KEGG   PATHWAY: mni04218
Entry
mni04218                    Pathway                                
Name
Cellular senescence - Macaca nemestrina (pig-tailed macaque)
Description
Cellular senescence is a state of irreversible cellular arrest and can be triggered by a number of factors, such as telomere shortening, oncogene activation, irradiation, DNA damage and oxidative stress. It is characterized by enlarged flattened morphology, senescence-associated beta-galactosidase (SA-b-gal) activity, secretion of inflammatory cytokines, growth factors and matrix metalloproteinases, as part of the senescence-associated secretory phenotype (SASP). Cellular senescence is functionally associated with many biological processes including aging, tumor suppression, placental biology, embryonic development, and wound healing.
Class
Cellular Processes; Cell growth and death
Pathway map
mni04218  Cellular senescence
mni04218

Other DBs
GO: 0090398
Organism
Macaca nemestrina (pig-tailed macaque) [GN:mni]
Gene
105495300  TGFB1; transforming growth factor beta-1 [KO:K13375]
105493507  TGFB2; transforming growth factor beta-2 isoform X1 [KO:K13376]
105495762  TGFB3; transforming growth factor beta-3 [KO:K13377]
105477209  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
105470963  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
105489370  SMAD2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
105488126  SMAD3; mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
105498411  CDKN2B; cyclin-dependent kinase 4 inhibitor B [KO:K04685]
105474081  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
105475503  CDK6; cyclin-dependent kinase 6 isoform X1 [KO:K02091] [EC:2.7.11.22]
105469727  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
105484147  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
105489611  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
105490695  RB1; retinoblastoma-associated protein isoform X1 [KO:K06618]
105496302  RBL1; retinoblastoma-like protein 1 isoform X1 [KO:K04681]
105494099  RBL2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
105496223  E2F1; transcription factor E2F1 [KO:K17454]
105494424  E2F2; LOW QUALITY PROTEIN: transcription factor E2F2 [KO:K09389]
105482518  E2F3; transcription factor E2F3 isoform X1 [KO:K06620]
105477135  E2F5; transcription factor E2F5 isoform X1 [KO:K04682]
105491436  E2F4; transcription factor E2F4 isoform X1 [KO:K04682]
105478978  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
105489973  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
105469947  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
105475205  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
105488082  PIK3R2; LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
105494953  PIK3R3; LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
105491751  FOXO1; forkhead box protein O1 [KO:K07201]
105492041  FOXO3; forkhead box protein O3 [KO:K09408]
105474528  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
105474169  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
105497230  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
105487658  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
105464138  MANE-B; LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, B-67 alpha chain [KO:K06751]
105468977  Mane-B; class I histocompatibility antigen, Gogo-B*0103 alpha chain-like precursor [KO:K06751]
105464135  Mane-B; class I histocompatibility antigen, Gogo-B*0101 alpha chain-like precursor [KO:K06751]
105467986  Mane-B; HLA class I histocompatibility antigen, B-45 alpha chain-like precursor [KO:K06751]
105466239  class I histocompatibility antigen, Gogo-B*0103 alpha chain [KO:K06751]
105466487  MANE-B; class I histocompatibility antigen, Gogo-B*0102 alpha chain isoform X1 [KO:K06751]
105498605  MANE-E; popy class I histocompatibility antigen, alpha chain E isoform X2 [KO:K06751]
105467297  class I histocompatibility antigen, Gogo-B*0101 alpha chain [KO:K06751]
105498584  MANE-A; LOW QUALITY PROTEIN: popy Class I histocompatibility antigen, A-1 alpha chain [KO:K06751]
105498640  MANE-E; patr class I histocompatibility antigen, alpha chain E [KO:K06751]
105498601  popy Class I histocompatibility antigen, A-1 alpha chain-like [KO:K06751]
105464109  MANE-B; HLA class I histocompatibility antigen, B-14 alpha chain [KO:K06751]
105466472  class I histocompatibility antigen, Gogo-B*0103 alpha chain-like isoform X1 [KO:K06751]
105491567  MANE-F; mamu class I histocompatibility antigen, alpha chain F [KO:K06751]
105491570  HLA class I histocompatibility antigen, A-24 alpha chain [KO:K06751]
105469851  LOW QUALITY PROTEIN: popy Class I histocompatibility antigen, A-1 alpha chain [KO:K06751]
105497653  HLA class I histocompatibility antigen, B-14 alpha chain-like isoform X1 [KO:K06751]
105497650  HLA class I histocompatibility antigen, B-14 alpha chain-like [KO:K06751]
105471000  MANE-B; class I histocompatibility antigen, Gogo-B*0101 alpha chain [KO:K06751]
112429386  LOW QUALITY PROTEIN: killer cell immunoglobulin-like receptor 2DL4 [KO:K24231]
105492133  KRAS; GTPase KRas isoform X1 [KO:K07827]
105479146  NRAS; GTPase NRas [KO:K07828]
105497191  RRAS; ras-related protein R-Ras [KO:K07829]
105486925  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
105469940  MRAS; ras-related protein M-Ras isoform X1 [KO:K07831]
105494134  HRAS; GTPase HRas isoform X1 [KO:K02833]
105474669  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105489842  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
105495343  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105464069  TSC1; LOW QUALITY PROTEIN: hamartin [KO:K07206]
105485816  TSC2; tuberin isoform X13 [KO:K07207]
105474923  RHEB; GTP-binding protein Rheb [KO:K07208]
105473151  MTOR; LOW QUALITY PROTEIN: serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
105480917  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
105466131  SIRT1; NAD-dependent protein deacetylase sirtuin-1 isoform X1 [KO:K11411] [EC:2.3.1.286]
105486045  CCNA1; cyclin-A1 isoform X1 [KO:K06627]
105486148  CCNA2; cyclin-A2 [KO:K06627]
105496382  MYBL2; myb-related protein B [KO:K21769]
105478599  LIN9; protein lin-9 homolog isoform X1 [KO:K21773]
105495502  LIN37; protein lin-37 homolog [KO:K21774]
105495803  LIN52; LOW QUALITY PROTEIN: protein lin-52 homolog [KO:K21775]
105496859  LIN54; protein lin-54 homolog isoform X1 [KO:K21776]
105494649  RBBP4; histone-binding protein RBBP4 [KO:K10752]
105484126  FOXM1; forkhead box protein M1 isoform X1 [KO:K09406]
105492792  MYC; myc proto-oncogene protein isoform X1 [KO:K04377]
105498410  CDKN2A; cyclin-dependent kinase inhibitor 2A [KO:K06621]
105473404  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
105473688  TP53; cellular tumor antigen p53 [KO:K04451]
105484844  RASSF5; ras association domain-containing protein 5 isoform X1 [KO:K08015]
105478371  BTRC; F-box/WD repeat-containing protein 1A isoform X1 [KO:K03362]
105480870  FBXW11; F-box/WD repeat-containing protein 11 isoform X1 [KO:K03362]
105479159  HIPK1; homeodomain-interacting protein kinase 1 isoform X1 [KO:K08826] [EC:2.7.11.1]
105471291  HIPK2; homeodomain-interacting protein kinase 2 isoform X1 [KO:K08826] [EC:2.7.11.1]
105471525  HIPK3; homeodomain-interacting protein kinase 3 isoform X1 [KO:K08826] [EC:2.7.11.1]
105495340  HIPK4; homeodomain-interacting protein kinase 4 [KO:K08826] [EC:2.7.11.1]
105479729  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
105469672  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
105493733  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
105477727  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
105488275  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
105485357  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
105480656  MAPK1; LOW QUALITY PROTEIN: mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
105482882  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
105476220  ETS1; protein C-ets-1 isoform X1 [KO:K02678]
105493311  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
105469063  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
105474512  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
105474514  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
105489757  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
105489758  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
105485789  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
105498437  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
105498812  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
105466181  CDK1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
105475199  CCNB1; G2/mitotic-specific cyclin-B1 [KO:K05868]
105489522  CCNB2; G2/mitotic-specific cyclin-B2 isoform X1 [KO:K21770]
105493944  CCNB3; G2/mitotic-specific cyclin-B3 isoform X1 [KO:K21771]
105484335  MRE11; double-strand break repair protein MRE11 isoform X1 [KO:K10865]
105467173  RAD50; DNA repair protein RAD50 [KO:K10866] [EC:3.6.-.-]
105497284  NBN; nibrin [KO:K10867]
105493755  ATM; serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
105487285  CHEK2; serine/threonine-protein kinase Chk2 isoform X3 [KO:K06641] [EC:2.7.11.1]
105469673  RAD9A; cell cycle checkpoint control protein RAD9A isoform X1 [KO:K10994] [EC:3.1.11.2]
105493420  RAD9B; cell cycle checkpoint control protein RAD9B isoform X2 [KO:K10995]
105473058  RAD1; cell cycle checkpoint protein RAD1 isoform X1 [KO:K02830] [EC:3.1.11.2]
105492351  HUS1; checkpoint protein HUS1 isoform X1 [KO:K10903]
105469998  ATR; serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
105476258  CHEK1; serine/threonine-protein kinase Chk1 isoform X1 [KO:K02216] [EC:2.7.11.1]
105480393  CDC25A; M-phase inducer phosphatase 1 isoform X2 [KO:K06645] [EC:3.1.3.48]
105483997  SQSTM1; sequestosome-1 isoform X1 [KO:K14381]
105491184  GATA4; transcription factor GATA-4 isoform X1 [KO:K09183]
105492086  TRAF3IP2; adapter protein CIKS isoform X1 [KO:K21124]
105486337  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X3 [KO:K02580]
105469585  RELA; transcription factor p65 isoform X1 [KO:K04735]
105471785  IL1A; interleukin-1 alpha [KO:K04383]
105475680  IL6; interleukin-6 isoform X1 [KO:K05405]
105477300  CXCL8; interleukin-8 precursor [KO:K10030]
105494236  IGFBP3; insulin-like growth factor-binding protein 3 [KO:K10138]
105492730  SERPINE1; LOW QUALITY PROTEIN: plasminogen activator inhibitor 1 [KO:K03982]
105476575  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
105484848  MAPKAPK2; LOW QUALITY PROTEIN: MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
105464929  ZFP36L2; mRNA decay activator protein ZFP36L2 [KO:K18753]
105472883  ZFP36L1; mRNA decay activator protein ZFP36L1 [KO:K18753]
105480573  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
105493440  TRPV4; transient receptor potential cation channel subfamily V member 4 isoform X2 [KO:K04973]
105490436  TRPM7; LOW QUALITY PROTEIN: transient receptor potential cation channel subfamily M member 7 [KO:K04982] [EC:2.7.11.1]
105469562  CAPN1; calpain-1 catalytic subunit isoform X1 [KO:K01367] [EC:3.4.22.52]
105478205  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
105464979  CALM2; calmodulin-2 [KO:K02183]
105496718  CALML6; calmodulin-like protein 6 isoform X1 [KO:K02183]
105488029  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
105478585  CALM3; calmodulin-3 isoform X1 [KO:K02183]
105467562  CALM1; calmodulin-1 isoform X1 [KO:K02183]
105483519  calmodulin-like [KO:K02183]
105492388  calmodulin-like [KO:K02183]
105494378  CALML3; calmodulin-like protein 3 [KO:K02183]
105494380  CALML5; calmodulin-like protein 5 [KO:K02183]
105486352  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
105466019  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
105482080  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
105465186  PPP3R1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
105480992  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
105489353  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
105470668  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
105491383  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
105477874  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
105477623  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
105492154  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
105474470  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
105486103  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
105478053  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
105466570  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
105468552  SLC25A5; LOW QUALITY PROTEIN: ADP/ATP translocase 2 [KO:K05863]
105488640  PPID; LOW QUALITY PROTEIN: peptidyl-prolyl cis-trans isomerase D [KO:K05864] [EC:5.2.1.8]
105467147  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
105465993  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
105476522  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
105466039  MCU; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C07909  Sirolimus
C16844  Hydroxyl radical
Reference
PMID:24954210
  Authors
Munoz-Espin D, Serrano M
  Title
Cellular senescence: from physiology to pathology.
  Journal
Nat Rev Mol Cell Biol 15:482-96 (2014)
DOI:10.1038/nrm3823
Reference
PMID:26646499
  Authors
Childs BG, Durik M, Baker DJ, van Deursen JM
  Title
Cellular senescence in aging and age-related disease: from mechanisms to therapy.
  Journal
Nat Med 21:1424-35 (2015)
DOI:10.1038/nm.4000
Reference
PMID:26105537
  Authors
Sharpless NE, Sherr CJ
  Title
Forging a signature of in vivo senescence.
  Journal
Nat Rev Cancer 15:397-408 (2015)
DOI:10.1038/nrc3960
Reference
PMID:26435346
  Authors
Fridlyanskaya I, Alekseenko L, Nikolsky N
  Title
Senescence as a general cellular response to stress: A mini-review.
  Journal
Exp Gerontol 72:124-8 (2015)
DOI:10.1016/j.exger.2015.09.021
Reference
PMID:27417123
  Authors
Lujambio A
  Title
To clear, or not to clear (senescent cells)? That is the question.
  Journal
Bioessays 38 Suppl 1:S56-64 (2016)
DOI:10.1002/bies.201670910
Reference
PMID:26564316
  Authors
Di Mitri D, Alimonti A
  Title
Non-Cell-Autonomous Regulation of Cellular Senescence in Cancer.
  Journal
Trends Cell Biol 26:215-26 (2016)
DOI:10.1016/j.tcb.2015.10.005
Reference
PMID:27574725
  Authors
Francica P, Aebersold DM, Medova M
  Title
Senescence as biologic endpoint following pharmacological targeting of receptor tyrosine kinases in cancer.
  Journal
Biochem Pharmacol 126:1-12 (2017)
DOI:10.1016/j.bcp.2016.08.022
Reference
PMID:23982440
  Authors
Bartling B
  Title
Cellular senescence in normal and premature lung aging.
  Journal
Z Gerontol Geriatr 46:613-22 (2013)
DOI:10.1007/s00391-013-0543-3
Reference
PMID:24238962
  Authors
Munoz-Espin D, Canamero M, Maraver A, Gomez-Lopez G, Contreras J, Murillo-Cuesta S, Rodriguez-Baeza A, Varela-Nieto I, Ruberte J, Collado M, Serrano M
  Title
Programmed cell senescence during mammalian embryonic development.
  Journal
Cell 155:1104-18 (2013)
DOI:10.1016/j.cell.2013.10.019
Reference
PMID:26697828
  Authors
Herranz N, Gallage S, Gil J
  Title
TORn about SASP regulation.
  Journal
Cell Cycle 14:3771-2 (2015)
DOI:10.1080/15384101.2015.1105694
Reference
PMID:28410770
  Authors
Martin N, Bernard D
  Title
Calcium signaling and cellular senescence.
  Journal
Cell Calcium S0143-4160(17)30049-0 (2017)
DOI:10.1016/j.ceca.2017.04.001
Reference
PMID:25764980
  Authors
Farfariello V, Iamshanova O, Germain E, Fliniaux I, Prevarskaya N
  Title
Calcium homeostasis in cancer: A focus on senescence.
  Journal
Biochim Biophys Acta 1853:1974-9 (2015)
DOI:10.1016/j.bbamcr.2015.03.005
Reference
PMID:24062309
  Authors
McCarthy DA, Clark RR, Bartling TR, Trebak M, Melendez JA
  Title
Redox control of the senescence regulator interleukin-1alpha and the secretory phenotype.
  Journal
J Biol Chem 288:32149-59 (2013)
DOI:10.1074/jbc.M113.493841
Reference
PMID:27288568
  Authors
Donninger H, Schmidt ML, Mezzanotte J, Barnoud T, Clark GJ
  Title
Ras signaling through RASSF proteins.
  Journal
Semin Cell Dev Biol 58:86-95 (2016)
DOI:10.1016/j.semcdb.2016.06.007
Reference
PMID:28455242
  Authors
Barnoud T, Schmidt ML, Donninger H, Clark GJ
  Title
The role of the NORE1A tumor suppressor in Oncogene-Induced Senescence.
  Journal
Cancer Lett 400:30-36 (2017)
DOI:10.1016/j.canlet.2017.04.030
Reference
PMID:26404840
  Authors
Kang C, Xu Q, Martin TD, Li MZ, Demaria M, Aron L, Lu T, Yankner BA, Campisi J, Elledge SJ
  Title
The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4.
  Journal
Science 349:aaa5612 (2015)
DOI:10.1126/science.aaa5612
Reference
PMID:26777575
  Authors
Cao X, Li M
  Title
A New Pathway for Senescence Regulation.
  Journal
Genomics Proteomics Bioinformatics 13:333-5 (2015)
DOI:10.1016/j.gpb.2015.11.002
Reference
PMID:25564883
  Authors
Gire V, Dulic V
  Title
Senescence from G2 arrest, revisited.
  Journal
Cell Cycle 14:297-304 (2015)
DOI:10.1080/15384101.2014.1000134
Reference
PMID:24981831
  Authors
Mowla SN, Lam EW, Jat PS
  Title
Cellular senescence and aging: the role of B-MYB.
  Journal
Aging Cell 13:773-9 (2014)
DOI:10.1111/acel.12242
Reference
PMID:22546858
  Authors
Yao H, Chung S, Hwang JW, Rajendrasozhan S, Sundar IK, Dean DA, McBurney MW, Guarente L, Gu W, Ronty M, Kinnula VL, Rahman I
  Title
SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice.
  Journal
J Clin Invest 122:2032-45 (2012)
DOI:10.1172/JCI60132
Reference
PMID:23542362
  Authors
Hwang JW, Yao H, Caito S, Sundar IK, Rahman I
  Title
Redox regulation of SIRT1 in inflammation and cellular senescence.
  Journal
Free Radic Biol Med 61:95-110 (2013)
DOI:10.1016/j.freeradbiomed.2013.03.015
Related
pathway
mni04020  Calcium signaling pathway
mni04068  FoxO signaling pathway
mni04110  Cell cycle
mni04115  p53 signaling pathway
mni04150  mTOR signaling pathway
KO pathway
ko04218   
LinkDB

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