KEGG   PATHWAY: amex04110
Entry
amex04110                   Pathway                                
Name
Cell cycle - Astyanax mexicanus (Mexican tetra)
Description
Mitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cyclin-dependent kinases (CDKs) are key regulatory enzymes, each consisting of a catalytic CDK subunit and an activating cyclin subunit. CDKs regulate the cell's progression through the phases of the cell cycle by modulating the activity of key substrates. Downstream targets of CDKs include transcription factor E2F and its regulator Rb. Precise activation and inactivation of CDKs at specific points in the cell cycle are required for orderly cell division. Cyclin-CDK inhibitors (CKIs), such as p16Ink4a, p15Ink4b, p27Kip1, and p21Cip1, are involved in the negative regulation of CDK activities, thus providing a pathway through which the cell cycle is negatively regulated.
 Eukaryotic cells respond to DNA damage by activating signaling pathways that promote cell cycle arrest and DNA repair. In response to DNA damage, the checkpoint kinase ATM phosphorylates and activates Chk2, which in turn directly phosphorylates and activates p53 tumor suppressor protein. p53 and its transcriptional targets play an important role in both G1 and G2 checkpoints. ATR-Chk1-mediated protein degradation of Cdc25A protein phosphatase is also a mechanism conferring intra-S-phase checkpoint activation.
Class
Cellular Processes; Cell growth and death
Pathway map
amex04110  Cell cycle
amex04110

Other DBs
GO: 0000278
Organism
Astyanax mexicanus (Mexican tetra) [GN:amex]
Gene
103031956  ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
103031397  ccnd2a; G1/S-specific cyclin-D2a [KO:K10151]
111193357  ccndx; cyclin Dx [KO:K10151]
125799128  ccnd2b; G1/S-specific cyclin-D2b [KO:K10151]
103045792  ccnd3; G1/S-specific cyclin-D3 [KO:K10152]
103034254  cdk4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
103047757  cdk6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
103040648  rb1; retinoblastoma-associated protein [KO:K06618]
103024081  rbl1; retinoblastoma-like protein 1 [KO:K04681]
103033933  rbl2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
103046185  abl1; tyrosine-protein kinase ABL1 isoform X1 [KO:K06619] [EC:2.7.10.2]
103046670  hdac1; histone deacetylase 1 isoform X1 [KO:K06067] [EC:3.5.1.98]
103028934  histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
103022816  e2f1; transcription factor E2F1 [KO:K17454]
103027354  e2f2; transcription factor E2F2 [KO:K09389]
103022559  e2f3; transcription factor E2F3 [KO:K06620]
103038273  transcription factor E2F3 [KO:K06620]
103027226  e2f5; transcription factor E2F5 [KO:K04682]
103045951  tfdp1a; transcription factor Dp-1a [KO:K04683]
103023623  tfdp1b; transcription factor Dp-1b [KO:K04683]
103043872  tfdp2; transcription factor Dp-2 isoform X1 [KO:K09392]
103021870  gsk3ba; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
103043574  gsk3bb; glycogen synthase kinase 3 beta, genome duplicate b isoform X1 [KO:K03083] [EC:2.7.11.26]
103033069  tgfb1b; transforming growth factor beta-1 proprotein [KO:K13375]
103024607  tgfb1a; transforming growth factor, beta 1a [KO:K13375]
103042476  tgfb5; transforming growth factor beta-2 proprotein [KO:K13376]
103026112  tgfb2; transforming growth factor beta-2 proprotein [KO:K13376]
103032923  tgfb3; transforming growth factor beta-3 proprotein [KO:K13377]
103025750  smad2; mothers against decapentaplegic homolog 2 isoform X2 [KO:K04500]
103027004  smad3b; mothers against decapentaplegic homolog 3b [KO:K23605]
103027811  smad3a; mothers against decapentaplegic homolog 3a [KO:K23605]
103033599  smad4; mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
103033551  smad10a; mothers against decapentaplegic homolog 4 [KO:K04501]
103029394  smad4a; mothers against decapentaplegic homolog 4a isoform X1 [KO:K04501]
103022359  smad10b; mothers against decapentaplegic homolog 4 [KO:K04501]
103038167  mycb; transcriptional regulator Myc-B [KO:K04377]
103033997  myca; transcriptional regulator Myc-A [KO:K04377]
103027285  zbtb17; zinc finger and BTB domain-containing protein 17 isoform X1 [KO:K10500]
111189396  cdkn2a/b; cyclin-dependent kinase 4 inhibitor B isoform X1 [KO:K04685]
103024048  cdkn2c; cyclin-dependent kinase 4 inhibitor C [KO:K06622]
103044441  cdkn2d; cyclin-dependent kinase 4 inhibitor D [KO:K06623]
103030485  cdkn1ba; cyclin-dependent kinase inhibitor 1Ba [KO:K06624]
103025923  cdkn1bb; cyclin-dependent kinase inhibitor 1Bb [KO:K06624]
103044644  cdkn1ca; cyclin-dependent kinase inhibitor 1Ca [KO:K09993]
103033872  cdkn1cb; cyclin-dependent kinase inhibitor 1B [KO:K09993]
103047217  cdkn1a; cyclin-dependent kinase inhibitor 1 isoform X1 [KO:K06625]
103041774  cdkn1d; cyclin-dependent kinase inhibitor 1D [KO:K06625]
103030457  ccne2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
103028876  G1/S-specific cyclin-E2 [KO:K06626]
103042001  ccne1; G1/S-specific cyclin-E1 [KO:K06626]
103028318  cdk2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
103045526  skp1; S-phase kinase-associated protein 1 [KO:K03094]
103026940  cul1b; cullin-1b [KO:K03347]
111194478  cul1a; cullin-1a isoform X1 [KO:K03347]
107197156  E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
125799446  E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
103047278  skp2; S-phase kinase-associated protein 2 [KO:K03875]
103039512  ccna1; cyclin-A1 [KO:K06627]
103035499  ccna2; cyclin-A2 [KO:K06627]
103046129  cdc6; cell division control protein 6 homolog [KO:K02213]
103035122  cdt1; DNA replication factor Cdt1 isoform X1 [KO:K10727]
103030513  orc1; origin recognition complex subunit 1 isoform X1 [KO:K02603]
103036654  orc2; origin recognition complex subunit 2 [KO:K02604]
103029540  orc3; origin recognition complex subunit 3 [KO:K02605]
103040073  orc4; origin recognition complex subunit 4 [KO:K02606]
103037958  orc5; origin recognition complex subunit 5 [KO:K02607]
103023881  orc6; origin recognition complex subunit 6 [KO:K02608]
103045462  mcm2; DNA replication licensing factor MCM2 isoform X1 [KO:K02540] [EC:5.6.2.3]
103041645  mcm3; DNA replication licensing factor MCM3 [KO:K02541] [EC:5.6.2.3]
103027693  mcm3l; MCM3 minichromosome maintenance deficient 3 (S. cerevisiae), like [KO:K02541] [EC:5.6.2.3]
103034183  mcm4; DNA replication licensing factor MCM4 [KO:K02212] [EC:5.6.2.3]
103021452  mcm5; DNA replication licensing factor MCM5 [KO:K02209] [EC:5.6.2.3]
111194477  mcm6l; MCM6 minichromosome maintenance deficient 6, like [KO:K02542] [EC:5.6.2.3]
103037949  mcm6; DNA replication licensing factor MCM6 [KO:K02542] [EC:5.6.2.3]
103041632  mcm7; DNA replication licensing factor MCM7 isoform X1 [KO:K02210] [EC:5.6.2.3]
103021511  cdc45; cell division control protein 45 homolog [KO:K06628]
103025577  ticrr; treslin isoform X1 [KO:K26117]
103031236  cdc7; cell division cycle 7-related protein kinase isoform X1 [KO:K02214] [EC:2.7.11.1]
103043907  dbf4; protein DBF4 homolog A [KO:K06629]
103021596  dbf4b; protein DBF4 homolog A isoform X1 [KO:K06629]
103047431  cdk1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
103046107  ccnb1; G2/mitotic-specific cyclin-B1 isoform X1 [KO:K05868]
103043733  ccnb2; G2/mitotic-specific cyclin-B2 [KO:K21770]
103043213  ccnb3; G2/mitotic-specific cyclin-B3 isoform X1 [KO:K21771]
103027909  G2/mitotic-specific cyclin-B3 [KO:K21771]
103034961  cdc25b; M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
103042311  ywhaqa; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide a [KO:K16197]
103026368  ywhaba; 14-3-3 protein beta/alpha-A [KO:K16197]
107197738  ywhaqb; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide b [KO:K16197]
103023259  14-3-3 protein beta/alpha-A [KO:K16197]
103045356  ywhabl; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide like [KO:K16197]
103023504  ywhaz; 14-3-3 protein zeta/delta [KO:K16197]
103036068  ywhae2; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 2 isoform X1 [KO:K06630]
103034995  ywhae1; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 1 isoform X1 [KO:K06630]
103021402  ywhag2; 14-3-3 protein gamma-B [KO:K16198]
103042914  ywhah; 14-3-3 protein eta [KO:K16198]
103041195  ywhag1; 14-3-3 protein gamma-1 [KO:K16198]
103034005  plk1; serine/threonine-protein kinase PLK1 [KO:K06631] [EC:2.7.11.21]
103034180  wee2; wee1-like protein kinase 2 isoform X2 [KO:K06632] [EC:2.7.11.1]
103022665  wee1; wee1-like protein kinase [KO:K06632] [EC:2.7.11.1]
103038604  pkmyt1; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase [KO:K06633] [EC:2.7.11.1]
103036394  ccnh; cyclin-H [KO:K06634]
103042052  cdk7; cyclin-dependent kinase 7 isoform X1 [KO:K02202] [EC:2.7.11.22 2.7.11.23]
103021413  anapc1; anaphase-promoting complex subunit 1 [KO:K03348]
103044783  anapc2; anaphase-promoting complex subunit 2 [KO:K03349]
103035712  cdc27; cell division cycle protein 27 homolog [KO:K03350]
103036806  anapc4; anaphase-promoting complex subunit 4 [KO:K03351]
103032970  anapc5; anaphase-promoting complex subunit 5 isoform X1 [KO:K03352]
103045132  cdc16; cell division cycle protein 16 homolog [KO:K03353]
103024126  anapc7; anaphase-promoting complex subunit 7 [KO:K03354]
103043782  cdc23; cell division cycle protein 23 homolog [KO:K03355]
103021775  anapc10; anaphase-promoting complex subunit 10 [KO:K03357]
103021554  anapc11; anaphase-promoting complex subunit 11 isoform X2 [KO:K03358]
103024983  cdc26; anaphase-promoting complex subunit CDC26 [KO:K03359]
103032080  anapc13; anaphase-promoting complex subunit 13 [KO:K12456]
103026613  anapc15; anaphase-promoting complex subunit 15 isoform X1 [KO:K25228]
103021957  anapc16; anaphase-promoting complex subunit 16 [KO:K25229]
103046720  cdc20; cell division cycle protein 20 homolog [KO:K03363]
103033759  pttg1; securin [KO:K06635]
103046696  espl1; separin [KO:K02365] [EC:3.4.22.49]
103021942  smc1a; structural maintenance of chromosomes protein 1A [KO:K06636]
107196953  structural maintenance of chromosomes protein 1A [KO:K06636]
103025786  smc1b; structural maintenance of chromosomes protein 1B isoform X1 [KO:K06636]
103034304  smc3; structural maintenance of chromosomes protein 3 [KO:K06669]
103023059  rad21b; double-strand-break repair protein rad21 homolog A [KO:K06670]
103039334  rad21a; double-strand-break repair protein rad21 homolog A isoform X1 [KO:K06670]
103030832  rad21l1; double-strand-break repair protein rad21-like protein 1 isoform X1 [KO:K06670]
103041458  si:ch211-269e2.1; cohesin subunit SA-2 [KO:K06671]
103022896  stag1b; cohesin subunit SA-1 [KO:K06671]
103038235  stag2b; cohesin subunit SA-2 [KO:K06671]
103044077  stag2a; cohesin subunit SA-2a [KO:K06671]
103023812  atrx; transcriptional regulator ATRX isoform X1 [KO:K10779]
103028388  transcriptional regulator ATRX isoform X1 [KO:K10779]
103040310  ddx11; ATP-dependent DNA helicase DDX11 [KO:K11273] [EC:5.6.2.7]
103034231  nipbla; nipped-B-like protein A isoform X1 [KO:K06672]
103029793  nipblb; nipped-B-like protein B isoform X1 [KO:K06672]
103028532  mau2; MAU2 chromatid cohesion factor homolog [KO:K11266]
103047773  hdac8; histone deacetylase 8 isoform X1 [KO:K11405] [EC:3.5.1.98]
103026243  esco1; N-acetyltransferase ESCO1 [KO:K11268] [EC:2.3.1.-]
103024882  esco2; N-acetyltransferase ESCO2 [KO:K11268] [EC:2.3.1.-]
103036319  pds5b; sister chromatid cohesion protein PDS5 homolog B isoform X2 [KO:K11267]
103044840  pds5a; sister chromatid cohesion protein PDS5 homolog A isoform X2 [KO:K11267]
103045703  waplb; wings apart-like protein homolog isoform X2 [KO:K25163]
125781091  wapla; wings apart-like protein homolog [KO:K25163]
103041892  cdca5; sororin isoform X1 [KO:K17390]
103024192  aurkb; aurora kinase B [KO:K11479] [EC:2.7.11.1]
103037157  sgo1; shugoshin 1 isoform X1 [KO:K11580]
103045214  ppp2cab; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
103031614  ppp2r1bb; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
103032850  ppp2r1ba; protein phosphatase 2, regulatory subunit A, beta a [KO:K03456]
103030974  ppp2r5b; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
103032801  ppp2r5ea; protein phosphatase 2, regulatory subunit B', epsilon [KO:K11584]
103042799  ppp2r5eb; protein phosphatase 2, regulatory subunit B', epsilon isoform X1 [KO:K11584]
103036695  ppp2r5a; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
103022659  ppp2r5d; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform X1 [KO:K11584]
103040906  ppp2r5ca; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
103025090  ppp2r5cb; protein phosphatase 2, regulatory subunit B', gamma b isoform X1 [KO:K11584]
103037330  ndc80; kinetochore protein NDC80 homolog [KO:K11547]
103025668  knl1; uncharacterized protein knl1 isoform X2 [KO:K11542]
103035483  ttk; dual specificity protein kinase Ttk isoform X1 [KO:K08866] [EC:2.7.12.1]
103029264  mad1l1; mitotic spindle assembly checkpoint protein MAD1 isoform X1 [KO:K06679]
111191357  mad2l2; mitotic spindle assembly checkpoint protein MAD2B [KO:K13728]
103028940  bub3; mitotic checkpoint protein BUB3 isoform X1 [KO:K02180]
103021907  bub1; mitotic checkpoint serine/threonine-protein kinase BUB1 isoform X1 [KO:K02178] [EC:2.7.11.1]
103027422  trip13; pachytene checkpoint protein 2 homolog [KO:K22399]
103024292  MAD2L1-binding protein [KO:K26093]
103024543  fzr1b; fizzy-related protein homolog [KO:K03364]
103039491  fzr1a; fizzy/cell division cycle 20 related 1a [KO:K03364]
103047033  fizzy-related protein homolog [KO:K03364]
103022362  fbxo5; F-box only protein 5 [KO:K10292]
103025254  cdc14ab; dual specificity protein phosphatase CDC14AB isoform X1 [KO:K06639] [EC:3.1.3.16 3.1.3.48]
103036275  cdc14aa; cell division cycle 14Aa isoform X1 [KO:K06639] [EC:3.1.3.16 3.1.3.48]
103040153  cdc14b; dual specificity protein phosphatase CDC14B isoform X1 [KO:K06639] [EC:3.1.3.16 3.1.3.48]
103044365  ep300a; histone acetyltransferase p300 isoform X4 [KO:K04498] [EC:2.3.1.48]
103032522  ep300b; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
103035824  crebbpa; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
125780395  histone acetyltransferase p300-like [KO:K04498] [EC:2.3.1.48]
103028565  prkdc; DNA-dependent protein kinase catalytic subunit [KO:K06642] [EC:2.7.11.1]
103045062  atm; serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
103039064  mdm2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
103037427  cellular tumor antigen p53 [KO:K04451]
103046742  tp53; cellular tumor antigen p53 isoform X1 [KO:K04451]
103029638  gadd45aa; growth arrest and DNA-damage-inducible, alpha, a [KO:K04402]
103042551  gadd45ba; growth arrest and DNA-damage-inducible, beta a [KO:K04402]
103038163  gadd45ab; growth arrest and DNA-damage-inducible, alpha, b [KO:K04402]
103036194  gadd45bb; growth arrest and DNA-damage-inducible, beta b [KO:K04402]
103039224  growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
103036359  gadd45ga; growth arrest and DNA-damage-inducible, gamma a [KO:K04402]
125782414  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
103027123  pcna; proliferating cell nuclear antigen [KO:K04802]
103021956  chek1; serine/threonine-protein kinase Chk1 [KO:K02216] [EC:2.7.11.1]
103034962  chek2; serine/threonine-protein kinase Chk2 isoform X1 [KO:K06641] [EC:2.7.11.1]
Reference
PMID:7908906
  Authors
Matsuoka S, Yamaguchi M, Matsukage A
  Title
D-type cyclin-binding regions of proliferating cell nuclear antigen.
  Journal
J Biol Chem 269:11030-6 (1994)
Reference
PMID:8242749
  Authors
Welch PJ, Wang JY
  Title
A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle.
  Journal
Cell 75:779-90 (1993)
DOI:10.1016/0092-8674(93)90497-E
Reference
PMID:16936746
  Authors
Macaluso M, Montanari M, Giordano A
  Title
Rb family proteins as modulators of gene expression and new aspects regarding the interaction with chromatin remodeling enzymes.
  Journal
Oncogene 25:5263-7 (2006)
DOI:10.1038/sj.onc.1209680
Reference
PMID:15838516
  Authors
Cobrinik D
  Title
Pocket proteins and cell cycle control.
  Journal
Oncogene 24:2796-809 (2005)
DOI:10.1038/sj.onc.1208619
Reference
PMID:17568790
  Authors
Boutros R, Lobjois V, Ducommun B
  Title
CDC25 phosphatases in cancer cells: key players? Good targets?
  Journal
Nat Rev Cancer 7:495-507 (2007)
DOI:10.1038/nrc2169
Reference
PMID:9832503
  Authors
Diehl JA, Cheng M, Roussel MF, Sherr CJ
  Title
Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization.
  Journal
Genes Dev 12:3499-511 (1998)
DOI:10.1101/gad.12.22.3499
Reference
PMID:19020303
  Authors
Klein EA, Assoian RK
  Title
Transcriptional regulation of the cyclin D1 gene at a glance.
  Journal
J Cell Sci 121:3853-7 (2008)
DOI:10.1242/jcs.039131
Reference
PMID:10385618
  Authors
Sherr CJ, Roberts JM
  Title
CDK inhibitors: positive and negative regulators of G1-phase progression.
  Journal
Genes Dev 13:1501-12 (1999)
DOI:10.1101/gad.13.12.1501
Reference
PMID:12809600
  Authors
Shi Y, Massague J.
  Title
Mechanisms of TGF-beta signaling from cell membrane to the nucleus.
  Journal
Cell 113:685-700 (2003)
DOI:10.1016/S0092-8674(03)00432-X
Reference
PMID:12925736
  Authors
Kamura T, Hara T, Kotoshiba S, Yada M, Ishida N, Imaki H, Hatakeyama S, Nakayama K, Nakayama KI
  Title
Degradation of p57Kip2 mediated by SCFSkp2-dependent ubiquitylation.
  Journal
Proc Natl Acad Sci U S A 100:10231-6 (2003)
DOI:10.1073/pnas.1831009100
Reference
PMID:16212951
  Authors
Bond M, Sala-Newby GB, Wu YJ, Newby AC
  Title
Biphasic effect of p21Cip1 on smooth muscle cell proliferation: role of PI 3-kinase and Skp2-mediated degradation.
  Journal
Cardiovasc Res 69:198-206 (2006)
DOI:10.1016/j.cardiores.2005.08.020
Reference
PMID:15838523
  Authors
Harris SL, Levine AJ.
  Title
The p53 pathway: positive and negative feedback loops.
  Journal
Oncogene 24:2899-908 (2005)
DOI:10.1038/sj.onc.1208615
Reference
PMID:11099028
  Authors
Vogelstein B, Lane D, Levine AJ
  Title
Surfing the p53 network.
  Journal
Nature 408:307-10 (2000)
DOI:10.1038/35042675
Reference
PMID:7973727
  Authors
Smith ML, Chen IT, Zhan Q, Bae I, Chen CY, Gilmer TM, Kastan MB, O'Connor PM, Fornace AJ Jr
  Title
Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen.
  Journal
Science 266:1376-80 (1994)
DOI:10.1126/science.7973727
Reference
PMID:9889196
  Authors
Petersen BO, Lukas J, Sorensen CS, Bartek J, Helin K
  Title
Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization.
  Journal
EMBO J 18:396-410 (1999)
DOI:10.1093/emboj/18.2.396
Reference
PMID:17018296
  Authors
Sheu YJ, Stillman B
  Title
Cdc7-Dbf4 phosphorylates MCM proteins via a docking site-mediated mechanism to promote S phase progression.
  Journal
Mol Cell 24:101-13 (2006)
DOI:10.1016/j.molcel.2006.07.033
Reference
PMID:9029154
  Authors
Martinez AM, Afshar M, Martin F, Cavadore JC, Labbe JC, Doree M
  Title
Dual phosphorylation of the T-loop in cdk7: its role in controlling cyclin H binding and CAK activity.
  Journal
EMBO J 16:343-54 (1997)
DOI:10.1093/emboj/16.2.343
Reference
PMID:15876871
  Authors
Lolli G, Johnson LN
  Title
CAK-Cyclin-dependent Activating Kinase: a key kinase in cell cycle control and a target for drugs?
  Journal
Cell Cycle 4:572-7 (2005)
DOI:10.4161/cc.4.4.1607
Reference
PMID:17426725
  Authors
Musacchio A, Salmon ED
  Title
The spindle-assembly checkpoint in space and time.
  Journal
Nat Rev Mol Cell Biol 8:379-93 (2007)
DOI:10.1038/nrm2163
Reference
PMID:12573239
  Authors
Uhlmann F
  Title
Chromosome cohesion and separation: from men and molecules.
  Journal
Curr Biol 13:R104-14 (2003)
DOI:10.1016/S0960-9822(03)00039-3
Reference
PMID:15568976
  Authors
Stegmeier F, Amon A
  Title
Closing mitosis: the functions of the Cdc14 phosphatase and its regulation.
  Journal
Annu Rev Genet 38:203-32 (2004)
DOI:10.1146/annurev.genet.38.072902.093051
Reference
PMID:9618481
  Authors
Moustakas A, Kardassis D
  Title
Regulation of the human p21/WAF1/Cip1 promoter in hepatic cells by functional interactions between Sp1 and Smad family members.
  Journal
Proc Natl Acad Sci U S A 95:6733-8 (1998)
DOI:10.1073/pnas.95.12.6733
Reference
PMID:26650195
  Authors
de Boer HR, Guerrero Llobet S, van Vugt MA
  Title
Controlling the response to DNA damage by the APC/C-Cdh1.
  Journal
Cell Mol Life Sci 73:949-60 (2016)
DOI:10.1007/s00018-015-2096-7
Reference
PMID:20935501
  Authors
Qiao X, Zhang L, Gamper AM, Fujita T, Wan Y
  Title
APC/C-Cdh1: from cell cycle to cellular differentiation and genomic integrity.
  Journal
Cell Cycle 9:3904-12 (2010)
DOI:10.4161/cc.9.19.13585
Related
pathway
amex03030  DNA replication
amex04010  MAPK signaling pathway
amex04120  Ubiquitin mediated proteolysis
amex04210  Apoptosis
KO pathway
ko04110   
LinkDB

DBGET integrated database retrieval system