KEGG ORTHOLOGY: K04355

ORTHOLOGY: K04355

Entry

K04355                      KO

Symbol

BDNF

Name

brain-derived neurotrophic factor

Pathway

map04010

MAPK signaling pathway

map04014

Ras signaling pathway

map04024

cAMP signaling pathway

map04151

PI3K-Akt signaling pathway

map04722

Neurotrophin signaling pathway

map05016

Huntington disease

map05022

Pathways of neurodegeneration - multiple diseases

map05030

Cocaine addiction

map05034

Alcoholism

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04355  BDNF; brain-derived neurotrophic factor
   04014 Ras signaling pathway
    K04355  BDNF; brain-derived neurotrophic factor
   04024 cAMP signaling pathway
    K04355  BDNF; brain-derived neurotrophic factor
   04151 PI3K-Akt signaling pathway
    K04355  BDNF; brain-derived neurotrophic factor
09150 Organismal Systems
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K04355  BDNF; brain-derived neurotrophic factor
09160 Human Diseases
  09164 Neurodegenerative disease
   05016 Huntington disease
    K04355  BDNF; brain-derived neurotrophic factor
   05022 Pathways of neurodegeneration - multiple diseases
    K04355  BDNF; brain-derived neurotrophic factor
  09165 Substance dependence
   05030 Cocaine addiction
    K04355  BDNF; brain-derived neurotrophic factor
   05034 Alcoholism
    K04355  BDNF; brain-derived neurotrophic factor
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides
    K04355  BDNF; brain-derived neurotrophic factor
Cytokines and neuropeptides [BR:ko04052]
Cytokines
  Growth factors (RTK binding)
   K04355  BDNF; brain-derived neurotrophic factor

Genes

HSA:

627(BDNF)

PTR:	503511(BDNF)

PPS:	100983866(BDNF)

GGO:	101134399(BDNF)

PON:	100447350(BDNF)

PPYG:

129008056(BDNF)

NLE:	100594402(BDNF)

HMH:	116476405(BDNF)

SSYN:

129484302(BDNF)

MCC:	701245(BDNF)

MCF:	102126294(BDNF)

MTHB:

126934686

MNI:	105463281(BDNF)

CSAB:

103238537(BDNF)

CATY:

105572781(BDNF)

PANU:

101007866(BDNF)

TGE:	112607193(BDNF)

MLEU:

105528120(BDNF)

RRO:	104671126(BDNF)

RBB:	108519651(BDNF)

TFN:	117080419(BDNF)

PTEH:

111554690(BDNF)

CANG:

105507710(BDNF)

CJC:	100409412(BDNF)

SBQ:	101037414(BDNF)

CIMI:

108311306(BDNF)

ANAN:

105717219(BDNF)

CSYR:

103252117(BDNF)

MMUR:

105860148(BDNF)

LCAT:

123642542(BDNF)

ERUF:

138384309(BDNF)

PCOQ:

105814556(BDNF)

OGA:	100958946(BDNF)

MMU:	12064(Bdnf)

MCAL:

110285237(Bdnf)

MPAH:

110318089(Bdnf)

RNO:	24225(Bdnf)

MCOC:

116090620(Bdnf)

ANU:	117704234(Bdnf)

ASYL:

127684471(Bdnf)

MUN:	110564258(Bdnf)

CGE:

113836414

MAUA:

101837384(Bdnf)

PROB:

127221796(Bdnf)

PLEU:

114702098(Bdnf)

PMAV:

102911929(Bdnf)

MORG:

121465693(Bdnf)

MFOT:

126490405

AAMP:

119815449(Bdnf)

NGI:	103748489(Bdnf)

HGL:	101704465(Bdnf)

CPOC:

100730257(Bdnf)

CCAN:

109695020(Bdnf)

DORD:

105988089(Bdnf)

DSP:	122117755(Bdnf)

DMER:

138834028(Bdnf)

PLOP:

125361587(Bdnf)

MMMA:

107134338(Bdnf)

ITI:	101954451(Bdnf)

OCU:

100356949

OPI:	101528222(BDNF)

OCZ:	121156520(BDNF)

TUP:	102475289(BDNF)

GVR:	103599960(BDNF)

CFA:	403461(BDNF)

CLUD:

112667789(BDNF)

VVP:	112935019(BDNF)

VLG:	121476611(BDNF)

NPO:	129504949(BDNF)

AML:	100467162(BDNF)

UMR:	103659367(BDNF)

UAH:	113265088(BDNF)

UAR:	123799466(BDNF)

ELK:

111150176

LLV:

125079596

MPUF:

101687038(BDNF)

MNP:	132021809(BDNF)

MLK:	131810728(BDNF)

NVS:	122912801(BDNF)

ORO:	101372507(BDNF)

EJU:	114220007(BDNF)

ZCA:	113913517(BDNF)

MLX:	118015716(BDNF)

NSU:	110576669(BDNF)

LWW:	102730927(BDNF)

FCA:	493690(BDNF)

PYU:	121043625(BDNF)

PCOO:

112865997(BDNF)

PBG:	122483648(BDNF)

PVIV:

125146904(BDNF)

LRUF:

124504727

LGF:	123601523(BDNF)

AJU:

106970278

PTG:	102958723(BDNF)

PPAD:

109271282(BDNF)

PUC:

125935341

PLEZ:

122199813(BDNF)

HHV:	120220096(BDNF)

BTA:	617701(BDNF)

BOM:	102279714(BDNF)

BIU:	109569212(BDNF)

BBUB:

102395046(BDNF)

BBIS:

104982427(BDNF)

CHX:	102180782(BDNF)

OAS:	101117275(BDNF)

BTAX:

128060339(BDNF)

CSUM:

138092878(BDNF)

ODA:	120876831(BDNF)

CCAD:

122450381(BDNF)

MREE:

136175018(BDNF)

OVR:	110143608(BDNF)

MBEZ:

129554712(BDNF)

SSC:	397495(BDNF)

CFR:	102511705(BDNF)

CBAI:

105076551(BDNF)

CDK:	105106448(BDNF)

VPC:	102532564(BDNF)

BACU:

103017938(BDNF)

BMUS:

118900201(BDNF)

LVE:	103085069(BDNF)

OOR:	101281702(BDNF)

LALB:

132525204(BDNF)

GMF:	115857612(BDNF)

DDP:	132429154(BDNF)

DLE:	111179820(BDNF)

PCAD:

102977934(BDNF)

PSIU:

116758559(BDNF)

PPHC:

136126531(BDNF)

NASI:

112412908(BDNF)

ECB:	100009689(BDNF)

EPZ:	103552694(BDNF)

EAI:	106824927(BDNF)

MYB:	102247090(BDNF)

MYD:	102754946(BDNF)

MMYO:

118664943(BDNF)

MLF:	102440705(BDNF)

MDT:	132241082(BDNF)

MYUM:

139017995(BDNF)

PKL:	118713266(BDNF)

EFUS:

103292699(BDNF)

MNA:	107531942(BDNF)

DRO:	112303343(BDNF)

SHON:

118983123(BDNF)

AJM:	119049902(BDNF)

PDIC:

114500881(BDNF)

PHAS:

123810054(BDNF)

MMF:	118628031(BDNF)

PPAM:

129080496(BDNF)

HAI:	109387036(BDNF)

RFQ:	117029758(BDNF)

PALE:

102896087(BDNF)

PGIG:

120605221(BDNF)

PVP:	105293721(BDNF)

RAY:	107512170(BDNF)

MJV:	108401589(BDNF)

TOD:	119255407(BDNF)

SARA:

101553155(BDNF)

SFUM:

130043822(BDNF)

SETR:

126019007(BDNF)

LAV:	100667885(BDNF)

TMU:

101350169

ETF:	101643198(BDNF)

DNM:	101428552(BDNF)

MDO:	554233(BDNF)

GAS:	123251915(BDNF)

SHR:	100934810(BDNF)

AFZ:

127539945

PCW:	110202027(BDNF)

TVP:	118853508(BDNF)

PBRV:

138163791(BDNF)

MLAO:

141516521(BDNF)

OAA:	100081142(BDNF)

TACU:

119943514(BDNF)

GGA:	396186(BDNF)

PCOC:

116237819(BDNF)

MGP:	100547785(BDNF)

CJO:	107314325(BDNF)

TPAI:

128085307(BDNF)

LMUT:

125694695(BDNF)

NMEL:

110400860(BDNF)

APLA:

101793720(BDNF)

AACU:

137857875(BDNF)

ACYG:

106033956(BDNF)

CATA:

118249880(BDNF)

AFUL:

116490119(BDNF)

TGU:	751584(BDNF)

LSR:	110475139(BDNF)

SCAN:

103822085(BDNF)

PMOA:

120509924(BDNF)

OTC:	121339721(BDNF)

PRUF:

121363021(BDNF)

ATRC:

139585515(BDNF)

GFR:	102041696(BDNF)

FAB:	101819815(BDNF)

OMA:	130254400(BDNF)

PHI:	102104483(BDNF)

PMAJ:

107206143(BDNF)

CCAE:

111930478(BDNF)

CBRC:

103624773(BDNF)

ACOE:

138111177(BDNF)

ETL:	114070984(BDNF)

ZAB:	102071426(BDNF)

ZLE:	135449068(BDNF)

ACHL:

103811115(BDNF)

SVG:	106861430(BDNF)

MMEA:

130581589(BDNF)

HRT:	120754094(BDNF)

SATI:

136362193(BDNF)

CFAI:

136292046(BDNF)

CCIC:

134045086(BDNF)

FPG:	101920877(BDNF)

FCH:	102053337(BDNF)

CCRI:

104168519(BDNF)

NNT:	104409217(BDNF)

SHAB:

115607481(BDNF)

ACUN:

113481351(BDNF)

SURA:

141950065(BDNF)

TALA:

104367413(BDNF)

ACHC:

115352126(BDNF)

HALD:

104318262(BDNF)

HLE:	104829468(BDNF)

AGEN:

126047571

HHAR:

128152914(BDNF)

BBUT:

142039951(BDNF)

GCL:

127016890

CSTI:

104562495(BDNF)

LDI:	104354654(BDNF)

MNB:	103778492(BDNF)

DPUB:

104300997(BDNF)

PPUS:

135186267(BDNF)

AVIT:

104279718(BDNF)

BRHI:

104497607(BDNF)

EGZ:	104123336(BDNF)

NNI:	104009422(BDNF)

PCRI:

104026574(BDNF)

PCAO:

104045959(BDNF)

PADL:

103925753(BDNF)

AFOR:

103906808(BDNF)

FGA:	104081661(BDNF)

CBOR:

142087984(BDNF)

GSTE:

104253520(BDNF)

CBOY:

140653452(BDNF)

MAME:

142410107(BDNF)

CLV:	102092034(BDNF)

CNIC:

135989447(BDNF)

MUI:	104535938(BDNF)

PGUU:

104472048(BDNF)

PLET:

104618430(BDNF)

EHS:	104505629(BDNF)

CMAC:

104475611(BDNF)

CUCA:

104054713(BDNF)

TEO:	104379965(BDNF)

BREG:

104631845(BDNF)

GAME:

129206953(BDNF)

OHA:	104331794(BDNF)

ACAR:

104524723(BDNF)

CPEA:

104394627(BDNF)

CVF:	104293195(BDNF)

RTD:	128908759(BDNF)

CRID:

134515173(BDNF)

LMIC:

141742849(BDNF)

AAM:	106498156(BDNF)

AROW:

112969631(BDNF)

NPD:	112948838(BDNF)

TGT:	104579047(BDNF)

DNE:	112996572(BDNF)

SCAM:

104147075(BDNF)

ASN:	102381545(BDNF)

AMJ:	102568446(BDNF)

CPOO:

109321582(BDNF)

GGN:	109299028(BDNF)

PSS:	102445524(BDNF)

CIZ:	142015466(BDNF)

CMY:	102942197(BDNF)

CCAY:

125638872(BDNF)

LKP:	140912763(BDNF)

NDS:	141990020(BDNF)

DCC:	119857383(BDNF)

CPIC:

101940773(BDNF)

TST:	117877165(BDNF)

CABI:

116819268(BDNF)

MRV:	120404509(BDNF)

ACS:	100564408(bdnf)

ASAO:

132769268(BDNF)

PVT:	110077404(BDNF)

SUND:

121936516(BDNF)

PBI:	103063519(BDNF)

PMUR:

107286944(BDNF)

CTIG:

120318934(BDNF)

TSR:	106544765(BDNF)

PGUT:

117665398(BDNF)

PCAE:

139327649(BDNF)

APRI:

131186956(BDNF)

PTEX:

113438878(BDNF)

NSS:	113410188(BDNF)

VKO:	123021214(BDNF)

PMUA:

114582060 114597199(BDNF)

PRAF:

128414382(BDNF)

ZVI:	118086319(BDNF) 118095898

HCG:	128340848(BDNF)

GJA:	107122569(BDNF)

STOW:

125427032(BDNF)

EMC:	129323335(BDNF)

XLA:	100048914(bdnf.S) 108715060

XTR:	100037853(bdnf)

NPR:	108796333(BDNF)

RTEM:

120917211(BDNF)

ACAT:

141112085(BDNF)

PADS:

140337950(BDNF)

BBUF:

120980400(BDNF)

BGAR:

122920365 122920372

DTC:	141090224(BDNF)

PWL:	138283839(BDNF)

MUO:	115467940(BDNF)

GSH:	117352231(BDNF)

DRE:	58118(bdnF)

SRX:	107740475 107755032(bdnf)

SANH:

107670730 107700392

SGH:	107554894 107595107

CCAR:

109095226 109102309

CAUA:

113051551 113105966(bdnf)

CGIB:

127961336 128016943

PTET:

122347827(bdnf)

LROH:

127168692(bdnf)

GRF:	141332018(bdnf)

OMC:	131544263(bdnf)

PPRM:

120475981(bdnf)

RKG:	130083010(bdnf)

MAMB:

125264749(bdnf)

CIDE:

127516382

CERY:

137030460(bdnf)

MASI:

127455484 127456718

TROS:

130558646(bdnf)

TDW:	130429666(bdnf)

MANU:

129443209(bdnf)

PDAB:

135749230(bdnf)

IPU:

108259104

IFU:	128603114(bdnf)

PHYP:

113540798(bdnf)

SMEO:

124379661(bdnf)

TFD:	113636839(bdnf)

TVC:	132838964(bdnf)

CGAR:

128518410(bdnf)

NGRA:

132874714(bdnf)

TRN:	134304050(bdnf)

AMEX:

103035730(bdnf)

CMAO:

118817676(bdnf)

EEE:	113576712(bdnf)

CHAR:

105893071(bdnf)

SPIL:

134068875(bdnf)

ASAD:

121694744(bdnf)

TRU:	101066049(bdnf)

TFS:	130521936(bdnf)

TNG:	GSTEN00007157G001

LCO:	104919246(bdnf)

NCC:	104964456(bdnf)

TBEN:

117471613(bdnf)

CGOB:

115028088(bdnf)

PGEO:

117466070(bdnf)

GACU:

117547511(bdnf)

EMAC:

134863420(bdnf)

ELY:	117268362(bdnf)

EFO:	125900692(bdnf)

PLEP:

121945072(bdnf)

SLUC:

116034023(bdnf)

ECRA:

117947818(bdnf)

ESP:	116682771(bdnf)

PFLV:

114558058(bdnf)

GAT:	120834252(bdnf)

PPUG:

119197935(bdnf)

AFB:	129101697(bdnf)

CLUM:

117726892(bdnf)

CANA:

137783591(bdnf)

CVE:	137874200(bdnf)

MSAM:

119889767(bdnf)

SCHU:

122880882(bdnf)

CUD:	121512394(bdnf)

SPUL:

138587554(bdnf)

LMIX:

132973322(bdnf)

HTC:	141787910(bdnf)

ALAT:

119017585(bdnf)

ASTR:

137593823(bdnf)

MZE:	101486366(bdnf)

ONL:	100691267(bdnf)

OAU:	116324294(bdnf)

OLA:	101167940(bdnf)

OML:	112161189(bdnf)

CSAI:

133420515 133420561(bdnf)

XMA:	102237475(bdnf)

XCO:	114142877(bdnf)

XHE:	116718342(bdnf)

PRET:

103462396(bdnf)

PFOR:

103139320(bdnf)

PLAI:

106957890(bdnf)

PMEI:

106924896(bdnf)

GAF:	122822273(bdnf)

PPRL:

129369618(bdnf)

CVG:	107090640(bdnf)

CTUL:

119782793(bdnf)

GMU:	124866445(bdnf)

NFU:	107381608(bdnf)

KMR:	108250531(bdnf)

ALIM:

106530394(bdnf)

NWH:	119427665(bdnf)

AOCE:

111580053(bdnf)

EJA:	138213259(bdnf)

BFRE:

138620454(bdnf)

MCEP:

125006007(bdnF)

CSEM:

103378703(bdnf)

POV:	109624905(bdnf)

SSEN:

122771911(bdnf)

SSOE:

131459333(bdnf)

HHIP:

117758678(bdnf)

HSP:	118109813(bdnf)

PPLT:

128440576(bdnf)

LCF:

108889717

SDU:	111238401(bdnf)

SLAL:

111668292(bdnf)

XGL:	120793953(bdnf)

HCQ:	109514265(bdnf)

SSCV:

125967483(bdnf)

SBIA:

133497872(bdnf)

PEE:	133416319(bdnf)

PTAO:

133470388(bdnf)

BPEC:

110173056(bdnf)

ENY:	140381051(bdnf)

MALB:

109963004(bdnf)

BSPL:

114852405(bdnf)

SJO:	128359234(bdnf)

SSCO:

133978897(bdnf)

TTY:	137181538(bdnf)

GMH:	115558227(bdnf)

SASA:

106563519 106587487

STRU:

115167112 115203218

OTW:	112249300 112263804

OMY:	110506655 110526524

OGO:	124033099 124035028

ONE:	115112421 115113708

OKI:	109873125 109881435

OKE:	118362595 118393975

OMM:	135503946 135558029(bdnf)

OCLA:

139384892 139412213

SALP:

111969472 112072508

SNH:	120025232 120036154

SFON:

129834622 129854381

CCLU:

121556294(bdnf)

ELS:	105022251(bdnf)

OEP:	134027734(bdnf)

SFM:	108939297 108940907(bdnf)

PKI:	111843262 111850518

AANG:

118226973(bdnf)

AROT:

135255057(bdnf)

CCOG:

133131248(bdnf)

LOC:	102697197(bdnf)

PSPA:

121294462 121329509

ARUT:

117432421 117434831

PSEX:

120529741(bdnf)

LCM:	102353793(BDNF)

CMK:	103174983(bdnf)

RTP:	109938236(bdnf)

CPLA:

122557648(bdnf)

CPUN:

140493812(bdnf)

HOC:	132824267(bdnf)

SCAU:

119971951(bdnf)

LERI:

129705559(bdnf)

HAKA:

140728770(bdnf)

PTRU:

VDE:

VJA:

GOE:

CSCU:

CRG:

MMER:

LAK:

Reference

PMID:2236018

Authors

Jones KR, Reichardt LF

Title

Molecular cloning of a human gene that is a member of the nerve growth factor family.

Journal

Proc Natl Acad Sci U S A 87:8060-4 (1990)
DOI:10.1073/pnas.87.20.8060

Sequence

[hsa:627]

Reference

PMID:19577647

Authors

Waterhouse EG, Xu B

Title

New insights into the role of brain-derived neurotrophic factor in synaptic plasticity.

Journal

Mol Cell Neurosci 42:81-9 (2009)
DOI:10.1016/j.mcn.2009.06.009

Reference

PMID:19498435

Authors

Zuccato C, Cattaneo E

Title

Brain-derived neurotrophic factor in neurodegenerative diseases.

Journal

Nat Rev Neurol 5:311-22 (2009)
DOI:10.1038/nrneurol.2009.54

LinkDB

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