KEGG   PATHWAY: mcoc05415
Entry
mcoc05415                   Pathway                                
Name
Diabetic cardiomyopathy - Mastomys coucha (southern multimammate mouse)
Description
Diabetic cardiomyopathy has been defined as left ventricular dysfunction that occurs among patients with diabetes mellitus independent of a recognized cause such as coronary artery disease or hypertension. The pathogenesis of diabetic cardiomyopathy broadly involves hyperglycemia, increased circulating fatty acids, and insulin resistance contributing to reactive oxygen species (ROS) generation, mitochondrial dysfunction, impaired calcium metabolism, Renin-Angiotensin System (RAS) activation, and altered substrate metabolism. These effects result in cardiac fibrosis, hypertrophy, cardiomyocyte death, contractile dysfunction, endothelial cell damage and eventually heart failure. In the process of cardiac fibrosis, cardiac fibroblasts are the final effector cell.
Class
Human Diseases; Cardiovascular disease
Pathway map
mcoc05415  Diabetic cardiomyopathy
mcoc05415

Organism
Mastomys coucha (southern multimammate mouse) [GN:mcoc]
Gene
116096528  Slc2a1; solute carrier family 2, facilitated glucose transporter member 1 [KO:K07299]
116079077  Slc2a4; solute carrier family 2, facilitated glucose transporter member 4 [KO:K07191]
116099198  Gfpt1; glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 [KO:K00820] [EC:2.6.1.16]
116077990  Gfpt2; glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 [KO:K00820] [EC:2.6.1.16]
116084777  Camk2g; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
116093748  Camk2d; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
116087223  Camk2a; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
116069264  Camk2b; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
116101548  Tnni3; troponin I, cardiac muscle [KO:K12044]
116081429  Ryr2; ryanodine receptor 2 isoform X1 [KO:K04962]
116075109  Pln; cardiac phospholamban [KO:K05852]
116102951  Atp2a1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
116068368  Atp2a2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
116077667  Atp2a3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
116080468  Sp1; transcription factor Sp1 isoform X1 [KO:K04684]
116070395  Agt; angiotensinogen [KO:K09821]
116099326  Ren; renin [KO:K01380] [EC:3.4.23.15]
116084365  mast cell protease 4 [KO:K01329] [EC:3.4.21.39]
116084422  mast cell protease 1-like [KO:K01329] [EC:3.4.21.39]
116084454  chymase [KO:K01329] [EC:3.4.21.39]
116084761  mast cell protease-like protein [KO:K01329] [EC:3.4.21.39]
116084762  mast cell protease 1-like [KO:K01329] [EC:3.4.21.39]
116102917  Prkcb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
116075328  Ager; advanced glycosylation end product-specific receptor isoform X1 [KO:K19722]
116069354  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
116104663  Ncf1; neutrophil cytosol factor 1 [KO:K08011]
116070330  cytochrome b-245 light chain [KO:K08009]
116101207  Ncf2; neutrophil cytosol factor 2 [KO:K08010]
116075335  Ncf4; neutrophil cytosol factor 4 [KO:K08012]
116068714  Rac1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
116075508  Rac2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
116094994  Agtr1; type-1 angiotensin II receptor [KO:K04166]
116082258  type-1A angiotensin II receptor [KO:K04166]
116093825  Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
116103403  Rela; transcription factor p65 isoform X1 [KO:K04735]
116075101  Mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
116075516  Mapk14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
116077765  Mapk11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
116077791  Mapk12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
116085336  Mapk8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
116067982  Mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
116076765  Mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
116069868  Mmp2; 72 kDa type IV collagenase [KO:K01398] [EC:3.4.24.24]
116092533  Mmp9; matrix metalloproteinase-9 [KO:K01403] [EC:3.4.24.35]
116098542  Col1a2; collagen alpha-2(I) chain [KO:K06236]
116078726  Col1a1; collagen alpha-1(I) chain [KO:K06236]
116088383  Col3a1; collagen alpha-1(III) chain [KO:K19720]
116101857  Tgfb1; transforming growth factor beta-1 proprotein [KO:K13375]
116068447  Tgfb2; transforming growth factor beta-2 proprotein [KO:K13376]
116080097  Tgfb3; transforming growth factor beta-3 proprotein [KO:K13377]
116097492  Cd36; platelet glycoprotein 4 [KO:K06259]
116077376  Ppara; peroxisome proliferator-activated receptor alpha [KO:K07294]
116078025  Cpt1b; carnitine O-palmitoyltransferase 1, muscle isoform [KO:K19523] [EC:2.3.1.21]
116098549  Pdk4; pyruvate dehydrogenase kinase, isozyme 4 [KO:K00898] [EC:2.7.11.2]
116086802  Pdk3; pyruvate dehydrogenase kinase, isozyme 3 isoform X1 [KO:K00898] [EC:2.7.11.2]
116078985  Pdk2; pyruvate dehydrogenase kinase, isozyme 2 isoform X1 [KO:K00898] [EC:2.7.11.2]
116076783  Prkca; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
116085415  Prkcd; protein kinase C delta type isoform X1 [KO:K06068] [EC:2.7.11.13]
116089949  Ptpa; serine/threonine-protein phosphatase 2A activator [KO:K17605]
116103326  Ppp1ca; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
116104637  Ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
116079614  Ppp1cb; serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
116103240  Ctsd; cathepsin D [KO:K01379] [EC:3.4.23.5]
116095810  Prkcz; protein kinase C zeta type [KO:K18952] [EC:2.7.11.13]
116096366  Cpt2; carnitine O-palmitoyltransferase 2, mitochondrial [KO:K08766] [EC:2.3.1.21]
116101481  insulin-1 [KO:K04526]
116068825  Insr; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
116088647  Irs1; insulin receptor substrate 1 [KO:K16172]
116095058  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
116097037  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
116073929  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
116096465  Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
116083721  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
116069491  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
116103746  Pten; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
116101889  Akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
116104026  Akt3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
116079779  Akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
116097015  Mtor; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
116085894  Gsk3b; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
116102200  Gys1; glycogen [starch] synthase, muscle [KO:K00693] [EC:2.4.1.11]
116098429  Gys2; glycogen [starch] synthase, liver [KO:K00693] [EC:2.4.1.11]
116085380  Tbc1d4; TBC1 domain family member 4 isoform X1 [KO:K17902]
116077258  Mpc1; mitochondrial pyruvate carrier 1 isoform X1 [KO:K22138]
116091648  Mpc1l; mitochondrial pyruvate carrier 1-like protein [KO:K22138]
116102833  Mpc2; mitochondrial pyruvate carrier 2 [KO:K22139]
116099600  Pdha1; pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial [KO:K00161] [EC:1.2.4.1]
116093861  Pdha2; pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial [KO:K00161] [EC:1.2.4.1]
116072771  Pdhb; pyruvate dehydrogenase E1 component subunit beta, mitochondrial [KO:K00162] [EC:1.2.4.1]
34682989  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
34682993  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
34683008  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
34683011  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
34683010  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
34683015  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
34683016  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
116103309  Ndufv1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
116088857  Ndufv2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
116075130  Ndufv3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
116077484  Ndufa1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
116087026  Ndufa2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
116101528  Ndufa3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
116098581  Ndufa4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
116076179  Ndufa4l2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
116098636  Ndufa5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
116080991  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like [KO:K03949]
116076712  Ndufa6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
116076307  Ndufa7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
116090075  Ndufa8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
116099623  Ndufa9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
116088778  Ndufa10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [KO:K03954]
116102910  Ndufab1; acyl carrier protein, mitochondrial [KO:K03955]
116074922  Ndufa11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
116076188  Ndufa12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
116069436  Ndufa13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
116079733  Ndufb1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
116098773  Ndufb2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
116088464  Ndufb3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
116085890  Ndufb4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
116095068  Ndufb5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
116095820  Ndufb6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
116069684  Ndufb7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
116103899  Ndufb8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
116082796  Ndufb9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 isoform X1 [KO:K03965]
116077266  Ndufb10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
116073091  Ndufb11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
116089452  Ndufs1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
116103359  Ndufs2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
116090451  Ndufs3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
116083700  Ndufs4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [KO:K03937]
116096591  Ndufs5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
116083218  Ndufs6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
116075723  Ndufs7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial [KO:K03940] [EC:7.1.1.2]
116103302  Ndufs8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [KO:K03941] [EC:7.1.1.2]
116102591  Ndufc2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
116083193  Sdha; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial [KO:K00234] [EC:1.3.5.1]
116096943  Sdhb; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
116103322  Sdhc; succinate dehydrogenase cytochrome b560 subunit, mitochondrial [KO:K00236]
116073180  Sdhd; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial [KO:K00237]
116082198  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
34683018  CYTB; cytochrome b [KO:K00412]
116074595  cytochrome c1, heme protein, mitochondrial [KO:K00413]
116073065  cytochrome b-c1 complex subunit 1, mitochondrial [KO:K00414]
116102887  cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
116096453  cytochrome b-c1 complex subunit 6, mitochondrial [KO:K00416]
116082347  cytochrome b-c1 complex subunit 7 [KO:K00417]
116077290  cytochrome b-c1 complex subunit 8 [KO:K00418]
116069534  cytochrome b-c1 complex subunit 9 isoform X1 [KO:K00419]
116075740  cytochrome b-c1 complex subunit 10 [KO:K00420]
34683006  COX3; cytochrome c oxidase subunit III [KO:K02262]
34682999  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
34683002  COX2; cytochrome c oxidase subunit II [KO:K02261]
116092456  cytochrome c oxidase subunit 4 isoform 2, mitochondrial [KO:K02263]
116070294  cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
116071976  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
116088312  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
116100918  cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
116068251  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
116101988  cytochrome c oxidase subunit 6B1 [KO:K02267]
116101559  cytochrome c oxidase subunit 6B2 isoform X1 [KO:K02267]
116082439  cytochrome c oxidase subunit 6C [KO:K02268]
116100436  cytochrome c oxidase subunit 7A1, mitochondrial [KO:K02270]
116080462  cytochrome c oxidase subunit 7A-related protein, mitochondrial [KO:K02270]
116073347  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
116087988  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
116071167  cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
116083615  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
116103484  cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
116100960  cytochrome c oxidase subunit 8B, mitochondrial-like [KO:K02273]
116080263  cytochrome c oxidase subunit 8C, mitochondrial [KO:K02273]
116087380  Atp5f1a; ATP synthase subunit alpha, mitochondrial [KO:K02132]
116076143  Atp5f1b; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
116098989  ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
116082579  ATP synthase subunit gamma, mitochondrial-like [KO:K02136]
116076583  Atp5f1d; ATP synthase subunit delta, mitochondrial isoform X1 [KO:K02134]
116091503  Atp5f1e; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
34683005  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
116093578  Atp5pb; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
116077055  Atp5mc1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
116090323  Atp5mc3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
116080645  Atp5mc2; ATP synthase F(0) complex subunit C2, mitochondrial isoform X1 [KO:K02128]
116077859  Atp5pd; ATP synthase subunit d, mitochondrial [KO:K02138]
116086146  Atp5po; ATP synthase subunit O, mitochondrial [KO:K02137]
34683004  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
116099029  voltage-dependent anion-selective channel protein 1 [KO:K05862]
116078655  Vdac1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
116084380  Vdac2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
116069012  Vdac3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
116094815  Slc25a31; ADP/ATP translocase 4 [KO:K05863]
116068035  LOW QUALITY PROTEIN: ADP/ATP translocase 2-like [KO:K05863]
116068749  ADP/ATP translocase 2-like isoform X1 [KO:K05863]
116069234  Slc25a4; ADP/ATP translocase 1 [KO:K05863]
116091233  Slc25a5; ADP/ATP translocase 2 [KO:K05863]
116084704  Ppif; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
116101512  Prkcg; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
116097543  Nos3; nitric oxide synthase, endothelial isoform X1 [KO:K13242] [EC:1.14.13.39]
116095814  glyceraldehyde-3-phosphate dehydrogenase-like isoform X1 [KO:K00134] [EC:1.2.1.12]
116096692  LOW QUALITY PROTEIN: uncharacterized protein LOC116096692 [KO:K00134] [EC:1.2.1.12]
116083881  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
116091871  glyceraldehyde-3-phosphate dehydrogenase isoform X1 [KO:K00134] [EC:1.2.1.12]
116104693  Parp1; poly [ADP-ribose] polymerase 1 [KO:K24070] [EC:2.4.2.30]
116086269  G6pd; LOW QUALITY PROTEIN: glucose-6-phosphate 1-dehydrogenase [KO:K00036] [EC:1.1.1.49 1.1.1.363]
116069130  Gsr; glutathione reductase, mitochondrial [KO:K00383] [EC:1.8.1.7]
116095983  Tgfbr1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
116073579  Tgfbr2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
116087365  Smad2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
116073193  Smad3; mothers against decapentaplegic homolog 3 [KO:K23605]
116103465  Plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
116090695  Plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
116090998  Plcb1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
116090999  Plcb4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
116077933  Ace; angiotensin-converting enzyme isoform X1 [KO:K01283] [EC:3.4.15.1]
116078573  angiotensin-converting enzyme-like protein Ace3 isoform X1 [KO:K01283] [EC:3.4.15.1]
Compound
C00001  H2O
C00002  ATP
C00005  NADPH
C00006  NADP+
C00022  Pyruvate
C00024  Acetyl-CoA
C00027  Hydrogen peroxide
C00031  D-Glucose
C00043  UDP-N-acetyl-alpha-D-glucosamine
C00051  Glutathione
C00076  Calcium cation
C00085  D-Fructose 6-phosphate
C00092  D-Glucose 6-phosphate
C00095  D-Fructose
C00118  D-Glyceraldehyde 3-phosphate
C00127  Glutathione disulfide
C00162  Fatty acid
C00165  Diacylglycerol
C00195  N-Acylsphingosine
C00236  3-Phospho-D-glyceroyl phosphate
C00318  L-Carnitine
C00352  D-Glucosamine 6-phosphate
C00369  Starch
C00533  Nitric oxide
C00546  Methylglyoxal
C00704  Superoxide
C00794  D-Sorbitol
C00873  Angiotensin I
C02135  Angiotensin II
C02843  Long-chain acyl-CoA
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06156  alpha-D-Glucosamine 1-phosphate
C16844  Hydroxyl radical
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
C22310  Fructose 3-phosphate
C22311  3-Deoxyglucosone
Reference
PMID:30443826
  Authors
Riehle C, Bauersachs J
  Title
Of mice and men: models and mechanisms of diabetic cardiomyopathy.
  Journal
Basic Res Cardiol 114:2 (2018)
DOI:10.1007/s00395-018-0711-0
Reference
PMID:24462787
  Authors
Huynh K, Bernardo BC, McMullen JR, Ritchie RH
  Title
Diabetic cardiomyopathy: mechanisms and new treatment strategies targeting antioxidant signaling pathways.
  Journal
Pharmacol Ther 142:375-415 (2014)
DOI:10.1016/j.pharmthera.2014.01.003
Reference
PMID:28231848
  Authors
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Related
pathway
mcoc00010  Glycolysis / Gluconeogenesis
mcoc00020  Citrate cycle (TCA cycle)
mcoc00190  Oxidative phosphorylation
mcoc00520  Amino sugar and nucleotide sugar metabolism
mcoc03320  PPAR signaling pathway
mcoc04071  Sphingolipid signaling pathway
mcoc04150  mTOR signaling pathway
mcoc04210  Apoptosis
mcoc04260  Cardiac muscle contraction
mcoc04350  TGF-beta signaling pathway
mcoc04614  Renin-angiotensin system
mcoc04910  Insulin signaling pathway
mcoc04930  Type II diabetes mellitus
mcoc04931  Insulin resistance
mcoc04933  AGE-RAGE signaling pathway in diabetic complications
mcoc04940  Type I diabetes mellitus
KO pathway
ko05415   
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