KEGG   PATHWAY: pprl03040
Entry
pprl03040                   Pathway                                
Name
Spliceosome - Poeciliopsis prolifica (blackstripe livebearer)
Description
After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified.
Class
Genetic Information Processing; Transcription
Pathway map
pprl03040  Spliceosome
pprl03040

Other DBs
GO: 0005681
Organism
Poeciliopsis prolifica (blackstripe livebearer) [GN:pprl]
Gene
129351477  snrpf; small nuclear ribonucleoprotein F [KO:K11098]
129352070  puf60b; poly(U)-binding-splicing factor PUF60-B isoform X1 [KO:K12838]
129352226  [KO:K12845]
129352474  [KO:K12816]
129352860  lsm8; LSM8 homolog, U6 small nuclear RNA associated [KO:K12627]
129353522  [KO:K12813] [EC:5.6.2.6]
129353661  crnkl1; LOW QUALITY PROTEIN: crooked neck-like protein 1 [KO:K12869]
129353928  cdc5l; cell division cycle 5-like protein [KO:K12860]
129353998  hspa8; heat shock cognate 71 kDa protein [KO:K03283]
129354099  ppil1; peptidyl-prolyl cis-trans isomerase-like 1 [KO:K12733] [EC:5.2.1.8]
129354519  snrpe; small nuclear ribonucleoprotein E [KO:K11097]
129354628  [KO:K12622]
129354665  cherp; calcium homeostasis endoplasmic reticulum protein [KO:K12841]
129354938  snrnp70; U1 small nuclear ribonucleoprotein 70 kDa [KO:K11093]
129355116  [KO:K12870]
129356017  snrpb2; LOW QUALITY PROTEIN: U2 small nuclear ribonucleoprotein B'' [KO:K11094]
129356043  [KO:K13025] [EC:5.6.2.7]
129356050  [KO:K12896]
129356065  [KO:K14280]
129356066  [KO:K14280]
129356193  prpf4; LOW QUALITY PROTEIN: U4/U6 small nuclear ribonucleoprotein Prp4 [KO:K12662]
129356265  [KO:K12870]
129356279  [KO:K11086]
129356424  [KO:K13025] [EC:5.6.2.7]
129356429  [KO:K14280]
129357636  [KO:K12662]
129358343  srsf3b; serine/arginine-rich splicing factor 3b [KO:K12892]
129358459  srsf3a; serine/arginine-rich splicing factor 3a [KO:K12892]
129358736  taf15; TATA-binding protein-associated factor 2N [KO:K13098]
129359145  snrpd2; small nuclear ribonucleoprotein Sm D2 [KO:K11096]
129359234  srsf7a; serine and arginine rich splicing factor 7a isoform X1 [KO:K12896]
129359285  prpf8; pre-mRNA-processing-splicing factor 8 [KO:K12856]
129359462  [KO:K14276]
129359463  [KO:K14276]
129359464  [KO:K14276]
129359465  [KO:K14276]
129359473  [KO:K14276]
129359481  [KO:K14276]
129359482  [KO:K14276]
129359483  [KO:K14276]
129359779  sf3b5; splicing factor 3B subunit 5 [KO:K12832]
129359944  smndc1; survival of motor neuron-related-splicing factor 30 [KO:K12839]
129360649  [KO:K12882]
129360652  [KO:K12882]
129360706  [KO:K12885]
129360716  [KO:K12885]
129361153  hnrnpa3; heterogeneous nuclear ribonucleoprotein A3 [KO:K12741]
129361260  u2af1; splicing factor U2AF 35 kDa subunit [KO:K12836]
129361323  tra2b; transformer-2 protein homolog beta [KO:K12897]
129361326  prpf40a; pre-mRNA-processing factor 40 homolog A [KO:K12821]
129361708  acin1a; LOW QUALITY PROTEIN: apoptotic chromatin condensation inducer in the nucleus [KO:K12875]
129361858  prpf38b; pre-mRNA-splicing factor 38B [KO:K12850]
129361966  sf3a2; splicing factor 3A subunit 2 [KO:K12826]
129362184  thoc1; THO complex subunit 1 isoform X1 [KO:K12878]
129362405  thoc3; THO complex subunit 3 [KO:K12880]
129362719  rbm22; pre-mRNA-splicing factor RBM22 [KO:K12872]
129362911  slu7; pre-mRNA-splicing factor SLU7 [KO:K12819]
129362916  prpf19; pre-mRNA-processing factor 19 [KO:K10599] [EC:2.3.2.27]
129363235  xab2; pre-mRNA-splicing factor SYF1 [KO:K12867]
129363384  [KO:K12866]
129363387  ddx5; probable ATP-dependent RNA helicase DDX5 isoform X1 [KO:K12823] [EC:5.6.2.7]
129363625  bud31; protein BUD31 homolog [KO:K12873]
129363707  alyref; THO complex subunit 4 isoform X1 [KO:K12881]
129363752  prpf18; pre-mRNA-splicing factor 18 isoform X1 [KO:K12817]
129364000  dhx38; pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 [KO:K12815] [EC:5.6.2.6]
129364367  sf3b3; splicing factor 3B subunit 3 [KO:K12830]
129364478  [KO:K14277]
129364479  [KO:K14277]
129364480  [KO:K14277]
129364481  [KO:K14277]
129364482  [KO:K14277]
129364488  [KO:K14277]
129364489  [KO:K14277]
129364500  u2surp; U2 snRNP-associated SURP motif-containing protein isoform X1 [KO:K12842]
129365105  srsf5a; serine and arginine rich splicing factor 5a [KO:K12893]
129365330  syf2; pre-mRNA-splicing factor syf2 [KO:K12868]
129365357  [KO:K12897]
129365404  ppie; peptidyl-prolyl cis-trans isomerase E isoform X1 [KO:K09564] [EC:5.2.1.8]
129365481  aqr; RNA helicase aquarius [KO:K12874]
129365746  hnrnpk; heterogeneous nuclear ribonucleoprotein K [KO:K12886]
129366352  srsf9; serine/arginine-rich splicing factor 9 [KO:K21123]
129366498  snrpd3l; small nuclear ribonucleoprotein D3 polypeptide, like [KO:K11088]
129367006  [KO:K12820] [EC:5.6.2.6]
129367013  [KO:K12881]
129368034  [KO:K14278]
129368042  [KO:K14278]
129368045  [KO:K14278]
129368051  [KO:K14278]
129368052  [KO:K14280]
129368053  [KO:K14280]
129368054  [KO:K14280]
129368055  dhx8; LOW QUALITY PROTEIN: ATP-dependent RNA helicase DHX8 [KO:K12818] [EC:5.6.2.6]
129368057  [KO:K14280]
129368061  [KO:K14280]
129368067  [KO:K14280]
129368073  [KO:K14280]
129368083  [KO:K14280]
129368088  [KO:K14280]
129368091  [KO:K14280]
129368248  srsf2a; serine and arginine rich splicing factor 2a isoform X1 [KO:K12891]
129368360  [KO:K14279]
129368361  [KO:K14279]
129368405  zgc:163098; U2 snRNP-associated SURP motif-containing protein isoform X1 [KO:K12842]
129368493  thoc2; THO complex subunit 2 isoform X1 [KO:K12879]
129368651  cwc15; protein CWC15 homolog [KO:K12863]
129368686  srsf1b; serine/arginine-rich splicing factor 1B [KO:K12890]
129369073  hnrnpub; heterogeneous nuclear ribonucleoprotein Ub [KO:K12888]
129369103  sf3b6; splicing factor 3B subunit 6 [KO:K12833]
129369237  snw1; SNW domain-containing protein 1 [KO:K06063]
129369295  [KO:K14277]
129369297  [KO:K14277]
129369298  [KO:K14277]
129369299  [KO:K14277]
129369808  hspa8b; heat shock protein family A (Hsp70) member 8b [KO:K03283]
129369823  srsf1a; LOW QUALITY PROTEIN: serine/arginine-rich splicing factor 1A [KO:K12890]
129369876  snrpa; U1 small nuclear ribonucleoprotein A [KO:K11091]
129370028  [KO:K14277]
129370140  pqbp1; polyglutamine-binding protein 1 [KO:K12865]
129370273  ddx23; probable ATP-dependent RNA helicase DDX23 [KO:K12858] [EC:5.6.2.7]
129370415  prpf6; pre-mRNA-processing factor 6 [KO:K12855]
129370718  zmat2; zinc finger matrin-type protein 2 [KO:K12848]
129370760  [KO:K14279]
129370761  [KO:K14279]
129370762  [KO:K14279]
129370763  [KO:K14279]
129370764  [KO:K14279]
129370765  [KO:K14279]
129370766  [KO:K14279]
129370767  [KO:K14279]
129370798  rbm8a; RNA-binding protein 8A isoform X1 [KO:K12876]
129371089  smx5; smx5 [KO:K12621]
129371110  prpf31; U4/U6 small nuclear ribonucleoprotein Prp31 [KO:K12844]
129371142  ccdc12; coiled-coil domain-containing protein 12 [KO:K12871]
129371382  u2af2a; U2 small nuclear RNA auxiliary factor 2a isoform X1 [KO:K12837]
129371389  [KO:K03283]
129371549  prpf3; U4/U6 small nuclear ribonucleoprotein Prp3 isoform X1 [KO:K12843]
129371753  snrpg; small nuclear ribonucleoprotein G [KO:K11099]
129371802  bcas2; pre-mRNA-splicing factor SPF27 [KO:K12861]
129371836  ctnnbl1; beta-catenin-like protein 1 [KO:K12864]
129371879  [KO:K14279]
129371881  [KO:K14279]
129371882  [KO:K14279]
129371969  usp39; U4/U6.U5 tri-snRNP-associated protein 2 [KO:K12847]
129372251  hnrnpa1b; heterogeneous nuclear ribonucleoprotein A1b [KO:K12741]
129372274  hspa1b; heat shock 70 kDa protein-like [KO:K03283]
129372382  [KO:K12893]
129372405  ppih; peptidyl-prolyl cis-trans isomerase H isoform X1 [KO:K09567] [EC:5.2.1.8]
129372582  [KO:K14279]
129372611  snrpc; U1 small nuclear ribonucleoprotein C isoform X1 [KO:K11095]
129372794  [KO:K12622]
129372945  snrnp27; U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein [KO:K12846]
129373084  sf3a1; splicing factor 3A subunit 1 isoform X1 [KO:K12825]
129373121  snrnp200; U5 small nuclear ribonucleoprotein 200 kDa helicase [KO:K12854] [EC:5.6.2.6]
129373212  ncbp2; nuclear cap-binding protein subunit 2 [KO:K12883]
129373244  dhx15; pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 isoform X1 [KO:K12820] [EC:5.6.2.6]
129373419  [KO:K12811] [EC:5.6.2.7]
129373613  tcerg1b; transcription elongation regulator 1 isoform X1 [KO:K12824]
129373688  eftud2; 116 kDa U5 small nuclear ribonucleoprotein component [KO:K12852]
129373825  [KO:K03283]
129373828  [KO:K03283]
129373960  ddx42; ATP-dependent RNA helicase DDX42 [KO:K12835] [EC:5.6.2.7]
129373991  [KO:K12837]
129374343  hnrpkl; heterogeneous nuclear ribonucleoprotein K, like isoform X1 [KO:K12886]
129374360  [KO:K14277]
129374361  [KO:K14277]
129374644  lsm7; U6 snRNA-associated Sm-like protein LSm7 [KO:K12626]
129374937  sf3b4; splicing factor 3B subunit 4 [KO:K12831]
129375035  snrnp40; U5 small nuclear ribonucleoprotein 40 kDa protein [KO:K12857]
129375082  snrpd1; small nuclear ribonucleoprotein Sm D1 [KO:K11087]
129375226  rbm25b; RNA-binding protein 25b [KO:K12822]
129375245  srsf5b; serine and arginine rich splicing factor 5b [KO:K12893]
129375762  hnrnpm; heterogeneous nuclear ribonucleoprotein M [KO:K12887]
129375773  [KO:K12900]
129375801  srsf4; serine/arginine-rich splicing factor 4 [KO:K12893]
129376101  rbm17; splicing factor 45 [KO:K12840]
129376253  [KO:K14276]
129376258  txnl4a; thioredoxin-like protein 4A [KO:K12859]
129376411  sf3a3; splicing factor 3A subunit 3 [KO:K12827]
129376788  sart1; U4/U6.U5 tri-snRNP-associated protein 1 [KO:K11984]
129376962  plrg1; pleiotropic regulator 1 isoform X1 [KO:K12862]
129377195  lsm4; LOW QUALITY PROTEIN: U6 snRNA-associated Sm-like protein LSm4 [KO:K12623]
129377574  phf5a; PHD finger-like domain-containing protein 5A [KO:K12834]
129377903  [KO:K14276]
129377904  [KO:K14276]
129377905  [KO:K14276]
129377906  [KO:K14276]
129377907  [KO:K14276]
129377908  [KO:K14276]
129377909  [KO:K14276]
129377910  [KO:K14276]
129377911  [KO:K14276]
129377912  [KO:K14276]
129377913  [KO:K14276]
129377915  [KO:K14276]
129377916  [KO:K14276]
129377917  [KO:K14276]
129377918  [KO:K14276]
129377919  [KO:K14276]
129377920  [KO:K14276]
129377921  [KO:K14276]
129377922  [KO:K14276]
129377923  [KO:K14276]
129377924  [KO:K14276]
129377925  [KO:K14276]
129377963  [KO:K12884]
129378338  hnrnpc; heterogeneous nuclear ribonucleoproteins C1/C2 isoform X1 [KO:K12884]
129378656  [KO:K12836]
129378979  lsm5; U6 snRNA-associated Sm-like protein LSm5 [KO:K12624]
129379207  sf3b1; splicing factor 3B subunit 1 isoform X1 [KO:K12828]
129379321  snrpa1; U2 small nuclear ribonucleoprotein A' [KO:K11092]
129379329  prpf38a; pre-mRNA-splicing factor 38A isoform X1 [KO:K12849]
129379389  acin1b; apoptotic chromatin condensation inducer 1b [KO:K12875]
129379513  sf3b2; splicing factor 3B subunit 2 [KO:K12829]
129379700  magoh; protein mago nashi homolog [KO:K12877]
129379998  [KO:K12813] [EC:5.6.2.6]
Reference
PMID:19239890
  Authors
Wahl MC, Will CL, Luhrmann R
  Title
The spliceosome: design principles of a dynamic RNP machine.
  Journal
Cell 136:701-18 (2009)
DOI:10.1016/j.cell.2009.02.009
Reference
PMID:10978320
  Authors
Morris DP, Greenleaf AL
  Title
The splicing factor, Prp40, binds the phosphorylated carboxyl-terminal domain of RNA polymerase II.
  Journal
J Biol Chem 275:39935-43 (2000)
DOI:10.1074/jbc.M004118200
Reference
PMID:17537823
  Authors
Chen YI, Moore RE, Ge HY, Young MK, Lee TD, Stevens SW
  Title
Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors.
  Journal
Nucleic Acids Res 35:3928-44 (2007)
DOI:10.1093/nar/gkm347
Reference
PMID:19733268
  Authors
Ritchie DB, Schellenberg MJ, MacMillan AM
  Title
Spliceosome structure: piece by piece.
  Journal
Biochim Biophys Acta 1789:624-33 (2009)
DOI:10.1016/j.bbagrm.2009.08.010
KO pathway
ko03040   

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