KEGG   PATHWAY: scan04060
Entry
scan04060                   Pathway                                
Name
Cytokine-cytokine receptor interaction - Serinus canaria (common canary)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
scan04060  Cytokine-cytokine receptor interaction
scan04060

Organism
Serinus canaria (common canary) [GN:scan]
Gene
103812309  TNFSF13B; tumor necrosis factor ligand superfamily member 13B [KO:K05476]
103812320  [KO:K05066]
103812321  CRLF2; cytokine receptor-like factor 2 [KO:K05078]
103812363  [KO:K04386]
103812364  IL1RL1; interleukin-1 receptor-like 1 isoform X1 [KO:K05171]
103812366  IL18R1; interleukin-18 receptor 1 isoform X1 [KO:K05173]
103812385  EDAR; tumor necrosis factor receptor superfamily member EDAR isoform X1 [KO:K05162]
103812440  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X2 [KO:K03158]
103812453  CD4; T-cell surface glycoprotein CD4 [KO:K06454]
103812581  TNFSF11; tumor necrosis factor ligand superfamily member 11 [KO:K05473]
103812628  [KO:K05066]
103812645  IL1R2; interleukin-1 receptor type 2 isoform X2 [KO:K04387]
103812646  [KO:K05172]
103812647  IL18RAP; interleukin-18 receptor accessory protein [KO:K05174]
103812710  ACVR2B; activin receptor type-2B isoform X1 [KO:K13596] [EC:2.7.11.30]
103812972  ACKR4; LOW QUALITY PROTEIN: atypical chemokine receptor 4 [KO:K04186]
103812980  [KO:K04180]
103812982  XCR1; chemokine XC receptor 1 [KO:K04193]
103812985  [KO:K04179]
103812986  CX3CR1; CX3C chemokine receptor 1 [KO:K04192]
103812987  [KO:K04183]
103813132  IL6; interleukin-6 [KO:K05405]
103813156  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
103813169  [KO:K04183]
103813170  CCR9; C-C chemokine receptor type 9 [KO:K04184]
103813225  CSF2RB; cytokine receptor common subunit beta [KO:K04738]
103813230  IL2RB; interleukin-2 receptor subunit beta isoform X1 [KO:K05069]
103813616  [KO:K05151]
103813941  CXCL12; stromal cell-derived factor 1 isoform X1 [KO:K10031]
103813950  [KO:K22674]
103813951  GDF2; growth/differentiation factor 2 [KO:K05503]
103814044  BMPR1A; bone morphogenetic protein receptor type-1A [KO:K04673] [EC:2.7.11.30]
103814184  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
103814240  TNFRSF11B; tumor necrosis factor receptor superfamily member 11B [KO:K05148]
103814244  ACVR1; activin receptor type-1 isoform X1 [KO:K04675] [EC:2.7.11.30]
103814245  ACVR1C; activin receptor type-1C [KO:K13568] [EC:2.7.11.30]
103814260  ACVR2A; activin receptor type-2A isoform X2 [KO:K04670] [EC:2.7.11.30]
103814274  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
103814344  CXCR2; C-X-C chemokine receptor type 2 [KO:K05050]
103814380  INHA; inhibin alpha chain [KO:K05500]
103814497  BMPR2; bone morphogenetic protein receptor type-2 isoform X1 [KO:K04671] [EC:2.7.11.30]
103814546  MSTN; growth/differentiation factor 8 [KO:K05497]
103814641  [KO:K04388] [EC:2.7.11.30]
103814653  INHBB; LOW QUALITY PROTEIN: inhibin beta B chain [KO:K22687]
103814762  ACKR3; atypical chemokine receptor 3 [KO:K04304]
103814953  MPL; thrombopoietin receptor [KO:K05082]
103815145  BMP6; bone morphogenetic protein 6 [KO:K16620]
103815223  LEPR; leptin receptor [KO:K05062]
103815228  [KO:K05064]
103815299  TNFRSF11A; tumor necrosis factor receptor superfamily member 11A isoform X1 [KO:K05147]
103815595  TNFSF10; tumor necrosis factor ligand superfamily member 10 [KO:K04721]
103815603  THPO; thrombopoietin isoform X2 [KO:K06854]
103815624  IL1RAP; interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
103815652  CCL20; C-C motif chemokine 20 [KO:K14625]
103816051  IL16; pro-interleukin-16 isoform X1 [KO:K22628]
103816297  BMP15; bone morphogenetic protein 15 [KO:K05498]
103816360  IL7; interleukin-7 [KO:K05431]
103816427  EDA; ectodysplasin-A isoform X1 [KO:K05480]
103816467  CD40LG; CD40 ligand isoform X2 [KO:K03161]
103816510  IL13RA2; interleukin-13 receptor subunit alpha-2 [KO:K05077]
103816543  IL13RA1; interleukin-13 receptor subunit alpha-1 [KO:K05076]
103816559  EDA2R; tumor necrosis factor receptor superfamily member 27 [KO:K05163]
103816671  IL34; interleukin-34 isoform X1 [KO:K22633]
103817182  IL17RE; interleukin-17 receptor E [KO:K05168]
103817183  IL17RC; interleukin-17 receptor C isoform X1 [KO:K05166]
103817263  CXCL14; C-X-C motif chemokine 14 [KO:K10033]
103817300  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
103817377  IL17B; interleukin-17B [KO:K05490]
103817383  IL12B; interleukin-12 subunit beta [KO:K05425]
103817387  GDF9; growth/differentiation factor 9 [KO:K22673]
103817419  RELL2; LOW QUALITY PROTEIN: RELT-like protein 2 [KO:K26541]
103817551  IL21R; interleukin-21 receptor isoform X1 [KO:K05075]
103817606  TNFRSF13B; tumor necrosis factor receptor superfamily member 13B [KO:K05150]
103817740  IL20RB; interleukin-20 receptor subunit beta [KO:K05137]
103817792  IL4R; interleukin-4 receptor subunit alpha isoform X1 [KO:K05071]
103817903  TNFRSF17; tumor necrosis factor receptor superfamily member 17 isoform X1 [KO:K05153]
103818394  RELT; tumor necrosis factor receptor superfamily member 19L [KO:K05156]
103818467  IL20RA; interleukin-20 receptor subunit alpha isoform X2 [KO:K05136]
103818469  IFNGR1; interferon gamma receptor 1 isoform X1 [KO:K05132]
103818543  CCR6; C-C chemokine receptor type 6 [KO:K04181]
103818693  TNFRSF6B; tumor necrosis factor receptor superfamily member 6B [KO:K05143]
103818753  BMP7; bone morphogenetic protein 7 [KO:K16621]
103818815  CD40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160]
103819164  TNFSF8; tumor necrosis factor ligand superfamily member 8 [KO:K05471]
103819165  TNFSF15; tumor necrosis factor ligand superfamily member 15 [KO:K05478]
103819311  BMP2; bone morphogenetic protein 2 isoform X1 [KO:K21283]
103819353  INHBA; inhibin beta A chain [KO:K04667]
103819385  TGFBR1; TGF-beta receptor type-1 isoform X3 [KO:K04674] [EC:2.7.11.30]
103819399  PRL; prolactin [KO:K05439]
103819513  [KO:K05414]
103819908  BMP5; bone morphogenetic protein 5 isoform X1 [KO:K04663]
103820034  [KO:K12964]
103820035  [KO:K12964]
103820036  [KO:K12499]
103820086  [KO:K05408]
103820410  IFNG; interferon gamma [KO:K04687]
103820411  IL22; interleukin-22 [KO:K05445]
103820421  [KO:K05439]
103820435  IL26; interleukin-26 [KO:K05446]
103820522  IL17RA; interleukin-17 receptor A isoform X1 [KO:K05164]
103820859  GDF7; LOW QUALITY PROTEIN: growth/differentiation factor 7 [KO:K20013]
103820900  TNFRSF4; tumor necrosis factor receptor superfamily member 4 isoform X1 [KO:K05142]
103820936  TNFRSF25; tumor necrosis factor receptor superfamily member 25 isoform X1 [KO:K05160]
103820940  TNFRSF9; tumor necrosis factor receptor superfamily member 9 [KO:K05146]
103820948  TNFRSF1B; tumor necrosis factor receptor superfamily member 1B [KO:K05141]
103820949  TNFRSF8; tumor necrosis factor receptor superfamily member 8 [KO:K05145]
103821001  TNFRSF21; tumor necrosis factor receptor superfamily member 21 isoform X2 [KO:K05157]
103821012  LIFR; leukemia inhibitory factor receptor [KO:K05058]
103821014  [KO:K05057]
103821021  GHR; growth hormone receptor [KO:K05080]
103821034  IL6ST; interleukin-6 receptor subunit beta [KO:K05060]
103821063  IL7R; interleukin-7 receptor subunit alpha isoform X1 [KO:K05072]
103821099  IL31RA; interleukin-31 receptor subunit alpha isoform X1 [KO:K22630]
103821503  TGFB2; transforming growth factor beta-2 proprotein [KO:K13376]
103821617  CCR7; C-C chemokine receptor type 7 [KO:K04182]
103821672  [KO:K05438]
103821712  CCR10; C-C chemokine receptor type 10 [KO:K04185]
103821754  CSF3; granulocyte colony-stimulating factor [KO:K05423]
103821808  NGFR; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 16 [KO:K02583]
103821883  [KO:K21283]
103822000  AMH; muellerian-inhibiting factor [KO:K04665]
103822011  IL12RB1; interleukin-12 receptor subunit beta-1 [KO:K05063]
103822134  CLCF1; cardiotrophin-like cytokine factor 1 [KO:K05421]
103822284  CNTF; ciliary neurotrophic factor [KO:K05420]
103822331  NGF; beta-nerve growth factor [KO:K02582]
103822394  IL10; interleukin-10 [KO:K05443]
103822395  [KO:K22667]
103822422  CSF1; LOW QUALITY PROTEIN: macrophage colony-stimulating factor 1 [KO:K05453]
103822505  IL15RA; interleukin-15 receptor subunit alpha [KO:K05074]
103822517  [KO:K05068]
103822525  IL15; interleukin-15 [KO:K05433]
103822640  CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
103822662  IL1B; interleukin-1 beta isoform X2 [KO:K04519]
103822672  BMP10; bone morphogenetic protein 10 [KO:K22670]
103822748  [KO:K04666]
103822775  CXCR5; C-X-C chemokine receptor type 5 [KO:K04190]
103822904  [KO:K16062]
103822905  CNTFR; ciliary neurotrophic factor receptor subunit alpha isoform X1 [KO:K05059]
103822936  [KO:K05512]
103822937  IL11RA; interleukin-11 receptor subunit alpha isoform X3 [KO:K05056]
103822985  IL18; interleukin-18 isoform X1 [KO:K05482]
103823016  IL10RA; interleukin-10 receptor subunit alpha isoform X1 [KO:K05134]
103823110  [KO:K05425]
103823232  IL17A; interleukin-17A [KO:K05489]
103823243  [KO:K05494]
103823387  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
103823445  [KO:K10030]
103823463  [KO:K10032]
103823464  [KO:K10032]
103823469  [KO:K05505]
103823470  [KO:K10030]
103823472  [KO:K10030]
103823474  BMP3; bone morphogenetic protein 3 [KO:K05496]
103823557  BMP8A; bone morphogenetic protein 8A [KO:K16622]
103823566  IL22RA1; interleukin-22 receptor subunit alpha-1 isoform X1 [KO:K05138]
103823567  IFNLR1; interferon lambda receptor 1 isoform X1 [KO:K05140]
103823653  GDF5; growth/differentiation factor 5 [KO:K04664]
103823698  IL5RA; interleukin-5 receptor subunit alpha [KO:K05067]
103823758  [KO:K05438]
103823970  [KO:K05408]
103824053  IL6R; LOW QUALITY PROTEIN: interleukin-6 receptor subunit alpha [KO:K05055]
103824248  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
103824420  IFNGR2; interferon gamma receptor 2 [KO:K05133]
103824423  [KO:K04722]
103824542  [KO:K05495]
103824552  EBI3; interleukin-27 subunit beta [KO:K24476]
103824632  [KO:K22688]
103824712  RELL1; RELT-like protein 1 isoform X1 [KO:K26541]
103824806  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
103824809  [KO:K05135]
103824810  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
103825003  ACVR1B; activin receptor type-1B [KO:K13567] [EC:2.7.11.30]
103825260  [KO:K05483]
103826038  BMPR1B; bone morphogenetic protein receptor type-1B [KO:K13578] [EC:2.7.11.30]
103826326  BMP4; LOW QUALITY PROTEIN: bone morphogenetic protein 4 [KO:K04662]
103826906  [KO:K13377]
103827017  [KO:K04722]
103827070  [KO:K05507]
103827311  IL17D; interleukin-17D [KO:K05492]
103827320  TNFRSF19; tumor necrosis factor receptor superfamily member 19 [KO:K05155]
108961668  [KO:K21283]
108961726  GDF6; LOW QUALITY PROTEIN: growth/differentiation factor 6 [KO:K20012]
108962145  CX3CL1; fractalkine [KO:K05508]
108962293  [KO:K05073]
108962800  [KO:K05415]
108963366  [KO:K10032]
108963451  ACVRL1; serine/threonine-protein kinase receptor R3 [KO:K13594] [EC:2.7.11.30]
108964078  [KO:K05488]
115483909  [KO:K05479]
115484344  [KO:K22669]
115484490  [KO:K22689]
115484567  [KO:K05419]
115485133  IFNK; interferon kappa [KO:K05414]
115485148  CCL28; C-C motif chemokine 28 [KO:K05513]
115485432  [KO:K13377]
115485542  [KO:K22674]
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Reference
PMID:21106488
  Authors
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V
  Title
Evolutionary divergence and functions of the human interleukin (IL) gene family.
  Journal
Hum Genomics 5:30-55 (2010)
DOI:10.1186/1479-7364-5-1-30
Reference
PMID:27577879
  Authors
Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA
  Title
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases.
  Journal
J Allergy Clin Immunol 138:984-1010 (2016)
DOI:10.1016/j.jaci.2016.06.033
Reference
PMID:15500860
  Authors
Boulanger MJ, Garcia KC
  Title
Shared cytokine signaling receptors: structural insights from the gp130 system.
  Journal
Adv Protein Chem 68:107-46 (2004)
DOI:10.1016/S0065-3233(04)68004-1
Reference
PMID:16034365
  Authors
Allan SM, Tyrrell PJ, Rothwell NJ
  Title
Interleukin-1 and neuronal injury.
  Journal
Nat Rev Immunol 5:629-40 (2005)
DOI:10.1038/nri1664
Reference
PMID:23847622
  Authors
Lopetuso LR, Chowdhry S, Pizarro TT
  Title
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
  Journal
Front Immunol 4:181 (2013)
DOI:10.3389/fimmu.2013.00181
Reference
PMID:21349428
  Authors
Iwakura Y, Ishigame H, Saijo S, Nakae S
  Title
Functional specialization of interleukin-17 family members.
  Journal
Immunity 34:149-62 (2011)
DOI:10.1016/j.immuni.2011.02.012
Reference
PMID:17530315
  Authors
Fischer P, Hilfiker-Kleiner D
  Title
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
  Journal
Basic Res Cardiol 102:279-97 (2007)
DOI:10.1007/s00395-007-0658-z
Reference
PMID:24381786
  Authors
Richards CD
  Title
The enigmatic cytokine oncostatin m and roles in disease.
  Journal
ISRN Inflamm 2013:512103 (2013)
DOI:10.1155/2013/512103
Reference
PMID:18926762
  Authors
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W
  Title
Structures and biological functions of IL-31 and IL-31 receptors.
  Journal
Cytokine Growth Factor Rev 19:347-56 (2008)
DOI:10.1016/j.cytogfr.2008.08.003
Reference
PMID:21155715
  Authors
Meenhuis A, Verwijmeren C, Roovers O, Touw IP
  Title
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.
  Journal
Biochem J 434:343-51 (2011)
DOI:10.1042/BJ20101628
Reference
PMID:22410872
  Authors
de Weerd NA, Nguyen T
  Title
The interferons and their receptors--distribution and regulation.
  Journal
Immunol Cell Biol 90:483-91 (2012)
DOI:10.1038/icb.2012.9
Reference
PMID:12949498
  Authors
Aggarwal BB
  Title
Signalling pathways of the TNF superfamily: a double-edged sword.
  Journal
Nat Rev Immunol 3:745-56 (2003)
DOI:10.1038/nri1184
Reference
PMID:12189384
  Authors
Ashkenazi A
  Title
Targeting death and decoy receptors of the tumour-necrosis factor superfamily.
  Journal
Nat Rev Cancer 2:420-30 (2002)
DOI:10.1038/nrc821
Reference
PMID:26115564
  Authors
Seeger P, Musso T, Sozzani S
  Title
The TGF-beta superfamily in dendritic cell biology.
  Journal
Cytokine Growth Factor Rev 26:647-57 (2015)
DOI:10.1016/j.cytogfr.2015.06.002
Reference
PMID:23612460
  Authors
Wakefield LM, Hill CS
  Title
Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer.
  Journal
Nat Rev Cancer 13:328-41 (2013)
DOI:10.1038/nrc3500
Reference
PMID:22710174
  Authors
Mueller TD, Nickel J
  Title
Promiscuity and specificity in BMP receptor activation.
  Journal
FEBS Lett 586:1846-59 (2012)
DOI:10.1016/j.febslet.2012.02.043
KO pathway
ko04060   

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