KEGG   ORTHOLOGY: K04519
Entry
K04519                      KO                                     

Name
IL1B
Definition
interleukin 1 beta
Pathway
map01523  Antifolate resistance
map04010  MAPK signaling pathway
map04060  Cytokine-cytokine receptor interaction
map04064  NF-kappa B signaling pathway
map04217  Necroptosis
map04380  Osteoclast differentiation
map04620  Toll-like receptor signaling pathway
map04621  NOD-like receptor signaling pathway
map04623  Cytosolic DNA-sensing pathway
map04625  C-type lectin receptor signaling pathway
map04640  Hematopoietic cell lineage
map04657  IL-17 signaling pathway
map04659  Th17 cell differentiation
map04668  TNF signaling pathway
map04750  Inflammatory mediator regulation of TRP channels
map04932  Non-alcoholic fatty liver disease
map04933  AGE-RAGE signaling pathway in diabetic complications
map04940  Type I diabetes mellitus
map05010  Alzheimer disease
map05020  Prion disease
map05022  Pathways of neurodegeneration - multiple diseases
map05130  Pathogenic Escherichia coli infection
map05131  Shigellosis
map05132  Salmonella infection
map05133  Pertussis
map05134  Legionellosis
map05135  Yersinia infection
map05140  Leishmaniasis
map05142  Chagas disease
map05143  African trypanosomiasis
map05144  Malaria
map05146  Amoebiasis
map05152  Tuberculosis
map05162  Measles
map05163  Human cytomegalovirus infection
map05164  Influenza A
map05168  Herpes simplex virus 1 infection
map05171  Coronavirus disease - COVID-19
map05321  Inflammatory bowel disease
map05323  Rheumatoid arthritis
map05332  Graft-versus-host disease
map05417  Lipid and atherosclerosis
map05418  Fluid shear stress and atherosclerosis
Disease
H01492  Systemic sclerosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04519  IL1B; interleukin 1 beta
   04064 NF-kappa B signaling pathway
    K04519  IL1B; interleukin 1 beta
   04668 TNF signaling pathway
    K04519  IL1B; interleukin 1 beta
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K04519  IL1B; interleukin 1 beta
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    K04519  IL1B; interleukin 1 beta
 09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    K04519  IL1B; interleukin 1 beta
   04620 Toll-like receptor signaling pathway
    K04519  IL1B; interleukin 1 beta
   04621 NOD-like receptor signaling pathway
    K04519  IL1B; interleukin 1 beta
   04623 Cytosolic DNA-sensing pathway
    K04519  IL1B; interleukin 1 beta
   04625 C-type lectin receptor signaling pathway
    K04519  IL1B; interleukin 1 beta
   04659 Th17 cell differentiation
    K04519  IL1B; interleukin 1 beta
   04657 IL-17 signaling pathway
    K04519  IL1B; interleukin 1 beta
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K04519  IL1B; interleukin 1 beta
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K04519  IL1B; interleukin 1 beta
 09160 Human Diseases
  09172 Infectious disease: viral
   05171 Coronavirus disease - COVID-19
    K04519  IL1B; interleukin 1 beta
   05164 Influenza A
    K04519  IL1B; interleukin 1 beta
   05162 Measles
    K04519  IL1B; interleukin 1 beta
   05168 Herpes simplex virus 1 infection
    K04519  IL1B; interleukin 1 beta
   05163 Human cytomegalovirus infection
    K04519  IL1B; interleukin 1 beta
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    K04519  IL1B; interleukin 1 beta
   05132 Salmonella infection
    K04519  IL1B; interleukin 1 beta
   05131 Shigellosis
    K04519  IL1B; interleukin 1 beta
   05135 Yersinia infection
    K04519  IL1B; interleukin 1 beta
   05133 Pertussis
    K04519  IL1B; interleukin 1 beta
   05134 Legionellosis
    K04519  IL1B; interleukin 1 beta
   05152 Tuberculosis
    K04519  IL1B; interleukin 1 beta
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    K04519  IL1B; interleukin 1 beta
   05144 Malaria
    K04519  IL1B; interleukin 1 beta
   05140 Leishmaniasis
    K04519  IL1B; interleukin 1 beta
   05142 Chagas disease
    K04519  IL1B; interleukin 1 beta
   05143 African trypanosomiasis
    K04519  IL1B; interleukin 1 beta
  09163 Immune disease
   05323 Rheumatoid arthritis
    K04519  IL1B; interleukin 1 beta
   05321 Inflammatory bowel disease
    K04519  IL1B; interleukin 1 beta
   05332 Graft-versus-host disease
    K04519  IL1B; interleukin 1 beta
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K04519  IL1B; interleukin 1 beta
   05020 Prion disease
    K04519  IL1B; interleukin 1 beta
   05022 Pathways of neurodegeneration - multiple diseases
    K04519  IL1B; interleukin 1 beta
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K04519  IL1B; interleukin 1 beta
   05418 Fluid shear stress and atherosclerosis
    K04519  IL1B; interleukin 1 beta
  09167 Endocrine and metabolic disease
   04940 Type I diabetes mellitus
    K04519  IL1B; interleukin 1 beta
   04932 Non-alcoholic fatty liver disease
    K04519  IL1B; interleukin 1 beta
   04933 AGE-RAGE signaling pathway in diabetic complications
    K04519  IL1B; interleukin 1 beta
  09176 Drug resistance: antineoplastic
   01523 Antifolate resistance
    K04519  IL1B; interleukin 1 beta
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and growth factors
    K04519  IL1B; interleukin 1 beta
   00536 Glycosaminoglycan binding proteins
    K04519  IL1B; interleukin 1 beta
Cytokines and growth factors [BR:ko04052]
 Cytokines
  Interleukins
   K04519  IL1B; interleukin 1 beta
Glycosaminoglycan binding proteins [BR:ko00536]
 Heparan sulfate / Heparin
  Cytokines
   K04519  IL1B; interleukin 1 beta
Other DBs
GO: 0005149
Genes
HSA: 3553(IL1B)
PTR: 450200(IL1B)
PPS: 100993613(IL1B)
GGO: 101130571(IL1B)
PON: 100454379(IL1B)
NLE: 100587357(IL1B)
MCC: 704701(IL1B)
MCF: 102119749(IL1B)
CSAB: 103241278(IL1B)
CATY: 105591123(IL1B)
PANU: 101023446(IL1B)
RRO: 104672547(IL1B)
RBB: 108541809(IL1B)
TFN: 117062188(IL1B)
PTEH: 111528224(IL1B)
CJC: 100406769(IL1B)
SBQ: 101033664(IL1B)
MMUR: 105859190(IL1B)
MMU: 16176(Il1b)
MCAL: 110290100(Il1b)
MPAH: 110319321(Il1b)
RNO: 24494(Il1b)
MCOC: 116090916(Il1b)
MUN: 110551400(Il1b)
CGE: 100775079(Il1b)
PLEU: 114709520(Il1b)
NGI: 103739899(Il1b)
HGL: 101704309(Il1b)
CCAN: 109701168(Il1b)
OCU: 100008990(IL1B)
TUP: 102475138(IL1B)
CFA: 403974(IL1B)
VVP: 112916797(IL1B)
VLG: 121490494(IL1B)
AML: 100480874(IL1B)
UMR: 103671495(IL1B)
UAH: 113242506(IL1B)
ORO: 101383005(IL1B)
ELK: 111158456
MPUF: 101688006(IL1B)
EJU: 114223431(IL1B)
MLX: 118007867(IL1B)
FCA: 768274(IL1B)
PTG: 102951272(IL1B)
PPAD: 109264508(IL1B)
AJU: 106976013(IL1B)
HHV: 120231517(IL1B)
BTA: 281251(IL1B)
BOM: 102282890(IL1B)
BIU: 109566133(IL1B)
BBUB: 102396262(IL1B)
CHX: 100860816(IL1B)
OAS: 443539(IL1B)
ODA: 120851459(IL1B)
SSC: 396565(IL1B2) 397122(IL1B)
CFR: 102521979(IL1B)
CDK: 105093155(IL1B)
BACU: 103008438(IL1B)
LVE: 103090784(IL1B)
OOR: 101284892(IL1B)
DLE: 111187492(IL1B)
PCAD: 102994188(IL1B)
ECB: 100034237(IL1B) 100052414(IL1B) 111768185
EPZ: 103544835(IL1B)
EAI: 106838557(IL1B)
MYB: 102251576(IL1B)
MYD: 102769803(IL1B)
MMYO: 118657544(IL1B)
MNA: 107528631(IL1B)
HAI: 109393524(IL1B)
DRO: 112302944(IL1B)
SHON: 118981894(IL1B)
AJM: 119045049 119065847(IL1B)
MMF: 118630740(IL1B)
PALE: 102893238(IL1B)
RAY: 107514900(IL1B)
MJV: 108393034(IL1B)
TOD: 119259188(IL1B)
LAV: 100674746(IL1B)
TMU: 101359415(IL1B)
MDO: 100026024(IL1B)
SHR: 100922350(IL1B)
PCW: 110192539(IL1B)
OAA: 103165286
GGA: 395196(IL1B)
PCOC: 116231323
MGP: 100034741(IL1RN)
CJO: 107323637
NMEL: 110387108
TGU: 100227014(IL1B)
LSR: 110478285(IL1B)
SCAN: 103822662(IL1B)
PMOA: 120505484(IL1B)
GFR: 102041770(IL1B)
FAB: 101819115(IL1B)
PHI: 102108659(IL1B)
PMAJ: 107213896
CCAE: 111938925
CCW: 104683159
ETL: 114070272(IL1B)
FPG: 101924267
FCH: 102050776
CLV: 102090585(IL1B)
EGZ: 104132895(IL1RN)
NNI: 104022599
ACUN: 113488139
PADL: 103912923
AMJ: 102570262(IL1B) 102575353
CPOO: 109313276
PSS: 102448244
CPIC: 101943587(IL1B) 101949861
PVT: 110072197(IL1B)
PBI: 103055254(IL1B)
PMUR: 107283245(IL1B)
TSR: 106544675
PMUA: 114603303(IL1B)
ZVI: 118086854 118087328(IL1B)
GJA: 107118765
XLA: 108711577(il1b.L) 108712739 373606(il1b.S)
XTR: 100487038(il1b) 116409784
DRE: 405770(il1b)
IPU: 100304696(il1b) 100304697(il1b)
PHYP: 113544737
EEE: 113584063
TRU: 101080001(il1b)
LCO: 104923462
NCC: 104948030 104955090(il1b)
ELY: 117252862
PLEP: 121944262
SLUC: 116054171
ECRA: 117944585
PFLV: 114555628(il1b)
GAT: 120831355(il1b)
MSAM: 119914255(il1b)
CUD: 121510460
OLA: 101169209
OML: 112148302
CTUL: 119791888
NFU: 107386182
KMR: 108242738(il1b)
ALIM: 106510763(il1b) 106522184
HCQ: 109513432
BPEC: 110166705 110172087(il1b)
LCM: 102364535
CMK: 103187802
 » show all
Reference
PMID:6083565
  Authors
Auron PE, Webb AC, Rosenwasser LJ, Mucci SF, Rich A, Wolff SM, Dinarello CA
  Title
Nucleotide sequence of human monocyte interleukin 1 precursor cDNA.
  Journal
Proc Natl Acad Sci U S A 81:7907-11 (1984)
DOI:10.1073/pnas.81.24.7907
  Sequence
[hsa:3553]
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