KEGG   PATHWAY: xco04060
Entry
xco04060                    Pathway                                
Name
Cytokine-cytokine receptor interaction - Xiphophorus couchianus (Monterrey platyfish)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
xco04060  Cytokine-cytokine receptor interaction
xco04060

Organism
Xiphophorus couchianus (Monterrey platyfish) [GN:xco]
Gene
114133202  [KO:K05155]
114133430  [KO:K21283]
114133570  [KO:K05134]
114133841  [KO:K04181]
114133909  [KO:K04721]
114134077  tgfb3; transforming growth factor beta-3 proprotein [KO:K13377]
114134098  [KO:K04675] [EC:2.7.11.30]
114134262  ebi3; interleukin-27 subunit beta [KO:K24476]
114134479  bmp4; bone morphogenetic protein 4 [KO:K04662]
114134540  [KO:K05060]
114134902  [KO:K05142]
114134980  il10; interleukin-10 [KO:K05443]
114135141  [KO:K22679]
114135308  [KO:K05166]
114135795  [KO:K22667]
114135903  [KO:K16621]
114136056  gdf5; growth/differentiation factor 5 [KO:K04664]
114136097  [KO:K22687]
114136151  il34; interleukin-34 [KO:K22633]
114136158  [KO:K05491]
114136240  [KO:K05141]
114136304  [KO:K02582]
114136513  [KO:K14625]
114136539  bmp6; bone morphogenetic protein 6 [KO:K16620]
114136607  [KO:K13596] [EC:2.7.11.30]
114136640  [KO:K04721]
114136712  [KO:K04178]
114136713  [KO:K04178]
114136881  [KO:K04186]
114136901  [KO:K04184]
114136920  [KO:K05147]
114137052  [KO:K04667]
114137075  [KO:K04178]
114137186  [KO:K04178]
114137800  [KO:K05416]
114137823  [KO:K04390]
114137918  ifngr1; interferon gamma receptor 1 [KO:K05132]
114138037  bmpr1a; bone morphogenetic protein receptor type-1A isoform X1 [KO:K04673] [EC:2.7.11.30]
114138152  bmp5; bone morphogenetic protein 5 [KO:K04663]
114138309  [KO:K05075]
114138337  [KO:K10031]
114138551  [KO:K22674]
114139005  [KO:K04389]
114139160  [KO:K04180]
114139162  [KO:K05155]
114139172  [KO:K05425]
114139212  gdf9; growth/differentiation factor 9 [KO:K22673]
114139270  [KO:K04178]
114139318  [KO:K05417]
114139321  eda; ectodysplasin-A isoform X1 [KO:K05480]
114139322  [KO:K05476]
114139338  [KO:K05143]
114139432  [KO:K05468]
114139436  [KO:K13376]
114139479  [KO:K05090] [EC:2.7.10.1]
114139484  clcf1; cardiotrophin-like cytokine factor 1 [KO:K05421]
114139531  cxcl14; C-X-C motif chemokine 14 [KO:K10033]
114140241  [KO:K05050]
114140572  [KO:K05080]
114140597  [KO:K22687]
114140601  [KO:K05497]
114140602  [KO:K04304]
114140764  [KO:K03160]
114140973  bmpr2; bone morphogenetic protein receptor type-2 [KO:K04671] [EC:2.7.11.30]
114141013  acvr2a; activin receptor type-2A isoform X1 [KO:K04670] [EC:2.7.11.30]
114141083  inha; inhibin alpha chain isoform X1 [KO:K05500]
114141553  [KO:K04188]
114141554  [KO:K04188]
114141556  [KO:K04188]
114141557  [KO:K04188]
114141624  tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
114141898  cd27; CD27 antigen isoform X1 [KO:K05144]
114142021  csf3r; granulocyte colony-stimulating factor receptor [KO:K05061]
114142025  [KO:K02583]
114142044  [KO:K22628]
114142164  ltbr; tumor necrosis factor receptor superfamily member 3 [KO:K03160]
114142195  [KO:K05136]
114142260  [KO:K06454]
114142297  [KO:K05055]
114142311  tnfrsf11b; tumor necrosis factor receptor superfamily member 11B [KO:K05148]
114142320  [KO:K04188]
114142343  [KO:K05152]
114142351  [KO:K04180]
114142427  [KO:K05152]
114142495  [KO:K05173]
114142500  tnfrsf14; tumor necrosis factor receptor superfamily member 14 [KO:K05152]
114142714  [KO:K05173]
114142890  [KO:K05174]
114143292  [KO:K05146]
114143401  [KO:K05071]
114143534  bmp7; bone morphogenetic protein 7 [KO:K16621]
114143630  acvr1b; activin receptor type-1B [KO:K13567] [EC:2.7.11.30]
114143691  [KO:K05491]
114143693  [KO:K05494]
114143856  [KO:K20012]
114143925  [KO:K05069]
114143947  [KO:K10030]
114144226  [KO:K05132]
114144364  [KO:K05168]
114144667  [KO:K05477]
114144829  [KO:K05069]
114144877  [KO:K05166]
114144944  [KO:K04675] [EC:2.7.11.30]
114145015  [KO:K04388] [EC:2.7.11.30]
114145173  [KO:K10031]
114145554  ccr7; C-C chemokine receptor type 7 [KO:K04182]
114145631  [KO:K10030]
114145884  [KO:K14625]
114145968  [KO:K05504]
114146004  [KO:K04193]
114146037  [KO:K04193]
114146341  [KO:K05137]
114146504  [KO:K04667]
114146577  [KO:K05067]
114146641  [KO:K04189]
114146822  [KO:K13596] [EC:2.7.11.30]
114146897  [KO:K04184]
114146935  [KO:K04186]
114147055  [KO:K04179]
114147081  [KO:K21283]
114147215  [KO:K13072]
114147228  [KO:K04193]
114147477  [KO:K05439]
114147496  acvr1c; activin receptor type-1C [KO:K13568] [EC:2.7.11.30]
114147517  [KO:K04670] [EC:2.7.11.30]
114147525  tnfsf13b; tumor necrosis factor ligand superfamily member 13B [KO:K05476]
114147537  [KO:K05131]
114147656  mstn; growth/differentiation factor 8 [KO:K05497]
114147746  [KO:K22672]
114147823  epor; erythropoietin receptor [KO:K05079]
114147900  [KO:K22687]
114148012  il17d; interleukin-17D [KO:K05492]
114148020  [KO:K05050]
114148164  acvr1; activin receptor type-1 [KO:K04675] [EC:2.7.11.30]
114148407  [KO:K04304]
114148628  tnfsf11; tumor necrosis factor ligand superfamily member 11 [KO:K05473]
114148631  [KO:K05135]
114148637  [KO:K05135]
114148652  edar; tumor necrosis factor receptor superfamily member EDAR isoform X1 [KO:K05162]
114148669  [KO:K05050]
114148728  [KO:K04386]
114148729  cxcr4; C-X-C chemokine receptor type 4 [KO:K04189]
114148735  [KO:K05135]
114148757  [KO:K04671] [EC:2.7.11.30]
114148816  [KO:K04387]
114148911  [KO:K05172]
114148942  [KO:K05171]
114148943  [KO:K05171]
114149066  [KO:K04519]
114149096  [KO:K22630]
114149108  il6st; interleukin-6 receptor subunit beta isoform X1 [KO:K05060]
114149248  [KO:K05074]
114149261  [KO:K22670]
114149417  [KO:K04722]
114149477  [KO:K13578] [EC:2.7.11.30]
114149603  prlr; prolactin receptor [KO:K05081]
114149697  cntfr; ciliary neurotrophic factor receptor subunit alpha isoform X1 [KO:K05059]
114149724  [KO:K05058]
114149781  [KO:K05080]
114149782  [KO:K04674] [EC:2.7.11.30]
114149981  [KO:K05056]
114150135  [KO:K05164]
114150206  [KO:K04666]
114150235  il7r; interleukin-7 receptor subunit alpha isoform X1 [KO:K05072]
114150309  [KO:K04193]
114150356  mpl; thrombopoietin receptor [KO:K05082]
114150361  faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
114150524  lepr; leptin receptor isoform X1 [KO:K05062]
114150959  [KO:K21083]
114151005  [KO:K04665]
114151130  [KO:K12964]
114151281  [KO:K05423]
114151303  [KO:K12964]
114151356  [KO:K13072]
114151489  il12rb1; interleukin-12 receptor subunit beta-1 isoform X1 [KO:K05063]
114151582  [KO:K05064]
114151602  [KO:K05064]
114151693  [KO:K05414]
114151694  [KO:K05414]
114151702  tnfrsf13b; tumor necrosis factor receptor superfamily member 13B [KO:K05150]
114151802  nodal; nodal homolog [KO:K04666]
114151930  [KO:K04182]
114151976  [KO:K12964]
114152147  [KO:K02583]
114152238  gdf10; growth/differentiation factor 10 [KO:K22674]
114152239  [KO:K22670]
114152279  [KO:K05414]
114152283  [KO:K02582]
114152754  [KO:K05070]
114153102  [KO:K26541]
114153116  [KO:K05090] [EC:2.7.10.1]
114153313  [KO:K05425]
114153333  [KO:K22629]
114153351  [KO:K05077]
114153590  [KO:K04179]
114153988  [KO:K04519]
114154033  [KO:K12671]
114154037  [KO:K05080]
114154064  [KO:K05425]
114154085  [KO:K05512]
114154111  bmp10; bone morphogenetic protein 10 [KO:K22670]
114154204  [KO:K05058]
114154314  [KO:K04722]
114154520  cxcl13; C-X-C motif chemokine 13 isoform X1 [KO:K10032]
114154825  [KO:K14625]
114154915  [KO:K05478]
114154918  bmpr1b; bone morphogenetic protein receptor type-1B isoform X1 [KO:K13578] [EC:2.7.11.30]
114154947  bmp3; bone morphogenetic protein 3 [KO:K05496]
114155120  [KO:K04519]
114155136  [KO:K04666]
114155340  [KO:K05143]
114155448  bmp8a; bone morphogenetic protein 8A [KO:K16622]
114156140  [KO:K04388] [EC:2.7.11.30]
114156470  [KO:K03156]
114156845  bmp15; bone morphogenetic protein 15 [KO:K05498]
114157299  [KO:K10030]
114157450  [KO:K05408]
114157708  tnfsf12; tumor necrosis factor ligand superfamily member 12 [KO:K05474]
114157725  [KO:K05076]
114157781  [KO:K05075]
114157834  [KO:K05505]
114157835  [KO:K05506]
114157862  rell1; LOW QUALITY PROTEIN: RELT-like protein 1 [KO:K26541]
114158019  epo; erythropoietin [KO:K05437]
114158040  [KO:K05408]
114158041  [KO:K05408]
114158128  [KO:K04181]
114158174  [KO:K13377]
114158609  bmp2; bone morphogenetic protein 2 [KO:K21283]
114158700  tnfrsf21; tumor necrosis factor receptor superfamily member 21 [KO:K05157]
114158746  [KO:K05494]
114158756  [KO:K05408]
114158815  [KO:K05136]
114159143  [KO:K04181]
114159144  [KO:K04181]
114159145  [KO:K04181]
114159494  [KO:K05438]
114159757  il17rb; interleukin-17 receptor B [KO:K05165]
114159818  [KO:K02583]
114159999  [KO:K04738]
114160086  [KO:K05477]
114160353  [KO:K05064]
114160471  [KO:K05069]
114160697  [KO:K12964]
114160701  [KO:K12964]
114160883  [KO:K05439]
114160973  il17ra; interleukin-17 receptor A [KO:K05164]
114161061  il15ra; interleukin-15 receptor subunit alpha isoform X1 [KO:K05074]
114161243  [KO:K05424]
114161391  [KO:K05438]
114161405  [KO:K13375]
114161440  [KO:K05406]
114161671  cxcr5; C-X-C chemokine receptor type 5 [KO:K04190]
114161721  il1rap; interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
114161850  relt; tumor necrosis factor receptor superfamily member 19L [KO:K05156]
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Reference
PMID:21106488
  Authors
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V
  Title
Evolutionary divergence and functions of the human interleukin (IL) gene family.
  Journal
Hum Genomics 5:30-55 (2010)
DOI:10.1186/1479-7364-5-1-30
Reference
PMID:27577879
  Authors
Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA
  Title
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases.
  Journal
J Allergy Clin Immunol 138:984-1010 (2016)
DOI:10.1016/j.jaci.2016.06.033
Reference
PMID:15500860
  Authors
Boulanger MJ, Garcia KC
  Title
Shared cytokine signaling receptors: structural insights from the gp130 system.
  Journal
Adv Protein Chem 68:107-46 (2004)
DOI:10.1016/S0065-3233(04)68004-1
Reference
PMID:16034365
  Authors
Allan SM, Tyrrell PJ, Rothwell NJ
  Title
Interleukin-1 and neuronal injury.
  Journal
Nat Rev Immunol 5:629-40 (2005)
DOI:10.1038/nri1664
Reference
PMID:23847622
  Authors
Lopetuso LR, Chowdhry S, Pizarro TT
  Title
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
  Journal
Front Immunol 4:181 (2013)
DOI:10.3389/fimmu.2013.00181
Reference
PMID:21349428
  Authors
Iwakura Y, Ishigame H, Saijo S, Nakae S
  Title
Functional specialization of interleukin-17 family members.
  Journal
Immunity 34:149-62 (2011)
DOI:10.1016/j.immuni.2011.02.012
Reference
PMID:17530315
  Authors
Fischer P, Hilfiker-Kleiner D
  Title
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
  Journal
Basic Res Cardiol 102:279-97 (2007)
DOI:10.1007/s00395-007-0658-z
Reference
PMID:24381786
  Authors
Richards CD
  Title
The enigmatic cytokine oncostatin m and roles in disease.
  Journal
ISRN Inflamm 2013:512103 (2013)
DOI:10.1155/2013/512103
Reference
PMID:18926762
  Authors
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W
  Title
Structures and biological functions of IL-31 and IL-31 receptors.
  Journal
Cytokine Growth Factor Rev 19:347-56 (2008)
DOI:10.1016/j.cytogfr.2008.08.003
Reference
PMID:21155715
  Authors
Meenhuis A, Verwijmeren C, Roovers O, Touw IP
  Title
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.
  Journal
Biochem J 434:343-51 (2011)
DOI:10.1042/BJ20101628
Reference
PMID:22410872
  Authors
de Weerd NA, Nguyen T
  Title
The interferons and their receptors--distribution and regulation.
  Journal
Immunol Cell Biol 90:483-91 (2012)
DOI:10.1038/icb.2012.9
Reference
PMID:12949498
  Authors
Aggarwal BB
  Title
Signalling pathways of the TNF superfamily: a double-edged sword.
  Journal
Nat Rev Immunol 3:745-56 (2003)
DOI:10.1038/nri1184
Reference
PMID:12189384
  Authors
Ashkenazi A
  Title
Targeting death and decoy receptors of the tumour-necrosis factor superfamily.
  Journal
Nat Rev Cancer 2:420-30 (2002)
DOI:10.1038/nrc821
Reference
PMID:26115564
  Authors
Seeger P, Musso T, Sozzani S
  Title
The TGF-beta superfamily in dendritic cell biology.
  Journal
Cytokine Growth Factor Rev 26:647-57 (2015)
DOI:10.1016/j.cytogfr.2015.06.002
Reference
PMID:23612460
  Authors
Wakefield LM, Hill CS
  Title
Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer.
  Journal
Nat Rev Cancer 13:328-41 (2013)
DOI:10.1038/nrc3500
Reference
PMID:22710174
  Authors
Mueller TD, Nickel J
  Title
Promiscuity and specificity in BMP receptor activation.
  Journal
FEBS Lett 586:1846-59 (2012)
DOI:10.1016/j.febslet.2012.02.043
KO pathway
ko04060   

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