KEGG ORTHOLOGY: K09186

ORTHOLOGY: K09186

Entry

K09186                      KO

Symbol

MLL1

Name

[histone H3]-lysine4 N-trimethyltransferase MLL1 [EC:2.1.1.354]

Pathway

map00310

Lysine degradation

map01100

Metabolic pathways

map04934

Cushing syndrome

map05202

Transcriptional misregulation in cancer

Reaction

R03875

R04866

S-adenosyl-L-methionine:cytochrome-c-L-lysine N6-methyltransferase

R04867

S-adenosyl-L-methionine:cytochrome-c-L-lysine N6-methyltransferase

Disease

H00001

B-cell acute lymphoblastic leukemia

H00002

T-cell acute lymphoblastic leukemia

H01879

Wiedemann-Steiner syndrome

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09105 Amino acid metabolism
   00310 Lysine degradation
    K09186  MLL1; [histone H3]-lysine4 N-trimethyltransferase MLL1
09160 Human Diseases
  09161 Cancer: overview
   05202 Transcriptional misregulation in cancer
    K09186  MLL1; [histone H3]-lysine4 N-trimethyltransferase MLL1
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K09186  MLL1; [histone H3]-lysine4 N-trimethyltransferase MLL1
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K09186  MLL1; [histone H3]-lysine4 N-trimethyltransferase MLL1
   03036 Chromosome and associated proteins
    K09186  MLL1; [histone H3]-lysine4 N-trimethyltransferase MLL1
Enzymes [BR:ko01000]
2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.354  [histone H3]-lysine4 N-trimethyltransferase
     K09186  MLL1; [histone H3]-lysine4 N-trimethyltransferase MLL1
Transcription factors [BR:ko03000]
Eukaryotic type
  Zinc finger
   CXXC CpG-binding proteins
    K09186  MLL1; [histone H3]-lysine4 N-trimethyltransferase MLL1
Chromosome and associated proteins [BR:ko03036]
Eukaryotic type
  Histone modification proteins
   HMTs (histone methyltransferases)
    HKMTs (histone lysine methyltransferases)
     K09186  MLL1; [histone H3]-lysine4 N-trimethyltransferase MLL1
   HMT complexes
    MLL-HCF complex
     K09186  MLL1; [histone H3]-lysine4 N-trimethyltransferase MLL1

Other DBs

GO:

0042800

Genes

HSA:	4297(KMT2A)

PTR:	451587(KMT2A)

PPS:	100984332(KMT2A)

GGO:	101129366(KMT2A)

PON:	100441102(KMT2A)

PPYG:

129007976(KMT2A)

NLE:	100604245(KMT2A)

HMH:	116477013(KMT2A)

SSYN:

129479721(KMT2A)

MCC:	705511(KMT2A)

MCF:	101866311(KMT2A)

MTHB:

126936036

MNI:	105476407(KMT2A)

CSAB:

103248594(KMT2A)

CATY:

105582478(KMT2A)

PANU:

101019707(KMT2A)

TGE:	112606639(KMT2A)

MLEU:

105528288(KMT2A)

RRO:	104665589(KMT2A)

RBB:	108536375(KMT2A)

TFN:	117081434(KMT2A)

PTEH:

111540209(KMT2A)

CANG:

105501211(KMT2A)

CJC:	100391138(KMT2A)

SBQ:	101029847(KMT2A)

CIMI:

108300601(KMT2A)

ANAN:

105729547(KMT2A)

CSYR:

103265207(KMT2A)

MMUR:

105876097(KMT2A)

LCAT:

123641515(KMT2A)

PCOQ:

105819233(KMT2A)

OGA:	100960499(KMT2A)

MMU:	214162(Kmt2a)

MCAL:

110301786(Kmt2a)

MPAH:

110327485(Kmt2a)

RNO:	315606(Kmt2a)

MCOC:

116073930(Kmt2a)

ANU:	117698937(Kmt2a)

ASYL:

127689151(Kmt2a)

MUN:	110549115(Kmt2a)

CGE:	100760424(Kmt2a)

MAUA:

101829158(Kmt2a)

PROB:

127231612(Kmt2a)

PLEU:

114691187(Kmt2a)

MORG:

121438253(Kmt2a)

MFOT:

126510029

AAMP:

119809915(Kmt2a)

NGI:	103748298(Kmt2a)

HGL:	101716671(Kmt2a)

CPOC:

100727230(Kmt2a)

CCAN:

109689973(Kmt2a)

DORD:

105980771(Kmt2a)

DSP:	122110350(Kmt2a)

DMER:

138810769 138838986

PLOP:

125349620(Kmt2a)

NCAR:

124958853

MMMA:

107145668(Kmt2a)

ITI:	101961637(Kmt2a)

OCU:

100353733

OPI:	101530610(KMT2A)

TUP:	102473382(KMT2A)

GVR:	103592282(KMT2A)

CFA:	479417(KMT2A)

CLUD:

112671243(KMT2A)

VVP:	112920160(KMT2A)

VLG:	121499474(KMT2A)

NPO:	129496993(KMT2A)

AML:	100484220(KMT2A)

UMR:	103662507(KMT2A)

UAH:	113259992(KMT2A)

UAR:	123792623(KMT2A)

ELK:

111153928

LLV:

125080181

MPUF:

101677851(KMT2A)

MNP:	132027434(KMT2A)

MLK:	131836642(KMT2A)

NVS:	122912328(KMT2A)

ORO:	101363669(KMT2A)

EJU:	114211262(KMT2A)

ZCA:	113915195(KMT2A)

MLX:	118013279(KMT2A)

NSU:	110586354(KMT2A)

LWW:	102734687(KMT2A)

FCA:	101090288(KMT2A)

PYU:	121035470(KMT2A)

PCOO:

112865847(KMT2A)

PBG:	122483027(KMT2A)

PVIV:

125176515(KMT2A)

LRUF:

124504766

LGF:	123600748(KMT2A)

AJU:

106966460

PTG:	102956940(KMT2A)

PPAD:

109278556(KMT2A)

PUC:

125909145

PLEZ:

122201062(KMT2A)

HHV:	120230018(KMT2A)

BTA:	508330(KMT2A)

BOM:	102280025(KMT2A)

BIU:	109569413(KMT2A)

BBUB:

102401126(KMT2A)

BBIS:

104981499(KMT2A)

CHX:	102169033(KMT2A)

OAS:	101101916(KMT2A)

BTAX:

128060105(KMT2A)

CSUM:

138092640(KMT2A)

ODA:	120876324(KMT2A)

CCAD:

122449209(KMT2A)

MREE:

136174130(KMT2A)

OVR:	110133004(KMT2A)

MBEZ:

129554385(KMT2A)

SSC:	100623006(KMT2A)

CFR:	102517824(KMT2A)

CBAI:

105067814(KMT2A)

CDK:	105090168(KMT2A)

VPC:	102533506(KMT2A)

BACU:

103014183(KMT2A)

BMUS:

118899217(KMT2A)

LVE:	103068531(KMT2A)

OOR:	101278571(KMT2A)

LALB:

132526350(KMT2A)

GMF:	115842856(KMT2A)

DDP:	132429488(KMT2A)

DLE:	111166868(KMT2A)

PSIU:

116758514(KMT2A)

PPHC:

136127422(KMT2A)

NASI:

112403956(KMT2A)

ECB:	100071238(KMT2A)

EPZ:	103546689(KMT2A)

EAI:	106840333(KMT2A)

MMYO:

118664230(KMT2A)

MLF:	102438683(KMT2A)

MDT:	132240487(KMT2A)

MYUM:

139017565(KMT2A)

PKL:	118710551(KMT2A)

EFUS:

103293817(KMT2A)

DRO:	112314381(KMT2A)

SHON:

118994753(KMT2A)

AJM:	119050761(KMT2A)

PDIC:

114498625(KMT2A)

PHAS:

123818140(KMT2A)

MMF:	118629080(KMT2A)

PPAM:

129085933(KMT2A)

HAI:	109385301(KMT2A)

RFQ:	117030043(KMT2A)

PGIG:

120622054(KMT2A)

PVP:	105310196(KMT2A)

RAY:	107502258(KMT2A)

MJV:	108384991(KMT2A)

TOD:	119240728(KMT2A)

SARA:

101546445(KMT2A)

SFUM:

130016909(KMT2A)

SETR:

126015812(KMT2A)

LAV:	100653681(KMT2A)

TMU:

101351964

ETF:	101655592(KMT2A)

DNM:	101421357(KMT2A)

MDO:	100031440(KMT2A)

GAS:	123242101(KMT2A)

SHR:	100924557(KMT2A)

PCW:	110207193(KMT2A)

TVP:	118837971(KMT2A)

PBRV:

138145060(KMT2A)

MLAO:

141507490(KMT2A)

OAA:	100086068(KMT2A)

TACU:

119934755(KMT2A)

GGA:	414897(KMT2A)

PCOC:

116233137(KMT2A)

MGP:	100540662(KMT2A)

CJO:	107324133(KMT2A)

TPAI:

128087482(KMT2A)

LMUT:

125703648(KMT2A)

NMEL:

110387546(KMT2A)

APLA:

101797321(KMT2A)

ACYG:

106039772(KMT2A)

CATA:

118252552(KMT2A)

AFUL:

116497834(KMT2A)

TGU:	100231049(KMT2A)

LSR:	110470458(KMT2A)

SCAN:

103822784(KMT2A)

PMOA:

120508316(KMT2A)

OTC:	121340745(KMT2A)

PRUF:

121348548(KMT2A)

ATRC:

139600989(KMT2A)

GFR:	102036439(KMT2A)

FAB:	101813917(KMT2A)

OMA:	130262575(KMT2A)

PHI:	102103515(KMT2A)

PMAJ:

107214385(KMT2A)

CCAE:

111939213(KMT2A)

CCW:	104692048(KMT2A)

CBRC:

103618527(KMT2A)

ACOE:

138098262(KMT2A)

ETL:	114056306(KMT2A)

ZAB:	102071495(KMT2A)

ZLE:	135457443(KMT2A)

ACHL:

103803311(KMT2A)

SVG:	106858174(KMT2A)

MMEA:

130581108(KMT2A)

HRT:	120762671(KMT2A)

SATI:

136371048(KMT2A)

CCIC:

134053591(KMT2A)

FPG:	101922729(KMT2A)

FCH:	102059401(KMT2A)

CCRI:

104158728(KMT2A)

NNT:

104406956

SHAB:

115616428(KMT2A)

ACUN:

113488577(KMT2A)

TALA:

104359457(KMT2A)

ACHC:

115344881(KMT2A)

HALD:

104316581

HLE:	104836373(KMT2A)

AGEN:

126038415

HHAR:

128140278(KMT2A)

GCL:

CSTI:

LDI:

MNB:

DPUB:

104307283(KMT2A)

PPUS:

135191161(KMT2A)

AVIT:

104279618

BRHI:

104499796(KMT2A)

EGZ:	104135361(KMT2A)

NNI:	104016208(KMT2A)

PCRI:

104031628

PCAO:

104051828

PADL:

103916551(KMT2A)

AFOR:

103894085(KMT2A)

FGA:

104074657

GSTE:

104256027

CBOY:

140661755(KMT2A)

CLV:	102084453(KMT2A)

CNIC:

135998712(KMT2A)

MUI:

PGUU:

PLET:

CMAC:

CUCA:

104068899(KMT2A)

TEO:

104377302

BREG:

104636978

OHA:	104338074(KMT2A)

ACAR:

104527626

CPEA:

104398655(KMT2A)

CVF:	104296092(KMT2A)

RTD:	128918752(KMT2A)

CRID:

134524915(KMT2A)

LMIC:

141732434(KMT2A)

AAM:	106485191(KMT2A)

AROW:

112962037(KMT2A)

NPD:	112948101(KMT2A)

TGT:	104580926(KMT2A)

DNE:	112991639(KMT2A)

SCAM:

104140985(KMT2A)

ASN:	102385246(KMT2A)

AMJ:	102572253(KMT2A)

CPOO:

109315397(KMT2A)

GGN:	109293959(KMT2A)

PSS:	102463628(KMT2A)

CMY:	102941272(KMT2A)

CCAY:

125625353(KMT2A)

DCC:	119846728(KMT2A)

CPIC:

101941687(KMT2A)

TST:	117868628(KMT2A)

CABI:

116822931(KMT2A)

MRV:	120375573(KMT2A)

ACS:	100560745(kmt2a)

ASAO:

132782442(KMT2A)

SUND:

121935627(KMT2A)

PBI:	103067762(KMT2A)

PMUR:

107284778(KMT2A)

CTIG:

120307243(KMT2A)

PGUT:

117670190(KMT2A)

PCAE:

139323184(KMT2A)

APRI:

131203834(KMT2A)

PTEX:

113441927(KMT2A)

NSS:	113420873(KMT2A)

VKO:	123020231(KMT2A)

PMUA:

114585722(KMT2A)

PRAF:

128403173(KMT2A)

ZVI:	118096807(KMT2A)

HCG:	128333633(KMT2A)

GJA:	107112539(KMT2A)

STOW:

125441702(KMT2A)

EMC:	129342610(KMT2A)

XLA:	108696457 108705229(kmt2a.S)

XTR:	100135006(kmt2a)

NPR:	108794984(KMT2A)

RTEM:

120915166(KMT2A)

ACAT:

141110826(KMT2A)

BBUF:

120995916(KMT2A)

BGAR:

122935504(KMT2A)

DTC:	141097816(KMT2A)

PWL:	138285155(KMT2A)

MUO:	115481502(KMT2A)

GSH:	117347268(KMT2A)

DRE:	557048(kmt2a)

SRX:	107718271 107743706

SANH:

107683818 107690455

SGH:	107585544 107601691

CCAR:

109103205 109103211

CAUA:

113058440 113115076

CGIB:

127972680 128029223

PTET:

122358751(kmt2a)

LROH:

127176714(kmt2a)

GRF:	141284512(kmt2a)

OMC:	131554129(kmt2a)

PPRM:

120478575(kmt2a)

RKG:	130096738(kmt2a)

MAMB:

125249738(kmt2a)

CERY:

137004875(kmt2a)

MASI:

127421727 127429777

TROS:

130564365(kmt2a)

TDW:	130428963(kmt2a)

MANU:

129437998(kmt2a)

PDAB:

135771111(kmt2a)

IPU:

108277661

IFU:	128620982(kmt2a)

PHYP:

113533005(kmt2a)

SMEO:

124394449(kmt2a)

TFD:	113660479(kmt2a)

TVC:	132857686(kmt2a)

CGAR:

128533640(kmt2a)

NGRA:

132901458(kmt2a)

TRN:

134334567

AMEX:

103035686(kmt2a)

CMAO:

118800792(kmt2a)

EEE:	113579441(kmt2a)

CHAR:

105893748(kmt2a)

SPIL:

134065776(kmt2a)

ASAD:

121688354(kmt2a)

TRU:	101079297(kmt2a)

TFS:	130535396(kmt2a)

TNG:	GSTEN00035709G001

LCO:	104936774(kmt2a)

TBEN:

117470424(kmt2a)

CGOB:

115018265(kmt2a)

PGEO:

117457455(kmt2a)

GACU:

117552304(kmt2a)

EMAC:

134879878(kmt2a)

ELY:	117260183(kmt2a)

EFO:	125888606(kmt2a)

PLEP:

121942999(kmt2a)

SLUC:

116047987(kmt2a)

ECRA:

117938109(kmt2a)

ESP:	116671708(kmt2a)

PFLV:

114549562(kmt2a)

GAT:	120809005(kmt2a)

PPUG:

119227019(kmt2a)

AFB:	129092493(kmt2a)

CLUM:

117741232(kmt2a)

PSWI:

130210992(kmt2a)

CANA:

137791029(kmt2a)

CVE:	137872382(kmt2a)

MSAM:

119882412(kmt2a)

SCHU:

122878580(kmt2a)

CUD:	121520197(kmt2a)

SPUL:

138597528(kmt2a)

LMIX:

132980398(kmt2a)

ALAT:

119032097(kmt2a)

ASTR:

137596227(kmt2a)

MZE:	101478918(kmt2a)

ONL:	100700211(kmt2a)

OAU:	116328181(kmt2a)

OLA:	101171020(kmt2a)

OML:	112149217(kmt2a)

CSAI:

133441738(kmt2a)

XMA:	102233842(kmt2a)

XCO:	114133379(kmt2a)

XHE:	116708135(kmt2a)

PRET:

103474566(kmt2a)

PFOR:

103155206(kmt2a)

PLAI:

106957246(kmt2a)

PMEI:

106908737(kmt2a)

GAF:	122833182(kmt2a)

PPRL:

129358723(kmt2a)

CVG:	107088316(kmt2a)

CTUL:

119782827(kmt2a)

GMU:	124883798(kmt2a)

NFU:	107380358(kmt2a)

KMR:	108246035(kmt2a)

ALIM:

106533989(kmt2a)

NWH:	119410864 119410869(kmt2a)

AOCE:

111584353(kmt2a)

EJA:	138197306(kmt2a)

BFRE:

138616114(kmt2a)

MCEP:

125013317(kmt2a)

CSEM:

103378141(kmt2a)

POV:	109630237(kmt2a)

SSEN:

122760603(kmt2a)

SSOE:

131462935(kmt2a)

HHIP:

117772370(kmt2a)

HSP:	118105801(kmt2a)

PPLT:

128440625(kmt2a)

SMAU:

118299902(kmt2a)

LCF:

108886384

SDU:	111228034(kmt2a)

SLAL:

111650938(kmt2a)

XGL:	120791877(kmt2a)

HCQ:	109529394(kmt2a)

SSCV:

125972871(kmt2a)

SBIA:

133505393(kmt2a)

PEE:	133405558(kmt2a)

PTAO:

133482808(kmt2a)

BPEC:

110154093(kmt2a)

ENY:	140377477(kmt2a)

MALB:

109960262(kmt2a)

BSPL:

114867615(kmt2a)

SJO:	128359941(kmt2a)

SSCO:

133979941(kmt2a)

TTY:	137186060(kmt2a)

GMH:	115560884(kmt2a)

SASA:

106612477(kmt2a)

STRU:

115162944 115205898

OTW:	112244682 112266726

OMY:	110503544 110507387(kmt2a)

OGO:	124006249 124018147

ONE:	115137115 115141498

OKI:	109905387 109908869

OKE:	118386248 118397094(kmt2a)

OMM:	135546068 135552540(kmt2a)

OCLA:

139383158 139386363

SALP:

111949850 111960556

SNH:	120018423(kmt2a) 120029128

SFON:

129821807(kmt2a) 129832411

CCLU:

121560747 121567356

ELS:	105011706(kmt2a)

OEP:	134029151(kmt2a)

SFM:	108936191(kmt2a)

PKI:	111846253(kmt2a)

AANG:

118209436 118236776

AROT:

135236253 135263208

CCOG:

133107546(kmt2a) 133132198

LOC:	102694582(kmt2a)

PSPA:

121309421(kmt2a)

ARUT:

117397194 117962449

PSEX:

120536063(kmt2a)

LCM:	102357046(KMT2A)

CPLA:

122540591(kmt2a)

HOC:	132829694(kmt2a)

LERI:

129712254(kmt2a)

HAKA:

140716897(kmt2a)

CIN:

100180972

SCLV:

120325631

DME:	Dmel_CG8651(trx)

DER:

6552649

DSE:

6606415

DSI:	Dsimw501_GD20433(Dsim_GD20433)

DYA:	Dyak_GE26459

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI24532

DAZ:

108621479

DNV:

115563744

DHE:

111593273

DVI:	6630169(trx)

CCAT:

BOD:

BDR:

AOQ:

ALUD:

TDA:

SCAC:

LCQ:

LSQ:

CVJ:	135949443(trx)

GFS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AMAP:

AMRS:

ACOS:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ013972

CPII:

CBRI:

CNS:

BCOO:

LLL:

PPAP:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BHUN:

BTER:

BAFF:

BPYO:

BPAS:

CCAL:

MGEN:

NMEA:

CGIG:

PCF:

PFUC:

VPS:

VCRB:

VVE:

FAS:

DAM:

AGIF:

CCIN:

TCA:	658843(trithorax)

TMOL:

138139813(trx)

ESIM:

136409341(trx)

EFOR:

136348455(trx)

SOY:

HAXR:

LDC:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_212487

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

BPHI:

137920213(trx)

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

ONU:

ATRA:

GMW:

PXY:

LGLY:

CSTB:

PHU:	Phum_PHUM079870

FOC:

113207551

PCHN:

125032378 125032379

HAME:

121869610

PCLA:

123775287(trx)

PTRU:

DSV:

RSAN:

RMP:

VDE:

VJA:

SDM:

BGT:

GAE:

HRF:

HRJ:

CRG:

PMAX:

OSN:

XEN:

TAD:	TRIADDRAFT_50258

» show all

Reference

PMID:21220120

Authors

Avdic V, Zhang P, Lanouette S, Groulx A, Tremblay V, Brunzelle J, Couture JF

Title

Structural and biochemical insights into MLL1 core complex assembly.

Journal

Structure 19:101-8 (2011)
DOI:10.1016/j.str.2010.09.022

Sequence

[hsa:4297]

Reference

PMID:20236313

Authors

Ansari KI, Mandal SS

Title

Mixed lineage leukemia: roles in gene expression, hormone signaling and mRNA processing.

Journal

FEBS J 277:1790-804 (2010)
DOI:10.1111/j.1742-4658.2010.07606.x

Reference

PMID:8703835

Authors

Nilson I, Lochner K, Siegler G, Greil J, Beck JD, Fey GH, Marschalek R

Title

Exon/intron structure of the human ALL-1 (MLL) gene involved in translocations to chromosomal region 11q23 and acute leukaemias.

Journal

Br J Haematol 93:966-72 (1996)
DOI:10.1046/j.1365-2141.1996.d01-1748.x

Sequence

[hsa:4297]

LinkDB

ORTHOLOGY: K15184

Entry

K15184                      KO

Symbol

AFF1

Name

AF4/FMR2 family member 1

Pathway

map05202

Transcriptional misregulation in cancer

Disease

H00001

B-cell acute lymphoblastic leukemia

Brite

KEGG Orthology (KO) [BR:ko00001]
09160 Human Diseases
  09161 Cancer: overview
   05202 Transcriptional misregulation in cancer
    K15184  AFF1; AF4/FMR2 family member 1
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03021 Transcription machinery
    K15184  AFF1; AF4/FMR2 family member 1
Transcription machinery [BR:ko03021]
Eukaryotic type
  RNA polymerase II system
   Other transcription-related factors
    Super elongation complex (SEC)
     K15184  AFF1; AF4/FMR2 family member 1

Genes

HSA:	4299(AFF1)

PTR:	461362(AFF1)

PPS:	100986387(AFF1)

GGO:	101129648(AFF1)

PON:	100460235(AFF1)

PPYG:

129035545(AFF1)

NLE:	100604892(AFF1)

HMH:	116462312(AFF1)

SSYN:

129492150(AFF1)

MCC:	700733(AFF1)

MCF:	102127513(AFF1)

MTHB:

126954677

MNI:	105479662(AFF1)

CSAB:

103235927(AFF1)

CATY:

105576768(AFF1)

PANU:

101009853(AFF1)

TGE:	112624496(AFF1)

MLEU:

105547240(AFF1)

RRO:	104677962(AFF1)

RBB:	108520619(AFF1)

TFN:	117085347(AFF1)

PTEH:

111530870(AFF1)

CANG:

105518708(AFF1)

CJC:	100387576(AFF1)

SBQ:	101050392(AFF1)

CIMI:

108315645(AFF1)

ANAN:

105707022(AFF1)

CSYR:

103257134

MMUR:

105858338

LCAT:

123627299(AFF1)

PCOQ:

105812702(AFF1)

OGA:	100961632(AFF1)

MMU:	17355(Aff1)

MCAL:

110294174(Aff1)

MPAH:

110330552(Aff1)

RNO:	305152(Aff1)

MCOC:

116067990(Aff1)

ANU:	117699943(Aff1)

ASYL:

127696430(Aff1)

MUN:	110561182(Aff1)

CGE:	100751914(Aff1)

MAUA:

101842801(Aff1)

PROB:

127232162(Aff1)

PLEU:

114691781(Aff1)

MORG:

121440931(Aff1) 121464524

MFOT:

126496186 126499987 126509753

AAMP:

119809482 119810323(Aff1)

NGI:	103748967(Aff1)

HGL:	101719249(Aff1)

CPOC:

100716638(Aff1)

CCAN:

109699383(Aff1)

DORD:

105995931(Aff1)

DSP:	122097795(Aff1)

DMER:

138821091(Aff1)

PLOP:

125364832(Aff1)

NCAR:

124994368

MMMA:

107153609(Aff1)

ITI:	101960937(Aff1)

OCU:

100352431

OPI:	101524970(AFF1)

TUP:	102473626(AFF1)

GVR:	103600828(AFF1)

CFA:	100683405(AFF1)

CLUD:

112645833(AFF1)

VVP:	112919671(AFF1)

VLG:	121493244(AFF1)

NPO:	129501795(AFF1)

AML:	100482315(AFF1)

UMR:	103676970(AFF1)

UAH:	113263175(AFF1)

UAR:	123788194(AFF1)

ELK:

111153808

LLV:

125093144

MPUF:

101679180(AFF1)

MNP:	132001165(AFF1)

MLK:	131830923(AFF1)

NVS:	122889442(AFF1)

ORO:	101385833(AFF1)

EJU:	114203028 114203032

ZCA:	113925539(AFF1)

MLX:	118010358(AFF1)

NSU:	110591394(AFF1)

LWW:	102729471(AFF1)

FCA:	101099959(AFF1)

PYU:	121032933(AFF1)

PCOO:

112858768(AFF1)

PBG:	122478685(AFF1)

PVIV:

125164313(AFF1)

LRUF:

124520808

LGF:	123595728(AFF1)

AJU:

106970736

PTG:	102962294(AFF1)

PPAD:

109276267(AFF1)

PUC:

125922899

PLEZ:

122218066(AFF1)

HHV:	120244175(AFF1)

BTA:	781149(AFF1)

BOM:	102276209(AFF1)

BIU:	109560656(AFF1)

BBUB:

102399437(AFF1)

BBIS:

104984144(AFF1)

CHX:	102185996(AFF1)

OAS:	101111967(AFF1)

BTAX:

128049414(AFF1)

CSUM:

138081873(AFF1)

ODA:	120861544(AFF1)

CCAD:

122428279(AFF1)

MREE:

136153011(AFF1)

OVR:	110145596(AFF1)

MBEZ:

129561595(AFF1)

SSC:	100739621(AFF1)

CFR:	102513615(AFF1)

CBAI:

105077739(AFF1)

CDK:

105091585

VPC:	102539381(AFF1)

BACU:

103004875(AFF1)

BMUS:

118895476(AFF1)

LVE:	103081984(AFF1)

OOR:	101269758(AFF1)

LALB:

132519726(AFF1)

GMF:	115847315(AFF1)

DDP:	132425843(AFF1)

DLE:	111168096(AFF1)

PCAD:

102982098(AFF1)

PSIU:

116753900(AFF1)

PPHC:

136123299(AFF1)

NASI:

112412505(AFF1)

ECB:	100062821(AFF1)

EPZ:	103561614(AFF1)

EAI:	106828861(AFF1)

MYB:	102260820(AFF1)

MYD:	102769006(AFF1)

MMYO:

118671169(AFF1)

MLF:	102439608(AFF1)

MDT:	132216615(AFF1)

MYUM:

138993758(AFF1)

PKL:	118727003(AFF1)

EFUS:

103287985(AFF1)

MNA:	107537135(AFF1)

DRO:	112317662(AFF1)

SHON:

118976177(AFF1)

AJM:	119039610(AFF1)

PDIC:

114493197(AFF1)

PHAS:

123806677(AFF1)

MMF:	118629140(AFF1)

PPAM:

129085373(AFF1)

HAI:	109396335(AFF1)

RFQ:	117022189(AFF1)

PALE:

102883711(AFF1)

PGIG:

120588292(AFF1)

PVP:	105289580(AFF1)

RAY:	107518921(AFF1)

MJV:	108384255(AFF1)

TOD:	119260173(AFF1)

SARA:

101547607(AFF1)

SFUM:

130020807(AFF1)

SETR:

126032213(AFF1)

LAV:	100675867(AFF1)

TMU:

101353116

ETF:	101646985(AFF1)

DNM:

101411392

MDO:	100017144(AFF1)

GAS:	123252221(AFF1)

SHR:	100925988(AFF1)

AFZ:

127541162

PCW:	110209704(AFF1)

TVP:	118853004(AFF1)

PBRV:

138165322(AFF1)

OAA:	100085607(AFF1)

TACU:

119947556(AFF1)

GGA:	422590(AFF1)

PCOC:

116231095(AFF1)

MGP:	100540587(AFF1)

CJO:	107313389(AFF1)

TPAI:

128080632(AFF1)

LMUT:

125692649(AFF1)

NMEL:

110398550(AFF1)

APLA:

101793143(AFF1)

ACYG:

106041871(AFF1)

CATA:

118248364(AFF1)

AFUL:

116488724(AFF1)

TGU:	100226441(AFF1)

LSR:	110480897(AFF1)

SCAN:

103826067(AFF1)

PMOA:

120502711(AFF1)

OTC:	121339811(AFF1)

PRUF:

121365216(AFF1)

ATRC:

139592104(AFF1)

GFR:	102043450(AFF1)

FAB:	101808336(AFF1)

OMA:	130252197(AFF1)

PHI:	102104833(AFF1)

PMAJ:

107203074(AFF1)

CCAE:

111928825(AFF1)

CCW:	104697229(AFF1)

CBRC:

103622410(AFF1)

ACOE:

138109472(AFF1)

ETL:	114059153(AFF1)

ZAB:	102070706 113459109(AFF1)

ZLE:	135446816(AFF1)

ACHL:

103806219(AFF1)

SVG:	106855697(AFF1)

MMEA:

130581508(AFF1)

HRT:	120752613(AFF1)

SATI:

136360664(AFF1)

CCIC:

134044060(AFF1)

FPG:	101920038(AFF1)

FCH:	102056004(AFF1)

CCRI:

104159566(AFF1)

NNT:	104401895(AFF1)

SHAB:

115610870(AFF1)

ACUN:

113479575

TALA:

104365360(AFF1)

ACHC:

115346121(AFF1)

HALD:

104315486(AFF1)

HLE:	104829903(AFF1)

AGEN:

126044884

HHAR:

128134805(AFF1)

GCL:

127015435

CSTI:

104563224(AFF1)

LDI:	104352927(AFF1)

MNB:	103780012(AFF1)

PPUS:

135178597(AFF1)

AVIT:

104271102(AFF1)

EGZ:	104128550(AFF1)

NNI:	104019822(AFF1)

PCRI:

104028284(AFF1)

PCAO:

104049639(AFF1)

AFOR:

103899711(AFF1)

FGA:	104077494(AFF1)

GSTE:

104261830(AFF1)

CBOY:

140652480(AFF1)

CLV:	102085365(AFF1)

CNIC:

135987983(AFF1)

PLET:

104627095(AFF1)

EHS:	104512894(AFF1)

CMAC:

104481132(AFF1)

CUCA:

104058079(AFF1)

TEO:	104374380(AFF1)

BREG:

104632977(AFF1)

OHA:	104331783(AFF1)

ACAR:

104530923(AFF1)

CPEA:

104385376(AFF1)

RTD:	128910550(AFF1)

CRID:

134516149(AFF1)

LMIC:

141744004(AFF1)

AAM:	106496661(AFF1)

AROW:

112967354(AFF1)

NPD:	112948940(AFF1)

TGT:	104580950(AFF1)

DNE:	112984714(AFF1)

SCAM:

104145153(AFF1)

ASN:	102376518(AFF1)

AMJ:	102560688(AFF1)

CPOO:

109322025(AFF1)

GGN:	109303769(AFF1)

PSS:	102459614(AFF1)

CMY:	102936838(AFF1)

CCAY:

125635877(AFF1)

DCC:	119854392(AFF1)

CPIC:

101934683(AFF1)

TST:	117877576(AFF1)

CABI:

116836552(AFF1)

MRV:	120406275(AFF1)

ACS:	100566940(aff1)

ASAO:

132777022(AFF1)

PVT:	110085321(AFF1)

SUND:

121931999(AFF1)

PBI:	103048503(AFF1)

PMUR:

107293599(AFF1)

CTIG:

120316043(AFF1)

TSR:	106550739(AFF1)

PGUT:

117678931(AFF1)

PCAE:

139320515(AFF1)

APRI:

131203540(AFF1)

PTEX:

113434850(AFF1)

NSS:	113425687(AFF1)

VKO:	123022512(AFF1)

PMUA:

114603985(AFF1)

PRAF:

128421394(AFF1)

ZVI:	118083448(AFF1)

HCG:	128326942(AFF1)

GJA:	107113248(AFF1)

STOW:

125439639

EMC:	129336471(AFF1)

XLA:	108711465(aff1.L)

XTR:	100497189(aff1)

NPR:	108804453(AFF1)

RTEM:

120915870(AFF1)

ACAT:

141108359(AFF1)

BBUF:

120989709(AFF1)

BGAR:

122944971(AFF1)

DTC:	141046802(AFF1)

MUO:	115461065(AFF1)

GSH:	117368980(AFF1)

IPU:	108279014(aff1)

IFU:	128621983(aff1)

PHYP:

113535523

SMEO:

124398442(aff1)

TFD:	113650413(aff1)

TVC:	132859684(aff1)

CGAR:

128508040(aff1)

NGRA:

132895131(aff1)

TRN:	134330930(aff1)

AMEX:

103045661(aff1)

CMAO:

118820718

EEE:

113586284

CHAR:

105890137(aff1)

SPIL:

134100883(aff1)

ASAD:

121680607(aff1)

TRU:

101077779

TFS:	130517768(aff1)

TNG:	GSTEN00014441G001

LCO:

104926472

NCC:

104954544

TBEN:

117476307(aff1)

CGOB:

115016535

PGEO:

117455947

GACU:

117551265(aff1)

EMAC:

134868406(aff1)

ELY:	117269809(aff1)

EFO:	125905495(aff1)

PLEP:

121959555(aff1)

SLUC:

116062826(aff1)

ECRA:

117959108(aff1)

ESP:

116704212

PFLV:

114570922

GAT:	120831817(aff1)

PPUG:

119226238(aff1)

AFB:	129102363(aff1)

CLUM:

117740285(aff1)

PSWI:

130205096

CANA:

137783829(aff1)

CVE:	137869378(aff1)

MSAM:

119914383

SCHU:

122865811(aff1)

CUD:	121525036(aff1)

SPUL:

138602440(aff1)

LMIX:

132991794(aff1)

ALAT:

119029996(aff1)

ASTR:

137608193(aff1)

MZE:

101464123

ONL:

100699586

OAU:	116331727(aff1)

OLA:

101169625

OML:	112163005(aff1)

XMA:

102220674

XCO:

114149052

XHE:

116724258

PRET:

103473488(aff1)

PFOR:

103142781

PLAI:

106959059

PMEI:

106917992(aff1)

GAF:	122846855(aff1)

PPRL:

129374208(aff1)

CVG:	107085831(aff1)

CTUL:

119776534(aff1)

GMU:	124872745(aff1)

NFU:	107374724(aff1)

KMR:	108231075(aff1)

ALIM:

106516227

NWH:

119424511

AOCE:

111575643(aff1)

EJA:	138210773(aff1)

BFRE:

MCEP:

CSEM:

POV:

SSEN:

122758058(aff1)

SSOE:

131446182(aff1)

HHIP:

117771832(aff1)

HSP:	118125552(aff1)

PPLT:

128462302

SMAU:

118284569(aff1)

LCF:

108874046

SDU:

111239873

SLAL:

111656821

XGL:	120806082(aff1)

HCQ:

SBIA:

PEE:

PTAO:

MALB:

BSPL:

114867429(aff1)

SJO:	128380360(aff1)

SSCO:

133995114(aff1)

TTY:	137170274(aff1)

SASA:

106560682 106568507

STRU:

115149491(aff1) 115159074

OTW:	112219622 112259488

OMY:	110523980 110536914

OGO:	123999414 124047659

ONE:	115106032 115127956

OKI:	109877937 109893611

OKE:	118387814 118391635

OMM:	135517575 135548076

OCLA:

139408944 139422686

SALP:

111961219 111980068

SNH:	120025650 120044852

SFON:

129812767 129819098

CCLU:

121573394 121582740

ELS:	105007529(aff1)

OEP:	134039084(aff1)

SFM:

108936227

PKI:

111852596

AANG:

118212831(aff1)

AROT:

135239666(aff1)

CCOG:

133141866(aff1)

LOC:	102693993(aff1)

PSPA:

121301515 121316180

ARUT:

117400839 117409413

LCM:	102361211(AFF1)

CMK:

103180863

CPLA:

122552813

HOC:

132816400

LERI:

129699821(aff1)

HAKA:

140738124

VJA:

111271343

» show all

Reference

PMID:24367103

Authors

Lu H, Li Z, Xue Y, Schulze-Gahmen U, Johnson JR, Krogan NJ, Alber T, Zhou Q

Title

AFF1 is a ubiquitous P-TEFb partner to enable Tat extraction of P-TEFb from 7SK snRNP and formation of SECs for HIV transactivation.

Journal

Proc Natl Acad Sci U S A 111:E15-24 (2014)
DOI:10.1073/pnas.1318503111

Sequence

[hsa:4299]

LinkDB

DBGET integrated database retrieval system