KEGG   PATHWAY: obi03040
Entry
obi03040                    Pathway                                
Name
Spliceosome - Octopus bimaculoides (California two-spot octopus)
Description
After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified.
Class
Genetic Information Processing; Transcription
Pathway map
obi03040  Spliceosome
obi03040

Other DBs
GO: 0005681
Organism
Octopus bimaculoides (California two-spot octopus) [GN:obi]
Gene
128248955  U1 spliceosomal RNA [KO:K14276]
128250174  U2 spliceosomal RNA [KO:K14277]
128248443  U2 spliceosomal RNA [KO:K14277]
128251321  U2 spliceosomal RNA [KO:K14277]
128250839  U5 spliceosomal RNA [KO:K14279]
128250840  U5 spliceosomal RNA [KO:K14279]
128251486  U5 spliceosomal RNA [KO:K14279]
128249225  U6 spliceosomal RNA [KO:K14280]
128248217  U6 spliceosomal RNA [KO:K14280]
128247446  U6 spliceosomal RNA [KO:K14280]
128247705  U6 spliceosomal RNA [KO:K14280]
128250087  U6 spliceosomal RNA [KO:K14280]
128247163  U6 spliceosomal RNA [KO:K14280]
128249649  U6 spliceosomal RNA [KO:K14280]
128249454  U6 spliceosomal RNA [KO:K14280]
128247145  U6 spliceosomal RNA [KO:K14280]
128247153  U6 spliceosomal RNA [KO:K14280]
128250090  U6 spliceosomal RNA [KO:K14280]
106869362  probable ATP-dependent RNA helicase DDX46 isoform X1 [KO:K12811] [EC:5.6.2.7]
106879226  spliceosome RNA helicase DDX39B [KO:K12812] [EC:5.6.2.7]
106876964  pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 [KO:K12813] [EC:5.6.2.6]
106878466  pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 [KO:K12815] [EC:5.6.2.6]
106870024  pre-mRNA-processing factor 17 [KO:K12816]
106882627  pre-mRNA-splicing factor 18 [KO:K12817]
106871512  ATP-dependent RNA helicase DHX8 [KO:K12818] [EC:5.6.2.6]
106868620  pre-mRNA-splicing factor SLU7 [KO:K12819]
106876850  putative pre-mRNA-splicing factor ATP-dependent RNA helicase PRP1 [KO:K12820] [EC:5.6.2.6]
106884303  small nuclear ribonucleoprotein-associated protein B isoform X1 [KO:K11086]
106881112  small nuclear ribonucleoprotein Sm D2 [KO:K11096]
106867236  small nuclear ribonucleoprotein Sm D3 [KO:K11088]
106877797  small nuclear ribonucleoprotein E [KO:K11097]
106883615  small nuclear ribonucleoprotein F [KO:K11098]
106876131  small nuclear ribonucleoprotein G [KO:K11099]
106873934  U1 small nuclear ribonucleoprotein 70 kDa [KO:K11093]
106878535  U1 small nuclear ribonucleoprotein A [KO:K11091]
106877223  U1 small nuclear ribonucleoprotein C [KO:K11095]
106881150  pre-mRNA-processing factor 40 homolog A isoform X1 [KO:K12821]
106870847  RNA-binding protein 25 [KO:K12822]
106878808  RNA-binding protein 25 [KO:K12822]
106880622  probable ATP-dependent RNA helicase DDX5 isoform X1 [KO:K12823] [EC:5.6.2.7]
106876133  transcription elongation regulator 1 [KO:K12824]
106872884  RNA-binding protein cabeza [KO:K13098]
106874661  splicing factor 3A subunit 1 [KO:K12825]
106867349  splicing factor 3A subunit 2 [KO:K12826]
106868824  splicing factor 3A subunit 3 [KO:K12827]
106875096  splicing factor 3B subunit 1 isoform X1 [KO:K12828]
106869620  splicing factor 3B subunit 2 [KO:K12829]
106867716  splicing factor 3B subunit 3 [KO:K12830]
106883966  splicing factor 3B subunit 4 [KO:K12831]
106876661  splicing factor 3B subunit 6 [KO:K12833]
106873513  PHD finger-like domain-containing protein 5A isoform X1 [KO:K12834]
106871744  ATP-dependent RNA helicase DDX42 [KO:K12835] [EC:5.6.2.7]
106871304  splicing factor U2AF 35 kDa subunit isoform X3 [KO:K12836]
106879966  splicing factor U2AF 50 kDa subunit [KO:K12837]
106882518  poly(U)-binding-splicing factor PUF60-B isoform X1 [KO:K12838]
106875499  survival of motor neuron-related-splicing factor 30 [KO:K12839]
106875044  splicing factor 45 [KO:K12840]
128250638  calcium homeostasis endoplasmic reticulum protein-like [KO:K12841]
106873080  U2 snRNP-associated SURP motif-containing protein [KO:K12842]
106882765  U6 snRNA-associated Sm-like protein LSm2 [KO:K12621]
106870208  U6 snRNA-associated Sm-like protein LSm3 [KO:K12622]
106876251  U6 snRNA-associated Sm-like protein LSm4 [KO:K12623]
106871729  U6 snRNA-associated Sm-like protein LSm5 [KO:K12624]
106879912  U6 snRNA-associated Sm-like protein LSm6 [KO:K12625]
106881825  U6 snRNA-associated Sm-like protein LSm7 [KO:K12626]
106870841  U6 snRNA-associated Sm-like protein LSm8 isoform X1 [KO:K12627]
106871454  U4/U6 small nuclear ribonucleoprotein Prp3 isoform X2 [KO:K12843]
106872767  U4/U6 small nuclear ribonucleoprotein Prp4 [KO:K12662]
106884478  peptidyl-prolyl cis-trans isomerase H [KO:K09567] [EC:5.2.1.8]
106872744  U4/U6 small nuclear ribonucleoprotein Prp31 [KO:K12844]
106882140  NHP2-like protein 1 [KO:K12845]
106877118  U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein isoform X1 [KO:K12846]
106880809  U4/U6.U5 tri-snRNP-associated protein 2 [KO:K12847]
106880297  U4/U6.U5 tri-snRNP-associated protein 1 [KO:K11984]
106880505  zinc finger matrin-type protein 2 [KO:K12848]
106867643  pre-mRNA-splicing factor 38B [KO:K12850]
106867796  116 kDa U5 small nuclear ribonucleoprotein component [KO:K12852]
106873134  U5 small nuclear ribonucleoprotein 200 kDa helicase [KO:K12854] [EC:5.6.2.6]
106876317  pre-mRNA-processing factor 6 [KO:K12855]
106883575  pre-mRNA-processing-splicing factor 8 [KO:K12856]
106880024  U5 small nuclear ribonucleoprotein 40 kDa protein [KO:K12857]
106868731  probable ATP-dependent RNA helicase DDX23 [KO:K12858] [EC:5.6.2.7]
106871927  thioredoxin-like protein 4A [KO:K12859]
106881452  pre-mRNA-processing factor 19 [KO:K10599] [EC:2.3.2.27]
106873214  cell division cycle 5-like protein [KO:K12860]
106878732  pre-mRNA-splicing factor SPF27 [KO:K12861]
106868965  pleiotropic regulator 1 [KO:K12862]
106877386  spliceosome-associated protein CWC15 homolog [KO:K12863]
106880108  beta-catenin-like protein 1 isoform X1 [KO:K12864]
106878391  heat shock cognate 71 kDa protein [KO:K03283]
106879627  heat shock cognate 71 kDa protein [KO:K03283]
106881232  LOW QUALITY PROTEIN: heat shock protein 68-like [KO:K03283]
106867573  polyglutamine-binding protein 1 [KO:K12865]
106880741  WW domain-binding protein 11 [KO:K12866]
106879519  SNW domain-containing protein 1 [KO:K06063]
106870639  pre-mRNA-splicing factor SYF1 [KO:K12867]
106884364  pre-mRNA-splicing factor SYF2 [KO:K12868]
106872978  crooked neck-like protein 1 [KO:K12869]
106871043  pre-mRNA-splicing factor ISY1 homolog [KO:K12870]
106871245  peptidyl-prolyl cis-trans isomerase-like 1 isoform X3 [KO:K12733] [EC:5.2.1.8]
106884302  peptidyl-prolyl cis-trans isomerase [KO:K09564] [EC:5.2.1.8]
106871470  coiled-coil domain-containing protein 12 [KO:K12871]
106870699  pre-mRNA-splicing factor RBM22 [KO:K12872]
106875354  protein BUD31 homolog [KO:K12873]
106878040  RNA helicase aquarius [KO:K12874]
106877945  apoptotic chromatin condensation inducer in the nucleus isoform X1 [KO:K12875]
106878204  eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
106876598  RNA-binding protein 8A [KO:K12876]
106879653  protein mago nashi homolog [KO:K12877]
106878146  THO complex subunit 1 [KO:K12878]
106878851  THO complex subunit 2 [KO:K12879]
106882936  THO complex subunit 3 [KO:K12880]
106867362  THO complex subunit 4 isoform X1 [KO:K12881]
106867281  nuclear cap-binding protein subunit 1 [KO:K12882]
106871005  nuclear cap-binding protein subunit 2B isoform X1 [KO:K12883]
106878018  heterogeneous nuclear ribonucleoprotein A1 [KO:K12741]
106874279  heterogeneous nuclear ribonucleoprotein 87F [KO:K12741]
106871774  heterogeneous nuclear ribonucleoprotein A1, A2/B1 homolog [KO:K12741]
106873544  heterogeneous nuclear ribonucleoprotein A1 isoform X1 [KO:K12741]
106882823  heterogeneous nuclear ribonucleoprotein A2 homolog 1 [KO:K12741]
106881753  heterogeneous nuclear ribonucleoprotein A1 [KO:K12741]
106875419  RNA binding motif protein, X-linked-like-1 isoform X1 [KO:K12885]
106871239  heterogeneous nuclear ribonucleoprotein K-like [KO:K12886]
106880849  heterogeneous nuclear ribonucleoprotein K isoform X1 [KO:K12886]
106876771  serine/arginine-rich splicing factor 1B [KO:K12890]
106871612  serine/arginine-rich splicing factor 2 [KO:K12891]
106873382  serine/arginine-rich splicing factor 6 [KO:K12893]
106868844  probable splicing factor, arginine/serine-rich 6 isoform X1 [KO:K12896]
106873054  serine/arginine-rich splicing factor 7 isoform X1 [KO:K12896]
106882865  probable splicing factor, arginine/serine-rich 5 isoform X1 [KO:K12896]
106878321  serine/arginine-rich splicing factor 7 [KO:K12896]
106872282  transformer-2 protein homolog beta [KO:K12897]
106876386  serine/arginine-rich splicing factor 6 isoform X1 [KO:K12900]
Reference
PMID:19239890
  Authors
Wahl MC, Will CL, Luhrmann R
  Title
The spliceosome: design principles of a dynamic RNP machine.
  Journal
Cell 136:701-18 (2009)
DOI:10.1016/j.cell.2009.02.009
Reference
PMID:10978320
  Authors
Morris DP, Greenleaf AL
  Title
The splicing factor, Prp40, binds the phosphorylated carboxyl-terminal domain of RNA polymerase II.
  Journal
J Biol Chem 275:39935-43 (2000)
DOI:10.1074/jbc.M004118200
Reference
PMID:17537823
  Authors
Chen YI, Moore RE, Ge HY, Young MK, Lee TD, Stevens SW
  Title
Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors.
  Journal
Nucleic Acids Res 35:3928-44 (2007)
DOI:10.1093/nar/gkm347
Reference
PMID:19733268
  Authors
Ritchie DB, Schellenberg MJ, MacMillan AM
  Title
Spliceosome structure: piece by piece.
  Journal
Biochim Biophys Acta 1789:624-33 (2009)
DOI:10.1016/j.bbagrm.2009.08.010
KO pathway
ko03040   
LinkDB

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