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Entry |
Name |
Definition |
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N00041
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EGFR-overexpression to RAS-ERK signaling pathway
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EGFR* → GRB2 → SOS → RAS → RAF → MEK → ERK
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N00042
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EGFR-overexpression to PI3K signaling pathway
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EGFR* → PI3K → PIP3 → AKT → MTOR → S6K
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N00043
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HGF-MET-PI3K signaling pathway
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HGF → MET → GAB1 → PI3K → PIP3 → AKT ⊣ BAD
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N00044
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Mutation-activated MET to PI3K signaling pathway
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MET* → GAB1 → PI3K → PIP3 → AKT ⊣ BAD
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N00045
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KITLG-KIT-PI3K signaling pathway
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KITLG → KIT → PI3K → PIP3 → AKT → MTOR → S6K
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N00046
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Mutation-activated KIT to PI3K signaling pathway
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KIT* → PI3K → PIP3 → AKT ⊣ BAD
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N00047
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EML4-ALK fusion kinase to PI3K signaling pathway
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EML4-ALK → PI3K → PIP3 → AKT ⊣ BAD
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N00048
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BCR-ABL fusion kinase to PI3K signaling pathway
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BCR-ABL → (CRKL+CBL+CRK) → PI3K → PIP3 → AKT ⊣ BAD
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N00049
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Mutation-activated PI3K to PI3K signaling pathway
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PI3K* → PIP3 → AKT → MTOR → S6K
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N00050
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Amplified PI3K to PI3K signaling pathway
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PI3K* → PIP3 → AKT → MTOR → S6K
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N00051
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Deleted PTEN to PI3K signaling pathway
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PTEN* ⌿ PIP3 → AKT
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N00052
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Mutation-inactivated PTEN to PI3K signaling pathway
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PTEN* ⌿ PIP3 → AKT
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N00053
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Cytokine-Jak-STAT signaling pathway
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Cytokine → Receptor → JAK → STAT ⇒ PIM1
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N00054
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Duplication or mutation-activated FLT3 to Jak-STAT signaling pathway
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FLT3* → STAT5 ⇒ PIM1/2
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N00055
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BCR-ABL fusion kinase to Jak-STAT signaling pathway
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BCR-ABL → STAT5 ⇒ BCL2L1
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N00056
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Wnt signaling pathway
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WNT → (FZD+LRP5/6) → (DVL+FRAT) ⊣ (GSK3B+AXIN+APC) ⊣ CTNNB1 → TCF/LEF ⇒ (MYC,CCND1)
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N00057
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Mutation-inactivated APC to Wnt signaling pathway
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(GSK3B+AXIN) ⌿ APC* ⌿ CTNNB1 → TCF/LEF ⇒ (BIRC5,MYC,CCND1)
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N00058
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Mutation-activated CTNNB1 to Wnt signaling pathway
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(GSK3B+AXIN+APC) ⌿ CTNNB1* → TCF/LEF ⇒ (BIRC5,MYC,CCND1)
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N00059
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FZD7-overexpression to Wnt signaling pathway
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WNT → (FZD7*+LRP5/6) → (DVL+FRAT) ⊣ (GSK3B+AXIN+APC) ⊣ CTNNB1 → TCF/LEF ⇒ (MYC,CCND1)
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N00060
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LRP6-overexpression to Wnt signaling pathway
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WNT → (FZD+LRP6*) → (DVL+FRAT) ⊣ (GSK3B+AXIN+APC) ⊣ CTNNB1 → TCF/LEF ⇒ (MYC,CCND1)
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N00061
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CDH1-reduced expression to beta-catenin signaling pathway
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CDH1* ⌿ CTNNB1 → TCF/LEF ⇒ (MYC,CCND1)
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N00062
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Hedgehog signaling pathway
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HH → PTCH ⌿ SMO → (SMO+EVC) → (SUFU+KIF7) ⌿ GLI ⇒ (GLI1,PTCH,HHIP)
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N00063
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TGF-beta signaling pathway
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TGFB → (TGFBR2+TGFBR1) → (SMAD2,SMAD3) == SMAD4
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N00064
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Mutation-inactivated TGFBR2 to TGF-beta signaling pathway
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(TGFBR2*+TGFBR1) ⌿ (SMAD2,SMAD3)
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N00065
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Mutation-inactivated SMAD2 to TGF-beta signaling pathway
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(TGFBR2+TGFBR1) ⌿ (SMAD2*,SMAD3)
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N00066
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MDM2-p21-Cell cycle G1/S
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CDKN2A ⊣ MDM2 ⊣ TP53 ⇒ CDKN1A ⊣ (CCND+CDK4/6) → RB1 ⌿ E2F
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N00067
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Deleted p14(ARF) to p21-cell cycle G1/S
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CDKN2A* ⌿ MDM2 ⊣ TP53 ⇒ CDKN1A ⊣ (CCND+CDK4/6) → RB1 ⌿ E2F
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N00068
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Amplified MDM2 to p21-cell cycle G1/S
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MDM2* ⊣ TP53 ⇒ CDKN1A ⊣ (CCND+CDK4/6) → RB1 ⌿ E2F
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N00069
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p16-Cell cycle G1/S
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CDKN2A ⊣ (CCND+CDK4/6) → RB1 ⌿ E2F
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N00070
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Mutation-inactivated p16(INK4a) to p16-cell cycle G1/S
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CDKN2A* ⌿ (CCND+CDK4/6) → RB1 ⌿ E2F
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N00071
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Deleted p16(INK4a) to p16-cell cycle G1/S
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CDKN2A* ⌿ (CCND+CDK4/6) → RB1 ⌿ E2F
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N00072
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Amplified CDK4 to cell cycle G1/S
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(CCND+CDK4*) → RB1 ⌿ E2F
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N00073
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Mutation-activated CDK4 to cell cycle G1/S
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(CCND+CDK4*) → RB1 ⌿ E2F
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N00074
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Loss of RB1 to cell cycle G1/S
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RB1* ⌿ E2F
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N00075
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Mutation-inactivated RB1 to cell cycle G1/S
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RB1* ⌿ E2F
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N00076
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Mutation-inactivated p14(ARF) to p21-cell cycle G1/S
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CDKN2A* ⌿ MDM2 ⊣ TP53 ⇒ CDKN1A ⊣ (CCND+CDK4/6) → RB1 ⌿ E2F
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N00077
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HRAS-overexpression to ERK signaling pathway
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HRAS* → RAF → MEK → ERK → MSK1 → MYC
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N00078
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Mutation-activated HRAS to ERK signaling pathway
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HRAS* → RAF → MEK → ERK → MSK1 → MYC
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N00079
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HIF-1 signaling pathway
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HIF1A == ARNT ⇒ (SLC2A1,VEGFA,TGFB,PDGFB,TGFA)
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N00080
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Loss of VHL to HIF-1 signaling pathway
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(VHL*+RBX1+ELOC+ELOB+CUL2) ⌿ HIF1A == ARNT ⇒ (SLC2A1,VEGFA,TGFB,PDGFB,TGFA)
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