KEGG   PATHWAY: one04141
Entry
one04141                    Pathway                                
Name
Protein processing in endoplasmic reticulum - Oncorhynchus nerka (sockeye salmon)
Description
The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
one04141  Protein processing in endoplasmic reticulum
one04141

Other DBs
GO: 0030433 0034976
Organism
Oncorhynchus nerka (sockeye salmon) [GN:one]
Gene
115143146  protein transport protein Sec61 subunit alpha [KO:K10956]
115143343  protein transport protein Sec61 subunit alpha [KO:K10956]
115137968  protein transport protein Sec61 subunit alpha [KO:K10956]
115140062  protein transport protein Sec61 subunit alpha-like [KO:K10956]
115135768  sec61b; protein transport protein Sec61 subunit beta [KO:K09481]
115113961  protein transport protein Sec61 subunit gamma-like [KO:K07342]
115101778  protein transport protein Sec61 subunit gamma-like [KO:K07342]
115127575  protein transport protein Sec61 subunit gamma [KO:K07342]
115114111  translocation protein SEC62-like [KO:K12275]
115103339  translocation protein SEC62-like isoform X1 [KO:K12275]
115143334  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1-like [KO:K12666]
115138070  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1-like [KO:K12666]
115118672  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2-like isoform X1 [KO:K12667]
115136867  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2-like isoform X1 [KO:K12667]
115145480  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1-like [KO:K12668]
115108468  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1-like [KO:K12668]
115132243  dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit-like [KO:K12670]
115102263  dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit [KO:K12670]
115135887  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A [KO:K07151] [EC:2.4.99.18]
115105571  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A-like [KO:K07151] [EC:2.4.99.18]
115131752  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B-like [KO:K07151] [EC:2.4.99.18]
115128231  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B isoform X1 [KO:K07151] [EC:2.4.99.18]
115119692  magt1; magnesium transporter protein 1 [KO:K19478]
115138225  oligosaccharyltransferase complex subunit ostc-like [KO:K26501]
115133295  oligosaccharyltransferase complex subunit ostc isoform X1 [KO:K26501]
115122625  transmembrane protein 258 [KO:K26502]
115123753  transmembrane protein 258 [KO:K26502]
115137269  mogs; mannosyl-oligosaccharide glucosidase isoform X1 [KO:K01228] [EC:3.2.1.106]
115132946  cytoskeleton-associated protein 4-like [KO:K13999]
115133687  cytoskeleton-associated protein 4-like [KO:K13999]
115142689  ribosome-binding protein 1-like isoform X1 [KO:K14000]
115112953  ribosome-binding protein 1-like isoform X1 [KO:K14000]
115144468  ribosome-binding protein 1-like isoform X1 [KO:K14000]
115129305  sil1; nucleotide exchange factor SIL1 [KO:K14001]
115131131  nucleotide exchange factor SIL1-like [KO:K14001]
115136031  hypoxia up-regulated protein 1-like [KO:K09486]
115105368  hypoxia up-regulated protein 1-like [KO:K09486]
115119775  endoplasmic reticulum chaperone BiP [KO:K09490] [EC:3.6.4.10]
115122895  endoplasmic reticulum chaperone BiP-like [KO:K09490] [EC:3.6.4.10]
115110396  dnaJ homolog subfamily B member 11-like [KO:K09517]
115120428  dnajb11; dnaJ homolog subfamily B member 11 [KO:K09517]
115114085  dnaJ homolog subfamily C member 1-like isoform X1 [KO:K09521]
115103368  dnaJ homolog subfamily C member 1-like isoform X1 [KO:K09521]
115138055  dnaJ homolog subfamily C member 3-like [KO:K09523]
115133526  dnaJ homolog subfamily C member 3-like [KO:K09523]
115109646  dnajc3; dnaJ homolog subfamily C member 3 isoform X1 [KO:K09523]
115129495  dnajc10; dnaJ homolog subfamily C member 10 [KO:K09530] [EC:1.8.4.-]
115133071  endoplasmin-like isoform X1 [KO:K09487]
115116223  endoplasmin-like [KO:K09487]
115109727  endoplasmin-like [KO:K09487]
115129232  neutral alpha-glucosidase AB-like isoform X1 [KO:K05546] [EC:3.2.1.207]
115130934  neutral alpha-glucosidase AB-like isoform X1 [KO:K05546] [EC:3.2.1.207]
115101346  neutral alpha-glucosidase AB-like isoform X1 [KO:K05546] [EC:3.2.1.207]
115104229  glucosidase 2 subunit beta-like [KO:K08288]
115104235  glucosidase 2 subunit beta-like isoform X1 [KO:K08288]
115129532  calnexin-like isoform X1 [KO:K08054]
115130790  calnexin-like isoform X1 [KO:K08054]
115119420  protein disulfide-isomerase A3-like [KO:K08056] [EC:5.3.4.1]
115131552  protein disulfide-isomerase A3-like [KO:K08056] [EC:5.3.4.1]
115103155  protein disulfide-isomerase A3-like [KO:K08056] [EC:5.3.4.1]
115134531  protein disulfide-isomerase A3-like [KO:K08056] [EC:5.3.4.1]
115128447  protein disulfide-isomerase A3-like [KO:K08056] [EC:5.3.4.1]
115122236  calreticulin-like [KO:K08057]
115145012  calreticulin-like [KO:K08057]
115108229  calreticulin-like [KO:K08057]
115114298  calreticulin-like isoform X1 [KO:K08057]
115109203  calreticulin-like [KO:K08057]
115103188  calreticulin-like [KO:K08057]
115128576  mannosyl-oligosaccharide 1,2-alpha-mannosidase IB-like [KO:K01230] [EC:3.2.1.113]
115105343  mannosyl-oligosaccharide 1,2-alpha-mannosidase IA-like isoform X1 [KO:K01230] [EC:3.2.1.113]
115112303  man1a2; mannosyl-oligosaccharide 1,2-alpha-mannosidase IB [KO:K01230] [EC:3.2.1.113]
115131359  mannosyl-oligosaccharide 1,2-alpha-mannosidase IA-like [KO:K01230] [EC:3.2.1.113]
115107726  man1a1; mannosyl-oligosaccharide 1,2-alpha-mannosidase IA [KO:K01230] [EC:3.2.1.113]
115139444  mannosyl-oligosaccharide 1,2-alpha-mannosidase IA-like [KO:K01230] [EC:3.2.1.113]
115141202  mannosyl-oligosaccharide 1,2-alpha-mannosidase IA-like isoform X1 [KO:K01230] [EC:3.2.1.113]
115111439  endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase-like isoform X1 [KO:K23741] [EC:3.2.1.209]
115139862  endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase-like [KO:K23741] [EC:3.2.1.209]
115147146  endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase-like [KO:K23741] [EC:3.2.1.209]
115119017  vesicular integral-membrane protein VIP36-like isoform X1 [KO:K10082]
115129187  vesicular integral-membrane protein VIP36-like isoform X1 [KO:K10082]
115106024  lman1; protein ERGIC-53 isoform X1 [KO:K10080]
115128152  protein ERGIC-53-like [KO:K10080]
115106669  prolactin regulatory element-binding protein-like isoform X1 [KO:K14003]
115141419  prolactin regulatory element-binding protein-like isoform X1 [KO:K14003]
115105289  GTP-binding protein SAR1b [KO:K07953] [EC:3.6.5.-]
115136138  GTP-binding protein SAR1a [KO:K07953] [EC:3.6.5.-]
115120975  GTP-binding protein SAR1b-like [KO:K07953] [EC:3.6.5.-]
115112677  GTP-binding protein SAR1a-like isoform X1 [KO:K07953] [EC:3.6.5.-]
115134982  GTP-binding protein SAR1b-like [KO:K07953] [EC:3.6.5.-]
115124143  sec13; protein SEC13 homolog isoform X1 [KO:K14004]
115126485  LOW QUALITY PROTEIN: protein transport protein Sec31A-like [KO:K14005]
115142398  protein transport protein Sec23B [KO:K14006]
115138701  protein transport protein Sec23A [KO:K14006]
115146003  protein transport protein Sec23A-like [KO:K14006]
115129505  protein transport protein Sec24B-like isoform X1 [KO:K14007]
115105290  protein transport protein Sec24A-like isoform X1 [KO:K14007]
115136137  protein transport protein Sec24A-like isoform X1 [KO:K14007]
115121580  protein transport protein Sec24C-like isoform X1 [KO:K14007]
115130756  protein transport protein Sec24B-like isoform X1 [KO:K14007]
115144078  protein transport protein Sec24C-like isoform X1 [KO:K14007]
115138084  protein transport protein Sec24D-like [KO:K14007]
115125117  protein transport protein Sec24C-like [KO:K14007]
115133554  protein transport protein Sec24D-like [KO:K14007]
115129796  UDP-glucose:glycoprotein glucosyltransferase 1-like isoform X1 [KO:K11718] [EC:2.4.1.-]
115123924  UDP-glucose:glycoprotein glucosyltransferase 1-like isoform X1 [KO:K11718] [EC:2.4.1.-]
115109632  UDP-glucose:glycoprotein glucosyltransferase 2-like isoform X1 [KO:K11718] [EC:2.4.1.-]
115136246  edem1; ER degradation-enhancing alpha-mannosidase-like protein 1 [KO:K10084]
115132171  ER degradation-enhancing alpha-mannosidase-like protein 2 [KO:K10085]
115121758  ER degradation-enhancing alpha-mannosidase-like protein 3 [KO:K10086]
115144943  ER degradation-enhancing alpha-mannosidase-like protein 3 isoform X1 [KO:K10086]
115108366  ER degradation-enhancing alpha-mannosidase-like protein 3 isoform X1 [KO:K10086]
115147141  ER degradation-enhancing alpha-mannosidase-like protein 3 isoform X1 [KO:K10086]
115142577  protein disulfide-isomerase-like [KO:K09580] [EC:5.3.4.1]
115103792  protein disulfide-isomerase-like [KO:K09580] [EC:5.3.4.1]
115105002  protein disulfide-isomerase A4-like [KO:K09582] [EC:5.3.4.1]
115116301  protein disulfide-isomerase A4-like [KO:K09582] [EC:5.3.4.1]
115107552  protein disulfide-isomerase A6-like [KO:K09584] [EC:5.3.4.1]
115139553  protein disulfide-isomerase A6-like isoform X1 [KO:K09584] [EC:5.3.4.1]
115104864  thioredoxin domain-containing protein 5-like [KO:K13984] [EC:5.3.4.1]
115130221  txndc5; thioredoxin domain-containing protein 5 isoform X1 [KO:K13984] [EC:5.3.4.1]
115138248  ero1a; ERO1-like protein alpha [KO:K10950] [EC:1.8.4.-]
115103914  ERO1-like protein beta isoform X1 [KO:K10976] [EC:1.8.4.-]
115119688  ERO1-like protein beta isoform X1 [KO:K10976] [EC:1.8.4.-]
115139812  protein OS-9-like isoform X1 [KO:K10088]
115119866  erlec1; endoplasmic reticulum lectin 1 [KO:K14008]
115120904  endoplasmic reticulum lectin 1-like [KO:K14008]
115104912  ssr1; translocon-associated protein subunit alpha isoform X1 [KO:K13249]
115130158  translocon-associated protein subunit alpha-like isoform X1 [KO:K13249]
115143684  translocon-associated protein subunit alpha-like isoform X1 [KO:K13249]
115141493  translocon-associated protein subunit alpha [KO:K13249]
115131509  translocon-associated protein subunit beta [KO:K13250]
115128497  translocon-associated protein subunit beta-like [KO:K13250]
115124584  translocon-associated protein subunit gamma [KO:K13251]
115127657  translocon-associated protein subunit gamma-like [KO:K13251]
115125585  translocon-associated protein subunit delta-like [KO:K04571]
115102681  translocon-associated protein subunit delta-like [KO:K04571]
115101965  bcap31; B-cell receptor-associated protein 31 [KO:K14009]
115123169  translocating chain-associated membrane protein 1-like 1 [KO:K14010]
115131907  translocating chain-associated membrane protein 1-like 1 [KO:K14010]
115102129  translocating chain-associated membrane protein 1-like 1 isoform X1 [KO:K14010]
115118432  derl1; derlin-1 [KO:K11519]
115105469  derlin-2 [KO:K13989]
115111473  derlin-2-like [KO:K13989]
115105704  derlin-2-like isoform X1 [KO:K13989]
115129229  UBX domain-containing protein 1-like isoform X1 [KO:K24348]
115130268  UBX domain-containing protein 4-like isoform X1 [KO:K24348]
115130936  UBX domain-containing protein 1-like [KO:K24348]
115110089  ubxn4; UBX domain-containing protein 4 isoform X1 [KO:K24348]
115139227  ubxn2a; UBX domain-containing protein 2A isoform X1 [KO:K24349]
115144923  UBX domain-containing protein 6-like [KO:K14011]
115108348  UBX domain-containing protein 6-like [KO:K14011]
115118428  ubxn8; UBX domain-containing protein 8 [KO:K24351]
115132132  NSFL1 cofactor p47-like isoform X1 [KO:K14012]
115116432  NSFL1 cofactor p47-like isoform X1 [KO:K14012]
115120046  small VCP/p97-interacting protein-like [KO:K14014]
115126554  small VCP/p97-interacting protein-like isoform X1 [KO:K14014]
115111685  transitional endoplasmic reticulum ATPase-like [KO:K13525]
115120267  transitional endoplasmic reticulum ATPase-like [KO:K13525]
115101111  transitional endoplasmic reticulum ATPase-like [KO:K13525]
115140149  transitional endoplasmic reticulum ATPase [KO:K13525]
115112977  nuclear protein localization protein 4 homolog [KO:K14015]
115117682  nuclear protein localization protein 4 homolog isoform X1 [KO:K14015]
115111717  ubiquitin recognition factor in ER-associated degradation protein 1 [KO:K14016]
115140191  ubiquitin recognition factor in ER-associated degradation protein 1-like isoform X1 [KO:K14016]
115110272  heat shock 70 kDa protein [KO:K03283]
115141860  heat shock cognate 70 kDa protein-like [KO:K03283]
115136027  hspa8; heat shock cognate 71 kDa protein [KO:K03283]
115105372  heat shock cognate 70 kDa protein-like [KO:K03283]
115105375  heat shock cognate 70 kDa protein [KO:K03283]
115136708  heat shock cognate 70 kDa protein-like [KO:K03283]
115101923  LOW QUALITY PROTEIN: heat shock 70 kDa protein-like [KO:K03283]
115140833  heat shock cognate 71 kDa protein-like [KO:K03283]
115137210  dnaJ homolog subfamily A member 1-like [KO:K09502]
115145820  dnaJ homolog subfamily A member 1-like [KO:K09502]
115112129  dnaJ homolog subfamily A member 2-like [KO:K09503]
115113529  dnaJ homolog subfamily A member 2 [KO:K09503]
115114969  dnaJ homolog subfamily A member 2-like [KO:K09503]
115109482  dnaJ homolog subfamily A member 2-like [KO:K09503]
115104343  dnajb1; dnaJ homolog subfamily B member 1 [KO:K09507]
115127631  dnaJ homolog subfamily B member 1-like [KO:K09507]
115120064  dnaJ homolog subfamily B member 6-like [KO:K09508]
115126706  dnaJ homolog subfamily B member 6-like [KO:K09508]
115113116  dnajb12; dnaJ homolog subfamily B member 12 [KO:K09518]
115104934  dnaJ homolog subfamily C member 5-like [KO:K09525]
115121772  dnaJ homolog subfamily C member 5-like isoform X1 [KO:K09525]
115107796  dnaJ homolog subfamily C member 5-like isoform X1 [KO:K09525]
115113930  dnaJ homolog subfamily C member 5-like [KO:K09525]
115132356  dnajc5; dnaJ homolog subfamily C member 5 isoform X1 [KO:K09525]
115138772  dnaJ homolog subfamily C member 5-like [KO:K09525]
115101789  dnaJ homolog subfamily C member 5-like [KO:K09525]
115139376  dnaJ homolog subfamily C member 5-like isoform X1 [KO:K09525]
115145904  dnaJ homolog subfamily C member 5B-like [KO:K09525]
115102387  dnaJ homolog subfamily C member 5-like isoform X1 [KO:K09525]
115118567  heat shock protein HSP 90-alpha isoform X1 [KO:K04079]
115107603  heat shock protein HSP 90-beta-like [KO:K04079]
115107965  heat shock protein HSP 90-alpha [KO:K04079]
115107966  heat shock protein HSP 90-alpha 1-like [KO:K04079]
115139654  heat shock protein HSP 90-beta [KO:K04079]
115138551  heat shock 70 kDa protein 4L-like isoform X1 [KO:K09485]
115146180  heat shock 70 kDa protein 4L-like [KO:K09485]
115119757  bag1; BAG family molecular chaperone regulator 1 [KO:K09555]
115119467  BAG family molecular chaperone regulator 2-like [KO:K09556]
115113050  BAG family molecular chaperone regulator 2-like [KO:K09556]
115113051  BAG family molecular chaperone regulator 2-like [KO:K09556]
115117844  hsp70-binding protein 1-like [KO:K09562]
115143281  ubiquitin thioesterase OTU1 [KO:K13719] [EC:3.1.2.-]
115145750  ubiquitin thioesterase OTU1-like [KO:K13719] [EC:3.1.2.-]
115138099  phospholipase A-2-activating protein-like [KO:K14018]
115133561  phospholipase A-2-activating protein-like [KO:K14018]
115106008  UV excision repair protein RAD23 homolog B-like [KO:K10839]
115106105  UV excision repair protein RAD23 homolog B-like [KO:K10839]
115123099  UV excision repair protein RAD23 homolog A-like isoform X1 [KO:K10839]
115108227  UV excision repair protein RAD23 homolog B-like [KO:K10839]
115125243  UV excision repair protein RAD23 homolog A-like isoform X1 [KO:K10839]
115109202  UV excision repair protein RAD23 homolog B-like [KO:K10839]
115104149  ubiquilin-4-like [KO:K04523]
115128678  ubiquilin-4-like [KO:K04523]
115120398  ubiquilin-1-like isoform X1 [KO:K04523]
115131289  LOW QUALITY PROTEIN: ubiquilin-4-like [KO:K04523]
115141088  ubiquilin-4-like [KO:K04523]
115131430  ngly1; peptide-N(4)-(N-acetyl-beta- glucosaminyl)asparagine amidase [KO:K01456] [EC:3.5.1.52]
115146190  atxn3; ataxin-3 isoform X1 [KO:K11863] [EC:3.4.22.-]
115132202  ube4b; ubiquitin conjugation factor E4 B isoform X1 [KO:K10597] [EC:2.3.2.27]
115102707  LOW QUALITY PROTEIN: ubiquitin conjugation factor E4 B-like [KO:K10597] [EC:2.3.2.27]
115107904  eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
115138726  eukaryotic translation initiation factor 2 subunit 1-like [KO:K03237]
115145964  eukaryotic translation initiation factor 2 subunit 1-like [KO:K03237]
115109360  nuclear factor erythroid 2-related factor 2-like [KO:K05638]
115117468  nuclear factor erythroid 2-related factor 2-like [KO:K05638]
115134767  nuclear factor erythroid 2-related factor 2-like isoform X1 [KO:K05638]
115102535  transcription factor NF-E2 45 kDa subunit-like [KO:K05638]
115122810  transcription factor NF-E2 45 kDa subunit-like [KO:K05638]
115104014  cyclic AMP-dependent transcription factor ATF-4-like [KO:K04374]
115115684  cyclic AMP-dependent transcription factor ATF-4-like [KO:K04374]
115110115  cyclic AMP-dependent transcription factor ATF-4-like isoform X1 [KO:K04374]
115135327  DNA damage-inducible transcript 3 protein-like [KO:K04452]
115119825  uncharacterized protein LOC115119825 isoform X1 [KO:K04452]
115104895  apoptosis regulator Bcl-2-like [KO:K02161]
115130175  apoptosis regulator Bcl-2-like [KO:K02161]
115114494  apoptosis regulator Bcl-2-like [KO:K02161]
115103013  apoptosis regulator Bcl-2-like [KO:K02161]
115121331  cyclic AMP-dependent transcription factor ATF-6 alpha-like [KO:K09054]
115114283  cyclic AMP-dependent transcription factor ATF-6 alpha-like isoform X1 [KO:K09054]
115103203  cyclic AMP-dependent transcription factor ATF-6 alpha-like isoform X1 [KO:K09054]
115131598  cyclic AMP-dependent transcription factor ATF-6 beta-like isoform X1 [KO:K09049]
115128397  cyclic AMP-dependent transcription factor ATF-6 beta-like isoform X1 [KO:K09049]
115130554  wolframin-like [KO:K14020]
115122863  wfs1; wolframin [KO:K14020]
115109390  membrane-bound transcription factor site-1 protease-like [KO:K08653] [EC:3.4.21.112]
115118504  mbtps2; membrane-bound transcription factor site-2 protease isoform X1 [KO:K07765] [EC:3.4.24.85]
115125312  serine/threonine-protein kinase/endoribonuclease IRE1-like [KO:K08852] [EC:2.7.11.1 3.1.26.-]
115111813  TNF receptor-associated factor 2-like isoform X1 [KO:K03173] [EC:2.3.2.27]
115121372  LOW QUALITY PROTEIN: TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
115122481  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
115101153  TNF receptor-associated factor 2-like isoform X1 [KO:K03173] [EC:2.3.2.27]
115147161  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
115105478  mitogen-activated protein kinase kinase kinase 5-like [KO:K04426] [EC:2.7.11.25]
115107688  mitogen-activated protein kinase kinase kinase 5-like [KO:K04426] [EC:2.7.11.25]
115139480  mitogen-activated protein kinase kinase kinase 5-like [KO:K04426] [EC:2.7.11.25]
115141219  mitogen-activated protein kinase kinase kinase 5-like [KO:K04426] [EC:2.7.11.25]
115142490  dual specificity mitogen-activated protein kinase kinase 7-like isoform X1 [KO:K04431] [EC:2.7.12.2]
115142491  dual specificity mitogen-activated protein kinase kinase 7-like isoform X1 [KO:K04431] [EC:2.7.12.2]
115128757  mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
115135343  mitogen-activated protein kinase 8-like isoform X1 [KO:K04440] [EC:2.7.11.24]
115119601  mitogen-activated protein kinase 10-like [KO:K04440] [EC:2.7.11.24]
115130519  mitogen-activated protein kinase 9-like isoform X1 [KO:K04440] [EC:2.7.11.24]
115106409  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
115144005  mitogen-activated protein kinase 8-like isoform X1 [KO:K04440] [EC:2.7.11.24]
115113414  mitogen-activated protein kinase 8-like isoform X1 [KO:K04440] [EC:2.7.11.24]
115146824  mitogen-activated protein kinase 9-like [KO:K04440] [EC:2.7.11.24]
115104160  apoptosis regulator BAX-like [KO:K02159]
115104161  apoptosis regulator BAX-like [KO:K02159]
115110306  uncharacterized protein LOC115110306 isoform X1 [KO:K02159]
115112092  apoptosis regulator BAX-like isoform X1 [KO:K02159]
115113507  apoptosis regulator BAX-like [KO:K02159]
115110050  apoptosis regulator BAX-like [KO:K02159]
115145272  apoptosis regulator BAX-like isoform X1 [KO:K02159]
115142698  calpain-1 catalytic subunit-like [KO:K01367] [EC:3.4.22.52]
115120433  calpain-1 catalytic subunit-like isoform X1 [KO:K01367] [EC:3.4.22.52]
115120435  calpain-1 catalytic subunit-like [KO:K01367] [EC:3.4.22.52]
115137941  calpain-1 catalytic subunit-like [KO:K01367] [EC:3.4.22.52]
115101443  calpain-1 catalytic subunit-like [KO:K01367] [EC:3.4.22.52]
115133377  calpain-1 catalytic subunit-like isoform X1 [KO:K01367] [EC:3.4.22.52]
115142697  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
115142699  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
115122462  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
115107157  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
115126231  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
115104510  E3 ubiquitin-protein ligase MARCH6-like [KO:K10661] [EC:2.3.2.27]
115114458  E3 ubiquitin-protein ligase MARCH6-like isoform X1 [KO:K10661] [EC:2.3.2.27]
115103046  E3 ubiquitin-protein ligase MARCH6-like isoform X1 [KO:K10661] [EC:2.3.2.27]
115116893  E3 ubiquitin-protein ligase MARCH6-like isoform X1 [KO:K10661] [EC:2.3.2.27]
115139588  ube2j1; ubiquitin-conjugating enzyme E2 J1 [KO:K10578] [EC:2.3.2.23]
115107654  ubiquitin-conjugating enzyme E2 J1-like isoform X1 [KO:K10578] [EC:2.3.2.23]
115123613  ube2j2; ubiquitin-conjugating enzyme E2 J2 [KO:K04554] [EC:2.3.2.23]
115111010  ubiquitin-conjugating enzyme E2 G1-like [KO:K10575] [EC:2.3.2.23]
115119476  ubiquitin-conjugating enzyme E2 G1-like [KO:K10575] [EC:2.3.2.23]
115105404  ubiquitin-conjugating enzyme E2 G1 [KO:K10575] [EC:2.3.2.23]
115121929  ubiquitin-conjugating enzyme E2 G1-like [KO:K10575] [EC:2.3.2.23]
115125733  ubiquitin-conjugating enzyme E2 G1-like isoform X1 [KO:K10575] [EC:2.3.2.23]
115139917  ubiquitin-conjugating enzyme E2 G1-like [KO:K10575] [EC:2.3.2.23]
115115620  E3 ubiquitin-protein ligase synoviolin-like [KO:K10601] [EC:2.3.2.27]
115128287  E3 ubiquitin-protein ligase RNF5-like isoform X1 [KO:K10666] [EC:2.3.2.27]
115131725  E3 ubiquitin-protein ligase RNF5-like [KO:K10666] [EC:2.3.2.27]
115125053  E3 ubiquitin-protein ligase RNF185 [KO:K10666] [EC:2.3.2.27]
115115441  selenos; selenoprotein S [KO:K14025]
115107887  protein sel-1 homolog 1-like isoform X1 [KO:K14026]
115139579  LOW QUALITY PROTEIN: protein sel-1 homolog 1-like [KO:K14026]
115109364  homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein [KO:K14027]
115134300  herpud1; homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein isoform X1 [KO:K14027]
115113777  E3 ubiquitin-protein ligase AMFR-like [KO:K10636] [EC:2.3.2.36]
115113785  E3 ubiquitin-protein ligase AMFR-like [KO:K10636] [EC:2.3.2.36]
115134000  E3 ubiquitin-protein ligase AMFR-like isoform X1 [KO:K10636] [EC:2.3.2.36]
115106584  stub1; E3 ubiquitin-protein ligase CHIP [KO:K09561] [EC:2.3.2.27]
115135046  ubiquitin-conjugating enzyme E2 D4-like [KO:K06689] [EC:2.3.2.23]
115118659  ubiquitin-conjugating enzyme E2 D2 [KO:K06689] [EC:2.3.2.23]
115129373  ubiquitin-conjugating enzyme E2 D2-like isoform X1 [KO:K06689] [EC:2.3.2.23]
115135518  ubiquitin-conjugating enzyme E2 D2 [KO:K06689] [EC:2.3.2.23]
115111608  ubiquitin-conjugating enzyme E2 D4 isoform X1 [KO:K06689] [EC:2.3.2.23]
115130600  ubiquitin-conjugating enzyme E2 D2-like isoform X1 [KO:K06689] [EC:2.3.2.23]
115113182  ubiquitin-conjugating enzyme E2 D4-like [KO:K06689] [EC:2.3.2.23]
115101435  ubiquitin-conjugating enzyme E2 D2 [KO:K06689] [EC:2.3.2.23]
115124839  ubiquitin-conjugating enzyme E2 D2 [KO:K06689] [EC:2.3.2.23]
115115406  ubiquitin-conjugating enzyme E2 D4-like [KO:K06689] [EC:2.3.2.23]
115125783  ubiquitin-conjugating enzyme E2 D3-like isoform X1 [KO:K06689] [EC:2.3.2.23]
115140049  ubiquitin-conjugating enzyme E2 D4 isoform X1 [KO:K06689] [EC:2.3.2.23]
115135230  prkn; E3 ubiquitin-protein ligase parkin [KO:K04556] [EC:2.3.2.31]
115104268  RING-box protein 1 [KO:K03868] [EC:2.3.2.32]
115109887  RING-box protein 1 [KO:K03868] [EC:2.3.2.32]
115105004  cullin-1-like [KO:K03347]
115114462  cullin-1-like [KO:K03347]
115103042  cullin-1 [KO:K03347]
115105286  S-phase kinase-associated protein 1 [KO:K03094]
115136185  S-phase kinase-associated protein 1 [KO:K03094]
115139216  fbxo2; F-box only protein 2 [KO:K10099]
115132319  F-box only protein 6-like isoform X1 [KO:K10100]
115102344  F-box only protein 44-like isoform X1 [KO:K10100]
115132317  F-box only protein 44-like isoform X1 [KO:K10100]
Compound
C00076  Calcium cation
G00009   
G00010   
G00011   
G00012   
G10694   
Reference
PMID:19491040
  Authors
Naidoo N
  Title
ER and aging-Protein folding and the ER stress response.
  Journal
Ageing Res Rev 8:150-9 (2009)
DOI:10.1016/j.arr.2009.03.001
Reference
PMID:18023214
  Authors
Malhotra JD, Kaufman RJ
  Title
The endoplasmic reticulum and the unfolded protein response.
  Journal
Semin Cell Dev Biol 18:716-31 (2007)
DOI:10.1016/j.semcdb.2007.09.003
Reference
PMID:20347046
  Authors
Maattanen P, Gehring K, Bergeron JJ, Thomas DY
  Title
Protein quality control in the ER: the recognition of misfolded proteins.
  Journal
Semin Cell Dev Biol 21:500-11 (2010)
DOI:10.1016/j.semcdb.2010.03.006
Reference
PMID:20219571
  Authors
Stolz A, Wolf DH
  Title
Endoplasmic reticulum associated protein degradation: a chaperone assisted journey to hell.
  Journal
Biochim Biophys Acta 1803:694-705 (2010)
DOI:10.1016/j.bbamcr.2010.02.005
Reference
PMID:20112977
  Authors
Dejgaard K, Theberge JF, Heath-Engel H, Chevet E, Tremblay ML, Thomas DY
  Title
Organization of the Sec61 translocon, studied by high resolution native electrophoresis.
  Journal
J Proteome Res 9:1763-71 (2010)
DOI:10.1021/pr900900x
Related
pathway
one00510  N-Glycan biosynthesis
one03050  Proteasome
one03060  Protein export
one04210  Apoptosis
KO pathway
ko04141   
LinkDB

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