KEGG   PATHWAY: oml04110
Entry
oml04110                    Pathway                                
Name
Cell cycle - Oryzias melastigma (Indian medaka)
Description
Mitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cyclin-dependent kinases (CDKs) are key regulatory enzymes, each consisting of a catalytic CDK subunit and an activating cyclin subunit. CDKs regulate the cell's progression through the phases of the cell cycle by modulating the activity of key substrates. Downstream targets of CDKs include transcription factor E2F and its regulator Rb. Precise activation and inactivation of CDKs at specific points in the cell cycle are required for orderly cell division. Cyclin-CDK inhibitors (CKIs), such as p16Ink4a, p15Ink4b, p27Kip1, and p21Cip1, are involved in the negative regulation of CDK activities, thus providing a pathway through which the cell cycle is negatively regulated.
 Eukaryotic cells respond to DNA damage by activating signaling pathways that promote cell cycle arrest and DNA repair. In response to DNA damage, the checkpoint kinase ATM phosphorylates and activates Chk2, which in turn directly phosphorylates and activates p53 tumor suppressor protein. p53 and its transcriptional targets play an important role in both G1 and G2 checkpoints. ATR-Chk1-mediated protein degradation of Cdc25A protein phosphatase is also a mechanism conferring intra-S-phase checkpoint activation.
Class
Cellular Processes; Cell growth and death
Pathway map
oml04110  Cell cycle
oml04110

Other DBs
GO: 0000278
Organism
Oryzias melastigma (Indian medaka) [GN:oml]
Gene
112141930  ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
112154304  G1/S-specific cyclin-D2 isoform X1 [KO:K10151]
112146031  ccndx; cyclin Dx [KO:K10151]
112152245  ccnd2a; G1/S-specific cyclin-D2a [KO:K10151]
112144604  ccnd3; G1/S-specific cyclin-D3 [KO:K10152]
112145080  cdk4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
112137343  cdk6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
112146964  cdk21; cyclin-dependent kinase 6 isoform X1 [KO:K02091] [EC:2.7.11.22]
112142671  rb1; retinoblastoma-associated protein [KO:K06618]
112161200  retinoblastoma-like protein 2 isoform X1 [KO:K04681]
112159335  rbl1; retinoblastoma-like protein 1 [KO:K04681]
112163252  abl1; tyrosine-protein kinase ABL1 isoform X1 [KO:K06619] [EC:2.7.10.2]
112140744  probable histone deacetylase 1-B [KO:K06067] [EC:3.5.1.98]
112148948  histone deacetylase 1 isoform X1 [KO:K06067] [EC:3.5.1.98]
112157922  histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
112159014  e2f1; transcription factor E2F1 [KO:K17454]
112149842  e2f2; transcription factor E2F2 isoform X1 [KO:K09389]
112143867  transcription factor E2F3 isoform X1 [KO:K06620]
112136256  e2f3; transcription factor E2F3 [KO:K06620]
112160553  transcription factor E2F4 isoform X1 [KO:K04682]
112147850  e2f5; transcription factor E2F5 [KO:K04682]
112152252  e2f4; transcription factor E2F4 [KO:K04682]
112154954  tfdp1a; transcription factor Dp-1a [KO:K04683]
112155060  gsk3ba; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
112149754  tgfb1a; transforming growth factor, beta 1a [KO:K13375]
112152993  tgfb5; transforming growth factor beta-2 proprotein [KO:K13376]
112162206  tgfb3; transforming growth factor beta-3 proprotein [KO:K13377]
112157680  transforming growth factor beta-3 proprotein [KO:K13377]
112148478  mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
112160873  smad3a; mothers against decapentaplegic homolog 3a [KO:K23605]
112148176  mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
112136177  smad4a; mothers against decapentaplegic homolog 4a isoform X1 [KO:K04501]
112136593  mothers against decapentaplegic homolog 4 [KO:K04501]
112144350  transcriptional regulator Myc-2 isoform X1 [KO:K04377]
112151214  myca; transcriptional regulator Myc-A isoform X1 [KO:K04377]
112141945  zbtb17; zinc finger and BTB domain-containing protein 17 isoform X1 [KO:K10500]
112157283  cdkn2a/b; cyclin-dependent kinase 4 inhibitor B [KO:K04685]
112150567  cdkn2c; cyclin-dependent kinase 4 inhibitor C [KO:K06622]
112157563  cdkn2d; cyclin-dependent kinase 4 inhibitor D [KO:K06623]
118598090  cdkn1ba; cyclin-dependent kinase inhibitor 1Ba [KO:K06624]
112151979  cdkn1bb; cyclin-dependent kinase inhibitor 1Bb [KO:K06624]
112161170  cdkn1ca; cyclin-dependent kinase inhibitor 1B [KO:K09993]
112152793  cyclin-dependent kinase inhibitor 1C [KO:K09993]
112144588  cdkn1a; cyclin-dependent kinase inhibitor 1 isoform X1 [KO:K06625]
112158072  cyclin-dependent kinase inhibitor 1 [KO:K06625]
112160906  ccne1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
112143232  ccne2; G1/S-specific cyclin-E2 [KO:K06626]
112145163  cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
112142354  skp1; S-phase kinase-associated protein 1 [KO:K03094]
112152486  cullin-1 [KO:K03347]
112146889  rbx1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
112163437  skp2; S-phase kinase-associated protein 2 [KO:K03875]
112142889  ccna1; cyclin-A1 [KO:K06627]
112145573  ccna2; cyclin-A2 [KO:K06627]
112138109  cdc6; cell division control protein 6 homolog isoform X1 [KO:K02213]
112161542  cdt1; DNA replication factor Cdt1 isoform X1 [KO:K10727]
112150564  orc1; origin recognition complex subunit 1 [KO:K02603]
112147136  orc2; origin recognition complex subunit 2 [KO:K02604]
112143028  orc3; origin recognition complex subunit 3 [KO:K02605]
112156616  orc4; origin recognition complex subunit 4 [KO:K02606]
112154428  orc5; origin recognition complex subunit 5 [KO:K02607]
112144863  mcm2; DNA replication licensing factor MCM2 [KO:K02540] [EC:5.6.2.3]
112158405  mcm3; DNA replication licensing factor MCM3 [KO:K02541] [EC:5.6.2.3]
112147196  mcm4; DNA replication licensing factor MCM4 [KO:K02212] [EC:5.6.2.3]
112146992  mcm5; DNA replication licensing factor MCM5 [KO:K02209] [EC:5.6.2.3]
112147783  mcm6; DNA replication licensing factor MCM6 [KO:K02542] [EC:5.6.2.3]
112153599  mcm7; DNA replication licensing factor MCM7 [KO:K02210] [EC:5.6.2.3]
112148007  cdc45; cell division control protein 45 homolog [KO:K06628]
112151951  ticrr; treslin isoform X1 [KO:K26117]
112144072  mdm2-binding protein isoform X1 [KO:K26116]
112144234  cdc7; cell division cycle 7-related protein kinase isoform X1 [KO:K02214] [EC:2.7.11.1]
112143960  dbf4; protein DBF4 homolog A [KO:K06629]
112153931  uncharacterized protein LOC112153931 [KO:K06629]
112161823  cdk1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
112163494  ccnb1; G2/mitotic-specific cyclin-B1 [KO:K05868]
112161035  ccnb2; G2/mitotic-specific cyclin-B2 isoform X1 [KO:K21770]
112149155  ccnp; cyclin N-terminal domain-containing protein 2 [KO:K21770]
112141541  ccnb3; G2/mitotic-specific cyclin-B3 [KO:K21771]
112149242  cdc25b; M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
112162254  ywhaz; 14-3-3 protein zeta/delta [KO:K16197]
112143398  14-3-3 protein beta/alpha-1 [KO:K16197]
112144834  14-3-3 protein beta/alpha-1 [KO:K16197]
112152008  14-3-3 protein zeta/delta [KO:K16197]
112159120  14-3-3 protein beta/alpha-1 [KO:K16197]
112142568  14-3-3 protein epsilon isoform X1 [KO:K06630]
112149497  ywhae1; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 1 [KO:K06630]
112143003  14-3-3 protein gamma-1 isoform X2 [KO:K16198]
112149544  ywhag2; 14-3-3 protein gamma-B [KO:K16198]
112137374  plk1; serine/threonine-protein kinase PLK1 [KO:K06631] [EC:2.7.11.21]
112152385  wee2; wee1-like protein kinase 2 isoform X1 [KO:K06632] [EC:2.7.11.1]
112152942  wee1; wee1-like protein kinase [KO:K06632] [EC:2.7.11.1]
112154291  pkmyt1; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase [KO:K06633] [EC:2.7.11.1]
112148355  ccnh; cyclin-H [KO:K06634]
112148915  cdk7; cyclin-dependent kinase 7 [KO:K02202] [EC:2.7.11.22 2.7.11.23]
112161688  anapc1; anaphase-promoting complex subunit 1 isoform X1 [KO:K03348]
112146318  anapc2; anaphase-promoting complex subunit 2 isoform X1 [KO:K03349]
112139709  cdc27; cell division cycle protein 27 homolog isoform X1 [KO:K03350]
112136898  anapc4; anaphase-promoting complex subunit 4 [KO:K03351]
112148751  anapc5; anaphase-promoting complex subunit 5 [KO:K03352]
112155508  cdc16; cell division cycle protein 16 homolog [KO:K03353]
112148597  anapc7; anaphase-promoting complex subunit 7 isoform X1 [KO:K03354]
112142582  cdc23; cell division cycle protein 23 homolog [KO:K03355]
112156023  anapc10; anaphase-promoting complex subunit 10 isoform X1 [KO:K03357]
112156947  anapc11; anaphase-promoting complex subunit 11 [KO:K03358]
112138594  cdc26; anaphase-promoting complex subunit CDC26 isoform X1 [KO:K03359]
112151705  anapc13; anaphase-promoting complex subunit 13 [KO:K12456]
112149906  anapc15; anaphase-promoting complex subunit 15 [KO:K25228]
112154368  anapc16; anaphase-promoting complex subunit 16 [KO:K25229]
112147865  cdc20; cell division cycle protein 20 homolog [KO:K03363]
112148902  cell division cycle protein 20 homolog B [KO:K03363]
112153084  pttg1; securin [KO:K06635]
112145288  espl1; separin [KO:K02365] [EC:3.4.22.49]
112152400  smc1b; structural maintenance of chromosomes protein 1B [KO:K06636]
112159794  smc1a; structural maintenance of chromosomes protein 1A [KO:K06636]
112137375  smc3; structural maintenance of chromosomes protein 3 [KO:K06669]
112143771  double-strand-break repair protein rad21 homolog A [KO:K06670]
112159547  rad21l1; double-strand-break repair protein rad21-like protein 1 isoform X1 [KO:K06670]
112154960  si:ch211-269e2.1; cohesin subunit SA-2 isoform X1 [KO:K06671]
112142609  stag2a; cohesin subunit SA-2a isoform X1 [KO:K06671]
112145081  stag1a; cohesin subunit SA-1a [KO:K06671]
112153344  stag2b; cohesin subunit SA-2 [KO:K06671]
112153377  cohesin subunit SA-1 [KO:K06671]
112140023  transcriptional regulator ATRX [KO:K10779]
112153099  atrx; transcriptional regulator ATRX isoform X1 [KO:K10779]
112152135  ddx11; ATP-dependent DNA helicase DDX11 isoform X2 [KO:K11273] [EC:5.6.2.7]
112148189  nipbla; nipped-B-like protein A isoform X1 [KO:K06672]
112163071  nipped-B-like protein isoform X1 [KO:K06672]
112137007  mau2; MAU2 chromatid cohesion factor homolog [KO:K11266]
112155683  hdac8; histone deacetylase 8 isoform X1 [KO:K11405] [EC:3.5.1.98]
112140982  esco2; N-acetyltransferase ESCO2 [KO:K11268] [EC:2.3.1.-]
112142599  pds5b; sister chromatid cohesion protein PDS5 homolog B [KO:K11267]
112157518  pds5a; sister chromatid cohesion protein PDS5 homolog A [KO:K11267]
112154232  wings apart-like protein homolog [KO:K25163]
112161881  wapla; wings apart-like protein homolog [KO:K25163]
112163349  cdca5; sororin [KO:K17390]
112147920  aurkb; aurora kinase B [KO:K11479] [EC:2.7.11.1]
112163241  sgo1; shugoshin 1 isoform X1 [KO:K11580]
112142055  serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
112142644  ppp2cab; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
112149490  ppp2r1bb; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
112161867  ppp2r5d; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform X1 [KO:K11584]
112155834  ppp2r5b; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
112144359  ppp2r5ca; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
112158068  ppp2r5a; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
112137485  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
112145877  ppp2r5eb; protein phosphatase 2, regulatory subunit B', epsilon isoform X1 [KO:K11584]
112148821  ndc80; kinetochore protein NDC80 homolog [KO:K11547]
112157830  knl1; kinetochore scaffold 1 isoform X1 [KO:K11542]
112143964  ttk; dual specificity protein kinase Ttk isoform X1 [KO:K08866] [EC:2.7.12.1]
112137550  mad1l1; mitotic spindle assembly checkpoint protein MAD1 [KO:K06679]
112156185  mad2l1; mitotic spindle assembly checkpoint protein MAD2A isoform X1 [KO:K02537]
112138527  mad2l2; mitotic spindle assembly checkpoint protein MAD2B isoform X1 [KO:K13728]
112141506  bub1bb; mitotic checkpoint serine/threonine-protein kinase BUB1 beta [KO:K06637] [EC:2.7.11.1]
112154455  bub3; mitotic checkpoint protein BUB3 isoform X1 [KO:K02180]
112158454  bub1; mitotic checkpoint serine/threonine-protein kinase BUB1 [KO:K02178] [EC:2.7.11.1]
112143413  trip13; pachytene checkpoint protein 2 homolog [KO:K22399]
112161742  MAD2L1-binding protein isoform X1 [KO:K26093]
112147217  fzr1b; fizzy-related protein homolog isoform X1 [KO:K03364]
112147288  fzr1a; fizzy/cell division cycle 20 related 1a [KO:K03364]
112161413  fbxo5; F-box only protein 5 [KO:K10292]
112148265  cdc14b; dual specificity protein phosphatase CDC14B isoform X1 [KO:K06639] [EC:3.1.3.16 3.1.3.48]
112136689  cdc14ab; dual specificity protein phosphatase CDC14AB isoform X1 [KO:K06639] [EC:3.1.3.16 3.1.3.48]
112153984  ep300a; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
112137666  crebbpa; CREB-binding protein [KO:K04498] [EC:2.3.1.48]
112146043  ep300b; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
112146808  crebbpb; CREB binding protein b isoform X1 [KO:K04498] [EC:2.3.1.48]
112151428  prkdc; DNA-dependent protein kinase catalytic subunit isoform X1 [KO:K06642] [EC:2.7.11.1]
112140350  atr; serine/threonine-protein kinase ATR isoform X1 [KO:K06640] [EC:2.7.11.1]
112149326  atm; serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
112154812  mdm2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
112156259  tp53; cellular tumor antigen p53 isoform X2 [KO:K04451]
112147941  gadd45ga; growth arrest and DNA-damage-inducible, gamma a [KO:K04402]
112143441  growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
112150083  gadd45ba; growth arrest and DNA-damage-inducible, beta a [KO:K04402]
112144424  gadd45aa; growth arrest and DNA-damage-inducible, alpha, a [KO:K04402]
112152499  gadd45gb.1; growth arrest and DNA-damage-inducible, gamma b, tandem duplicate 1 [KO:K04402]
112152500  growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
112148642  pcna; proliferating cell nuclear antigen [KO:K04802]
112140828  chek1; serine/threonine-protein kinase Chk1 [KO:K02216] [EC:2.7.11.1]
112137749  chek2; serine/threonine-protein kinase Chk2 [KO:K06641] [EC:2.7.11.1]
Reference
PMID:7908906
  Authors
Matsuoka S, Yamaguchi M, Matsukage A
  Title
D-type cyclin-binding regions of proliferating cell nuclear antigen.
  Journal
J Biol Chem 269:11030-6 (1994)
Reference
PMID:8242749
  Authors
Welch PJ, Wang JY
  Title
A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle.
  Journal
Cell 75:779-90 (1993)
DOI:10.1016/0092-8674(93)90497-E
Reference
PMID:16936746
  Authors
Macaluso M, Montanari M, Giordano A
  Title
Rb family proteins as modulators of gene expression and new aspects regarding the interaction with chromatin remodeling enzymes.
  Journal
Oncogene 25:5263-7 (2006)
DOI:10.1038/sj.onc.1209680
Reference
PMID:15838516
  Authors
Cobrinik D
  Title
Pocket proteins and cell cycle control.
  Journal
Oncogene 24:2796-809 (2005)
DOI:10.1038/sj.onc.1208619
Reference
PMID:17568790
  Authors
Boutros R, Lobjois V, Ducommun B
  Title
CDC25 phosphatases in cancer cells: key players? Good targets?
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Nat Rev Cancer 7:495-507 (2007)
DOI:10.1038/nrc2169
Reference
PMID:9832503
  Authors
Diehl JA, Cheng M, Roussel MF, Sherr CJ
  Title
Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization.
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Genes Dev 12:3499-511 (1998)
DOI:10.1101/gad.12.22.3499
Reference
PMID:19020303
  Authors
Klein EA, Assoian RK
  Title
Transcriptional regulation of the cyclin D1 gene at a glance.
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J Cell Sci 121:3853-7 (2008)
DOI:10.1242/jcs.039131
Reference
PMID:10385618
  Authors
Sherr CJ, Roberts JM
  Title
CDK inhibitors: positive and negative regulators of G1-phase progression.
  Journal
Genes Dev 13:1501-12 (1999)
DOI:10.1101/gad.13.12.1501
Reference
PMID:12809600
  Authors
Shi Y, Massague J.
  Title
Mechanisms of TGF-beta signaling from cell membrane to the nucleus.
  Journal
Cell 113:685-700 (2003)
DOI:10.1016/S0092-8674(03)00432-X
Reference
PMID:12925736
  Authors
Kamura T, Hara T, Kotoshiba S, Yada M, Ishida N, Imaki H, Hatakeyama S, Nakayama K, Nakayama KI
  Title
Degradation of p57Kip2 mediated by SCFSkp2-dependent ubiquitylation.
  Journal
Proc Natl Acad Sci U S A 100:10231-6 (2003)
DOI:10.1073/pnas.1831009100
Reference
PMID:16212951
  Authors
Bond M, Sala-Newby GB, Wu YJ, Newby AC
  Title
Biphasic effect of p21Cip1 on smooth muscle cell proliferation: role of PI 3-kinase and Skp2-mediated degradation.
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Cardiovasc Res 69:198-206 (2006)
DOI:10.1016/j.cardiores.2005.08.020
Reference
PMID:15838523
  Authors
Harris SL, Levine AJ.
  Title
The p53 pathway: positive and negative feedback loops.
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Oncogene 24:2899-908 (2005)
DOI:10.1038/sj.onc.1208615
Reference
PMID:11099028
  Authors
Vogelstein B, Lane D, Levine AJ
  Title
Surfing the p53 network.
  Journal
Nature 408:307-10 (2000)
DOI:10.1038/35042675
Reference
PMID:7973727
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Smith ML, Chen IT, Zhan Q, Bae I, Chen CY, Gilmer TM, Kastan MB, O'Connor PM, Fornace AJ Jr
  Title
Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen.
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Science 266:1376-80 (1994)
DOI:10.1126/science.7973727
Reference
PMID:9889196
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Petersen BO, Lukas J, Sorensen CS, Bartek J, Helin K
  Title
Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization.
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EMBO J 18:396-410 (1999)
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Reference
PMID:17018296
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Sheu YJ, Stillman B
  Title
Cdc7-Dbf4 phosphorylates MCM proteins via a docking site-mediated mechanism to promote S phase progression.
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Mol Cell 24:101-13 (2006)
DOI:10.1016/j.molcel.2006.07.033
Reference
PMID:9029154
  Authors
Martinez AM, Afshar M, Martin F, Cavadore JC, Labbe JC, Doree M
  Title
Dual phosphorylation of the T-loop in cdk7: its role in controlling cyclin H binding and CAK activity.
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EMBO J 16:343-54 (1997)
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Reference
PMID:15876871
  Authors
Lolli G, Johnson LN
  Title
CAK-Cyclin-dependent Activating Kinase: a key kinase in cell cycle control and a target for drugs?
  Journal
Cell Cycle 4:572-7 (2005)
DOI:10.4161/cc.4.4.1607
Reference
PMID:17426725
  Authors
Musacchio A, Salmon ED
  Title
The spindle-assembly checkpoint in space and time.
  Journal
Nat Rev Mol Cell Biol 8:379-93 (2007)
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Reference
PMID:12573239
  Authors
Uhlmann F
  Title
Chromosome cohesion and separation: from men and molecules.
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Curr Biol 13:R104-14 (2003)
DOI:10.1016/S0960-9822(03)00039-3
Reference
PMID:15568976
  Authors
Stegmeier F, Amon A
  Title
Closing mitosis: the functions of the Cdc14 phosphatase and its regulation.
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Annu Rev Genet 38:203-32 (2004)
DOI:10.1146/annurev.genet.38.072902.093051
Reference
PMID:9618481
  Authors
Moustakas A, Kardassis D
  Title
Regulation of the human p21/WAF1/Cip1 promoter in hepatic cells by functional interactions between Sp1 and Smad family members.
  Journal
Proc Natl Acad Sci U S A 95:6733-8 (1998)
DOI:10.1073/pnas.95.12.6733
Reference
PMID:26650195
  Authors
de Boer HR, Guerrero Llobet S, van Vugt MA
  Title
Controlling the response to DNA damage by the APC/C-Cdh1.
  Journal
Cell Mol Life Sci 73:949-60 (2016)
DOI:10.1007/s00018-015-2096-7
Reference
PMID:20935501
  Authors
Qiao X, Zhang L, Gamper AM, Fujita T, Wan Y
  Title
APC/C-Cdh1: from cell cycle to cellular differentiation and genomic integrity.
  Journal
Cell Cycle 9:3904-12 (2010)
DOI:10.4161/cc.9.19.13585
Related
pathway
oml03030  DNA replication
oml04010  MAPK signaling pathway
oml04120  Ubiquitin mediated proteolysis
oml04210  Apoptosis
KO pathway
ko04110   
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