KEGG   PATHWAY: pbi05168
Entry
pbi05168                    Pathway                                
Name
Herpes simplex virus 1 infection - Python bivittatus (Burmese python)
Description
Herpes simplex virus 1(HSV-1) is a common human pathogen, which initially infects orofacial mucosal surfaces. The virus replicates in epithelial cells at these sites, causing clinically overt disease characterized by vesicular lesions. HSV-1 then penetrates to the nervous system and establishes latency in sensory neurons. Throughout the lifetime of the host, HSV-1 may reactivate from its latent state and reinitiate a lytic infection cycle. HSV-1 has developed various mechanisms to escape its host innate immune responses and increased its capacity to replicate and to persist. ICP34.5, ICP0, ICP27, Us11 and Vhs (UL41) are the proteins involved in viral interference.
Class
Human Diseases; Infectious disease: viral
Pathway map
pbi05168  Herpes simplex virus 1 infection
pbi05168

Disease
H00365  Herpes simplex virus infection
Organism
Python bivittatus (Burmese python) [GN:pbi]
Gene
103047962  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
103048059  C3; complement C3 [KO:K03990]
103048571  TSC2; tuberin isoform X1 [KO:K07207]
103048672  POU2F3; POU domain, class 2, transcription factor 3 [KO:K09364]
103048752  [KO:K07293] [EC:3.1.3.48]
103048782  POU2F1; POU domain, class 2, transcription factor 1 [KO:K09364]
103049109  [KO:K10159]
103049152  IFNGR2; LOW QUALITY PROTEIN: interferon gamma receptor 2 [KO:K05133]
103049228  [KO:K03158]
103049316  [KO:K06752]
103049386  [KO:K06752]
103049546  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
103049657  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
103049711  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
103049737  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
103049787  [KO:K06751]
103049819  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
103049822  [KO:K08057]
103049946  NECTIN2; nectin-2 [KO:K06531]
103050015  [KO:K03173] [EC:2.3.2.27]
103050043  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
103050089  TICAM1; TIR domain-containing adapter molecule 1 isoform X1 [KO:K05842]
103050181  [KO:K04390]
103050248  TLR3; toll-like receptor 3 isoform X1 [KO:K05401]
103050321  EIF2B5; translation initiation factor eIF-2B subunit epsilon [KO:K03240]
103050779  [KO:K06752]
103050794  IRF7; interferon regulatory factor 7 isoform X2 [KO:K09447]
103050942  RELA; transcription factor p65 [KO:K04735]
103050994  IFIH1; interferon-induced helicase C domain-containing protein 1 [KO:K12647] [EC:5.6.2.6]
103051040  CD74; HLA class II histocompatibility antigen gamma chain [KO:K06505]
103051153  [KO:K06752]
103051160  CFP; properdin [KO:K15412]
103051375  [KO:K28004]
103051580  RHEB; GTP-binding protein Rheb [KO:K07208]
103051809  [KO:K04389]
103052063  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
103052243  [KO:K06751]
103052349  [KO:K06752]
103052423  SRSF3; serine/arginine-rich splicing factor 3 [KO:K12892]
103052466  SRSF2; serine/arginine-rich splicing factor 2 [KO:K12891]
103052506  TSC1; hamartin [KO:K07206]
103052688  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
103052729  [KO:K03156]
103052845  BIRC2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
103052854  POU2F2; POU domain, class 2, transcription factor 2 [KO:K09364]
103052907  SRPK1; SRSF protein kinase 1 [KO:K15409] [EC:2.7.11.1]
103053194  [KO:K14216] [EC:2.7.7.84]
103053196  [KO:K06751]
103053332  MTOR; serine/threonine-protein kinase mTOR isoform X3 [KO:K07203] [EC:2.7.11.1]
103053361  IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
103053500  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
103053675  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
103053678  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 isoform X3 [KO:K08860] [EC:2.7.11.1]
103053728  [KO:K06752]
103053733  [KO:K06751]
103053989  [KO:K06752]
103054174  FADD; FAS-associated death domain protein [KO:K02373]
103054229  [KO:K06751]
103054237  EIF2B1; translation initiation factor eIF-2B subunit alpha isoform X1 [KO:K03239]
103054471  [KO:K06751]
103054541  [KO:K06751]
103054542  [KO:K08738]
103054570  SRSF1; serine/arginine-rich splicing factor 1 isoform X2 [KO:K12890]
103054695  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
103054749  IRF9; interferon regulatory factor 9 [KO:K04693]
103054799  [KO:K12893]
103054877  [KO:K06752]
103054952  [KO:K04404]
103055254  IL1B; interleukin-1 beta [KO:K04519]
103055280  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
103055493  [KO:K06752]
103055536  PTPN11; tyrosine-protein phosphatase non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
103055559  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
103055936  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
103056218  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
103056839  TAP2; antigen peptide transporter 2 isoform X1 [KO:K05654] [EC:7.4.2.14]
103056914  IFNGR1; interferon gamma receptor 1 [KO:K05132]
103057098  TNFRSF14; tumor necrosis factor receptor superfamily member 14 [KO:K05152]
103057161  [KO:K06751]
103057222  [KO:K04696]
103057226  CARD9; caspase recruitment domain-containing protein 9 isoform X1 [KO:K12794]
103057375  MAVS; mitochondrial antiviral-signaling protein isoform X1 [KO:K12648]
103057409  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
103057709  APAF1; apoptotic protease-activating factor 1 [KO:K02084]
103057757  CALR; calreticulin [KO:K08057]
103057929  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
103058396  [KO:K02159]
103058510  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
103058514  [KO:K06752]
103058524  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
103058885  [KO:K06751]
103059043  TAPBP; tapasin [KO:K08058]
103059077  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
103059200  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
103059257  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
103059405  IRF3; interferon regulatory factor 3 [KO:K05411]
103059522  HCFC2; host cell factor 2 [KO:K27390]
103059798  [KO:K06751]
103059813  NECTIN1; nectin-1 [KO:K06081]
103059890  [KO:K06752]
103059920  [KO:K08738]
103060112  STAT1; signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220]
103060352  ITGB3; integrin beta-3 [KO:K06493]
103060542  RNASEL; 2-5A-dependent ribonuclease [KO:K01165]
103060761  [KO:K06751]
103060861  SRSF6; serine/arginine-rich splicing factor 6 [KO:K12893]
103061011  [KO:K06752]
103061365  TP53; cellular tumor antigen p53 [KO:K04451]
103061370  EIF2AK4; eIF-2-alpha kinase GCN2 isoform X1 [KO:K16196] [EC:2.7.11.1]
103061514  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X2 [KO:K03171]
103061550  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
103061584  B2M; beta-2-microglobulin [KO:K08055]
103061849  BCL2L1; bcl-2-like protein 1 [KO:K04570]
103061866  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
103061898  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
103062116  C5; complement C5 [KO:K03994]
103062211  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
103062218  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
103062221  DDX58; probable ATP-dependent RNA helicase DDX58 [KO:K12646] [EC:5.6.2.6]
103062319  ITGA5; integrin alpha-5 [KO:K06484]
103062345  TYK2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
103062819  [KO:K04693]
103062910  EIF2B4; translation initiation factor eIF-2B subunit delta [KO:K03680]
103062968  [KO:K12893]
103063133  PDIA3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
103063177  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
103063236  TAP1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
103063403  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
103063466  IFNAR2; interferon alpha/beta receptor 2 [KO:K05131]
103063682  [KO:K00922] [EC:2.7.1.153]
103063914  SRSF9; serine/arginine-rich splicing factor 9 [KO:K21123]
103063999  NXF1; nuclear RNA export factor 1 isoform X1 [KO:K14284]
103064119  SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
103064440  ALYREF; THO complex subunit 4 [KO:K12881]
103064741  [KO:K06751]
103064751  [KO:K06752]
103064805  EIF2B3; translation initiation factor eIF-2B subunit gamma [KO:K03241]
103064827  TLR2; toll-like receptor 2 isoform X2 [KO:K10159]
103064852  SRSF7; serine/arginine-rich splicing factor 7 [KO:K12896]
103064879  TRAF5; TNF receptor-associated factor 5 [KO:K09849]
103064902  [KO:K06751]
103064959  BID; BH3-interacting domain death agonist [KO:K04726]
103064969  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
103065132  [KO:K02649]
103065155  EIF2AK1; eukaryotic translation initiation factor 2-alpha kinase 1 isoform X1 [KO:K16194] [EC:2.7.11.1]
103065697  [KO:K06751]
103065721  SRSF4; serine/arginine-rich splicing factor 4 [KO:K12893]
103065781  [KO:K06751]
103065958  STAT2; signal transducer and activator of transcription 2 isoform X2 [KO:K11221]
103065975  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
103066611  BAD; bcl2-associated agonist of cell death [KO:K02158]
103066656  [KO:K06752]
103066805  [KO:K06751]
103066818  [KO:K06751]
103066844  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
103066896  [KO:K06751]
103066991  TRAF2; TNF receptor-associated factor 2 isoform X2 [KO:K03173] [EC:2.3.2.27]
103067015  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
103067504  HCFC1; host cell factor 1 isoform X1 [KO:K14966]
103067562  IL6; interleukin-6 [KO:K05405]
103067633  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
103067636  [KO:K02159]
103067672  [KO:K06751]
103067765  EIF2B2; translation initiation factor eIF-2B subunit beta isoform X1 [KO:K03754]
103068084  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
107326358  CALR3; calreticulin-3 [KO:K08057]
112540104  [KO:K04687]
112540157  TNFSF14; tumor necrosis factor ligand superfamily member 14 [KO:K05477]
112540630  [KO:K05425]
112542108  [KO:K04451]
112542313  [KO:K05425]
112542419  [KO:K06751]
112542503  [KO:K06751]
Compound
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20640  Cyclic GMP-AMP
C20935  2-5A
Reference
PMID:12787566
  Authors
Granger SW, Rickert S
  Title
LIGHT-HVEM signaling and the regulation of T cell-mediated immunity.
  Journal
Cytokine Growth Factor Rev 14:289-96 (2003)
DOI:10.1016/S1359-6101(03)00031-5
Reference
PMID:19495760
  Authors
Steinberg MW, Shui JW, Ware CF, Kronenberg M
  Title
Regulating the mucosal immune system: the contrasting roles of LIGHT, HVEM, and their various partners.
  Journal
Semin Immunopathol 31:207-21 (2009)
DOI:10.1007/s00281-009-0157-4
Reference
PMID:20221426
  Authors
MacLeod IJ, Minson T
  Title
Binding of herpes simplex virus type-1 virions leads to the induction of intracellular signalling in the absence of virus entry.
  Journal
PLoS One 5:e9560 (2010)
DOI:10.1371/journal.pone.0009560
Reference
PMID:23150579
  Authors
Gianni T, Leoni V, Chesnokova LS, Hutt-Fletcher LM, Campadelli-Fiume G
  Title
alphavbeta3-integrin is a major sensor and activator of innate immunity to herpes simplex virus-1.
  Journal
Proc Natl Acad Sci U S A 109:19792-7 (2012)
DOI:10.1073/pnas.1212597109
Reference
PMID:25375272
  Authors
Gianni T, Campadelli-Fiume G
  Title
The epithelial alphavbeta3-integrin boosts the MYD88-dependent TLR2 signaling in response to viral and bacterial components.
  Journal
PLoS Pathog 10:e1004477 (2014)
DOI:10.1371/journal.ppat.1004477
Reference
PMID:15056211
  Authors
Spear PG
  Title
Herpes simplex virus: receptors and ligands for cell entry.
  Journal
Cell Microbiol 6:401-10 (2004)
DOI:10.1111/j.1462-5822.2004.00389.x
Reference
PMID:12855695
  Authors
Boutell C, Everett RD
  Title
The herpes simplex virus type 1 (HSV-1) regulatory protein ICP0 interacts with and Ubiquitinates p53.
  Journal
J Biol Chem 278:36596-602 (2003)
DOI:10.1074/jbc.M300776200
Reference
PMID:24262390
  Authors
Ma Y, He B
  Title
Recognition of herpes simplex viruses: toll-like receptors and beyond.
  Journal
J Mol Biol 426:1133-47 (2014)
DOI:10.1016/j.jmb.2013.11.012
Reference
PMID:26952111
  Authors
Su C, Zhan G, Zheng C
  Title
Evasion of host antiviral innate immunity by HSV-1, an update.
  Journal
Virol J 13:38 (2016)
DOI:10.1186/s12985-016-0495-5
Reference
PMID:21994567
  Authors
Melchjorsen J, Matikainen S, Paludan SR
  Title
Activation and evasion of innate antiviral immunity by herpes simplex virus.
  Journal
Viruses 1:737-59 (2009)
DOI:10.3390/v1030737
Reference
PMID:15276609
  Authors
Morrison LA
  Title
The Toll of herpes simplex virus infection.
  Journal
Trends Microbiol 12:353-6 (2004)
DOI:10.1016/j.tim.2004.06.001
Reference
PMID:29298887
  Authors
Zheng C
  Title
Evasion of Cytosolic DNA-Stimulated Innate Immune Responses by Herpes Simplex Virus 1.
  Journal
J Virol 92:e00099-17 (2018)
DOI:10.1128/JVI.00099-17
Reference
PMID:19344302
  Authors
Grandi P, Peruzzi P, Reinhart B, Cohen JB, Chiocca EA, Glorioso JC
  Title
Design and application of oncolytic HSV vectors for glioblastoma therapy.
  Journal
Expert Rev Neurother 9:505-17 (2009)
DOI:10.1586/ern.09.9
Reference
PMID:23115300
  Authors
Lussignol M, Queval C, Bernet-Camard MF, Cotte-Laffitte J, Beau I, Codogno P, Esclatine A
  Title
The herpes simplex virus 1 Us11 protein inhibits autophagy through its interaction with the protein kinase PKR.
  Journal
J Virol 87:859-71 (2013)
DOI:10.1128/JVI.01158-12
Reference
PMID:17229694
  Authors
Sanchez R, Mohr I
  Title
Inhibition of cellular 2'-5' oligoadenylate synthetase by the herpes simplex virus type 1 Us11 protein.
  Journal
J Virol 81:3455-64 (2007)
DOI:10.1128/JVI.02520-06
Reference
PMID:12826401
  Authors
Wysocka J, Herr W
  Title
The herpes simplex virus VP16-induced complex: the makings of a regulatory switch.
  Journal
Trends Biochem Sci 28:294-304 (2003)
DOI:10.1016/S0968-0004(03)00088-4
Reference
PMID:27367734
  Authors
Fleming SB
  Title
Viral Inhibition of the IFN-Induced JAK/STAT Signalling Pathway: Development of Live Attenuated Vaccines by Mutation of Viral-Encoded IFN-Antagonists.
  Journal
Vaccines (Basel) 4:E23 (2016)
DOI:10.3390/vaccines4030023
Reference
PMID:15163721
  Authors
Yokota S, Yokosawa N, Okabayashi T, Suzutani T, Miura S, Jimbow K, Fujii N
  Title
Induction of suppressor of cytokine signaling-3 by herpes simplex virus type 1 contributes to inhibition of the interferon signaling pathway.
  Journal
J Virol 78:6282-6 (2004)
DOI:10.1128/JVI.78.12.6282-6286.2004
Reference
PMID:23864622
  Authors
Gu H, Zheng Y, Roizman B
  Title
Interaction of herpes simplex virus ICP0 with ND10 bodies: a sequential process of adhesion, fusion, and retention.
  Journal
J Virol 87:10244-54 (2013)
DOI:10.1128/JVI.01487-13
Reference
PMID:21994592
  Authors
Tavalai N, Stamminger T
  Title
Interplay between Herpesvirus Infection and Host Defense by PML Nuclear Bodies.
  Journal
Viruses 1:1240-64 (2009)
DOI:10.3390/v1031240
Reference
PMID:21146386
  Authors
Horst D, Verweij MC, Davison AJ, Ressing ME, Wiertz EJ
  Title
Viral evasion of T cell immunity: ancient mechanisms offering new applications.
  Journal
Curr Opin Immunol 23:96-103 (2011)
DOI:10.1016/j.coi.2010.11.005
Reference
PMID:12960333
  Authors
Neumann J, Eis-Hubinger AM, Koch N
  Title
Herpes simplex virus type 1 targets the MHC class II processing pathway for immune evasion.
  Journal
J Immunol 171:3075-83 (2003)
DOI:10.4049/jimmunol.171.6.3075
Reference
PMID:25798530
  Authors
Liu X, Cohen JI
  Title
The role of PI3K/Akt in human herpesvirus infection: From the bench to the bedside.
  Journal
Virology 479-480:568-77 (2015)
DOI:10.1016/j.virol.2015.02.040
Reference
PMID:28468873
  Authors
Vink EI, Smiley JR, Mohr I
  Title
Subversion of Host Responses to Energy Insufficiency by Us3 Supports Herpes Simplex Virus 1 Replication during Stress.
  Journal
J Virol 91:e00295-17 (2017)
DOI:10.1128/JVI.00295-17
Reference
PMID:18508584
  Authors
Sandri-Goldin RM
  Title
The many roles of the regulatory protein ICP27 during herpes simplex virus infection.
  Journal
Front Biosci 13:5241-56 (2008)
DOI:10.2741/3078
Reference
PMID:15078920
  Authors
Sandri-Goldin RM
  Title
Viral regulation of mRNA export.
  Journal
J Virol 78:4389-96 (2004)
DOI:10.1128/JVI.78.9.4389-4396.2004
Reference
PMID:27154074
  Authors
Yu X, He S
  Title
The interplay between human herpes simplex virus infection and the apoptosis and necroptosis cell death pathways.
  Journal
Virol J 13:77 (2016)
DOI:10.1186/s12985-016-0528-0
Related
pathway
pbi03040  Spliceosome
pbi03050  Proteasome
pbi04115  p53 signaling pathway
pbi04210  Apoptosis
pbi04620  Toll-like receptor signaling pathway
pbi04622  RIG-I-like receptor signaling pathway
KO pathway
ko05168   

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