KEGG   PATHWAY: amex04010
Entry
amex04010                   Pathway                                
Name
MAPK signaling pathway - Astyanax mexicanus (Mexican tetra)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
amex04010  MAPK signaling pathway
amex04010

Disease
H02157  Short-rib thoracic dysplasia
Other DBs
GO: 0000165
Organism
Astyanax mexicanus (Mexican tetra) [GN:amex]
Gene
103021325  traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
103021450  efna1b; ephrin-A1b [KO:K05462]
103021516  hrasa; HRas proto-oncogene, GTPase a [KO:K02833]
103021658  [KO:K04348] [EC:3.1.3.16]
103021719  taok2b; serine/threonine-protein kinase TAO2 isoform X3 [KO:K04429] [EC:2.7.11.1]
103021852  tek; tyrosine-protein kinase receptor Tie-2 isoform X1 [KO:K05121] [EC:2.7.10.1]
103021920  june; junE proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
103021949  rps6ka3b; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
103022071  ntf3; neurotrophin-3 [KO:K04356]
103022197  [KO:K04359]
103022233  tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
103022292  cacna1sb; calcium channel, voltage-dependent, L type, alpha 1S subunit, b [KO:K04857]
103022298  kita; mast/stem cell growth factor receptor kita isoform X1 [KO:K05091] [EC:2.7.10.1]
103022553  [KO:K04723]
103022603  kdr; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
103022608  cacng8a; calcium channel, voltage-dependent, gamma subunit 8a [KO:K04873]
103022868  rap1ab; ras-related protein rap1ab [KO:K04353]
103022888  [KO:K04362] [EC:2.7.10.1]
103022965  pak2b; serine/threonine-protein kinase PAK 2b isoform X1 [KO:K04410] [EC:2.7.11.1]
103022996  ddit3; DNA damage-inducible transcript 3 protein [KO:K04452]
103023114  cacng6a; calcium channel, voltage-dependent, gamma subunit 6a [KO:K04871]
103023138  maptb; microtubule-associated protein tau isoform X1 [KO:K04380]
103023150  ptpn5; tyrosine-protein phosphatase non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
103023165  dusp7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
103023232  [KO:K04392]
103023241  prkacab; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
103023376  fgf16; fibroblast growth factor 16 [KO:K04358]
103023390  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
103023428  cacng7a; calcium channel, voltage-dependent, gamma subunit 7a [KO:K04872]
103023536  zgc:55558; GTPase KRas [KO:K07827]
103023550  nf1a; neurofibromin isoform X1 [KO:K08052]
103023809  flt3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
103023930  met; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
103024018  gna12a; guanine nucleotide-binding protein subunit alpha-12a [KO:K04346]
103024122  igf2b; insulin-like growth factor 2b [KO:K13769]
103024196  ppm1na; protein phosphatase, Mg2+/Mn2+ dependent, 1Na (putative) [KO:K04457] [EC:3.1.3.16]
103024363  map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
103024372  cacna1eb; voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
103024377  ppm1ba; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
103024512  mapkapk2b; MAP kinase-activated protein kinase 2b [KO:K04443] [EC:2.7.11.1]
103024574  dusp16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
103024575  akt3a; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
103024607  tgfb1a; transforming growth factor, beta 1a [KO:K13375]
103024805  cacna2d2a; voltage-dependent calcium channel subunit alpha-2/delta-2a isoform X1 [KO:K04859]
103024922  cacna1aa; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X18 [KO:K04344]
103024961  fgfr2; fibroblast growth factor receptor 2 isoform X2 [KO:K05093] [EC:2.7.10.1]
103024963  prkacaa; protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a isoform X1 [KO:K04345] [EC:2.7.11.11]
103024973  kitb; KIT proto-oncogene, receptor tyrosine kinase b isoform X2 [KO:K05091] [EC:2.7.10.1]
103025067  ppm1aa; protein phosphatase 1A isoform X1 [KO:K04457] [EC:3.1.3.16]
103025260  ntrk1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
103025376  taok1a; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
103025383  casp3b; caspase-3b [KO:K02187] [EC:3.4.22.56]
103025658  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
103025711  fgf17; fibroblast growth factor 17 isoform X1 [KO:K04358]
103025839  [KO:K25416]
103025965  rasgrp2; RAS guanyl-releasing protein 2 [KO:K12361]
103025973  prkcbb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
103026112  tgfb2; transforming growth factor beta-2 proprotein [KO:K13376]
103026117  daxx; death domain-associated protein 6 isoform X1 [KO:K02308]
103026177  fgf22; fibroblast growth factor 22 [KO:K04358]
103026214  [KO:K04519]
103026282  rps6ka3a; ribosomal protein S6 kinase alpha-1 [KO:K04373] [EC:2.7.11.1]
103026300  map4k3b; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
103026516  epha2b; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
103026554  fgf9; fibroblast growth factor 4A [KO:K04358]
103026692  [KO:K25415]
103026704  map3k2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
103026868  jun; transcription factor AP-1 [KO:K04448]
103026913  flna; filamin-A isoform X1 [KO:K04437]
103026930  [KO:K04456] [EC:2.7.11.1]
103027187  cacna2d1a; voltage-dependent calcium channel subunit alpha-2/delta-1a [KO:K04858]
103027336  cacng8b; voltage-dependent calcium channel gamma-4 subunit [KO:K04873]
103027348  fgf1a; putative fibroblast growth factor 1 [KO:K18496]
103027441  faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
103027486  map2k5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
103027492  stk3; serine/threonine-protein kinase 3 [KO:K04412]
103027563  rras2; ras-related protein R-Ras2 [KO:K07830]
103027656  igf3; insulin-like growth factor 3 [KO:K13769]
103027732  mapk8ip2; C-Jun-amino-terminal kinase-interacting protein 2 isoform X1 [KO:K04435]
103027859  cacng6b; voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
103027860  cacnb2b; voltage-dependent L-type calcium channel subunit beta-2b isoform X1 [KO:K04863]
103027930  raf1b; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
103027942  atf4a; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
103027970  nlk1; nemo-like kinase, type 1 [KO:K04468] [EC:2.7.11.24]
103027987  nfkb2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
103028053  erbb3a; receptor tyrosine-protein kinase erbB-3a isoform X1 [KO:K05084] [EC:2.7.10.1]
103028069  atf2; cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
103028079  arrb2a; arrestin, beta 2a isoform X1 [KO:K04439]
103028137  mapk14b; mitogen-activated protein kinase 14B isoform X1 [KO:K04441] [EC:2.7.11.24]
103028205  mknk1; MAP kinase-interacting serine/threonine-protein kinase 1 [KO:K04372] [EC:2.7.11.1]
103028261  traf2b; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
103028303  rps6ka1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
103028375  cacng7b; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
103028386  jund; transcription factor jun-D [KO:K04449]
103028458  map4k3a; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
103028544  insb; preproinsulin b [KO:K04526]
103028577  sos1; son of sevenless homolog 1 isoform X1 [KO:K03099]
103028592  srfa; serum response factor a isoform X1 [KO:K04378]
103028598  taok2a; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
103028644  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
103028645  dusp8a; dual specificity protein phosphatase 8 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
103028663  ret; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
103028778  cacna1ba; calcium channel, voltage-dependent, N type, alpha 1B subunit, a isoform X1 [KO:K04849]
103028810  efna5a; ephrin-A5 [KO:K05462]
103029075  nfatc3a; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
103029246  mrasa; ras-related protein M-Ras [KO:K07831]
103029257  vegfab; vascular endothelial growth factor Ab isoform X1 [KO:K05448]
103029308  prkacba; protein kinase, cAMP-dependent, catalytic, beta a isoform X1 [KO:K04345] [EC:2.7.11.11]
103029321  [KO:K05085] [EC:2.7.10.1]
103029408  taok3b; serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
103029481  fgf18a; fibroblast growth factor 18a isoform X1 [KO:K04358]
103029638  gadd45aa; growth arrest and DNA-damage-inducible, alpha, a [KO:K04402]
103029669  dusp4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
103029856  cacng2a; calcium channel, voltage-dependent, gamma subunit 2a [KO:K04867]
103029863  hspb15; heat shock protein, alpha-crystallin-related, b15 [KO:K04455]
103029900  gdnfb; glial cell line-derived neurotrophic factor [KO:K05452]
103029904  fgfr4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
103029952  fgf20a; fibroblast growth factor 20a [KO:K04358]
103030026  mapk7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
103030085  angpt2b; angiopoietin-2b isoform X1 [KO:K05466]
103030099  ins; insulin [KO:K04526]
103030200  [KO:K04852]
103030248  nfatc3b; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
103030496  dusp6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
103030512  map2k2b; dual specificity mitogen-activated protein kinase kinase 2b [KO:K04369] [EC:2.7.12.2]
103030522  vegfd; vascular endothelial growth factor D isoform X1 [KO:K05449]
103030564  [KO:K22428]
103030601  ngfa; neurotrophin-7 [KO:K02582]
103030644  pla2g4f.1; cytosolic phospholipase A2 zeta isoform X1 [KO:K16342] [EC:3.1.1.4]
103030690  [KO:K04859]
103030712  fgf20b; fibroblast growth factor 20b [KO:K04358]
103030718  taok1b; serine/threonine-protein kinase TAO1 isoform X1 [KO:K04429] [EC:2.7.11.1]
103031013  ecsit; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial [KO:K04405]
103031085  nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
103031091  [KO:K04419] [EC:2.7.11.25]
103031124  si:dkey-246i14.3; ephrin-A4 [KO:K05462]
103031239  mrasb; ras-related protein M-Ras [KO:K07831]
103031259  map3k8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
103031296  cacnb4a; voltage-dependent L-type calcium channel subunit beta-4a isoform X1 [KO:K04865]
103031363  cacng4b; calcium channel, voltage-dependent, gamma subunit 4b [KO:K04869]
103031426  fgf19; fibroblast growth factor 19 [KO:K22603]
103031435  efna3b; ephrin-A3b isoform X1 [KO:K05462]
103031546  map3k10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
103031629  egfra; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
103031633  ngfb; nerve growth factor [KO:K02582]
103031683  pdgfab; platelet-derived growth factor alpha polypeptide b [KO:K04359]
103031725  tgfbr2b; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
103031729  relb; transcription factor RelB isoform X1 [KO:K09253]
103031804  gdnfa; glial cell line-derived neurotrophic factor [KO:K05452]
103031965  map3k20a; mitogen-activated protein kinase kinase kinase 20 isoform X3 [KO:K04424] [EC:2.7.11.25]
103032041  rela; transcription factor p65 isoform X1 [KO:K04735]
103032103  erbb3b; receptor tyrosine-protein kinase erbB-3b [KO:K05084] [EC:2.7.10.1]
103032151  si:ch211-45c16.2; mitogen-activated protein kinase kinase kinase 13 isoform X1 [KO:K04422] [EC:2.7.11.25]
103032203  [KO:K04856]
103032355  flt1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
103032375  fgf3; fibroblast growth factor 3 [KO:K04358]
103032408  cacna2d3a; voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
103032478  ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
103032492  [KO:K04361] [EC:2.7.10.1]
103032568  tnfa; tumor necrosis factor a (TNF superfamily, member 2) [KO:K03156]
103032630  cacng1b; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
103032641  pdgfbb; uncharacterized protein pdgfbb [KO:K04359]
103032722  cacna1ia; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
103032786  tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
103032923  tgfb3; transforming growth factor beta-3 proprotein [KO:K13377]
103033000  map3k5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
103033069  tgfb1b; transforming growth factor beta-1 proprotein [KO:K13375]
103033234  map4k2; mitogen-activated protein kinase kinase kinase kinase 2 [KO:K04414] [EC:2.7.11.1]
103033357  cacna1db; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
103033415  chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
103033484  fgf7; fibroblast growth factor 7 [KO:K04358]
103033501  mapkapk2a; MAP kinase-activated protein kinase 2 isoform X1 [KO:K04443] [EC:2.7.11.1]
103033543  [KO:K05085] [EC:2.7.10.1]
103033612  angpt1; angiopoietin-1 isoform X1 [KO:K05465]
103033838  [KO:K05460]
103033875  nr4a1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
103033879  arrb1; beta-arrestin-1 [KO:K04439]
103033957  cacna1fb; calcium channel, voltage-dependent, L type, alpha 1F subunit isoform X2 [KO:K04853]
103033971  ngfrb; nerve growth factor receptor b [KO:K02583]
103033988  dusp5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
103033997  myca; transcriptional regulator Myc-A [KO:K04377]
103034053  rac1a; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
103034112  prkacbb; protein kinase, cAMP-dependent, catalytic, beta b [KO:K04345] [EC:2.7.11.11]
103034138  mapk8a; mitogen-activated protein kinase 8 isoform X3 [KO:K04440] [EC:2.7.11.24]
103034175  tgfbr1b; TGF-beta receptor type-1b [KO:K04674] [EC:2.7.11.30]
103034242  pla2g4ab; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
103034295  cacna1fa; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
103034298  cacnb1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
103034300  [KO:K25415]
103034315  dusp3a; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
103034322  rapgef2b; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
103034375  cacna1ab; calcium channel, voltage-dependent, P/Q type, alpha 1A subunit, b isoform X1 [KO:K04344]
103034468  cdc42l2; cell division cycle 42 like 2 [KO:K04393]
103034487  max; protein max isoform X1 [KO:K04453]
103034521  mapk8ip1b; C-Jun-amino-terminal kinase-interacting protein 1 isoform X2 [KO:K04434]
103034548  ppp5c; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
103034573  pla2g4aa; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
103034577  elk1; ETS domain-containing protein Elk-3 [KO:K04375]
103034596  map3k3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
103034617  kitlga; kit ligand a [KO:K05461]
103034712  mef2cb; myocyte enhancer factor 2cb isoform X2 [KO:K04454]
103034736  insrb; insulin receptor b [KO:K04527] [EC:2.7.10.1]
103034961  cdc25b; M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
103034963  fgf18b; fibroblast growth factor 18b [KO:K04358]
103034979  mef2ca; myocyte enhancer factor 2ca isoform X1 [KO:K04454]
103035144  cacna2d3; voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1 [KO:K04860]
103035182  angpt2a; angiopoietin-2a [KO:K05466]
103035254  rap1b; ras-related protein Rap-1b [KO:K07836]
103035300  cacnb2a; voltage-dependent L-type calcium channel subunit beta-2 isoform X2 [KO:K04863]
103035319  mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
103035330  fgf8a; fibroblast growth factor 8 precursor [KO:K04358]
103035447  vegfaa; vascular endothelial growth factor A-A isoform X1 [KO:K05448]
103035481  ppm1bb; protein phosphatase 1bb isoform X1 [KO:K04461] [EC:3.1.3.16]
103035530  crk; adapter molecule crk [KO:K04438]
103035578  mapk8ip3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
103035641  mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
103035730  bdnf; brain-derived neurotrophic factor isoform X2 [KO:K04355]
103035785  ppm1ab; protein phosphatase, Mg2+/Mn2+ dependent, 1Ab [KO:K04457] [EC:3.1.3.16]
103035815  taok3a; serine/threonine-protein kinase TAO3 isoform X1 [KO:K04429] [EC:2.7.11.1]
103035872  rasa1a; ras GTPase-activating protein 1 isoform X1 [KO:K04352]
103035950  cacnb3a; voltage-dependent L-type calcium channel subunit beta-3a isoform X1 [KO:K04864]
103035956  mapk12b; mitogen-activated protein kinase 12b [KO:K04441] [EC:2.7.11.24]
103036012  prkcba; protein kinase C, beta a isoform X1 [KO:K19662] [EC:2.7.11.13]
103036105  cacna1sa; calcium channel, voltage-dependent, L type, alpha 1S subunit, a [KO:K04857]
103036194  gadd45bb; growth arrest and DNA-damage-inducible, beta b [KO:K04402]
103036238  igf1; insulin-like growth factor I [KO:K05459]
103036243  rapgef2a; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
103036267  fgf6a; fibroblast growth factor 6a [KO:K04358]
103036359  gadd45ga; growth arrest and DNA-damage-inducible, gamma a [KO:K04402]
103036375  traf2a; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
103036376  rasa2; ras GTPase-activating protein 2 [KO:K08053]
103036414  ntrk2a; neurotrophic tyrosine kinase, receptor, type 2a [KO:K04360] [EC:2.7.10.1]
103036428  [KO:K05462]
103036450  mknk2a; MAP kinase-interacting serine/threonine-protein kinase 2a [KO:K04372] [EC:2.7.11.1]
103036483  pdgfrb; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
103036630  rps6ka2; ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
103036705  fosaa; protein c-Fos [KO:K04379]
103036708  cacnb3b; voltage-dependent L-type calcium channel subunit beta-4 [KO:K04864]
103036713  mapkapk5; MAP kinase-activated protein kinase 5 [KO:K04442] [EC:2.7.11.1]
103036820  [KO:K04386]
103036914  fgfr1a; fibroblast growth factor receptor 1-A isoform X1 [KO:K04362] [EC:2.7.10.1]
103036930  braf; serine/threonine-protein kinase B-raf isoform X2 [KO:K04365] [EC:2.7.11.1]
103037189  [KO:K04453]
103037278  arrb2b; arrestin, beta 2b [KO:K04439]
103037312  efna5b; ephrin-A5b [KO:K05462]
103037384  ppp3r1a; calcineurin subunit B type 1 [KO:K06268]
103037386  sos2; son of sevenless homolog 2 [KO:K03099]
103037427  [KO:K04451]
103037538  igf1ra; insulin-like growth factor 1a receptor [KO:K05087] [EC:2.7.10.1]
103037551  nlk2; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
103037777  si:ch211-79m20.1; bromodomain-containing protein 4B isoform X1 [KO:K17386]
103037892  fgf2; fibroblast growth factor 2 [KO:K18497]
103037902  flt4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
103037904  cacna1bb; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
103037950  kitlgb; kit ligand b [KO:K05461]
103037975  pak1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
103038099  [KO:K05085] [EC:2.7.10.1]
103038106  [KO:K04411]
103038135  fgf1b; fibroblast growth factor 1b [KO:K18496]
103038138  cacna1ha; voltage-dependent T-type calcium channel subunit alpha-1H isoform X2 [KO:K04855]
103038163  gadd45ab; growth arrest and DNA-damage-inducible, alpha, b [KO:K04402]
103038167  mycb; transcriptional regulator Myc-B [KO:K04377]
103038175  dusp2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
103038185  [KO:K25414]
103038226  rasgrf2b; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
103038241  kras; GTPase KRas isoform X1 [KO:K07827]
103038360  si:ch211-1i11.3; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
103038437  dusp1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
103038496  gng12b; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
103038577  tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
103038588  kdrl; vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
103038595  pak2a; serine/threonine-protein kinase PAK 2a [KO:K04410] [EC:2.7.11.1]
103038695  mapkapk3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
103038869  nfkb1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
103038949  [KO:K04438]
103039001  casp3a; caspase-3a [KO:K02187] [EC:3.4.22.56]
103039224  [KO:K04402]
103039333  map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
103039366  ppp3cca; protein phosphatase 3, catalytic subunit, gamma isozyme, a isoform X1 [KO:K04348] [EC:3.1.3.16]
103039395  rps6kal; ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
103039436  hsp70.3; heat shock cognate 70-kd protein, tandem duplicate 3 [KO:K03283]
103039445  insra; insulin receptor a [KO:K04527] [EC:2.7.10.1]
103039485  [KO:K04424] [EC:2.7.11.25]
103039613  [KO:K04393]
103039626  csf1ra; macrophage colony-stimulating factor 1 receptor isoform X1 [KO:K05090] [EC:2.7.10.1]
103039914  nras; GTPase NRas [KO:K07828]
103039925  [KO:K04867]
103040024  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
103040103  hrasb; HRas proto-oncogene, GTPase b [KO:K02833]
103040186  akt3b; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
103040240  stmn1b; stathmin 1b [KO:K04381]
103040333  mapk12a; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
103040527  nf1b; neurofibromin [KO:K08052]
103040566  rasgrp4; RAS guanyl-releasing protein 4 isoform X1 [KO:K04350]
103040580  mapk8b; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
103040584  dusp10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
103040612  rasgrp3; ras guanyl-releasing protein 3 [KO:K12362]
103040659  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
103040737  pdgfc; platelet-derived growth factor C [KO:K05450]
103040754  rasgrf2a; LOW QUALITY PROTEIN: ras-specific guanine nucleotide-releasing factor 2 [KO:K12326]
103040841  [KO:K04465]
103040978  rps6ka4; ribosomal protein S6 kinase alpha-4 [KO:K16510] [EC:2.7.11.1]
103041078  cacnb4b; voltage-dependent L-type calcium channel subunit beta-4b isoform X1 [KO:K04865]
103041310  ptprr; receptor-type tyrosine-protein phosphatase R isoform X1 [KO:K04458] [EC:3.1.3.48]
103041389  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
103041474  cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
103041634  map4k6; mitogen-activated protein kinase kinase kinase kinase 6 [KO:K04414] [EC:2.7.11.1]
103041713  [KO:K04407] [EC:2.7.11.1]
103041971  [KO:K04526]
103042110  zgc:171775; STKc_p38 domain-containing protein [KO:K04441] [EC:2.7.11.24]
103042184  cacng4a; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
103042386  ppm1nb; protein phosphatase, Mg2+/Mn2+ dependent, 1Nb (putative) [KO:K04457] [EC:3.1.3.16]
103042398  cacna2d4a; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
103042404  cacna2d4b; voltage-dependent calcium channel subunit alpha-2/delta-4 isoform X1 [KO:K04861]
103042447  mecom; MDS1 and EVI1 complex locus protein EVI1-A isoform X13 [KO:K04462] [EC:2.1.1.367]
103042476  tgfb5; transforming growth factor beta-2 proprotein [KO:K13376]
103042500  efna3a; ephrin-A3 [KO:K05462]
103042501  cacng1a; calcium channel, voltage-dependent, gamma subunit 1a [KO:K04866]
103042517  map3k1; mitogen-activated protein kinase kinase kinase 1 isoform X2 [KO:K04416] [EC:2.7.11.25]
103042520  hspb1; heat shock protein beta-1 [KO:K04455]
103042551  gadd45ba; growth arrest and DNA-damage-inducible, beta a [KO:K04402]
103042559  tgfbr2a; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
103042710  rps6ka5; ribosomal protein S6 kinase alpha-5 [KO:K04445] [EC:2.7.11.1]
103042822  map3k21; mitogen-activated protein kinase kinase kinase 21 isoform X1 [KO:K17534] [EC:2.7.11.25]
103042824  prkcg; protein kinase C alpha type [KO:K19663] [EC:2.7.11.13]
103042847  ppp3r1b; calcineurin subunit B type 1b [KO:K06268]
103042851  erbb2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
103042907  cacng5a; calcium channel, voltage-dependent, gamma subunit 5a isoform X1 [KO:K04870]
103042923  fgf4; fibroblast growth factor 4 [KO:K04358]
103042940  map2k4b; dual specificity mitogen-activated protein kinase kinase 4b isoform X1 [KO:K04430] [EC:2.7.12.2]
103042954  si:ch211-153j24.3; protein c-Fos [KO:K04379]
103043016  elk4; ETS domain-containing protein Elk-4 [KO:K04376]
103043065  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
103043112  mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
103043117  [KO:K04350]
103043155  cacna1g; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
103043165  csf1rb; macrophage colony-stimulating factor 1 receptor 1 [KO:K05090] [EC:2.7.10.1]
103043175  nrtn; neurturin [KO:K25414]
103043278  fosab; v-fos FBJ murine osteosarcoma viral oncogene homolog Ab [KO:K04379]
103043321  map3k14a; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
103043364  hspa8; heat shock cognate 71 kDa protein [KO:K03283]
103043494  mknk2b; MAP kinase-interacting serine/threonine-protein kinase 2b [KO:K04372] [EC:2.7.11.1]
103043654  araf; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
103043830  efna1a; ephrin-A1a [KO:K05462]
103043929  ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
103043949  ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
103043955  hspa1b; heat shock 70 kDa protein-like [KO:K03283]
103043956  cacna1da; calcium channel, voltage-dependent, L type, alpha 1D subunit, a isoform X2 [KO:K04851]
103044047  prkcaa; protein kinase C, alpha, a [KO:K02677] [EC:2.7.11.13]
103044147  [KO:K04858]
103044160  ntrk2b; neurotrophic tyrosine kinase, receptor, type 2b [KO:K04360] [EC:2.7.10.1]
103044166  myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
103044218  map4k4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
103044222  irak1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
103044267  pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
103044273  mapk8ip1a; C-Jun-amino-terminal kinase-interacting protein 1a [KO:K04434]
103044277  crkl; crk-like protein [KO:K04438]
103044388  dusp8b; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
103044488  cacng3a; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
103044858  tgfa; protransforming growth factor alpha isoform X1 [KO:K08774]
103044871  rasgrf1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
103044968  map3k22; mitogen-activated protein kinase kinase kinase 22 [KO:K04421] [EC:2.7.11.25]
103045018  map2k4a; dual specificity mitogen-activated protein kinase kinase 4a isoform X1 [KO:K04430] [EC:2.7.12.2]
103045058  fgfr3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
103045210  [KO:K04446]
103045269  igf2a; insulin-like growth factor 2a [KO:K13769]
103045439  igf1rb; insulin-like growth factor 1b receptor [KO:K05087] [EC:2.7.10.1]
103045444  pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
103045744  csf1a; macrophage colony-stimulating factor 1a [KO:K05453]
103045816  hsc70; heat shock cognate 71 kDa protein [KO:K03283]
103045891  nradd; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
103045938  hgfa; hepatocyte growth factor a isoform X1 [KO:K05460]
103045988  stmn1a; stathmin [KO:K04381]
103046070  cdc42; cell division control protein 42 homolog isoform X1 [KO:K04393]
103046193  ppp3ccb; protein phosphatase 3, catalytic subunit, gamma isozyme, b isoform X1 [KO:K04348] [EC:3.1.3.16]
103046249  irak4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
103046281  map3k4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
103046288  epha2a; ephrin type-A receptor 2a [KO:K05103] [EC:2.7.10.1]
103046441  efna2a; ephrin-A2 [KO:K05462]
103046526  fgf10b; fibroblast growth factor 10b [KO:K04358]
103046562  map3k12; mitogen-activated protein kinase kinase kinase 12 isoform X1 [KO:K04423] [EC:2.7.11.25]
103046657  fas; uncharacterized protein fas isoform X1 [KO:K04390]
103046713  grb2a; growth factor receptor-bound protein 2a [KO:K04364]
103046742  tp53; cellular tumor antigen p53 isoform X1 [KO:K04451]
103046764  fgf24; fibroblast growth factor 24 isoform X1 [KO:K04358]
103046990  [KO:K12361]
103046996  mapk14a; mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
103047011  rap1aa; RAP1A, member of RAS oncogene family a [KO:K04353]
103047036  lamtor3; ragulator complex protein LAMTOR3 [KO:K04370]
103047038  tgfbr2l; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
103047109  rac3a; ras-related C3 botulinum toxin substrate 3a [KO:K07861]
103047161  [KO:K04466] [EC:2.7.11.25]
103047218  cdc42l; cell division cycle 42, like [KO:K04393]
103047251  cacng3b; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
103047285  rras; ras-related protein R-Ras [KO:K07830]
103047344  hspa8b; heat shock protein family A (Hsp70) member 8b [KO:K03283]
103047585  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
103047588  si:ch211-195b15.8; tyrosine-protein phosphatase vhp-1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
103047603  fgf8b; fibroblast growth factor 8b [KO:K04358]
103047689  [KO:K04455]
103047794  mapta; microtubule-associated protein tau isoform X7 [KO:K04380]
107196809  srfb; serum response factor b isoform X1 [KO:K04378]
107196998  gng12a; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12a [KO:K04347]
107197750  fosl1b; protein c-Fos [KO:K04379]
107197829  pgfa; vascular endothelial growth factor A [KO:K16859]
111191028  grb2b; growth factor receptor-bound protein 2b [KO:K04364]
111191033  ngfra; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
111191037  [KO:K04347]
111191377  dusp3b; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
111191476  fgf10a; fibroblast growth factor 10a [KO:K04358]
111191499  map2k6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
111191504  [KO:K22429]
111191781  vegfc; vascular endothelial growth factor C [KO:K05449]
111192386  rac3b; ras-related C3 botulinum toxin substrate 3b [KO:K07861]
111192909  prkcab; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
111192910  cacng5b; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
111192975  rac1b; ras-related C3 botulinum toxin substrate 1b isoform X1 [KO:K04392]
111193007  rac2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
111193096  fgf21; fibroblast growth factor 21 isoform X2 [KO:K22429]
111193176  hsp70.1; heat shock cognate 70-kd protein, tandem duplicate 1 isoform X2 [KO:K03283]
111194918  [KO:K04392]
111194997  [KO:K04519]
111196468  [KO:K04386]
125781108  pgfb; placenta growth factor [KO:K16859]
125782187  map2k2a; dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
125782414  [KO:K04402]
125784446  [KO:K17614] [EC:3.1.3.16 3.1.3.48]
125785888  [KO:K05085] [EC:2.7.10.1]
125785907  [KO:K05085] [EC:2.7.10.1]
125788938  [KO:K04388] [EC:2.7.11.30]
125799130  fgf23; fibroblast growth factor 23 [KO:K22428]
125799131  fgf6b; fibroblast growth factor 6b [KO:K04358]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
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Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
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MAP kinases.
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Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
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Tanoue T, Nishida E.
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Docking interactions in the mitogen-activated protein kinase cascades.
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Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
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Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
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MAPK pathways in radiation responses.
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Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
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Huang EJ, Reichardt LF.
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Trk receptors: roles in neuronal signal transduction.
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Annu Rev Biochem 72:609-42 (2003)
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Reference
PMID:11369511
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Harper SJ, LoGrasso P.
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Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
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Cell Signal 13:299-310 (2001)
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Reference
PMID:12390245
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Takeda K, Ichijo H
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Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
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Genes Cells 7:1099-111 (2002)
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PMID:14597384
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Yang SH, Sharrocks AD, Whitmarsh AJ.
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Transcriptional regulation by the MAP kinase signaling cascades.
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Gene 320:3-21 (2003)
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PMID:12566928
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Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
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The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
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Neurosignals 11:270-81 (2002)
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Reference
PMID:12849693
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Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
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Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
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Toxicol Lett 143:323-30 (2003)
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PMID:20602996
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Lemmon MA, Schlessinger J
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Cell signaling by receptor tyrosine kinases.
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Cell 141:1117-34 (2010)
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Reference
PMID:22367796
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Skaper SD
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The neurotrophin family of neurotrophic factors: an overview.
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Methods Mol Biol 846:1-12 (2012)
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PMID:23085193
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Chu WM
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Tumor necrosis factor.
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Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
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Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
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Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
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Gaestel M, Kotlyarov A, Kracht M
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Targeting innate immunity protein kinase signalling in inflammation.
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Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
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Ajibade AA, Wang HY, Wang RF
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Cell type-specific function of TAK1 in innate immune signaling.
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Trends Immunol 34:307-16 (2013)
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Reference
PMID:24892271
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Turner MD, Nedjai B, Hurst T, Pennington DJ
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Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
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Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
amex04070  Phosphatidylinositol signaling system
amex04110  Cell cycle
amex04115  p53 signaling pathway
amex04210  Apoptosis
amex04310  Wnt signaling pathway
KO pathway
ko04010   

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