KEGG   PATHWAY: oga04148
Entry
oga04148                    Pathway                                
Name
Efferocytosis - Otolemur garnettii (small-eared galago)
Class
Cellular Processes; Transport and catabolism
Pathway map
oga04148  Efferocytosis
oga04148

Organism
Otolemur garnettii (small-eared galago) [GN:oga]
Gene
100961435  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
100942180  CASP7; caspase-7 [KO:K04397] [EC:3.4.22.60]
100954360  CASP1; caspase-1 [KO:K01370] [EC:3.4.22.36]
100956732  PANX1; pannexin-1 [KO:K03443]
100966915  P2RY2; P2Y purinoceptor 2 [KO:K04269]
100966601  P2RY6; P2Y purinoceptor 6 [KO:K04272]
100962339  P2RY12; P2Y purinoceptor 12 isoform X2 [KO:K04298]
100961067  SPHK2; sphingosine kinase 2 isoform X1 [KO:K04718] [EC:2.7.1.91]
100966333  SPHK1; sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
100958337  S1PR1; sphingosine 1-phosphate receptor 1 [KO:K04288]
100949513  PLA2G6; 85/88 kDa calcium-independent phospholipase A2 isoform X3 [KO:K16343] [EC:3.1.1.4]
100964745  ABCA1; ATP-binding cassette sub-family A member 1 isoform X2 [KO:K05641]
100950499  GPR132; probable G-protein coupled receptor 132 [KO:K08426]
100947870  ADAM17; LOW QUALITY PROTEIN: disintegrin and metalloproteinase domain-containing protein 17 [KO:K06059] [EC:3.4.24.86]
100962332  ADAM10; disintegrin and metalloproteinase domain-containing protein 10 [KO:K06704] [EC:3.4.24.81]
100945057  CX3CL1; fractalkine isoform X2 [KO:K05508]
100961970  CX3CR1; CX3C chemokine receptor 1 [KO:K04192]
100955220  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X2 [KO:K17332]
100940498  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
100966615  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
100950273  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
100941157  HIF1A; hypoxia-inducible factor 1-alpha isoform X2 [KO:K08268]
100941626  ARNT; aryl hydrocarbon receptor nuclear translocator isoform X1 [KO:K09097]
100961255  EPO; erythropoietin [KO:K05437]
100954028  EPOR; erythropoietin receptor [KO:K05079]
100948875  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
100951533  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100957343  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100952496  CEBPB; CCAAT/enhancer-binding protein beta [KO:K10048]
100943160  PPARG; peroxisome proliferator-activated receptor gamma isoform X2 [KO:K08530]
100962073  RXRA; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
100954384  MFGE8; lactadherin isoform X2 [KO:K17253]
100946567  GAS6; growth arrest-specific protein 6 isoform X1 [KO:K05464]
100964098  MERTK; tyrosine-protein kinase Mer isoform X1 [KO:K05117] [EC:2.7.10.1]
100962623  platelet glycoprotein 4 [KO:K06259]
100953094  platelet glycoprotein 4-like [KO:K06259]
100949247  THBS1; thrombospondin-1 [KO:K16857]
100959926  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
100956072  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X2 [KO:K04369] [EC:2.7.12.2]
100944482  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
100965094  PTGER2; prostaglandin E2 receptor EP2 subtype [KO:K04259]
100947256  PTGER4; prostaglandin E2 receptor EP4 subtype [KO:K04261]
100944387  DNMT3A; DNA (cytosine-5)-methyltransferase 3A isoform X2 [KO:K17398] [EC:2.1.1.37]
100964324  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X2 [KO:K05870]
100949640  TGFB1; transforming growth factor beta-1 isoform X2 [KO:K13375]
100951795  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X2 [KO:K05853] [EC:7.2.2.10]
100950947  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
100964408  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 [KO:K05853] [EC:7.2.2.10]
100941825  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma [KO:K04515] [EC:2.7.11.17]
100955681  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X2 [KO:K04515] [EC:2.7.11.17]
100956846  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X2 [KO:K04515] [EC:2.7.11.17]
100950655  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
100956269  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
100957118  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
100963993  MAPK11; mitogen-activated protein kinase 11 isoform X2 [KO:K04441] [EC:2.7.11.24]
100964304  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
100966784  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
100952067  ALOX5; arachidonate 5-lipoxygenase isoform X1 [KO:K00461] [EC:1.13.11.34]
100953458  ALOX15; arachidonate 15-lipoxygenase [KO:K00460] [EC:1.13.11.33]
100964438  DUSP8; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
100941794  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
100963229  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
100951294  DUSP2; dual specificity protein phosphatase 2 isoform X2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
100952920  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
100945252  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
100957956  ANO6; anoctamin-6 isoform X1 [KO:K19500]
100954851  ANO3; LOW QUALITY PROTEIN: anoctamin-3 [KO:K19498]
100955706  ANO4; anoctamin-4 [KO:K19499]
100947821  ANO5; anoctamin-5 [KO:K19480]
100944699  ANO9; anoctamin-9 [KO:K19503]
100962865  BSG; basigin isoform X1 [KO:K06535]
100940347  XKR8; XK-related protein 8 [KO:K26813]
105887743  XKR9; XK-related protein 9 isoform X1 [KO:K26814]
100946611  XKR7; XK-related protein 7 [KO:K26811]
100952105  XKR4; XK-related protein 4 [KO:K26811]
100954629  XKR6; XK-related protein 6 [KO:K26811]
100963328  ATP8A2; phospholipid-transporting ATPase IB isoform X1 [KO:K14802] [EC:7.6.2.1]
100966281  ATP11C; phospholipid-transporting ATPase IG isoform X1 [KO:K26934] [EC:7.6.2.1]
100943929  ATP11B; probable phospholipid-transporting ATPase IF [KO:K26934] [EC:7.6.2.1]
100948767  ATP11A; probable phospholipid-transporting ATPase IH isoform X3 [KO:K26934] [EC:7.6.2.1]
100957154  TMEM30A; cell cycle control protein 50A [KO:K26935]
100963050  PROS1; LOW QUALITY PROTEIN: vitamin K-dependent protein S [KO:K03908]
100945899  ITGAV; integrin alpha-V [KO:K06487]
100949430  ITGB3; integrin beta-3 [KO:K06493]
100941684  ITGB5; integrin beta-5 [KO:K06588]
100951637  AXL; tyrosine-protein kinase receptor UFO isoform X1 [KO:K05115] [EC:2.7.10.1]
100965092  TYRO3; tyrosine-protein kinase receptor TYRO3 [KO:K05116] [EC:2.7.10.1]
100948804  ADGRB1; adhesion G protein-coupled receptor B1 [KO:K04596]
100958221  TIMD4; T-cell immunoglobulin and mucin domain-containing protein 4 isoform X1 [KO:K26936]
100957570  HAVCR1; hepatitis A virus cellular receptor 1 [KO:K20413]
100957265  HAVCR2; hepatitis A virus cellular receptor 2 [KO:K20414]
100955543  AGER; advanced glycosylation end product-specific receptor [KO:K19722]
100962673  STAB1; stabilin-1 isoform X2 [KO:K19020]
100959917  STAB2; stabilin-2 isoform X1 [KO:K19013]
100962373  PTK2; focal adhesion kinase 1 isoform X2 [KO:K05725] [EC:2.7.10.2]
100955552  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
100958636  CRK; adapter molecule crk isoform X1 [KO:K04438]
100951208  CRKL; crk-like protein [KO:K04438]
100943327  ELMO1; engulfment and cell motility protein 1 [KO:K12366]
100963112  DOCK1; dedicator of cytokinesis protein 1 [KO:K13708]
100951369  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
100959148  ADAM9; disintegrin and metalloproteinase domain-containing protein 9 [KO:K06834] [EC:3.4.24.-]
100942739  CALR; calreticulin [KO:K08057]
100954043  calreticulin-like [KO:K08057]
100949568  LRP1; prolow-density lipoprotein receptor-related protein 1 isoform X1 [KO:K04550]
100963979  MEGF10; multiple epidermal growth factor-like domains protein 10 isoform X1 [KO:K24068]
100958020  MEGF11; multiple epidermal growth factor-like domains protein 11 [KO:K24068]
100944770  SCARF1; scavenger receptor class F member 1 [KO:K24318]
100955609  GULP1; PTB domain-containing engulfment adapter protein 1 isoform X1 [KO:K23285]
100949376  RAB17; ras-related protein Rab-17 isoform X2 [KO:K07909]
100949283  RAB5A; ras-related protein Rab-5A [KO:K07887]
100967196  RAB5B; ras-related protein Rab-5B [KO:K07888]
100961515  RAB5C; ras-related protein Rab-5C [KO:K07889]
100944420  TGFBRAP1; transforming growth factor-beta receptor-associated protein 1 [KO:K20177]
100952379  VPS8; vacuolar protein sorting-associated protein 8 homolog [KO:K20178]
100957972  VPS11; vacuolar protein sorting-associated protein 11 homolog isoform X2 [KO:K20179]
100967184  VPS16; vacuolar protein sorting-associated protein 16 homolog isoform X1 [KO:K20180]
100958271  VPS18; vacuolar protein sorting-associated protein 18 homolog [KO:K20181]
100962595  VPS33A; vacuolar protein sorting-associated protein 33A [KO:K20182]
100963383  RAB14; ras-related protein Rab-14 [KO:K07881]
100963840  VPS39; vam6/Vps39-like protein isoform X1 [KO:K20183]
100962501  VPS41; vacuolar protein sorting-associated protein 41 homolog isoform X1 [KO:K20184]
100955889  RAB7A; ras-related protein Rab-7a [KO:K07897]
100942705  RAB7B; ras-related protein Rab-7b [KO:K07898]
100959081  PQLC2; lysosomal amino acid transporter 1 homolog [KO:K23678]
100964594  ARG2; arginase-2, mitochondrial [KO:K01476] [EC:3.5.3.1]
100957781  arginase-1-like [KO:K01476] [EC:3.5.3.1]
100954542  arginase-1 isoform X2 [KO:K01476] [EC:3.5.3.1]
100944501  ODC1; ornithine decarboxylase [KO:K01581] [EC:4.1.1.17]
100962631  CH25H; cholesterol 25-hydroxylase [KO:K10223] [EC:1.14.99.38]
100963453  NR1H3; oxysterols receptor LXR-alpha isoform X1 [KO:K08536]
100941828  NR1H2; oxysterols receptor LXR-beta isoform X1 [KO:K08535]
100961040  CPT1A; carnitine O-palmitoyltransferase 1, liver isoform [KO:K08765] [EC:2.3.1.21]
100959176  CPT1B; carnitine O-palmitoyltransferase 1, muscle isoform [KO:K19523] [EC:2.3.1.21]
100947108  CPT1C; carnitine O-palmitoyltransferase 1, brain isoform isoform X1 [KO:K19524] [EC:2.3.1.21]
100949704  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
100966528  SIRT1; NAD-dependent protein deacetylase sirtuin-1 isoform X1 [KO:K11411] [EC:2.3.1.286]
100942162  PBX1; pre-B-cell leukemia transcription factor 1 isoform X1 [KO:K09355]
100966466  IL10; interleukin-10 [KO:K05443]
100962939  LIPA; lysosomal acid lipase/cholesteryl ester hydrolase isoform X1 [KO:K01052] [EC:3.1.1.13]
100966301  PLA2G15; group XV phospholipase A2 isoform X1 [KO:K06129] [EC:3.1.1.5]
100951033  PPARD; peroxisome proliferator-activated receptor delta isoform X2 [KO:K04504]
100959166  SLC2A1; solute carrier family 2, facilitated glucose transporter member 1 [KO:K07299]
100956929  SLC16A1; monocarboxylate transporter 1 [KO:K08179]
100948095  SGK1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
100948657  CD47; leukocyte surface antigen CD47 isoform X1 [KO:K06266]
100942174  PECAM1; platelet endothelial cell adhesion molecule [KO:K06471]
100961193  sialic acid-binding Ig-like lectin 10 [KO:K06749]
100950202  SIRPA; tyrosine-protein phosphatase non-receptor type substrate 1 isoform X1 [KO:K06551]
100952717  signal-regulatory protein beta-1-like [KO:K06551]
100952399  signal-regulatory protein beta-1-like [KO:K06551]
100944392  signal-regulatory protein beta-1-like [KO:K06551]
100944714  signal-regulatory protein beta-1-like isoform X1 [KO:K06551]
100946957  PTPN6; tyrosine-protein phosphatase non-receptor type 6 isoform X1 [KO:K05697] [EC:3.1.3.48]
100955860  PTPN11; tyrosine-protein phosphatase non-receptor type 11 isoform X2 [KO:K07293] [EC:3.1.3.48]
Compound
C00002  ATP
C00003  NAD+
C00019  S-Adenosyl-L-methionine
C00031  D-Glucose
C00062  L-Arginine
C00073  L-Methionine
C00075  UTP
C00077  L-Ornithine
C00134  Putrescine
C00162  Fatty acid
C00186  (S)-Lactate
C00187  Cholesterol
C00584  Prostaglandin E2
C02530  Cholesterol ester
C02737  Phosphatidylserine
C04230  1-Acyl-sn-glycero-3-phosphocholine
C06124  Sphingosine 1-phosphate
C06314  Lipoxin A4
C15519  25-Hydroxycholesterol
C15610  Cholest-5-ene-3beta,26-diol
C18178  Resolvin D1
Reference
PMID:31822793
  Authors
Doran AC, Yurdagul A Jr, Tabas I
  Title
Efferocytosis in health and disease.
  Journal
Nat Rev Immunol 20:254-267 (2020)
DOI:10.1038/s41577-019-0240-6
Reference
PMID:36028471
  Authors
Zhang J, Ding W, Zhao M, Liu J, Xu Y, Wan J, Wang M
  Title
Mechanisms of efferocytosis in determining inflammation resolution: Therapeutic potential and the association with cardiovascular disease.
  Journal
Br J Pharmacol 179:5151-5171 (2022)
DOI:10.1111/bph.15939
Reference
PMID:30165442
  Authors
Kawano M, Nagata S
  Title
Efferocytosis and autoimmune disease.
  Journal
Int Immunol 30:551-558 (2018)
DOI:10.1093/intimm/dxy055
Reference
PMID:35650427
  Authors
Mehrotra P, Ravichandran KS
  Title
Drugging the efferocytosis process: concepts and opportunities.
  Journal
Nat Rev Drug Discov 21:601-620 (2022)
DOI:10.1038/s41573-022-00470-y
Reference
PMID:28496201
  Authors
Park SY, Kim IS
  Title
Engulfment signals and the phagocytic machinery for apoptotic cell clearance.
  Journal
Exp Mol Med 49:e331 (2017)
DOI:10.1038/emm.2017.52
Reference
PMID:28137963
  Authors
Kojima Y, Weissman IL, Leeper NJ
  Title
The Role of Efferocytosis in Atherosclerosis.
  Journal
Circulation 135:476-489 (2017)
DOI:10.1161/CIRCULATIONAHA.116.025684
Related
pathway
oga00010  Glycolysis / Gluconeogenesis
oga04140  Autophagy - animal
oga04145  Phagosome
KO pathway
ko04148   
LinkDB

DBGET integrated database retrieval system