KEGG   PATHWAY: oda04934
Entry
oda04934                    Pathway                                
Name
Cushing syndrome - Oryx dammah (scimitar-horned oryx)
Description
Cushing syndrome (CS) is a rare disorder resulting from prolonged exposure to excess glucocorticoids via exogenous and endogenous sources. The typical clinical features of CS are related to hypercortisolism and include accumulation of central fat, moon facies, neuromuscular weakness, osteoporosis or bone fractures, metabolic complications, and mood changes. Traditionally, endogenous CS is classified as adrenocorticotropic hormone (ACTH)-dependent (about 80%) or ACTH- independent (about 20%). Among ACTH-dependent forms, pituitary corticotroph adenoma (Cushing's disease) is most common. Most pituitary tumors are sporadic, resulting from monoclonal expansion of a single mutated cell. Recently recurrent activating somatic driver mutations in the ubiquitin-specific protease 8 gene (USP8) were identified in almost half of corticotroph adenoma. Germline mutations in MEN1 (encoding menin), AIP (encoding aryl-hydrocarbon receptor-interacting protein), PRKAR1A (encoding cAMP-dependent protein kinase type I alpha regulatory subunit) and CDKN1B (encoding cyclin-dependent kinase inhibitor 1B; also known as p27 Kip1) have been identified in familial forms of pituitary adenomas. However, the frequency of familial pituitary adenomas is less than 5% in patients with pituitary adenomas. Among ACTH-independent CS, adrenal adenoma is most common. Rare adrenal causes of CS include primary bilateral macronodular adrenal hyperplasia (BMAH) or primary pigmented nodular adrenocortical disease (PPNAD).
Class
Human Diseases; Endocrine and metabolic disease
Pathway map
oda04934  Cushing syndrome
oda04934

Organism
Oryx dammah (scimitar-horned oryx) [GN:oda]
Gene
120878633  CRH; corticoliberin [KO:K05256]
120866984  CRHR1; corticotropin-releasing factor receptor 1 isoform X1 [KO:K04578]
120877397  CRHR2; corticotropin-releasing factor receptor 2 isoform X1 [KO:K04579]
120869377  guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
120869379  neuroendocrine secretory protein 55 [KO:K04632]
120877473  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
120879368  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
120851596  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
120853482  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
120870754  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
120861292  adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
120858160  adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
120872811  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
120878868  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
120874335  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
120864090  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
120856949  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
120854564  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
120854293  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
120857618  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
120876928  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X1 [KO:K09048]
120877626  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
120880365  CREB3; cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048]
120855782  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
120864822  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
120877414  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
120870582  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
120874646  MEN1; menin isoform X1 [KO:K14970]
120865657  ASH2L; set1/Ash2 histone methyltransferase complex subunit ASH2 isoform X1 [KO:K14964]
120879964  RBBP5; retinoblastoma-binding protein 5 isoform X1 [KO:K14961]
120881849  WDR5B; WD repeat-containing protein 5B [KO:K14963]
120852183  WDR5; WD repeat-containing protein 5 [KO:K14963]
120876324  KMT2A; histone-lysine N-methyltransferase 2A isoform X1 [KO:K09186] [EC:2.1.1.354]
120861279  histone-lysine N-methyltransferase 2D-like isoform X1 [KO:K09187] [EC:2.1.1.354]
120858214  histone-lysine N-methyltransferase 2D [KO:K09187] [EC:2.1.1.354]
120856165  CDKN2C; cyclin-dependent kinase 4 inhibitor C [KO:K06622]
120862151  CDKN2B; LOW QUALITY PROTEIN: cyclin-dependent kinase 4 inhibitor B [KO:K04685]
120862141  cyclin-dependent kinase inhibitor 2A-like isoform X1 [KO:K06621]
120857506  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
120877860  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
120874144  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
120883039  RB1; retinoblastoma-associated protein [KO:K06618]
120868702  E2F1; transcription factor E2F1 [KO:K17454]
120855099  E2F2; transcription factor E2F2 [KO:K09389]
120870281  E2F3; transcription factor E2F3 [KO:K06620]
120867376  RASD1; dexamethasone-induced Ras-related protein 1 [KO:K07843]
120878127  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
120868293  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
120856729  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
120878047  AHR; aryl hydrocarbon receptor [KO:K09093]
120874781  AH receptor-interacting protein isoform X1 [KO:K17767]
120866142  AIPL1; aryl-hydrocarbon-interacting protein-like 1 [KO:K17767]
120855911  ARNT; aryl hydrocarbon receptor nuclear translocator [KO:K09097]
120858866  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
120857423  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
120878476  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
120873257  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
120870199  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
120857839  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
120868392  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
120881638  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
120880100  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
120877497  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
120861703  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
120863412  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
120865286  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
120856682  RAP1A; ras-related protein Rap-1A [KO:K04353]
120857713  RAP1B; ras-related protein Rap-1b [KO:K07836]
120877657  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
120852527  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
120860906  dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
120864821  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
120882996  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
120876943  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
120871418  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
120858245  NR4A1; nuclear receptor subfamily 4 group A member 1 isoform X1 [KO:K04465]
120867903  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
120852979  USP8; ubiquitin carboxyl-terminal hydrolase 8 [KO:K11839] [EC:3.4.19.12]
120851603  POMC; pro-opiomelanocortin [KO:K05228]
120881034  MC2R; adrenocorticotropic hormone receptor [KO:K04200]
120854195  melanocortin-2 receptor accessory protein [KO:K22398]
120852588  PDE8B; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B [KO:K18437] [EC:3.1.4.53]
120875586  PDE8A; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X1 [KO:K18437] [EC:3.1.4.53]
120860936  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B [KO:K18437] [EC:3.1.4.53]
120853958  PDE11A; dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A [KO:K13298] [EC:3.1.4.17 3.1.4.35]
120851983  NR5A1; steroidogenic factor 1 [KO:K08560]
120858300  SP1; transcription factor Sp1 isoform X1 [KO:K04684]
120855497  PBX1; pre-B-cell leukemia transcription factor 1 isoform X1 [KO:K09355]
120859420  LOW QUALITY PROTEIN: cytochrome P450 11B1, mitochondrial-like [KO:K00497] [EC:1.14.15.4]
120873501  steroid 17-alpha-hydroxylase/17,20 lyase [KO:K00512] [EC:1.14.14.19 1.14.14.32]
120865658  STAR; steroidogenic acute regulatory protein, mitochondrial [KO:K16931]
120869552  NCEH1; neutral cholesterol ester hydrolase 1 [KO:K14349] [EC:3.1.1.-]
120877759  ARMC5; armadillo repeat-containing protein 5 [KO:K22499]
120865479  AGT; angiotensinogen [KO:K09821]
120858385  AGTR1; type-1 angiotensin II receptor [KO:K04166]
120875860  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
120864791  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
120853216  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
120869193  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
120869195  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
120874626  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
120867669  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
120858499  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
120869823  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
120880066  KCNK2; potassium channel subfamily K member 2 isoform X1 [KO:K04913]
120867316  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
120872782  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
120857616  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
120871068  ORAI1; calcium release-activated calcium channel protein 1 [KO:K16056]
120876043  KCNA4; potassium voltage-gated channel subfamily A member 4 [KO:K04877]
120851580  KCNK3; potassium channel subfamily K member 3 [KO:K04914]
120863950  LDLR; low-density lipoprotein receptor [KO:K12473]
120871011  SCARB1; scavenger receptor class B member 1 isoform X1 [KO:K13885]
120875441  cholesterol side-chain cleavage enzyme, mitochondrial [KO:K00498] [EC:1.14.15.6]
120855999  3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase [KO:K00070] [EC:1.1.1.145 5.3.3.1]
120870583  steroid 21-hydroxylase isoform X1 [KO:K00513] [EC:1.14.14.16]
120880294  FH; fumarate hydratase, mitochondrial isoform X1 [KO:K01679] [EC:4.2.1.2]
120861282  proto-oncogene Wnt-1 [KO:K03209]
120858193  proto-oncogene Wnt-1 [KO:K03209]
120878206  WNT2; protein Wnt-2 [KO:K00182]
120856080  WNT2B; protein Wnt-2b [KO:K00182]
120864656  WNT3A; protein Wnt-3a [KO:K00312]
120866987  WNT3; proto-oncogene Wnt-3 [KO:K00312]
120854508  WNT4; protein Wnt-4 [KO:K00408]
120867939  WNT5A; protein Wnt-5a [KO:K00444]
120857844  WNT5B; protein Wnt-5b [KO:K00444]
120854363  WNT6; protein Wnt-6 [KO:K00445]
120868443  WNT7A; protein Wnt-7a [KO:K00572]
120858471  WNT7B; protein Wnt-7b [KO:K00572]
120863617  WNT8A; protein Wnt-8a [KO:K00714]
120873949  WNT8B; protein Wnt-8b [KO:K00714]
120864325  WNT9A; protein Wnt-9a isoform X1 [KO:K01064]
120866573  WNT9B; protein Wnt-9b [KO:K01064]
120861284  protein Wnt-10b-like [KO:K01357]
120854362  WNT10A; protein Wnt-10a [KO:K01357]
120858215  protein Wnt-10b [KO:K01357]
120876802  WNT11; protein Wnt-11 [KO:K01384]
120877289  WNT16; protein Wnt-16 [KO:K01558]
120877844  FZD1; frizzled-1 [KO:K02432]
120854611  FZD7; frizzled-7 [KO:K02432]
120867021  FZD2; frizzled-2 [KO:K02235]
120860622  FZD3; frizzled-3 [KO:K02329]
120874234  FZD4; frizzled-4 [KO:K02354]
120860124  frizzled-8 [KO:K02375]
120854561  FZD5; frizzled-5 [KO:K02375]
120878963  FZD6; frizzled-6 isoform X1 [KO:K02376]
120878550  FZD9; frizzled-9 [KO:K02842]
120871557  FZD10; frizzled-10 [KO:K02842]
120880612  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
120871944  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
120866079  DVL2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
120871233  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
120854912  AXIN1; axin-1 isoform X1 [KO:K02157]
120866533  AXIN2; LOW QUALITY PROTEIN: axin-2 [KO:K04385]
120867709  CTNNB1; catenin beta-1 [KO:K02105]
120852624  adenomatous polyposis coli protein isoform X1 [KO:K02085]
120861004  adenomatous polyposis coli protein isoform X1 [KO:K02085]
120863696  APC2; adenomatous polyposis coli protein 2 isoform X1 [KO:K02085]
120863661  TCF7; transcription factor 7 isoform X1 [KO:K02620]
120851515  TCF7L1; transcription factor 7-like 1 [KO:K04490]
120873902  TCF7L2; transcription factor 7-like 2 isoform X1 [KO:K04491]
120861741  LEF1; lymphoid enhancer-binding factor 1 isoform X1 [KO:K04492]
Compound
C00020  AMP
C00076  Calcium cation
C00187  Cholesterol
C00238  Potassium cation
C00410  Progesterone
C00575  3',5'-Cyclic AMP
C00735  Cortisol
C01176  17alpha-Hydroxyprogesterone
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01953  Pregnenolone
C05138  17alpha-Hydroxypregnenolone
C05488  11-Deoxycortisol
C07557  2,3,7,8-Tetrachlorodibenzodioxin
Reference
PMID:26004339
  Authors
Lacroix A, Feelders RA, Stratakis CA, Nieman LK
  Title
Cushing's syndrome.
  Journal
Lancet 386:913-27 (2015)
DOI:10.1016/S0140-6736(14)61375-1
Reference
PMID:27588171
  Authors
Xiong Q, Ge W
  Title
Gene mutations in Cushing's disease.
  Journal
Biomed Rep 5:277-282 (2016)
DOI:10.3892/br.2016.729
Reference
PMID:25877147
  Authors
Fukuoka H, Takahashi Y
  Title
The role of genetic and epigenetic changes in pituitary tumorigenesis.
  Journal
Neurol Med Chir (Tokyo) 54 Suppl 3:943-57 (2014)
DOI:10.2176/nmc.suppl.2014-3
Reference
PMID:18987159
  Authors
Quereda V, Malumbres M
  Title
Cell cycle control of pituitary development and disease.
  Journal
J Mol Endocrinol 42:75-86 (2009)
DOI:10.1677/JME-08-0146
Reference
PMID:27742789
  Authors
Caimari F, Korbonits M
  Title
Novel Genetic Causes of Pituitary Adenomas.
  Journal
Clin Cancer Res 22:5030-5042 (2016)
DOI:10.1158/1078-0432.CCR-16-0452
Reference
PMID:25350067
  Authors
Lecoq AL, Kamenicky P, Guiochon-Mantel A, Chanson P
  Title
Genetic mutations in sporadic pituitary adenomas--what to screen for?
  Journal
Nat Rev Endocrinol 11:43-54 (2015)
DOI:10.1038/nrendo.2014.181
Reference
PMID:27625633
  Authors
Hannah-Shmouni F, Faucz FR, Stratakis CA
  Title
Alterations of Phosphodiesterases in Adrenocortical Tumors.
  Journal
Front Endocrinol (Lausanne) 7:111 (2016)
DOI:10.3389/fendo.2016.00111
Reference
PMID:21423242
  Authors
Melmed S
  Title
Pathogenesis of pituitary tumors.
  Journal
Nat Rev Endocrinol 7:257-66 (2011)
DOI:10.1038/nrendo.2011.40
Reference
PMID:19407507
  Authors
Daly AF, Tichomirowa MA, Beckers A
  Title
Genetic, molecular and clinical features of familial isolated pituitary adenomas.
  Journal
Horm Res 71 Suppl 2:116-22 (2009)
DOI:10.1159/000192448
Reference
PMID:28850717
  Authors
Albani A, Theodoropoulou M, Reincke M
  Title
Genetics of Cushing's disease.
  Journal
Clin Endocrinol (Oxf) 88:3-12 (2018)
DOI:10.1111/cen.13457
Reference
PMID:26045561
  Authors
Duan K, Hernandez KG, Mete O
  Title
Clinicopathological correlates of adrenal Cushing's syndrome.
  Journal
Postgrad Med J 91:331-42 (2015)
DOI:10.1136/postgradmedj-2014-202612rep
Reference
PMID:26264719
  Authors
Drougat L, Espiard S, Bertherat J
  Title
Genetics of primary bilateral macronodular adrenal hyperplasia: a model for early diagnosis of Cushing's syndrome?
  Journal
Eur J Endocrinol 173:M121-31 (2015)
DOI:10.1530/EJE-15-0532
Reference
PMID:17955016
  Authors
Stratakis CA, Boikos SA
  Title
Genetics of adrenal tumors associated with Cushing's syndrome: a new classification for bilateral adrenocortical hyperplasias.
  Journal
Nat Clin Pract Endocrinol Metab 3:748-57 (2007)
DOI:10.1038/ncpendmet0648
Reference
PMID:19906235
  Authors
Refojo D, Holsboer F
  Title
CRH signaling. Molecular specificity for drug targeting in the CNS.
  Journal
Ann N Y Acad Sci 1179:106-19 (2009)
DOI:10.1111/j.1749-6632.2009.04983.x
Reference
PMID:12089357
  Authors
Kovalovsky D, Refojo D, Liberman AC, Hochbaum D, Pereda MP, Coso OA, Stalla GK, Holsboer F, Arzt E
  Title
Activation and induction of NUR77/NURR1 in corticotrophs by CRH/cAMP: involvement of calcium, protein kinase A, and MAPK pathways.
  Journal
Mol Endocrinol 16:1638-51 (2002)
DOI:10.1210/mend.16.7.0863
Reference
PMID:15380809
  Authors
Lacroix A, Baldacchino V, Bourdeau I, Hamet P, Tremblay J
  Title
Cushing's syndrome variants secondary to aberrant hormone receptors.
  Journal
Trends Endocrinol Metab 15:375-82 (2004)
DOI:10.1016/j.tem.2004.08.007
Reference
PMID:25485838
  Authors
Reincke M, Sbiera S, Hayakawa A, Theodoropoulou M, Osswald A, Beuschlein F, Meitinger T, Mizuno-Yamasaki E, Kawaguchi K, Saeki Y, Tanaka K, Wieland T, Graf E, Saeger W, Ronchi CL, Allolio B, Buchfelder M, Strom TM, Fassnacht M, Komada M
  Title
Mutations in the deubiquitinase gene USP8 cause Cushing's disease.
  Journal
Nat Genet 47:31-8 (2015)
DOI:10.1038/ng.3166
Reference
PMID:25930709
  Authors
Kaiser UB
  Title
Cushing's disease: towards precision medicine.
  Journal
Cell Res 25:649-50 (2015)
DOI:10.1038/cr.2015.53
Reference
PMID:28487882
  Authors
Uzilov AV, Cheesman KC, Fink MY, Newman LC, Pandya C, Lalazar Y, Hefti M, Fowkes M, Deikus G, Lau CY, Moe AS, Kinoshita Y, Kasai Y, Zweig M, Gupta A, Starcevic D, Mahajan M, Schadt EE, Post KD, Donovan MJ, Sebra R, Chen R, Geer EB
  Title
Identification of a novel RASD1 somatic mutation in a USP8-mutated corticotroph adenoma.
  Journal
Cold Spring Harb Mol Case Stud 3:a001602 (2017)
DOI:10.1101/mcs.a001602
Reference
PMID:26285834
  Authors
Huang C, Shi Y, Zhao Y
  Title
USP8 mutation in Cushing's disease.
  Journal
Oncotarget 6:18240-1 (2015)
DOI:10.18632/oncotarget.4856
Reference
PMID:26012588
  Authors
Theodoropoulou M, Reincke M, Fassnacht M, Komada M
  Title
Decoding the genetic basis of Cushing's disease: USP8 in the spotlight.
  Journal
Eur J Endocrinol 173:M73-83 (2015)
DOI:10.1530/EJE-15-0320
Reference
PMID:29370219
  Authors
Yu L, Zhang J, Guo X, Chen X, He Z, He Q
  Title
ARMC5 mutations in familial and sporadic primary bilateral macronodular adrenal hyperplasia.
  Journal
PLoS One 13:e0191602 (2018)
DOI:10.1371/journal.pone.0191602
Reference
PMID:19075677
  Authors
Wu X, Hua X
  Title
Menin, histone h3 methyltransferases, and regulation of cell proliferation: current knowledge and perspective.
  Journal
Curr Mol Med 8:805-15 (2008)
DOI:10.2174/156652408786733702
Reference
PMID:20457215
  Authors
Ozfirat Z, Korbonits M
  Title
AIP gene and familial isolated pituitary adenomas.
  Journal
Mol Cell Endocrinol 326:71-9 (2010)
DOI:10.1016/j.mce.2010.05.001
Related
pathway
oda00020  Citrate cycle (TCA cycle)
oda00140  Steroid hormone biosynthesis
oda04020  Calcium signaling pathway
oda04024  cAMP signaling pathway
oda04110  Cell cycle
oda04310  Wnt signaling pathway
oda04927  Cortisol synthesis and secretion
oda04960  Aldosterone-regulated sodium reabsorption
KO pathway
ko04934   
LinkDB

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