KEGG   PATHWAY: shon04630
Entry
shon04630                   Pathway                                
Name
JAK-STAT signaling pathway - Sturnira hondurensis
Description
The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeostasis in animals, from humans to flies. In mammals, the JAK/STAT pathway is the principal signaling mechanism for a wide array of cytokines and growth factors. Following the binding of cytokines to their cognate receptor, STATs are activated by members of the JAK family of tyrosine kinases. Once activated, they dimerize and translocate to the nucleus and modulate the expression of target genes. In addition to the activation of STATs, JAKs mediate the recruitment of other molecules such as the MAP kinases, PI3 kinase etc. These molecules process downstream signals via the Ras-Raf-MAP kinase and PI3 kinase pathways which results in the activation of additional transcription factors.
Class
Environmental Information Processing; Signal transduction
Pathway map
shon04630  JAK-STAT signaling pathway
shon04630

Other DBs
GO: 0007259
Organism
Sturnira hondurensis [GN:shon]
Gene
118995277  IL2; interleukin-2 [KO:K05429]
118990129  IL4; interleukin-4 [KO:K05430]
118997775  IL7; interleukin-7 isoform X1 [KO:K05431]
118996212  IL9; interleukin-9 [KO:K05432]
118995438  IL15; interleukin-15 [KO:K05433]
118995486  IL21; interleukin-21 [KO:K05434]
119000807  IL2RA; interleukin-2 receptor subunit alpha isoform X1 [KO:K05068]
119002352  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
119001758  IL4R; interleukin-4 receptor subunit alpha isoform X1 [KO:K05071]
118998771  IL7R; interleukin-7 receptor subunit alpha [KO:K05072]
118978841  IL9R; interleukin-9 receptor [KO:K05073]
119000806  IL15RA; interleukin-15 receptor subunit alpha isoform X1 [KO:K05074]
118997219  cytokine receptor-like factor 2 [KO:K05078]
118974344  CRLF2; cytokine receptor-like factor 2 [KO:K05078]
118990131  IL5; LOW QUALITY PROTEIN: interleukin-5 [KO:K05428]
118990122  CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427]
118974342  IL3RA; interleukin-3 receptor subunit alpha [KO:K04737]
118989401  IL5RA; interleukin-5 receptor subunit alpha [KO:K05067]
118974340  CSF2RA; granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X1 [KO:K05066]
118974345  granulocyte-macrophage colony-stimulating factor receptor subunit alpha-like [KO:K05066]
119002296  CSF2RB; cytokine receptor common subunit beta isoform X1 [KO:K04738]
118981390  IL11; interleukin-11 [KO:K05417]
118990130  IL13; interleukin-13 [KO:K05435]
118991329  IL31; interleukin-31 [KO:K22631]
118991279  OSM; oncostatin-M [KO:K05418]
118991278  LIF; leukemia inhibitory factor [KO:K05419]
118996868  CNTF; ciliary neurotrophic factor [KO:K05420]
118991810  CLCF1; cardiotrophin-like cytokine factor 1 isoform X1 [KO:K05421]
118990189  IL6R; interleukin-6 receptor subunit alpha isoform X1 [KO:K05055]
118981655  IL6ST; interleukin-6 receptor subunit beta [KO:K05060]
118979605  GALT; galactose-1-phosphate uridylyltransferase isoform X1 [KO:K05056]
118989853  IL13RA1; interleukin-13 receptor subunit alpha-1 isoform X1 [KO:K05076]
118982604  IL13RA2; interleukin-13 receptor subunit alpha-2 [KO:K05077]
118984090  IL27RA; interleukin-27 receptor subunit alpha isoform X1 [KO:K19598]
118981665  IL31RA; interleukin-31 receptor subunit alpha [KO:K22630]
118998792  OSMR; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057]
118998788  LIFR; leukemia inhibitory factor receptor [KO:K05058]
118979714  CNTFR; ciliary neurotrophic factor receptor subunit alpha isoform X1 [KO:K05059]
119001704  IL10; interleukin-10 [KO:K05443]
119001718  IL19; interleukin-19 [KO:K05444]
118989638  IL22; interleukin-22 [KO:K05445]
119001703  IL20; interleukin-20 [KO:K22667]
119001640  IL24; LOW QUALITY PROTEIN: interleukin-24 [KO:K22668]
118989639  IL26; interleukin-26 [KO:K05446]
118994773  IL10RA; interleukin-10 receptor subunit alpha isoform X1 [KO:K05134]
119000286  IL10RB; interleukin-10 receptor subunit beta isoform X1 [KO:K05135]
118986671  IL20RA; interleukin-20 receptor subunit alpha [KO:K05136]
118997538  IL20RB; interleukin-20 receptor subunit beta [KO:K05137]
118977743  IL22RA1; interleukin-22 receptor subunit alpha-1 [KO:K05138]
118986791  IL22RA2; interleukin-22 receptor subunit alpha-2 [KO:K05139]
118987454  IL12A; interleukin-12 subunit alpha [KO:K05406]
118984138  IL12B; interleukin-12 subunit beta [KO:K05425]
118976004  IL23A; interleukin-23 subunit alpha [KO:K05426]
118975125  IL12RB1; interleukin-12 receptor subunit beta-1 isoform X1 [KO:K05063]
118984685  IL12RB2; interleukin-12 receptor subunit beta-2 isoform X1 [KO:K05064]
118985593  IL23R; interleukin-23 receptor [KO:K05065]
118992858  EPO; erythropoietin [KO:K05437]
119003505  somatotropin [KO:K05438]
118981253  PRL; prolactin isoform X1 [KO:K05439]
118974245  THPO; thrombopoietin isoform X1 [KO:K06854]
118978095  CSF3; granulocyte colony-stimulating factor [KO:K05423]
118989242  leptin isoform X1 [KO:K05424]
118998815  GHR; growth hormone receptor isoform X1 [KO:K05080]
118998769  PRLR; prolactin receptor isoform X1 [KO:K05081]
119003330  thrombopoietin receptor isoform X1 [KO:K05082]
118977656  CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
118984949  LEPR; leptin receptor isoform X1 [KO:K05062]
118997983  interferon alpha-2-like [KO:K05414]
118984066  interferon alpha-4-like [KO:K05414]
118978917  interferon alpha-2-like [KO:K05414]
118997987  interferon beta-2-like [KO:K05415]
118997988  interferon beta-2-like [KO:K05415]
118997989  interferon beta-2-like [KO:K05415]
118997990  interferon beta-2-like [KO:K05415]
118984054  IFNE; LOW QUALITY PROTEIN: interferon epsilon [KO:K05442]
118996980  IFNK; interferon kappa [KO:K05441]
118988117  IFNL1; interferon lambda-1 [KO:K05447]
118981884  interferon lambda-3-like [KO:K22669]
118988122  interferon lambda-3-like [KO:K22669]
118997982  interferon omega-2-like [KO:K05440]
118997984  interferon omega-1-like [KO:K05440]
118983307  interferon omega-2-like [KO:K05440]
118984056  LOW QUALITY PROTEIN: interferon omega-1-like [KO:K05440]
119000288  IFNAR1; interferon alpha/beta receptor 1 isoform X1 [KO:K05130]
119000285  IFNAR2; interferon alpha/beta receptor 2 [KO:K05131]
118977804  IFNLR1; interferon lambda receptor 1 [KO:K05140]
118989641  IFNG; interferon gamma [KO:K04687]
118986670  IFNGR1; interferon gamma receptor 1 isoform X1 [KO:K05132]
119000289  IFNGR2; interferon gamma receptor 2 [KO:K05133]
118977074  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
118995064  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
119002339  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
118983507  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
118978642  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
118986157  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
118985040  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
118975019  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
118985299  STAT1; signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220]
118975851  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
118978208  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
118985298  STAT4; signal transducer and activator of transcription 4 [KO:K11222]
118978082  signal transducer and activator of transcription 5A [KO:K11223]
118977990  signal transducer and activator of transcription 5B [KO:K11224]
118975844  STAT6; signal transducer and activator of transcription 6 isoform X1 [KO:K11225]
118980890  IRF9; interferon regulatory factor 9 isoform X1 [KO:K04693]
118989434  CISH; cytokine-inducible SH2-containing protein [KO:K04701]
119002932  SOCS1; suppressor of cytokine signaling 1 [KO:K04694]
118997337  suppressor of cytokine signaling 2-like [KO:K04695]
118999937  SOCS2; suppressor of cytokine signaling 2 [KO:K04695]
118999677  SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
118992421  SOCS4; suppressor of cytokine signaling 4 [KO:K04697]
119001249  SOCS5; suppressor of cytokine signaling 5 [KO:K04698]
118978224  SOCS7; suppressor of cytokine signaling 7 isoform X1 [KO:K04699]
118979586  SOCS6; suppressor of cytokine signaling 6 [KO:K04699]
118979386  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
118985337  BCL2L1; bcl-2-like protein 1 [KO:K04570]
118998952  PIM1; serine/threonine-protein kinase pim-1 [KO:K04702] [EC:2.7.11.1]
118988677  MYC; myc proto-oncogene protein isoform X1 [KO:K04377]
118998396  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
118999952  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
118991404  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
118998962  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
118985255  aldehyde oxidase 2 isoform X1 [KO:K00157] [EC:1.2.3.1]
118985256  AOX1; aldehyde oxidase isoform X1 [KO:K00157] [EC:1.2.3.1]
119001830  glial fibrillary acidic protein isoform X1 [KO:K05640]
118997146  STAM; signal transducing adapter molecule 1 isoform X1 [KO:K04705]
118974383  STAM2; signal transducing adapter molecule 2 isoform X1 [KO:K04705]
119001955  PTPN2; tyrosine-protein phosphatase non-receptor type 2 isoform X1 [KO:K18026] [EC:3.1.3.48]
119002403  PTPN6; tyrosine-protein phosphatase non-receptor type 6 isoform X1 [KO:K05697] [EC:3.1.3.48]
118975816  CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
119002487  EP300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
118992350  PIAS1; E3 SUMO-protein ligase PIAS1 isoform X1 [KO:K04706] [EC:2.3.2.-]
118978370  PIAS2; E3 SUMO-protein ligase PIAS2 isoform X1 [KO:K16063] [EC:2.3.2.-]
118982133  PIAS3; E3 SUMO-protein ligase PIAS3 isoform X1 [KO:K16064] [EC:2.3.2.-]
118984503  PIAS4; E3 SUMO-protein ligase PIAS4 isoform X1 [KO:K16065] [EC:2.3.2.27]
118982069  four and a half LIM domains protein 1 isoform X1 [KO:K14365]
118997701  four and a half LIM domains protein 1 isoform X1 [KO:K14365]
118976578  four and a half LIM domains protein 1-like [KO:K14365]
118991117  PTPN11; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
119000762  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
118992372  SOS2; son of sevenless homolog 2 [KO:K03099]
119001478  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
118982230  HRAS; GTPase HRas isoform X1 [KO:K02833]
118990300  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
118997522  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
118986375  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
118995662  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
118982454  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
118975178  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
118998595  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
118988441  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
119003271  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
118988089  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
118986352  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
Reference
PMID:22383755
  Authors
Harrison DA
  Title
The Jak/STAT pathway.
  Journal
Cold Spring Harb Perspect Biol 4:a011205 (2012)
DOI:10.1101/cshperspect.a011205
Reference
PMID:22339650
  Authors
Kiu H, Nicholson SE
  Title
Biology and significance of the JAK/STAT signalling pathways.
  Journal
Growth Factors 30:88-106 (2012)
DOI:10.3109/08977194.2012.660936
Reference
PMID:21372217
  Authors
Hervas-Stubbs S, Perez-Gracia JL, Rouzaut A, Sanmamed MF, Le Bon A, Melero I
  Title
Direct effects of type I interferons on cells of the immune system.
  Journal
Clin Cancer Res 17:2619-27 (2011)
DOI:10.1158/1078-0432.CCR-10-1114
Reference
PMID:25217450
  Authors
Fish EN, Platanias LC
  Title
Interferon receptor signaling in malignancy: a network of cellular pathways defining biological outcomes.
  Journal
Mol Cancer Res 12:1691-703 (2014)
DOI:10.1158/1541-7786.MCR-14-0450
Reference
PMID:21034406
  Authors
Ivanenkov YA, Balakin KV, Lavrovsky Y
  Title
Small molecule inhibitors of NF-kB and JAK/STAT signal transduction pathways as promising anti-inflammatory therapeutics.
  Journal
Mini Rev Med Chem 11:55-78 (2011)
DOI:10.2174/138955711793564079
Reference
PMID:25587654
  Authors
O'Shea JJ, Schwartz DM, Villarino AV, Gadina M, McInnes IB, Laurence A
  Title
The JAK-STAT pathway: impact on human disease and therapeutic intervention.
  Journal
Annu Rev Med 66:311-28 (2015)
DOI:10.1146/annurev-med-051113-024537
Reference
PMID:24069565
  Authors
Zoranovic T, Grmai L, Bach EA
  Title
Regulation of proliferation, cell competition, and cellular growth by the Drosophila JAK-STAT pathway.
  Journal
JAKSTAT 2:e25408 (2013)
DOI:10.4161/jkst.25408
Reference
PMID:16204702
  Authors
Ungureanu D, Silvennoinen O
  Title
SLIM trims STATs: ubiquitin E3 ligases provide insights for specificity in the regulation of cytokine signaling.
  Journal
Sci STKE 2005:pe49 (2005)
DOI:10.1126/stke.3042005pe49
Reference
PMID:23735217
  Authors
Richard AJ, Stephens JM
  Title
The role of JAK-STAT signaling in adipose tissue function.
  Journal
Biochim Biophys Acta 1842:431-9 (2014)
DOI:10.1016/j.bbadis.2013.05.030
Reference
PMID:24606160
  Authors
Sun Y, Lehmbecker A, Kalkuhl A, Deschl U, Sun W, Rohn K, Tzvetanova ID, Nave KA, Baumgartner W, Ulrich R
  Title
STAT3 represents a molecular switch possibly inducing astroglial instead of oligodendroglial differentiation of oligodendroglial progenitor cells in Theiler's murine encephalomyelitis.
  Journal
Neuropathol Appl Neurobiol 41:347-70 (2015)
DOI:10.1111/nan.12133
Reference
PMID:10851053
  Authors
Hirano T, Ishihara K, Hibi M
  Title
Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors.
  Journal
Oncogene 19:2548-56 (2000)
DOI:10.1038/sj.onc.1203551
Reference
PMID:11114747
  Authors
Rane SG, Reddy EP
  Title
Janus kinases: components of multiple signaling pathways.
  Journal
Oncogene 19:5662-79 (2000)
DOI:10.1038/sj.onc.1203925
Reference
PMID:8682149
  Authors
Heim MH
  Title
The Jak-STAT pathway: specific signal transduction from the cell membrane to the nucleus.
  Journal
Eur J Clin Invest 26:1-12 (1996)
DOI:10.1046/j.1365-2362.1996.103248.x
Reference
PMID:30267440
  Authors
Morris R, Kershaw NJ, Babon JJ
  Title
The molecular details of cytokine signaling via the JAK/STAT pathway.
  Journal
Protein Sci 27:1984-2009 (2018)
DOI:10.1002/pro.3519
Reference
PMID:34492272
  Authors
Tzeng HT, Chyuan IT, Lai JH
  Title
Targeting the JAK-STAT pathway in autoimmune diseases and cancers: A focus on molecular mechanisms and therapeutic potential.
  Journal
Biochem Pharmacol 193:114760 (2021)
DOI:10.1016/j.bcp.2021.114760
Reference
PMID:32203403
  Authors
Salas A, Hernandez-Rocha C, Duijvestein M, Faubion W, McGovern D, Vermeire S, Vetrano S, Vande Casteele N
  Title
JAK-STAT pathway targeting for the treatment of inflammatory bowel disease.
  Journal
Nat Rev Gastroenterol Hepatol 17:323-337 (2020)
DOI:10.1038/s41575-020-0273-0
Related
pathway
shon04010  MAPK signaling pathway
shon04060  Cytokine-cytokine receptor interaction
shon04110  Cell cycle
shon04120  Ubiquitin mediated proteolysis
shon04151  PI3K-Akt signaling pathway
shon04210  Apoptosis
KO pathway
ko04630   
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