KEGG   PATHWAY: sund04148
Entry
sund04148                   Pathway                                
Name
Efferocytosis - Sceloporus undulatus (fence lizard)
Class
Cellular Processes; Transport and catabolism
Pathway map
sund04148  Efferocytosis
sund04148

Organism
Sceloporus undulatus (fence lizard) [GN:sund]
Gene
121930895  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
121934729  caspase-3-like [KO:K04397] [EC:3.4.22.60]
121925218  CASP7; caspase-7 isoform X1 [KO:K04397] [EC:3.4.22.60]
121916819  caspase-1-like [KO:K01370] [EC:3.4.22.36]
121926656  PANX1; LOW QUALITY PROTEIN: pannexin-1 [KO:K03443]
121925777  P2RY2; P2Y purinoceptor 2 [KO:K04269]
121925766  P2RY6; P2Y purinoceptor 6 [KO:K04272]
121926817  P2RY12; P2Y purinoceptor 12 [KO:K04298]
121933175  SPHK2; sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
121921036  SPHK1; sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
121929330  S1PR1; sphingosine 1-phosphate receptor 1 [KO:K04288]
121923340  ABCA1; phospholipid-transporting ATPase ABCA1 [KO:K05641]
121937012  phospholipid-transporting ATPase ABCA1-like [KO:K05641]
121918428  GPR132; probable G-protein coupled receptor 132 [KO:K08426]
121927898  ADAM17; disintegrin and metalloproteinase domain-containing protein 17 isoform X1 [KO:K06059] [EC:3.4.24.86]
121932590  ADAM10; disintegrin and metalloproteinase domain-containing protein 10 isoform X1 [KO:K06704] [EC:3.4.24.81]
121936559  disintegrin and metalloproteinase domain-containing protein 10-like [KO:K06704] [EC:3.4.24.81]
121914592  CX3CL1; fractalkine isoform X1 [KO:K05508]
121934765  CX3CR1; CX3C chemokine receptor 1 isoform X1 [KO:K04192]
121929948  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332]
121927622  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
121937577  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
121935625  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
121927190  HIF1A; LOW QUALITY PROTEIN: hypoxia-inducible factor 1-alpha [KO:K08268]
121916247  ARNT; aryl hydrocarbon receptor nuclear translocator isoform X1 [KO:K09097]
121933283  erythropoietin-like isoform X1 [KO:K05437]
121933948  uncharacterized protein LOC121933948 [KO:K05437]
121923418  EPOR; erythropoietin receptor [KO:K05079]
121921762  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
121932739  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
121916521  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
121927914  CEBPB; CCAAT/enhancer-binding protein beta [KO:K10048]
121923490  PPARG; peroxisome proliferator-activated receptor gamma [KO:K08530]
121936176  RXRA; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
121935118  MFGE8; lactadherin isoform X1 [KO:K17253]
121925323  GAS6; growth arrest-specific protein 6 [KO:K05464]
121922512  MERTK; tyrosine-protein kinase Mer isoform X1 [KO:K05117] [EC:2.7.10.1]
121930698  CD36; platelet glycoprotein 4 [KO:K06259]
121929146  THBS1; thrombospondin-1 isoform X1 [KO:K16857]
121934449  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
121921221  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
121936502  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
121930072  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
121927244  PTGER2; prostaglandin E2 receptor EP2 subtype [KO:K04259]
121924160  PTGER4; prostaglandin E2 receptor EP4 subtype [KO:K04261]
121920028  DNMT3A; DNA (cytosine-5)-methyltransferase 3A isoform X1 [KO:K17398] [EC:2.1.1.37]
121933278  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
121917546  transforming growth factor beta-1 proprotein-like [KO:K13375]
121917598  transforming growth factor beta-1 proprotein-like [KO:K13375]
121916721  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
121917146  sarcoplasmic/endoplasmic reticulum calcium ATPase 3 [KO:K05853] [EC:7.2.2.10]
121934249  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
121935466  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
121925870  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma [KO:K04515] [EC:2.7.11.17]
121921364  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
121931840  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
121928200  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
121929971  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
121930696  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
121930697  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
121928398  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
121927518  ALOX5; polyunsaturated fatty acid 5-lipoxygenase [KO:K00461] [EC:1.13.11.34]
121922931  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
121919616  DUSP8; dual specificity protein phosphatase 8 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
121924880  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
121920567  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
121931008  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
121932412  DUSP2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
121931000  ANO6; anoctamin-6 isoform X1 [KO:K19500]
121919639  ANO3; anoctamin-3 isoform X1 [KO:K19498]
121931518  ANO4; anoctamin-4 isoform X1 [KO:K19499]
121915777  ANO5; anoctamin-5 isoform X1 [KO:K19480]
121936575  anoctamin-7-like isoform X1 [KO:K19501]
121926591  ANO7; anoctamin-7 [KO:K19501]
121929735  ANO9; anoctamin-9 isoform X1 [KO:K19503]
121936555  BSG; basigin [KO:K06535]
121915497  XKR8; XK-related protein 8 [KO:K26813]
121929605  XKR9; XK-related protein 9 isoform X1 [KO:K26814]
121928836  XKR7; XK-related protein 7 [KO:K26811]
121930102  XKR4; XK-related protein 4 [KO:K26811]
121929920  XKR6; XK-related protein 6 [KO:K26811]
121925210  ATP8A2; phospholipid-transporting ATPase IB [KO:K14802] [EC:7.6.2.1]
121930741  ATP8A1; phospholipid-transporting ATPase IA isoform X1 [KO:K14802] [EC:7.6.2.1]
121937226  ATP11C; phospholipid-transporting ATPase IG isoform X1 [KO:K26934] [EC:7.6.2.1]
121924795  ATP11B; phospholipid-transporting ATPase IF isoform X1 [KO:K26934] [EC:7.6.2.1]
121925840  ATP11A; phospholipid-transporting ATPase IH [KO:K26934] [EC:7.6.2.1]
121932923  TMEM30A; cell cycle control protein 50A [KO:K26935]
121914546  TMEM30B; cell cycle control protein 50B [KO:K26935]
121917185  vitamin K-dependent protein S-like [KO:K03908]
121917232  vitamin K-dependent protein S-like [KO:K03908]
121929473  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
121934741  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
121923162  ITGB5; integrin beta-5 isoform X1 [KO:K06588]
121917549  LOW QUALITY PROTEIN: tyrosine-protein kinase receptor UFO-like [KO:K05115] [EC:2.7.10.1]
121917602  LOW QUALITY PROTEIN: tyrosine-protein kinase receptor UFO-like [KO:K05115] [EC:2.7.10.1]
121919234  TYRO3; tyrosine-protein kinase receptor TYRO3 [KO:K05116] [EC:2.7.10.1]
121929579  adhesion G protein-coupled receptor B1-like isoform X1 [KO:K04596]
121920369  uncharacterized protein LOC121920369 [KO:K26936]
121923498  STAB1; stabilin-1 isoform X1 [KO:K19020]
121930585  STAB2; stabilin-2 isoform X1 [KO:K19013]
121928719  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
121937506  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
121932763  crk-like protein [KO:K04438]
121917039  CRK; adapter molecule crk [KO:K04438]
121917981  CRKL; crk-like protein [KO:K04438]
121934710  ELMO1; engulfment and cell motility protein 1 isoform X1 [KO:K12366]
121927273  DOCK1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
121914295  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
121934819  ADAM9; disintegrin and metalloproteinase domain-containing protein 9 [KO:K06834] [EC:3.4.24.-]
121925915  disintegrin and metalloproteinase domain-containing protein 9-like [KO:K06834] [EC:3.4.24.-]
121922354  CALR; calreticulin [KO:K08057]
121927533  calreticulin-like isoform X1 [KO:K08057]
121917716  calreticulin-like [KO:K08057]
121936717  C1QA; complement C1q subcomponent subunit A [KO:K03986]
121936686  C1QB; complement C1q subcomponent subunit B [KO:K03987]
121936660  C1QC; complement C1q subcomponent subunit C [KO:K03988]
121920471  LRP1; prolow-density lipoprotein receptor-related protein 1 [KO:K04550]
121934442  MEGF11; multiple epidermal growth factor-like domains protein 11 isoform X1 [KO:K24068]
121924112  MEGF10; multiple epidermal growth factor-like domains protein 10 isoform X1 [KO:K24068]
121917100  SCARF1; scavenger receptor class F member 1 isoform X1 [KO:K24318]
121934149  GULP1; PTB domain-containing engulfment adapter protein 1 isoform X1 [KO:K23285]
121919525  RAB17; ras-related protein Rab-17 isoform X1 [KO:K07909]
121934513  RAB5A; ras-related protein Rab-5A [KO:K07887]
121921421  RAB5B; ras-related protein Rab-5B [KO:K07888]
121934553  RAB5C; ras-related protein Rab-5C [KO:K07889]
121925267  TGFBRAP1; transforming growth factor-beta receptor-associated protein 1 isoform X1 [KO:K20177]
121925574  VPS8; vacuolar protein sorting-associated protein 8 homolog isoform X1 [KO:K20178]
121934186  VPS11; vacuolar protein sorting-associated protein 11 homolog [KO:K20179]
121931961  VPS16; vacuolar protein sorting-associated protein 16 homolog [KO:K20180]
121919017  VPS18; LOW QUALITY PROTEIN: vacuolar protein sorting-associated protein 18 homolog [KO:K20181]
121916636  VPS33A; vacuolar protein sorting-associated protein 33A [KO:K20182]
121937032  RAB14; ras-related protein Rab-14 [KO:K07881]
121936688  VPS39; vam6/Vps39-like protein isoform X1 [KO:K20183]
121934179  VPS41; vacuolar protein sorting-associated protein 41 homolog [KO:K20184]
121922071  RAB7A; ras-related protein Rab-7a [KO:K07897]
121924308  ras-related protein Rab-7a-like isoform X1 [KO:K07897]
121929461  RAB7B; ras-related protein Rab-7b isoform X1 [KO:K07898]
121927128  lysosomal amino acid transporter 1 homolog [KO:K23678]
121936142  SLC66A1; lysosomal amino acid transporter 1 homolog [KO:K23678]
121915035  ARG2; arginase-2, mitochondrial [KO:K01476] [EC:3.5.3.1]
121915769  ODC1; ornithine decarboxylase [KO:K01581] [EC:4.1.1.17]
121926373  CH25H; cholesterol 25-hydroxylase [KO:K10223] [EC:1.14.99.38]
121922620  NR1H3; oxysterols receptor LXR-alpha isoform X1 [KO:K08536]
121935344  NR1H2; oxysterols receptor LXR-beta isoform X1 [KO:K08535]
121924351  CPT1A; carnitine O-palmitoyltransferase 1, liver isoform isoform X1 [KO:K08765] [EC:2.3.1.21]
121935133  CPT1C; LOW QUALITY PROTEIN: carnitine O-palmitoyltransferase 1, brain isoform [KO:K08765] [EC:2.3.1.21]
121932122  CPT1B; carnitine O-palmitoyltransferase 1, muscle isoform [KO:K19523] [EC:2.3.1.21]
121914703  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
121926399  SIRT1; NAD-dependent protein deacetylase sirtuin-1 isoform X1 [KO:K11411] [EC:2.3.1.286]
121928436  PBX1; pre-B-cell leukemia transcription factor 1 isoform X1 [KO:K09355]
121927618  IL10; interleukin-10 [KO:K05443]
121924681  lysosomal acid lipase/cholesteryl ester hydrolase-like [KO:K01052] [EC:3.1.1.13]
121925331  putative lysosomal acid lipase/cholesteryl ester hydrolase isoform X1 [KO:K01052] [EC:3.1.1.13]
121925784  gastric triacylglycerol lipase-like [KO:K01052] [EC:3.1.1.13]
121925896  lysosomal acid lipase/cholesteryl ester hydrolase-like [KO:K01052] [EC:3.1.1.13]
121926839  lysosomal acid lipase/cholesteryl ester hydrolase-like isoform X1 [KO:K01052] [EC:3.1.1.13]
121927011  lipase member M-like [KO:K01052] [EC:3.1.1.13]
121914148  PLA2G15; phospholipase A2 group XV [KO:K06129] [EC:3.1.1.5]
121936249  SLC2A1; solute carrier family 2, facilitated glucose transporter member 1 isoform X1 [KO:K07299]
121927837  SLC16A1; monocarboxylate transporter 1 isoform X1 [KO:K08179]
121928903  serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
121917205  leukocyte surface antigen CD47-like isoform X1 [KO:K06266]
121917250  leukocyte surface antigen CD47-like isoform X1 [KO:K06266]
121922806  PECAM1; platelet endothelial cell adhesion molecule isoform X1 [KO:K06471]
121929286  tyrosine-protein phosphatase non-receptor type substrate 1-like isoform X1 [KO:K06551]
121922064  tyrosine-protein phosphatase non-receptor type 6-like isoform X1 [KO:K05697] [EC:3.1.3.48]
121916573  PTPN11; tyrosine-protein phosphatase non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
121937372  tyrosine-protein phosphatase non-receptor type 11-like isoform X1 [KO:K07293] [EC:3.1.3.48]
Compound
C00002  ATP
C00003  NAD+
C00019  S-Adenosyl-L-methionine
C00031  D-Glucose
C00062  L-Arginine
C00073  L-Methionine
C00075  UTP
C00077  L-Ornithine
C00134  Putrescine
C00162  Fatty acid
C00186  (S)-Lactate
C00187  Cholesterol
C00584  Prostaglandin E2
C02530  Cholesterol ester
C02737  Phosphatidylserine
C04230  1-Acyl-sn-glycero-3-phosphocholine
C06124  Sphingosine 1-phosphate
C06314  Lipoxin A4
C15519  25-Hydroxycholesterol
C15610  Cholest-5-ene-3beta,26-diol
C18178  Resolvin D1
Reference
PMID:31822793
  Authors
Doran AC, Yurdagul A Jr, Tabas I
  Title
Efferocytosis in health and disease.
  Journal
Nat Rev Immunol 20:254-267 (2020)
DOI:10.1038/s41577-019-0240-6
Reference
PMID:36028471
  Authors
Zhang J, Ding W, Zhao M, Liu J, Xu Y, Wan J, Wang M
  Title
Mechanisms of efferocytosis in determining inflammation resolution: Therapeutic potential and the association with cardiovascular disease.
  Journal
Br J Pharmacol 179:5151-5171 (2022)
DOI:10.1111/bph.15939
Reference
PMID:30165442
  Authors
Kawano M, Nagata S
  Title
Efferocytosis and autoimmune disease.
  Journal
Int Immunol 30:551-558 (2018)
DOI:10.1093/intimm/dxy055
Reference
PMID:35650427
  Authors
Mehrotra P, Ravichandran KS
  Title
Drugging the efferocytosis process: concepts and opportunities.
  Journal
Nat Rev Drug Discov 21:601-620 (2022)
DOI:10.1038/s41573-022-00470-y
Reference
PMID:28496201
  Authors
Park SY, Kim IS
  Title
Engulfment signals and the phagocytic machinery for apoptotic cell clearance.
  Journal
Exp Mol Med 49:e331 (2017)
DOI:10.1038/emm.2017.52
Reference
PMID:28137963
  Authors
Kojima Y, Weissman IL, Leeper NJ
  Title
The Role of Efferocytosis in Atherosclerosis.
  Journal
Circulation 135:476-489 (2017)
DOI:10.1161/CIRCULATIONAHA.116.025684
Related
pathway
sund00010  Glycolysis / Gluconeogenesis
sund04140  Autophagy - animal
sund04145  Phagosome
KO pathway
ko04148   
LinkDB

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