KEGG   ORTHOLOGY: K04519
Entry
K04519                      KO                                     

Name
IL1B
Definition
interleukin 1 beta
Pathway
map01523  Antifolate resistance
map04010  MAPK signaling pathway
map04060  Cytokine-cytokine receptor interaction
map04064  NF-kappa B signaling pathway
map04217  Necroptosis
map04380  Osteoclast differentiation
map04620  Toll-like receptor signaling pathway
map04621  NOD-like receptor signaling pathway
map04623  Cytosolic DNA-sensing pathway
map04625  C-type lectin receptor signaling pathway
map04640  Hematopoietic cell lineage
map04657  IL-17 signaling pathway
map04659  Th17 cell differentiation
map04668  TNF signaling pathway
map04750  Inflammatory mediator regulation of TRP channels
map04932  Non-alcoholic fatty liver disease
map04933  AGE-RAGE signaling pathway in diabetic complications
map04940  Type I diabetes mellitus
map05010  Alzheimer disease
map05020  Prion disease
map05022  Pathways of neurodegeneration - multiple diseases
map05130  Pathogenic Escherichia coli infection
map05131  Shigellosis
map05132  Salmonella infection
map05133  Pertussis
map05134  Legionellosis
map05135  Yersinia infection
map05140  Leishmaniasis
map05142  Chagas disease
map05143  African trypanosomiasis
map05144  Malaria
map05146  Amoebiasis
map05152  Tuberculosis
map05162  Measles
map05163  Human cytomegalovirus infection
map05164  Influenza A
map05168  Herpes simplex virus 1 infection
map05171  Coronavirus disease - COVID-19
map05321  Inflammatory bowel disease
map05323  Rheumatoid arthritis
map05332  Graft-versus-host disease
map05417  Lipid and atherosclerosis
map05418  Fluid shear stress and atherosclerosis
Disease
H01492  Systemic sclerosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04519  IL1B; interleukin 1 beta
   04064 NF-kappa B signaling pathway
    K04519  IL1B; interleukin 1 beta
   04668 TNF signaling pathway
    K04519  IL1B; interleukin 1 beta
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K04519  IL1B; interleukin 1 beta
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    K04519  IL1B; interleukin 1 beta
 09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    K04519  IL1B; interleukin 1 beta
   04620 Toll-like receptor signaling pathway
    K04519  IL1B; interleukin 1 beta
   04621 NOD-like receptor signaling pathway
    K04519  IL1B; interleukin 1 beta
   04623 Cytosolic DNA-sensing pathway
    K04519  IL1B; interleukin 1 beta
   04625 C-type lectin receptor signaling pathway
    K04519  IL1B; interleukin 1 beta
   04659 Th17 cell differentiation
    K04519  IL1B; interleukin 1 beta
   04657 IL-17 signaling pathway
    K04519  IL1B; interleukin 1 beta
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K04519  IL1B; interleukin 1 beta
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K04519  IL1B; interleukin 1 beta
 09160 Human Diseases
  09172 Infectious disease: viral
   05171 Coronavirus disease - COVID-19
    K04519  IL1B; interleukin 1 beta
   05164 Influenza A
    K04519  IL1B; interleukin 1 beta
   05162 Measles
    K04519  IL1B; interleukin 1 beta
   05168 Herpes simplex virus 1 infection
    K04519  IL1B; interleukin 1 beta
   05163 Human cytomegalovirus infection
    K04519  IL1B; interleukin 1 beta
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    K04519  IL1B; interleukin 1 beta
   05132 Salmonella infection
    K04519  IL1B; interleukin 1 beta
   05131 Shigellosis
    K04519  IL1B; interleukin 1 beta
   05135 Yersinia infection
    K04519  IL1B; interleukin 1 beta
   05133 Pertussis
    K04519  IL1B; interleukin 1 beta
   05134 Legionellosis
    K04519  IL1B; interleukin 1 beta
   05152 Tuberculosis
    K04519  IL1B; interleukin 1 beta
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    K04519  IL1B; interleukin 1 beta
   05144 Malaria
    K04519  IL1B; interleukin 1 beta
   05140 Leishmaniasis
    K04519  IL1B; interleukin 1 beta
   05142 Chagas disease
    K04519  IL1B; interleukin 1 beta
   05143 African trypanosomiasis
    K04519  IL1B; interleukin 1 beta
  09163 Immune disease
   05323 Rheumatoid arthritis
    K04519  IL1B; interleukin 1 beta
   05321 Inflammatory bowel disease
    K04519  IL1B; interleukin 1 beta
   05332 Graft-versus-host disease
    K04519  IL1B; interleukin 1 beta
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K04519  IL1B; interleukin 1 beta
   05020 Prion disease
    K04519  IL1B; interleukin 1 beta
   05022 Pathways of neurodegeneration - multiple diseases
    K04519  IL1B; interleukin 1 beta
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K04519  IL1B; interleukin 1 beta
   05418 Fluid shear stress and atherosclerosis
    K04519  IL1B; interleukin 1 beta
  09167 Endocrine and metabolic disease
   04940 Type I diabetes mellitus
    K04519  IL1B; interleukin 1 beta
   04932 Non-alcoholic fatty liver disease
    K04519  IL1B; interleukin 1 beta
   04933 AGE-RAGE signaling pathway in diabetic complications
    K04519  IL1B; interleukin 1 beta
  09176 Drug resistance: antineoplastic
   01523 Antifolate resistance
    K04519  IL1B; interleukin 1 beta
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and growth factors
    K04519  IL1B; interleukin 1 beta
   00536 Glycosaminoglycan binding proteins
    K04519  IL1B; interleukin 1 beta
Cytokines and growth factors [BR:ko04052]
 Cytokines
  Interleukins
   K04519  IL1B; interleukin 1 beta
Glycosaminoglycan binding proteins [BR:ko00536]
 Heparan sulfate / Heparin
  Cytokines
   K04519  IL1B; interleukin 1 beta
Other DBs
GO: 0005149
Genes
HSA: 3553(IL1B)
PTR: 450200(IL1B)
PPS: 100993613(IL1B)
GGO: 101130571(IL1B)
PON: 100454379(IL1B)
NLE: 100587357(IL1B)
MCC: 704701(IL1B)
MCF: 102119749(IL1B)
CSAB: 103241278(IL1B)
CATY: 105591123(IL1B)
PANU: 101023446(IL1B)
RRO: 104672547(IL1B)
RBB: 108541809(IL1B)
TFN: 117062188(IL1B)
PTEH: 111528224(IL1B)
CJC: 100406769(IL1B)
SBQ: 101033664(IL1B)
MMUR: 105859190(IL1B)
MMU: 16176(Il1b)
MCAL: 110290100(Il1b)
MPAH: 110319321(Il1b)
RNO: 24494(Il1b)
MCOC: 116090916(Il1b)
MUN: 110551400(Il1b)
CGE: 100775079(Il1b)
PLEU: 114709520(Il1b)
NGI: 103739899(Il1b)
HGL: 101704309(Il1b)
CCAN: 109701168(Il1b)
OCU: 100008990(IL1B)
TUP: 102475138(IL1B)
CFA: 403974(IL1B)
VVP: 112916797(IL1B)
VLG: 121490494(IL1B)
AML: 100480874(IL1B)
UMR: 103671495(IL1B)
UAH: 113242506(IL1B)
ORO: 101383005(IL1B)
ELK: 111158456
MPUF: 101688006(IL1B)
EJU: 114223431(IL1B)
MLX: 118007867(IL1B)
FCA: 768274(IL1B)
PTG: 102951272(IL1B)
PPAD: 109264508(IL1B)
AJU: 106976013(IL1B)
HHV: 120231517(IL1B)
BTA: 281251(IL1B)
BOM: 102282890(IL1B)
BIU: 109566133(IL1B)
BBUB: 102396262(IL1B)
CHX: 100860816(IL1B)
OAS: 443539(IL1B)
ODA: 120851459(IL1B)
SSC: 396565(IL1B2) 397122(IL1B)
CFR: 102521979(IL1B)
CDK: 105093155(IL1B)
BACU: 103008438(IL1B)
LVE: 103090784(IL1B)
OOR: 101284892(IL1B)
DLE: 111187492(IL1B)
PCAD: 102994188(IL1B)
ECB: 100034237(IL1B) 100052414(IL1B) 111768185
EPZ: 103544835(IL1B)
EAI: 106838557(IL1B)
MYB: 102251576(IL1B)
MYD: 102769803(IL1B)
MMYO: 118657544(IL1B)
MNA: 107528631(IL1B)
HAI: 109393524(IL1B)
DRO: 112302944(IL1B)
SHON: 118981894(IL1B)
AJM: 119045049 119065847(IL1B)
MMF: 118630740(IL1B)
PALE: 102893238(IL1B)
RAY: 107514900(IL1B)
MJV: 108393034(IL1B)
TOD: 119259188(IL1B)
LAV: 100674746(IL1B)
TMU: 101359415(IL1B)
MDO: 100026024(IL1B)
SHR: 100922350(IL1B)
PCW: 110192539(IL1B)
OAA: 103165286
GGA: 395196(IL1B)
PCOC: 116231323
MGP: 100034741(IL1RN)
CJO: 107323637
NMEL: 110387108
TGU: 100227014(IL1B)
LSR: 110478285(IL1B)
SCAN: 103822662(IL1B)
PMOA: 120505484(IL1B)
GFR: 102041770(IL1B)
FAB: 101819115(IL1B)
PHI: 102108659(IL1B)
PMAJ: 107213896
CCAE: 111938925
CCW: 104683159
ETL: 114070272(IL1B)
FPG: 101924267
FCH: 102050776
CLV: 102090585(IL1B)
EGZ: 104132895(IL1RN)
NNI: 104022599
ACUN: 113488139
PADL: 103912923
ASN: 102369595 112547978
AMJ: 102570262(IL1B) 102575353
CPOO: 109313276
PSS: 102448244
CMY: 102933972 102936298
CPIC: 101943587(IL1B) 101949861
TST: 117872809 117872810
CABI: 116830711 116830722
PVT: 110072197(IL1B)
PBI: 103055254(IL1B)
PMUR: 107283245(IL1B)
TSR: 106544675
PGUT: 117673364 117677036
PMUA: 114603303(IL1B)
ZVI: 118086854 118087328(IL1B)
GJA: 107118765
XLA: 108711577(il1b.L) 108712739 373606(il1b.S)
XTR: 100487038(il1b) 116409784
NPR: 108785587 108785600
DRE: 405770(il1b)
SRX: 107706800 107735843
SANH: 107658569 107682454
SGH: 107554524 107581079 107589025
CCAR: 109062938 109062992 109062994 109097442
CAUA: 113054665 113054687 113110504 113110505 113110506 113110507
IPU: 100304696(il1b) 100304697(il1b)
PHYP: 113544737
AMEX: 103026214 111194997
EEE: 113584063
TRU: 101080001(il1b)
LCO: 104923462
NCC: 104948030 104955090(il1b)
ELY: 117252862
PLEP: 121944262
SLUC: 116054171
ECRA: 117944585
PFLV: 114555628(il1b)
GAT: 120831355(il1b)
MSAM: 119914255(il1b)
CUD: 121510460
MZE: 101472948 101473431 101481848 101485031
ONL: 100693282 100707066 100707443
OAU: 116313583 116333631
OLA: 101169209
OML: 112148302
XMA: 102231459 106700093 111610322
XCO: 114149066 114153988 114155120
XHE: 116730467 116730468
PRET: 103470686 103473214
CVG: 107099154 107099476
CTUL: 119791888
NFU: 107386182
KMR: 108242738(il1b)
ALIM: 106510763(il1b) 106522184
AOCE: 111580399 111583887
CSEM: 103389940 103396898 103397875
POV: 109626174 109641260
LCF: 108878374 108895307
SDU: 111227981 111227984 111239668
SLAL: 111659489 111660942 111660964 111666074
XGL: 120805320 120805321 120806021(il1b)
HCQ: 109513432
BPEC: 110166705 110172087(il1b)
MALB: 109951327 109953309
SASA: 100136449 106562915(IL-1b3) 106570815
OTW: 112219797 112230772 112248882
OMY: 100136024 110509557 110522811(il1b) 110536401
SALP: 111963800 111974578 112071295
ELS: 105007339 105009489
SFM: 108932396 108940319 114909774
PKI: 111848567 111851454
PSPA: 121302061 121303108 121303111
ARUT: 117397782 117397798 117397953 117397955 117397956 117397957 117969121 117969124 117969125 117970734
LCM: 102364535
CMK: 103187802
 » show all
Reference
PMID:6083565
  Authors
Auron PE, Webb AC, Rosenwasser LJ, Mucci SF, Rich A, Wolff SM, Dinarello CA
  Title
Nucleotide sequence of human monocyte interleukin 1 precursor cDNA.
  Journal
Proc Natl Acad Sci U S A 81:7907-11 (1984)
DOI:10.1073/pnas.81.24.7907
  Sequence
[hsa:3553]
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