KEGG   PATHWAY: setr04514
Entry
setr04514                   Pathway                                
Name
Cell adhesion molecules - Suncus etruscus (white-toothed pygmy shrew)
Description
Cell adhesion molecules (CAMs) are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, embryogenesis, and development of neuronal tissue. There are four main groups: the integrin family, the immunoglobulin superfamily, selectins, and cadherins. Membrane proteins that mediate immune cell–cell interactions fall into different categories, namely those involved in antigen recognition, costimulation and cellular adhesion. Furthermore cell-cell adhesions are important for brain morphology and highly coordinated brain functions such as memory and learning. During early development of the nervous system, neurons elongate their axons towards their targets and establish and maintain synapses through formation of cell-cell adhesions. Cell-cell adhesions also underpin axon-axon contacts and link neurons with supporting schwann cells and oligodendrocytes.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
setr04514  Cell adhesion molecules
setr04514

Other DBs
GO: 0050839
Organism
Suncus etruscus (white-toothed pygmy shrew) [GN:setr]
Gene
125995104  CLDN5; claudin-5 [KO:K06087]
125995697  [KO:K06752]
125995698  [KO:K06752]
125995700  [KO:K06752]
125995701  [KO:K06752]
125995706  [KO:K06752]
125995773  [KO:K06751]
125995779  [KO:K06751]
125995781  [KO:K06751]
125995790  [KO:K06751]
125995802  [KO:K06752]
125995804  [KO:K06752]
125995805  [KO:K06752]
125995808  [KO:K06752]
125995810  [KO:K06752]
125995811  [KO:K06752]
125995812  [KO:K06752]
125995813  [KO:K06752]
125995959  [KO:K06751]
125996242  [KO:K06751]
125996451  [KO:K06751]
125996455  [KO:K06751]
125996484  CLDN20; claudin-20 [KO:K06087]
125997253  VCAM1; vascular cell adhesion protein 1 [KO:K06527]
125997277  NTNG1; netrin-G1 isoform X1 [KO:K07522]
125997531  VTCN1; V-set domain-containing T-cell activation inhibitor 1 [KO:K06747]
125997971  NLGN2; neuroligin-2 isoform X1 [KO:K07378]
125998015  CLDN7; claudin-7 [KO:K06087]
125998190  ITGA9; integrin alpha-9 [KO:K06585]
125998595  CD40LG; CD40 ligand [KO:K03161]
125998649  CLDN2; claudin-2 [KO:K06087]
125999173  NLGN3; neuroligin-3 isoform X1 [KO:K07378]
125999421  L1CAM; neural cell adhesion molecule L1 isoform X1 [KO:K06550]
125999424  SLITRK2; SLIT and NTRK-like protein 2 [KO:K25833]
125999425  SLITRK4; SLIT and NTRK-like protein 4 [KO:K25835]
125999468  CD99L2; CD99 antigen-like protein 2 [KO:K06520]
126000570  NLGN4X; neuroligin-4, X-linked isoform X1 [KO:K07378]
126001136  ICAM2; intercellular adhesion molecule 2 [KO:K06523]
126001286  CLDN6; claudin-6 [KO:K06087]
126001287  CLDN9; claudin-9 [KO:K06087]
126001501  OCLN; occludin [KO:K06088]
126001622  [KO:K06567]
126001941  CLDN12; claudin-12 [KO:K06087]
126003370  CDH2; cadherin-2 [KO:K06736]
126003662  PTPRM; receptor-type tyrosine-protein phosphatase mu [KO:K05693] [EC:3.1.3.48]
126003939  PTPRD; receptor-type tyrosine-protein phosphatase delta isoform X1 [KO:K06777] [EC:3.1.3.48]
126003964  [KO:K07377]
126004167  NFASC; neurofascin isoform X1 [KO:K06757]
126004173  CNTN2; contactin-2 isoform X1 [KO:K06760]
126004303  CD34; hematopoietic progenitor cell antigen CD34 [KO:K06474]
126004337  PTPRC; receptor-type tyrosine-protein phosphatase C [KO:K06478] [EC:3.1.3.48]
126006585  NEGR1; neuronal growth regulator 1 [KO:K06775]
126006875  CLDN23; claudin-23 [KO:K06087]
126006959  CD4; T-cell surface glycoprotein CD4 [KO:K06454]
126007178  [KO:K06087]
126007179  [KO:K06087]
126007422  CD274; programmed cell death 1 ligand 1 [KO:K06745]
126008620  ITGA4; integrin alpha-4 [KO:K06483]
126008669  CD28; T-cell-specific surface glycoprotein CD28 [KO:K06470]
126008729  SDC2; syndecan-2 [KO:K16336]
126008895  ITGAV; integrin alpha-V [KO:K06487]
126008975  CTLA4; cytotoxic T-lymphocyte protein 4 isoform X1 [KO:K06538]
126009161  ITGA6; integrin alpha-6 [KO:K06485]
126009591  NTNG2; netrin-G2 [KO:K16359]
126010836  SLITRK3; SLIT and NTRK-like protein 3 [KO:K25834]
126010865  CLDN11; claudin-11 [KO:K06087]
126010952  LRRC4; leucine-rich repeat-containing protein 4 [KO:K16351]
126010994  PTPRF; LOW QUALITY PROTEIN: receptor-type tyrosine-protein phosphatase F [KO:K05695] [EC:3.1.3.48]
126011282  CLDN19; claudin-19 [KO:K06087]
126011472  NLGN1; neuroligin-1 [KO:K07378]
126011735  SDC3; syndecan-3 [KO:K16337]
126012173  CLDN18; claudin-18 [KO:K06087]
126012176  CLDN1; claudin-1 [KO:K06087]
126012195  CLDN16; claudin-16 [KO:K06087]
126013304  CDH4; cadherin-4 [KO:K06797]
126013707  CADM3; cell adhesion molecule 3 isoform X1 [KO:K06780]
126013868  F11R; junctional adhesion molecule A [KO:K06089]
126013943  ITGB1; integrin beta-1 [KO:K05719]
126013990  MPZ; myelin protein P0 [KO:K06770]
126014205  ITGA8; LOW QUALITY PROTEIN: integrin alpha-8 [KO:K06584]
126014276  NEO1; LOW QUALITY PROTEIN: neogenin [KO:K06766]
126014290  SELP; P-selectin [KO:K06496]
126014291  SELL; L-selectin [KO:K06495]
126014292  SELE; E-selectin [KO:K06494]
126014901  CD276; CD276 antigen isoform X1 [KO:K06746]
126015409  NECTIN1; nectin-1 [KO:K06081]
126015414  ESAM; endothelial cell-selective adhesion molecule [KO:K06787]
126015681  JAM3; junctional adhesion molecule C isoform X1 [KO:K06785]
126015816  JAML; junctional adhesion molecule-like [KO:K28137]
126015831  CLDN25; putative claudin-25 [KO:K06087]
126016132  NCAM1; neural cell adhesion molecule 1 isoform X1 [KO:K06491]
126016138  CADM1; LOW QUALITY PROTEIN: cell adhesion molecule 1 [KO:K06781]
126016165  CLDN10; claudin-10 isoform X1 [KO:K06087]
126016341  CNTNAP1; contactin-associated protein 1 isoform X1 [KO:K07379]
126016363  SLITRK6; SLIT and NTRK-like protein 6 [KO:K25837]
126016372  SLITRK1; SLIT and NTRK-like protein 1 [KO:K25832]
126016397  [KO:K06751]
126016457  SLITRK5; SLIT and NTRK-like protein 5 [KO:K25836]
126017229  PECAM1; platelet endothelial cell adhesion molecule [KO:K06471]
126017453  SDC4; syndecan-4 [KO:K16338]
126017549  SIGLEC1; sialoadhesin [KO:K06548]
126017583  NRXN2; neurexin-2-beta isoform X1 [KO:K07377]
126017619  LRRC4C; leucine-rich repeat-containing protein 4C [KO:K07523]
126018394  CD40; tumor necrosis factor receptor superfamily member 5 [KO:K03160]
126018764  CD6; LOW QUALITY PROTEIN: T-cell differentiation antigen CD6 [KO:K06456]
126020807  CD226; CD226 antigen [KO:K06567]
126022085  NRCAM; neuronal cell adhesion molecule isoform X1 [KO:K06756]
126022467  ITGB7; integrin beta-7 [KO:K06590]
126022847  CNTN1; LOW QUALITY PROTEIN: contactin-1 [KO:K06759]
126023914  NRXN1; neurexin-1 isoform X1 [KO:K07377]
126024177  CD8A; T-cell surface glycoprotein CD8 alpha chain [KO:K06458]
126024178  CD8B; T-cell surface glycoprotein CD8 beta chain [KO:K06459]
126024407  SDC1; syndecan-1 [KO:K06257]
126025610  CLDN14; claudin-14 [KO:K06087]
126025708  CXADR; coxsackievirus and adenovirus receptor [KO:K06788]
126025761  CD86; T-lymphocyte activation antigen CD86 [KO:K05413]
126025777  CD80; T-lymphocyte activation antigen CD80 [KO:K05412]
126025781  TIGIT; T-cell immunoreceptor with Ig and ITIM domains [KO:K16350]
126025825  JAM2; junctional adhesion molecule B [KO:K06735]
126025880  NECTIN3; nectin-3 [KO:K06592]
126025910  ICOSLG; ICOS ligand [KO:K06710]
126025916  ITGB2; integrin beta-2 [KO:K06464]
126025971  ALCAM; CD166 antigen isoform X1 [KO:K06547]
126025997  ITGB8; integrin beta-8 [KO:K06591]
126026022  NCAM2; neural cell adhesion molecule 2 isoform X1 [KO:K06491]
126026097  CLDN8; claudin-8 [KO:K06087]
126026098  CLDN17; claudin-17 [KO:K06087]
126026207  IGSF11; immunoglobulin superfamily member 11 [KO:K06791]
126027293  CDH15; cadherin-15 isoform X1 [KO:K06809]
126027340  GLG1; Golgi apparatus protein 1 [KO:K06816]
126027347  CDH1; cadherin-1 [KO:K05689]
126027355  CDH5; cadherin-5 [KO:K06533]
126027473  CDH3; cadherin-3 [KO:K06796]
126027589  CD22; B-cell receptor CD22 [KO:K06467]
126027601  MAG; myelin-associated glycoprotein [KO:K06771]
126027977  LRRC4B; leucine-rich repeat-containing protein 4B [KO:K16360]
126028225  NECTIN2; nectin-2 isoform X1 [KO:K06531]
126028566  [KO:K06539]
126029587  CLDN15; claudin-15 [KO:K06087]
126029757  PTPRS; receptor-type tyrosine-protein phosphatase S [KO:K06778] [EC:3.1.3.48]
126029883  ITGAL; integrin alpha-L [KO:K05718]
126029886  SPN; leukosialin [KO:K06477]
126030025  MADCAM1; mucosal addressin cell adhesion molecule 1 [KO:K06779]
126030162  ICAM1; intercellular adhesion molecule 1 [KO:K06490]
126030166  ICAM3; intercellular adhesion molecule 3 [KO:K06486]
126030918  VSIR; V-type immunoglobulin domain-containing suppressor of T-cell activation [KO:K23268]
126030989  ITGAM; integrin alpha-M [KO:K06461]
126031270  CLDN3; claudin-3 [KO:K06087]
126031273  CLDN4; claudin-4 [KO:K06087]
Reference
PMID:14690046
  Authors
Barclay AN.
  Title
Membrane proteins with immunoglobulin-like domains--a master superfamily of interaction molecules.
  Journal
Semin Immunol 15:215-23 (2003)
DOI:10.1016/S1044-5323(03)00047-2
Reference
PMID:11910893
  Authors
Sharpe AH, Freeman GJ.
  Title
The B7-CD28 superfamily.
  Journal
Nat Rev Immunol 2:116-26 (2002)
DOI:10.1038/nri727
Reference
PMID:9597126
  Authors
Grewal IS, Flavell RA.
  Title
CD40 and CD154 in cell-mediated immunity.
  Journal
Annu Rev Immunol 16:111-35 (1998)
DOI:10.1146/annurev.immunol.16.1.111
Reference
PMID:16034094
  Authors
Dardalhon V, Schubart AS, Reddy J, Meyers JH, Monney L, Sabatos CA, Ahuja R, Nguyen K, Freeman GJ, Greenfield EA, Sobel RA, Kuchroo VK.
  Title
CD226 is specifically expressed on the surface of Th1 cells and regulates their expansion and effector functions.
  Journal
J Immunol 175:1558-65 (2005)
DOI:10.4049/jimmunol.175.3.1558
Reference
PMID:12234363
  Authors
Montoya MC, Sancho D, Vicente-Manzanares M, Sanchez-Madrid F.
  Title
Cell adhesion and polarity during immune interactions.
  Journal
Immunol Rev 186:68-82 (2002)
DOI:10.1034/j.1600-065X.2002.18607.x
Reference
PMID:15071551
  Authors
Dejana E.
  Title
Endothelial cell-cell junctions: happy together.
  Journal
Nat Rev Mol Cell Biol 5:261-70 (2004)
DOI:10.1038/nrm1357
Reference
PMID:14519386
  Authors
Bazzoni G.
  Title
The JAM family of junctional adhesion molecules.
  Journal
Curr Opin Cell Biol 15:525-30 (2003)
DOI:10.1016/S0955-0674(03)00104-2
Reference
PMID:10798271
  Authors
Becker BF, Heindl B, Kupatt C, Zahler S.
  Title
Endothelial function and hemostasis.
  Journal
Z Kardiol 89:160-7 (2000)
DOI:10.1007/PL00007320
Reference
PMID:9150551
  Authors
Elangbam CS, Qualls CW Jr, Dahlgren RR.
  Title
Cell adhesion molecules--update.
  Journal
Vet Pathol 34:61-73 (1997)
DOI:10.1177/030098589703400113
Reference
PMID:12810109
  Authors
Muller WA.
  Title
Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response.
  Journal
Trends Immunol 24:327-34 (2003)
DOI:10.1016/S1471-4906(03)00117-0
Reference
PMID:14519398
  Authors
Yamagata M, Sanes JR, Weiner JA.
  Title
Synaptic adhesion molecules.
  Journal
Curr Opin Cell Biol 15:621-32 (2003)
DOI:10.1016/S0955-0674(03)00107-8
Reference
PMID:15882774
  Authors
Ethell IM, Pasquale EB.
  Title
Molecular mechanisms of dendritic spine development and remodeling.
  Journal
Prog Neurobiol 75:161-205 (2005)
DOI:10.1016/j.pneurobio.2005.02.003
Reference
PMID:11050419
  Authors
Benson DL, Schnapp LM, Shapiro L, Huntley GW.
  Title
Making memories stick: cell-adhesion molecules in synaptic plasticity.
  Journal
Trends Cell Biol 10:473-82 (2000)
DOI:10.1016/S0962-8924(00)01838-9
Reference
PMID:11860281
  Authors
Rosdahl JA, Mourton TL, Brady-Kalnay SM.
  Title
Protein kinase C delta (PKCdelta) is required for protein tyrosine phosphatase mu (PTPmu)-dependent neurite outgrowth.
  Journal
Mol Cell Neurosci 19:292-306 (2002)
DOI:10.1006/mcne.2001.1071
Reference
PMID:10964748
  Authors
Dunican DJ, Doherty P.
  Title
The generation of localized calcium rises mediated by cell adhesion molecules and their role in neuronal growth cone motility.
  Journal
Mol Cell Biol Res Commun 3:255-63 (2000)
DOI:10.1006/mcbr.2000.0225
Reference
PMID:12367625
  Authors
Girault JA, Peles E.
  Title
Development of nodes of Ranvier.
  Journal
Curr Opin Neurobiol 12:476-85 (2002)
DOI:10.1016/S0959-4388(02)00370-7
Reference
PMID:10664064
  Authors
Arroyo EJ, Scherer SS.
  Title
On the molecular architecture of myelinated fibers.
  Journal
Histochem Cell Biol 113:1-18 (2000)
DOI:10.1007/s004180050001
Reference
PMID:14556710
  Authors
Salzer JL.
  Title
Polarized domains of myelinated axons.
  Journal
Neuron 40:297-318 (2003)
DOI:10.1016/S0896-6273(03)00628-7
Reference
PMID:15561584
  Authors
Irie K, Shimizu K, Sakisaka T, Ikeda W, Takai Y.
  Title
Roles and modes of action of nectins in cell-cell adhesion.
  Journal
Semin Cell Dev Biol 15:643-56 (2004)
DOI:10.1016/j.semcdb.2004.09.002
Reference
PMID:15551862
  Authors
Nakanishi H, Takai Y.
  Title
Roles of nectins in cell adhesion, migration and polarization.
  Journal
Biol Chem 385:885-92 (2004)
DOI:10.1515/BC.2004.116
Reference
PMID:15115723
  Authors
Siu MK, Cheng CY.
  Title
Extracellular matrix: recent advances on its role in junction dynamics in the seminiferous epithelium during spermatogenesis.
  Journal
Biol Reprod 71:375-91 (2004)
DOI:10.1095/biolreprod.104.028225
Reference
PMID:15056568
  Authors
Lee NP, Cheng CY.
  Title
Adaptors, junction dynamics, and spermatogenesis.
  Journal
Biol Reprod 71:392-404 (2004)
DOI:10.1095/biolreprod.104.027268
Reference
PMID:15728677
  Authors
Inagaki M, Irie K, Ishizaki H, Tanaka-Okamoto M, Morimoto K, Inoue E, Ohtsuka T, Miyoshi J, Takai Y.
  Title
Roles of cell-adhesion molecules nectin 1 and nectin 3 in ciliary body development.
  Journal
Development 132:1525-37 (2005)
DOI:10.1242/dev.01697
Reference
PMID:12500939
  Authors
Marthiens V, Gavard J, Lambert M, Mege RM.
  Title
Cadherin-based cell adhesion in neuromuscular development.
  Journal
Biol Cell 94:315-26 (2002)
DOI:10.1016/S0248-4900(02)00005-9
Reference
PMID:15923648
  Authors
Krauss RS, Cole F, Gaio U, Takaesu G, Zhang W, Kang JS.
  Title
Close encounters: regulation of vertebrate skeletal myogenesis by cell-cell contact.
  Journal
J Cell Sci 118:2355-62 (2005)
DOI:10.1242/jcs.02397
Related
pathway
setr04520  Adherens junction
setr04530  Tight junction
setr04610  Complement and coagulation cascades
setr04660  T cell receptor signaling pathway
setr04670  Leukocyte transendothelial migration
KO pathway
ko04514   

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