KEGG   PATHWAY: padl04810
Entry
padl04810                   Pathway                                
Name
Regulation of actin cytoskeleton - Pygoscelis adeliae (Adelie penguin)
Class
Cellular Processes; Cell motility
Pathway map
padl04810  Regulation of actin cytoskeleton
padl04810

Other DBs
GO: 0030036
Organism
Pygoscelis adeliae (Adelie penguin) [GN:padl]
Gene
103917222  lysophosphatidic acid receptor 1-B-like [KO:K04289]
103921055  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
103920849  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
103919177  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
103922014  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
103913969  CXCL12; stromal cell-derived factor 1 [KO:K10031]
103912661  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
103921711  F2; prothrombin [KO:K01313] [EC:3.4.21.5]
103919756  F2R; proteinase-activated receptor 1 [KO:K03914]
103920695  INS; insulin [KO:K04526]
103926035  EGF; pro-epidermal growth factor [KO:K04357]
103923131  FGF1; fibroblast growth factor 1 [KO:K18496]
103926140  FGF2; fibroblast growth factor 2 [KO:K18497]
103916315  FGF8; fibroblast growth factor 8 [KO:K04358]
103920109  FGF9; fibroblast growth factor 9 [KO:K04358]
103923487  FGF22; fibroblast growth factor 22 [KO:K04358]
103926336  FGF20; fibroblast growth factor 20 [KO:K04358]
103917220  FGF6; fibroblast growth factor 6 [KO:K04358]
103921961  FGF18; fibroblast growth factor 18 [KO:K04358]
103917705  FGF5; fibroblast growth factor 5 [KO:K04358]
103925822  FGF3; fibroblast growth factor 3 [KO:K04358]
103922745  FGF7; fibroblast growth factor 7 isoform X1 [KO:K04358]
103917416  FGF10; fibroblast growth factor 10 [KO:K04358]
103920226  FGF16; fibroblast growth factor 16 [KO:K04358]
103917221  FGF23; fibroblast growth factor 23 [KO:K22428]
103913559  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
103915655  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
103915458  PDGFD; platelet-derived growth factor D [KO:K05450]
103918093  PDGFC; platelet-derived growth factor C [KO:K05450]
103914859  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
103912362  FGFR1; fibroblast growth factor receptor 1 [KO:K04362] [EC:2.7.10.1]
103918542  FGFR2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
103920985  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
103918814  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
103926287  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
103915745  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
103921663  FN1; fibronectin [KO:K05717]
103919453  ITGA1; integrin alpha-1 [KO:K06480]
103919452  ITGA2; integrin alpha-2 [KO:K06481]
103924599  ITGA4; integrin alpha-4 [KO:K06483]
103924246  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
103922457  ITGA8; integrin alpha-8 [KO:K06584]
103915134  ITGA9; integrin alpha-9 [KO:K06585]
103914802  ITGA11; integrin alpha-11 [KO:K06587]
103921674  ITGAV; LOW QUALITY PROTEIN: integrin alpha-V [KO:K06487]
103920810  ITGAE; integrin alpha-E [KO:K06524]
103918264  ITGB1; integrin beta-1 [KO:K05719]
103914154  ITGB2; integrin beta-2 [KO:K06464]
103926075  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
103917473  ITGB4; integrin beta-4 [KO:K06525]
103919602  ITGB5; integrin beta-5 [KO:K06588]
103918129  ITGB6; integrin beta-6 [KO:K06589]
103918721  ITGB8; integrin beta-8 [KO:K06591]
103914995  KNG1; kininogen-1 [KO:K03898]
103915668  BDKRB1; B1 bradykinin receptor [KO:K03915]
103915666  BDKRB2; B2 bradykinin receptor [KO:K03916]
103924397  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
103921225  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
103921716  CHRM4; muscarinic acetylcholine receptor M4 [KO:K04132]
103914355  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
103915323  C5; complement C5 [KO:K03994]
103917435  C6; complement component C6 [KO:K03995]
103917261  C7; complement component C7 [KO:K03996]
103913315  C8A; complement component C8 alpha chain [KO:K03997]
103913362  C8B; complement component C8 beta chain [KO:K03998]
103921473  C9; complement component C9 [KO:K04000]
103913532  GNA12; LOW QUALITY PROTEIN: guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
103916715  GNA13; guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
103913977  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
103924116  FGD3; FYVE, RhoGEF and PH domain-containing protein 3 [KO:K05722]
103920642  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
103924846  CRK; adapter molecule crk [KO:K04438]
103922609  CRKL; crk-like protein [KO:K04438]
103918635  DOCK1; dedicator of cytokinesis protein 1 [KO:K13708]
103912412  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
103914918  SOS2; son of sevenless homolog 2 [KO:K03099]
103925086  SOS1; son of sevenless homolog 1 [KO:K03099]
103916453  HRAS; GTPase HRas [KO:K02833]
103924322  KRAS; GTPase KRas isoform X1 [KO:K07827]
103923578  NRAS; GTPase NRas [KO:K07828]
103923806  RRAS2; ras-related protein R-Ras2 [KO:K07830]
103919617  MRAS; ras-related protein M-Ras [KO:K07831]
103923374  ARHGEF6; rho guanine nucleotide exchange factor 6 [KO:K05729]
103914966  PIK3CA; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
103917840  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
103917969  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
103926435  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
103919717  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
103919124  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
103915343  VAV2; guanine nucleotide exchange factor VAV2 [KO:K05730]
103917112  VAV3; guanine nucleotide exchange factor VAV3 [KO:K05730]
103920307  TIAM1; LOW QUALITY PROTEIN: T-lymphoma invasion and metastasis-inducing protein 1 [KO:K05731]
103924405  BRAF; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
103915210  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
103923665  MOS; proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
103914812  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
103916484  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
103922585  MAPK1; LOW QUALITY PROTEIN: mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
103914586  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
103919989  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
103916212  LOW QUALITY PROTEIN: RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
103915921  RGCC; regulator of cell cycle RGCC [KO:K26108]
103925895  regulator of cell cycle RGCC-like [KO:K26108]
103922296  ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
103922246  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
103925495  RHOA; transforming protein RhoA [KO:K04513]
103913498  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
103924148  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
103917419  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
103925407  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
103915162  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
103915938  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
103920160  PAK3; serine/threonine-protein kinase PAK 3 [KO:K05733] [EC:2.7.11.1]
103913122  PAK7; serine/threonine-protein kinase PAK 7 [KO:K05736] [EC:2.7.11.1]
103924947  PAK6; serine/threonine-protein kinase PAK 6 isoform X1 [KO:K05735] [EC:2.7.11.1]
103915647  ARHGEF7; rho guanine nucleotide exchange factor 7 isoform X1 [KO:K13710]
103923171  ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.39]
103924034  ROCK2; LOW QUALITY PROTEIN: rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.39]
103921929  myosin light chain kinase, smooth muscle-like [KO:K00907] [EC:2.7.11.18]
103913791  MYLK3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
103919008  MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
103919603  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
103914295  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
103914541  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
103919928  PPP1R12A; protein phosphatase 1 regulatory subunit 12A [KO:K06270]
103913809  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X1 [KO:K12329]
103914543  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform isoform X1 [KO:K10351]
103921386  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
103912916  MYL10; myosin regulatory light chain 10 [KO:K12756]
103917825  myosin regulatory light chain 2, smooth muscle minor isoform-like [KO:K12757]
103917836  myosin regulatory light chain 2, smooth muscle minor isoform [KO:K12757]
103917587  MYH11; myosin-11 [KO:K10352]
103924135  MYH9; myosin-9 [KO:K10352]
103925340  MYH10; myosin-10 [KO:K10352]
103923959  DIAPH2; LOW QUALITY PROTEIN: protein diaphanous homolog 2 [KO:K05741]
103925878  SLC9A1; sodium/hydrogen exchanger 1 [KO:K05742]
103924092  PIP5K1A; LOW QUALITY PROTEIN: phosphatidylinositol 4-phosphate 5-kinase type-1 alpha [KO:K00889] [EC:2.7.1.68]
103916065  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma [KO:K00889] [EC:2.7.1.68]
103920365  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [KO:K00889] [EC:2.7.1.68]
103918315  PIP4K2B; phosphatidylinositol 5-phosphate 4-kinase type-2 beta isoform X1 [KO:K00920] [EC:2.7.1.149]
103922423  PIP4K2A; phosphatidylinositol 5-phosphate 4-kinase type-2 alpha isoform X1 [KO:K00920] [EC:2.7.1.149]
103923799  PIKFYVE; 1-phosphatidylinositol 3-phosphate 5-kinase [KO:K00921] [EC:2.7.1.150]
103922685  LIMK2; LOW QUALITY PROTEIN: LIM domain kinase 2 [KO:K05744] [EC:2.7.11.1]
103916243  DIAPH3; protein diaphanous homolog 3 [KO:K05745]
103917437  BAIAP2; brain-specific angiogenesis inhibitor 1-associated protein 2 [KO:K05627]
103925016  ENAH; protein enabled homolog isoform X1 [KO:K05746]
103923835  WASL; neural Wiskott-Aldrich syndrome protein [KO:K23612]
103912774  WASF2; wiskott-Aldrich syndrome protein family member 2 [KO:K05748]
103924911  CYFIP2; cytoplasmic FMR1-interacting protein 2 isoform X1 [KO:K05749]
103923041  CYFIP1; cytoplasmic FMR1-interacting protein 1 [KO:K05749]
103921671  NCKAP1; nck-associated protein 1 [KO:K05750]
103923738  ABI2; abl interactor 2 isoform X1 [KO:K05751]
103918994  WASF1; wiskott-Aldrich syndrome protein family member 1 [KO:K05753]
103917830  ACTR2; actin-related protein 2 [KO:K17260]
103915636  ACTR3B; actin-related protein 3B [KO:K18584]
103918500  actin-related protein 3 [KO:K18584]
103914104  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
103918799  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
103914267  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
103914553  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
103917495  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
103913542  ACTB; actin, cytoplasmic 1 [KO:K05692]
103913191  PFN4; profilin-4 [KO:K05759]
103925063  PFN3; LOW QUALITY PROTEIN: profilin-3 [KO:K05759]
103925311  PFN2; profilin-2 [KO:K05759]
103922638  PXN; paxillin isoform X1 [KO:K05760]
103912723  EZR; ezrin isoform X1 [KO:K08007]
103926399  RDX; LOW QUALITY PROTEIN: radixin [KO:K05762]
103925544  MSN; moesin [KO:K05763]
103915764  TMSB4X; thymosin beta-4 [KO:K05764]
103912944  CFL2; cofilin-2 [KO:K05765]
103925659  SSH1; protein phosphatase Slingshot homolog 1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
103920805  SSH2; LOW QUALITY PROTEIN: protein phosphatase Slingshot homolog 2 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
103915612  VCL; vinculin [KO:K05700]
103914866  IQGAP1; ras GTPase-activating-like protein IQGAP1 [KO:K16848]
103913905  IQGAP3; LOW QUALITY PROTEIN: ras GTPase-activating-like protein IQGAP3 [KO:K05767]
103919755  IQGAP2; ras GTPase-activating-like protein IQGAP2 [KO:K05767]
103918729  SCIN; adseverin [KO:K05768]
103915243  GSN; gelsolin [KO:K05768]
103918284  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
103914450  APC; LOW QUALITY PROTEIN: adenomatous polyposis coli protein [KO:K02085]
103912571  ARHGEF4; rho guanine nucleotide exchange factor 4 [KO:K05769]
103920105  SPATA13; spermatogenesis-associated protein 13 isoform X1 [KO:K05769]
Compound
C00681  1-Acyl-sn-glycerol 3-phosphate
C01996  Acetylcholine
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:11152757
  Authors
Takai Y, Sasaki T, Matozaki T.
  Title
Small GTP-binding proteins.
  Journal
Physiol Rev 81:153-208 (2001)
DOI:10.1152/physrev.2001.81.1.153
Reference
PMID:12700767
  Authors
Pollard TD.
  Title
The cytoskeleton, cellular motility and the reductionist agenda.
  Journal
Nature 422:741-5 (2003)
DOI:10.1038/nature01598
Reference
PMID:14657486
  Authors
Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR.
  Title
Cell migration: integrating signals from front to back.
  Journal
Science 302:1704-9 (2003)
DOI:10.1126/science.1092053
Reference
PMID:11082272
  Authors
Sastry SK, Burridge K.
  Title
Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics.
  Journal
Exp Cell Res 261:25-36 (2000)
DOI:10.1006/excr.2000.5043
Reference
PMID:10574699
  Authors
Fukata M, Nakagawa M, Kuroda S, Kaibuchi K.
  Title
Cell adhesion and Rho small GTPases.
  Journal
J Cell Sci 112 ( Pt 24):4491-500 (1999)
Related
pathway
padl04010  MAPK signaling pathway
padl04510  Focal adhesion
padl04520  Adherens junction
KO pathway
ko04810   
LinkDB

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