KEGG ORTHOLOGY: K04519

ORTHOLOGY: K04519

Entry

K04519                      KO

Symbol

IL1B

Name

interleukin 1 beta

Pathway

map01523

Antifolate resistance

map04010

MAPK signaling pathway

map04060

Cytokine-cytokine receptor interaction

map04064

NF-kappa B signaling pathway

map04217

Necroptosis

map04380

Osteoclast differentiation

map04620

Toll-like receptor signaling pathway

map04621

NOD-like receptor signaling pathway

map04623

Cytosolic DNA-sensing pathway

map04625

C-type lectin receptor signaling pathway

map04640

Hematopoietic cell lineage

map04657

IL-17 signaling pathway

map04659

Th17 cell differentiation

map04668

TNF signaling pathway

map04750

Inflammatory mediator regulation of TRP channels

map04932

Non-alcoholic fatty liver disease

map04933

AGE-RAGE signaling pathway in diabetic complications

map04936

Alcoholic liver disease

map04940

Type I diabetes mellitus

map05010

Alzheimer disease

map05020

Prion disease

map05022

Pathways of neurodegeneration - multiple diseases

map05130

Pathogenic Escherichia coli infection

map05131

Shigellosis

map05132

Salmonella infection

map05133

Pertussis

map05134

Legionellosis

map05135

Yersinia infection

map05140

Leishmaniasis

map05142

Chagas disease

map05143

African trypanosomiasis

map05144

Malaria

map05146

Amoebiasis

map05152

Tuberculosis

map05162

Measles

map05163

Human cytomegalovirus infection

map05164

Influenza A

map05168

Herpes simplex virus 1 infection

map05171

Coronavirus disease - COVID-19

map05321

Inflammatory bowel disease

map05323

Rheumatoid arthritis

map05332

Graft-versus-host disease

map05417

Lipid and atherosclerosis

map05418

Fluid shear stress and atherosclerosis

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04519  IL1B; interleukin 1 beta
   04064 NF-kappa B signaling pathway
    K04519  IL1B; interleukin 1 beta
   04668 TNF signaling pathway
    K04519  IL1B; interleukin 1 beta
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K04519  IL1B; interleukin 1 beta
09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    K04519  IL1B; interleukin 1 beta
09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    K04519  IL1B; interleukin 1 beta
   04620 Toll-like receptor signaling pathway
    K04519  IL1B; interleukin 1 beta
   04621 NOD-like receptor signaling pathway
    K04519  IL1B; interleukin 1 beta
   04623 Cytosolic DNA-sensing pathway
    K04519  IL1B; interleukin 1 beta
   04625 C-type lectin receptor signaling pathway
    K04519  IL1B; interleukin 1 beta
   04659 Th17 cell differentiation
    K04519  IL1B; interleukin 1 beta
   04657 IL-17 signaling pathway
    K04519  IL1B; interleukin 1 beta
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K04519  IL1B; interleukin 1 beta
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K04519  IL1B; interleukin 1 beta
09160 Human Diseases
  09172 Infectious disease: viral
   05171 Coronavirus disease - COVID-19
    K04519  IL1B; interleukin 1 beta
   05164 Influenza A
    K04519  IL1B; interleukin 1 beta
   05162 Measles
    K04519  IL1B; interleukin 1 beta
   05168 Herpes simplex virus 1 infection
    K04519  IL1B; interleukin 1 beta
   05163 Human cytomegalovirus infection
    K04519  IL1B; interleukin 1 beta
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    K04519  IL1B; interleukin 1 beta
   05132 Salmonella infection
    K04519  IL1B; interleukin 1 beta
   05131 Shigellosis
    K04519  IL1B; interleukin 1 beta
   05135 Yersinia infection
    K04519  IL1B; interleukin 1 beta
   05133 Pertussis
    K04519  IL1B; interleukin 1 beta
   05134 Legionellosis
    K04519  IL1B; interleukin 1 beta
   05152 Tuberculosis
    K04519  IL1B; interleukin 1 beta
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    K04519  IL1B; interleukin 1 beta
   05144 Malaria
    K04519  IL1B; interleukin 1 beta
   05140 Leishmaniasis
    K04519  IL1B; interleukin 1 beta
   05142 Chagas disease
    K04519  IL1B; interleukin 1 beta
   05143 African trypanosomiasis
    K04519  IL1B; interleukin 1 beta
  09163 Immune disease
   05323 Rheumatoid arthritis
    K04519  IL1B; interleukin 1 beta
   05321 Inflammatory bowel disease
    K04519  IL1B; interleukin 1 beta
   05332 Graft-versus-host disease
    K04519  IL1B; interleukin 1 beta
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K04519  IL1B; interleukin 1 beta
   05020 Prion disease
    K04519  IL1B; interleukin 1 beta
   05022 Pathways of neurodegeneration - multiple diseases
    K04519  IL1B; interleukin 1 beta
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K04519  IL1B; interleukin 1 beta
   05418 Fluid shear stress and atherosclerosis
    K04519  IL1B; interleukin 1 beta
  09167 Endocrine and metabolic disease
   04940 Type I diabetes mellitus
    K04519  IL1B; interleukin 1 beta
   04936 Alcoholic liver disease
    K04519  IL1B; interleukin 1 beta
   04932 Non-alcoholic fatty liver disease
    K04519  IL1B; interleukin 1 beta
   04933 AGE-RAGE signaling pathway in diabetic complications
    K04519  IL1B; interleukin 1 beta
  09176 Drug resistance: antineoplastic
   01523 Antifolate resistance
    K04519  IL1B; interleukin 1 beta
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides
    K04519  IL1B; interleukin 1 beta
   00536 Glycosaminoglycan binding proteins
    K04519  IL1B; interleukin 1 beta
Cytokines and neuropeptides [BR:ko04052]
Cytokines
  Interleukins
   K04519  IL1B; interleukin 1 beta
Glycosaminoglycan binding proteins [BR:ko00536]
Heparan sulfate / Heparin
  Cytokines
   K04519  IL1B; interleukin 1 beta

Other DBs

GO:

0005149

Genes

HSA:	3553(IL1B)

PTR:	450200(IL1B)

PPS:	100993613(IL1B)

GGO:	101130571(IL1B)

PON:	100454379(IL1B)

PPYG:

129030333(IL1B)

NLE:	100587357(IL1B)

HMH:	116483283(IL1B)

SSYN:

129462037(IL1B)

MCC:	704701(IL1B)

MCF:	102119749(IL1B)

MTHB:

126933366

MNI:	105471787(IL1B)

CSAB:

103241278(IL1B)

CATY:

105591123(IL1B)

PANU:

101023446(IL1B)

TGE:	112604696(IL1B)

MLEU:

105530451(IL1B)

RRO:	104672547(IL1B)

RBB:	108541809(IL1B)

TFN:	117062188(IL1B)

PTEH:

111528224(IL1B)

CANG:

105519632(IL1B)

CJC:	100406769(IL1B)

SBQ:	101033664(IL1B)

CIMI:

108318634(IL1B)

ANAN:

105704925(IL1B)

CSYR:

103259440(IL1B)

MMUR:

105859190(IL1B)

LCAT:

123637166(IL1B)

PCOQ:

105820326(IL1B)

OGA:	100944877(IL1B)

MMU:	16176(Il1b)

MCAL:

110290100(Il1b)

MPAH:

110319321(Il1b)

RNO:	24494(Il1b)

MCOC:

116090916(Il1b)

ANU:	117704054(Il1b)

ASYL:

127685905(Il1b)

MUN:	110551400(Il1b)

CGE:	100775079(Il1b)

MAUA:

101839008(Il1b)

PROB:

127221462(Il1b)

PLEU:

114709520(Il1b)

MORG:

121460531(Il1b)

MFOT:

126496850

AAMP:

119814887(Il1b)

NGI:	103739899(Il1b)

HGL:	101704309(Il1b)

CPOC:

100135556(Il1b)

CCAN:

109701168(Il1b)

DORD:

105988300(Il1b)

DSP:	122100606(Il1b)

DMER:

138821217(Il1b)

PLOP:

125356827(Il1b)

MMMA:

107154164(Il1b)

ITI:	101963670(Il1b)

OCU:	100008990(IL1B)

OPI:	101529213(IL1B)

TUP:	102475138(IL1B)

GVR:	103595825(IL1B)

CFA:	403974(IL1B)

CLUD:

112664386(IL1B)

VVP:	112916797(IL1B)

VLG:	121490494(IL1B)

NPO:	129510730(IL1B)

AML:	100480874(IL1B)

UMR:	103671495(IL1B)

UAH:	113242506(IL1B)

UAR:	123799741(IL1B)

ELK:

111158456

LLV:

125109148

MPUF:

101688006(IL1B)

MNP:	132022474(IL1B)

MLK:	131840429(IL1B)

NVS:	122915760(IL1B)

ORO:	101383005(IL1B)

EJU:	114223431(IL1B)

ZCA:	113937839(IL1B)

MLX:	118007867(IL1B)

NSU:	110587160(IL1B)

LWW:	102739919(IL1B)

FCA:	768274(IL1B)

PYU:	121044460(IL1B)

PCOO:

112864068(IL1B)

PBG:	122497169(IL1B)

PVIV:

125162335(IL1B)

LRUF:

124503033

LGF:	123581110(IL1B)

AJU:

106976013

PTG:	102951272(IL1B)

PPAD:

109264508(IL1B)

PUC:

125937410

PLEZ:

122216319(IL1B)

HHV:	120231517(IL1B)

BTA:	281251(IL1B)

BOM:	102282890(IL1B)

BIU:	109566133(IL1B)

BBUB:

102396262(IL1B)

BBIS:

104984411(IL1B)

CHX:	100860816(IL1B)

OAS:	443539(IL1B)

BTAX:

128056569(IL1B)

CSUM:

138081260(IL1B)

ODA:	120851459(IL1B)

CCAD:

122441784(IL1B)

MREE:

136162876(IL1B)

OVR:	110132571(IL1B)

MBEZ:

129539906(IL1B)

SSC:	396565(IL1B2) 397122(IL1B)

CFR:	102521979(IL1B)

CBAI:

105072137(IL1B)

CDK:	105093155(IL1B)

VPC:	102529565(IL1B)

BACU:

103008438(IL1B)

BMUS:

118906007(IL1B)

LVE:	103090784(IL1B)

OOR:	101284892(IL1B)

LALB:

132531226(IL1B)

GMF:	115842455(IL1B)

DDP:	132435596(IL1B)

DLE:	111187492(IL1B)

PCAD:

102994188(IL1B)

PSIU:

116764546(IL1B)

PPHC:

136134031(IL1B)

NASI:

112398981(IL1B)

ECB:	100034237(IL1B) 100052414(IL1B) 111768185

EPZ:	103544835 103545473 139075665

EAI:	106838557 123286234 123286693

MYB:	102251576(IL1B)

MYD:	102769803(IL1B)

MMYO:

118657544(IL1B)

MLF:	102427189(IL1B)

MDT:	132213110(IL1B)

MYUM:

139019504(IL1B)

PKL:	118717646(IL1B)

EFUS:

103303246(IL1B)

MNA:	107528631(IL1B)

DRO:	112302944(IL1B)

SHON:

118981894(IL1B)

AJM:	119065847(IL1B)

PDIC:

114500536(IL1B)

PHAS:

123811854(IL1B)

MMF:	118630740(IL1B)

PPAM:

129072126(IL1B)

HAI:	109393524(IL1B)

RFQ:	117019267(IL1B)

PALE:

102893238(IL1B)

PGIG:

120593744(IL1B)

PVP:	105303982(IL1B)

RAY:	107514900(IL1B)

MJV:	108393034(IL1B)

TOD:	119259188(IL1B)

SARA:

101550075(IL1B)

SFUM:

130036776(IL1B)

SETR:

126024019(IL1B)

LAV:	100674746(IL1B)

TMU:	101359415(IL1B)

ETF:	101639333(IL1B)

DNM:	101445167(IL1B)

MDO:	100026024(IL1B)

GAS:	123234542(IL1B)

SHR:	100922350(IL1B)

AFZ:

127547601

PCW:	110192539(IL1B)

TVP:	118844336(IL1B)

PBRV:

138160790(IL1B)

OAA:

103165286

TACU:

119934295

GGA:	395196(IL1B)

PCOC:

116231323

MGP:	100034741(IL1RN)

CJO:

TPAI:

LMUT:

NMEL:

APLA:

ACYG:

CATA:

AFUL:

TGU:	100227014(IL1B)

LSR:

110478285

SCAN:

103822662(IL1B)

PMOA:

120505484(IL1B)

OTC:	121346759(IL1B)

PRUF:

121359483(IL1B)

ATRC:

139585184(IL1B)

GFR:	102041770(IL1B)

FAB:	101819115(IL1B)

OMA:	130262009 130266786

PHI:	102108659(IL1B)

PMAJ:

107213896

CCAE:

111938925

CCW:

104683159

CBRC:

103620337(IL1B)

ACOE:

138121709(IL1B)

ETL:	114070272(IL1B)

ZAB:	102073217(IL1B)

ZLE:	135456829(IL1B)

ACHL:

103811428(IL1B)

SVG:

MMEA:

HRT:

SATI:

CCIC:

134054759(IL1B)

FPG:

FCH:

CCRI:

NNT:

SHAB:

ACUN:

TALA:

104368503(IL1B)

ACHC:

HALD:

HLE:

AGEN:

HHAR:

GCL:

CSTI:

LDI:

MNB:

DPUB:

PPUS:

AVIT:

104272583(IL1B)

BRHI:

104500195(IL1B)

EGZ:

NNI:

PCRI:

PADL:

AFOR:

FGA:

CBOY:

CLV:	102090585(IL1B)

CNIC:

135998428

MUI:

104548801

PGUU:

104467681(IL1B)

PLET:

EHS:

CMAC:

CUCA:

TEO:	104374678(IL1B)

BREG:

OHA:

ACAR:

CPEA:

CVF:

RTD:

CRID:

AROW:

NPD:	112950535(IL1B)

DNE:	112994425(IL1B)

SCAM:

104148037(IL1B)

ASN:	102369595 112547978

AMJ:	102570262(IL1B) 102575353

CPOO:

109313276

PSS:

102448244

CMY:	102933972 102936298

CCAY:

125626289 125626342

DCC:	119848579 119848666

CPIC:

101943587(IL1B) 101949861

TST:	117872809 117872810

CABI:

116830711 116830722

MRV:	120397289 120399668

ASAO:

132782531(IL1B)

PVT:	110072197(IL1B)

SUND:

121932679(IL1B)

PBI:	103055254(IL1B)

PMUR:

107283245(IL1B)

CTIG:

120299419(IL1B)

TSR:

106544675

PGUT:

117658770 117673364 117677036

APRI:

131203631(IL1B)

PTEX:

113445875(IL1B)

NSS:	113423381(IL1B)

VKO:

123016817

PMUA:

114603303(IL1B)

PRAF:

128418163(IL1B)

ZVI:	118086854 118087328(IL1B)

HCG:	128333860(IL1B)

GJA:

107118765

STOW:

125441435

EMC:

129342322

XLA:	108711577(il1b.L) 108712739 373606(il1b.S)

XTR:	100487038(il1b) 116409784

NPR:	108785587 108785600

RTEM:

120933040 120933041 120933042(IL1B) 120933043

ACAT:

141133035 141133038 141133039 141134662

BBUF:

120986198 120986199 120986200

BGAR:

122927371 122929456 122929457(IL1B) 122929458 122929573

DTC:	141100304 141100306 141100307 141100310

PWL:	138266020 138266021 138266022 138266667

MUO:	115468080 115469252 115469253

GSH:	117362183 117362184 117362929

DRE:	405770(il1b)

SRX:	107706800 107735843

SANH:

107658569 107682454

SGH:	107554524 107581079 107589025

CCAR:

109062992(il1b) 109062994

CAUA:

113054665 113054687 113110504 113110505 113110506 113110507

CGIB:

127966795 128020778

PTET:

122333704(il1b)

LROH:

127172414(il1b)

OMC:	131548225(il1b)

PPRM:

120483159(il1b)

RKG:	130094933(il1b)

MAMB:

125262403 125262404

CIDE:

127520202

CERY:

137028548 137029421 137029422 137029423 137029424

MASI:

127432610 127433909

TROS:

130545717(il1b)

TDW:	130411792(il1b)

MANU:

129447053(il1b)

PDAB:

135739515(il1b)

IPU:	100304696 100304697

IFU:	128620209 128620859

PHYP:

113544737

SMEO:

124393376 124393511

TFD:	113635102 113638324(il1b) 113638465

TVC:	132863169 132863177 132863678

CGAR:

128545454(il1b)

NGRA:

132873305 132873542 132873705 132873725 132873737 132873765 132873794

TRN:	134332261(il1b)

AMEX:

103026214 111194997

CMAO:

118824594 118824620(il1b)

EEE:

113584063

CHAR:

105904765 105904955 116222824 116222930

SPIL:

134101127 134101128(il1b)

TRU:	101080001(il1b)

TFS:	130525376(il1b)

LCO:

104923462

NCC:	104955090(il1b)

TBEN:

117473213

CGOB:

115013355(il1b)

PGEO:

GACU:

EMAC:

ELY:

EFO:

PLEP:

SLUC:

ECRA:

ESP:	116689682(il1b)

PFLV:

114555628(il1b)

GAT:	120831355(il1b)

PPUG:

119225143

AFB:	129100909 129100910 129115985

CLUM:

PSWI:

CANA:

CVE:

SCHU:

CUD:

SPUL:

LMIX:

ALAT:

ASTR:

137592337(il1b)

MZE:	101472948 101473431 101481848 101485031

ONL:	100693282 100707066 100707443

OAU:	116313583 116333631

OLA:

101169209

OML:

112148302

CSAI:

133450972

XMA:	102231459 106700093 111610322

XCO:	114149066 114153988 114155120

XHE:	116730467 116730468

PRET:

PFOR:

PLAI:

PMEI:

GAF:	122828498 122828499

PPRL:

129365681 129365750

CVG:	107099154 107099476

CTUL:

119791888

GMU:	124877334 124877353

NFU:

107386182

KMR:	108242738(il1b)

ALIM:

106510763(il1b) 106522184

NWH:	119413167(il1b)

AOCE:

EJA:

BFRE:

MCEP:

CSEM:

103389940 103396898 103397875

POV:	109626174 109641260

SSEN:

SSOE:

HHIP:

HSP:

PPLT:

SMAU:

LCF:	108878374 108895307(il1b)

SDU:	111227981 111227984 111239668

SLAL:

111659489 111660942 111660964 111666074

XGL:	120805320 120805321 120806021(il1b)

HCQ:

109513432

SSCV:

125994186(il1b)

SBIA:

133498794(il1b)

PEE:	133400081(il1b)

PTAO:

133474935(il1b)

BPEC:

110166705 110172087(il1b)

ENY:

140346383

MALB:

109951327 109953309

BSPL:

114863211

SJO:	128364550 128364850 128364851 128364852

SSCO:

133978896 133978958 133978968

GMH:

115546067

SASA:

100136449 106562915(IL-1b3) 106570815

STRU:

115164103 115200532(il1b) 115203800

OTW:	112219797(il1b) 112230772 112248882 112262548 121838769 121847916 121847917

OMY:	100136024 110509557 110522811(il1b) 110536401

OGO:	124034025 124035292 124035294 124047941(il1b)

ONE:	115111931 115115548 115117458 115128854

OKI:	109874230 109883834 109896202

OKE:	118373089 118375506(il1b) 118393554 127911767 127911768 127911769

OMM:	135513776 135516918(il1b) 135544705 135545623

OCLA:

139388329 139389946 139409641 139412105

SALP:

111963800 111974578 112071295

SNH:	120021395 120026221(il1b) 120055353 120062835

CCLU:

121585177 121587276

ELS:	105007339 105009489

OEP:	134012105 134038662(il1b)

SFM:	108932396 108940319 114909774

PKI:	111848567 111851454

AANG:

118207102 118212525(il1b)

AROT:

135239240(il1b) 135264665

CCOG:

133105674(il1b) 133140984 133141012 133141039 133141064 133141112 133141116 133141131 133141140 133141187 133141250 133141287

PSPA:

121302061 121303108 121303111

ARUT:

117397782 117397798 117397953 117397955 117397956 117397957 117969121 117970734

LCM:

102364535

CMK:

103187802

CPLA:

122543239(il1b)

HOC:	132809349(il1b)

LERI:

129713422

HAKA:

140735377 140735382

» show all

Reference

PMID:6083565

Authors

Auron PE, Webb AC, Rosenwasser LJ, Mucci SF, Rich A, Wolff SM, Dinarello CA

Title

Nucleotide sequence of human monocyte interleukin 1 precursor cDNA.

Journal

Proc Natl Acad Sci U S A 81:7907-11 (1984)
DOI:10.1073/pnas.81.24.7907

Sequence

[hsa:3553]

LinkDB

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