in the children suffering from acute lymphoblastic leukaemia.
  Journal
Leuk Res 28:35-42 (2004)
DOI:10.1016/S0145-2126(03)00160-7
Reference
PMID:19141473
  Authors
Guenther MG, Lawton LN, Rozovskaia T, Frampton GM, Levine SS, Volkert TL, Croce CM, Nakamura T, Canaani E, Young RA
  Title
Aberrant chromatin at genes encoding stem cell regulators in human mixed-lineage leukemia.
  Journal
Genes Dev 22:3403-8 (2008)
DOI:10.1101/gad.1741408
Reference
PMID:16169901
  Authors
Xia ZB, Popovic R, Chen J, Theisler C, Stuart T, Santillan DA, Erfurth F, Diaz MO, Zeleznik-Le NJ
  Title
The MLL fusion gene, MLL-AF4, regulates cyclin-dependent kinase inhibitor CDKN1B (p27kip1) expression.
  Journal
Proc Natl Acad Sci U S A 102:14028-33 (2005)
DOI:10.1073/pnas.0506464102
Reference
PMID:21518926
  Authors
Wang QF, Wu G, Mi S, He F, Wu J, Dong J, Luo RT, Mattison R, Kaberlein JJ, Prabhakar S, Ji H, Thirman MJ
  Title
MLL fusion proteins preferentially regulate a subset of wild-type MLL target genes in the leukemic genome.
  Journal
Blood 117:6895-905 (2011)
DOI:10.1182/blood-2010-12-324699
Reference
PMID:14701735
  Authors
Zeisig BB, Milne T, Garcia-Cuellar MP, Schreiner S, Martin ME, Fuchs U, Borkhardt A, Chanda SK, Walker J, Soden R, Hess JL, Slany RK
  Title
Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization.
  Journal
Mol Cell Biol 24:617-28 (2004)
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Related
pathway
hai04115  p53 signaling pathway
hai05211  Renal cell carcinoma
hai05215  Prostate cancer
hai05216  Thyroid cancer
hai05221  Acute myeloid leukemia
KO pathway
ko05202   
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